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Artikel ; Online: Fat embolism and COVID-19 infection: autopsy and post-mortem laboratory findings in SARS-CoV-2 positive patients.

Gavronova, Adriana / Hamerlik, Lukas / Bartkova, Margita / Svrchokryl, Vaclav / Kralikova, Veronika / Vranova, Katerina / Ondra, Peter / Dobias, Martin

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia

2024

Abstract: Introduction: The article is one of the very first autopsy reports worldwide, which associates COVID-19 infection and pulmonary fat embolism.: Aims: To point to a crucial connection between a severe acute respiratory syndrome caused by coronavirus 2 ( ...

Abstract	Introduction: The article is one of the very first autopsy reports worldwide, which associates COVID-19 infection and pulmonary fat embolism. Aims: To point to a crucial connection between a severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) infection and pulmonary fat embolism as one of the possible major mechanisms of severe COVID-19 symptoms. Methods: Lung, brain and kidney tissues examination of 16 full human autopsy cases. All deceased suffered from COVID-19 infection, none of them was admitted to hospital prior to death, immediate causes of death vary. Autopsies accompanied by microbiological examination and histological examination using Oil Red O staining were performed. Consequently, we have implemented a control cohort consisting of 16 deceased with no presence of pulmonary infection and various immediate causes of death. Results: Of the 16 autopsy cases, 11 (68.8%) were males and 5 (31.3%) females, with overall mean age 68.1 (39-86) years. Causes of death of studied subjects were natural, mostly from respiratory failure (in 12 cases, 75%). Cardiopulmonary resuscitation was performed in 7 cases (43.8%). None of dissected persons had larger signs of body trauma. Pulmonary fat embolism was found in 11 cases (68.8%), which generalised to kidneys in 8 patients (50% of all cases, 72.3% of cases with pulmonary fat embolism) and to brain tissue in 1 case. Conclusion: We demonstrated a reasonable relation between a COVID-19 disease and a variously severe fat embolism, severity of which does not directly correlate with body weight. Further investigation or even change of medical treatment needs to be considered in patients with COVID-19.
Sprache	Englisch
Erscheinungsdatum	2024-05-28
Erscheinungsland	Czech Republic
Dokumenttyp	Journal Article
ZDB-ID	17196-7
ISSN	1804-7521 ; 1213-8118 ; 0231-5599 ; 0862-481X
ISSN (online)	1804-7521
ISSN	1213-8118 ; 0231-5599 ; 0862-481X
DOI	10.5507/bp.2024.014
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Traumatic dislocation of the eye into the maxillary sinus: Case report and literature review.

Vránová, Kateřina / Chytilová, Karin / Dobiáš, Martin / Tvrdý, Peter / Handlos, Petr

Journal of forensic sciences

2021 Band 66, Heft 5, Seite(n) 2002–2005

Abstract: Traumatic dislocation of the eye is usually encountered in high-energy injuries. These include traffic accidents, accidents at work, sporting accidents, falling from a height, impact of the hooves or horns of animals, gunshot injuries, and physical ... ...

Abstract	Traumatic dislocation of the eye is usually encountered in high-energy injuries. These include traffic accidents, accidents at work, sporting accidents, falling from a height, impact of the hooves or horns of animals, gunshot injuries, and physical assault. Such incidents are accompanied by facial soft tissue damage and injuries to the facial skeleton, especially the orbit, and can be associated with varying degrees of dislocation of the eye. We describe a rare case of non-fatal traumatic eye dislocation into the maxillary sinus, coupled with an orbital fracture resulting from a physical assault on a 63-year-old woman. The cause of death was asphyxiation due to manual strangulation and mechanical asphyxia. Even though dislocations of the eye are relatively rare, forensic pathologists should be aware of such injuries to correct assessment of injury mechanism. The available literature regarding eye dislocation is summarized, and the forensic issues applicable to the assessment of such cases are reviewed.
Mesh-Begriff(e)	Asphyxia/etiology ; Eye Injuries/complications ; Female ; Fracture Dislocation/etiology ; Homicide ; Humans ; Maxillary Sinus ; Middle Aged ; Neck Injuries/complications ; Orbital Fractures/etiology ; Prolapse
Sprache	Englisch
Erscheinungsdatum	2021-04-25
Erscheinungsland	United States
Dokumenttyp	Case Reports ; Journal Article ; Review
ZDB-ID	219216-0
ISSN	1556-4029 ; 0022-1198
ISSN (online)	1556-4029
ISSN	0022-1198
DOI	10.1111/1556-4029.14742
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Indeterminacy of the Diagnosis of Sudden Infant Death Syndrome Leading to Problems with the Validity of Data.

Olecká, Ivana / Dobiáš, Martin / Lemrová, Adéla / Ivanová, Kateřina / Fürst, Tomáš / Krajsa, Jan / Handlos, Petr

Diagnostics (Basel, Switzerland)

2022 Band 12, Heft 7

Abstract: The validity of infant mortality data is essential in assessing health care quality and in the setting of preventive measures. This study explores different diagnostic procedures used to determine the cause of death across forensic settings and thus the ... ...

Abstract	The validity of infant mortality data is essential in assessing health care quality and in the setting of preventive measures. This study explores different diagnostic procedures used to determine the cause of death across forensic settings and thus the issue of the reduced validity of data. All records from three forensic medical departments that conducted autopsies on children aged 12 months or younger (n = 204) who died during the years 2007-2016 in Moravia were included. Differences in diagnostic procedures were found to be statistically significant. Each department works with a different set of risk factors and places different emphasis on different types of examination. The most significant differences could be observed in sudden infant death syndrome and suffocation diagnosis frequency. The validity of statistical data on the causes of infant mortality is thus significantly reduced. Therefore, the possibilities of public health and social policy interventions toward preventing sudden and unexpected infant death are extraordinarily complicated by this lack of data validity.
Sprache	Englisch
Erscheinungsdatum	2022-06-21
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12071512
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Concurrent Infection of the Human Brain with Multiple

Golovchenko, Maryna / Opelka, Jakub / Vancova, Marie / Sehadova, Hana / Kralikova, Veronika / Dobias, Martin / Raska, Milan / Krupka, Michal / Sloupenska, Kristyna / Rudenko, Natalie

International journal of molecular sciences

2023 Band 24, Heft 23

Abstract: Lyme disease (LD) spirochetes are well known to be able to disseminate into the tissues of infected hosts, including humans. The diverse strategies used by spirochetes to avoid the host immune system and persist in the host include active immune ... ...

Abstract	Lyme disease (LD) spirochetes are well known to be able to disseminate into the tissues of infected hosts, including humans. The diverse strategies used by spirochetes to avoid the host immune system and persist in the host include active immune suppression, induction of immune tolerance, phase and antigenic variation, intracellular seclusion, changing of morphological and physiological state in varying environments, formation of biofilms and persistent forms, and, importantly, incursion into immune-privileged sites such as the brain. Invasion of immune-privileged sites allows the spirochetes to not only escape from the host immune system but can also reduce the efficacy of antibiotic therapy. Here we present a case of the detection of spirochetal DNA in multiple loci in a LD patient's post-mortem brain. The presence of co-infection with
Mesh-Begriff(e)	Humans ; Borrelia/genetics ; Borrelia burgdorferi/genetics ; Borrelia burgdorferi Group/genetics ; Brain ; Lyme Disease
Sprache	Englisch
Erscheinungsdatum	2023-11-29
Erscheinungsland	Switzerland
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242316906
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Penile carcinoma - a rare cause of sudden death.

Dobiáš, Martin / Marecová, Klára / Vránová, Kateřina / Handlos, Petr

Forensic science, medicine, and pathology

2019 Band 15, Heft 3, Seite(n) 506–508

Abstract: Penile carcinoma is an uncommon but potentially mutilating disease with a heterogeneous etiology. We present a case in which a man died due to severe blood loss from an amputated penis. It was initially regarded as a violent death with an external cause. ...

Abstract	Penile carcinoma is an uncommon but potentially mutilating disease with a heterogeneous etiology. We present a case in which a man died due to severe blood loss from an amputated penis. It was initially regarded as a violent death with an external cause. Autopsy found irregular defects with smooth edges in the external genital area and on both sides of the groin, with yellowish-gray callus-like structures and dried blood at the base of where the penis would have been located. Histological examination revealed the presence of squamous cell carcinoma with signs of keratinization. Subsequent investigation, along with information from the autopsy, revealed that the man suffered from penile carcinoma, thus death was attributed to exsanguination from an ulcerated femoral artery in a patient with penile carcinoma.
Mesh-Begriff(e)	Aged ; Carcinoma, Squamous Cell/pathology ; Death, Sudden/etiology ; Exsanguination/etiology ; Femoral Artery/pathology ; Humans ; Male ; Necrosis ; Penile Neoplasms/pathology
Sprache	Englisch
Erscheinungsdatum	2019-02-22
Erscheinungsland	United States
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	2195904-3
ISSN	1556-2891 ; 1547-769X
ISSN (online)	1556-2891
ISSN	1547-769X
DOI	10.1007/s12024-019-00098-2
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Burden of sudden cardiac death in persons aged 1-40 years in the Czech Republic.

Rücklová, Kristina / Dobiáš, Martin / Bílek, Matěj / Pohlová Kučerová, Štěpánka / Kulvajtová, Markéta / Tavačová, Terézia / Nagy, Ivan / Tomášek, Petr

Central European journal of public health

2022 Band 30, Heft 1, Seite(n) 58–64

Abstract: Objectives: The aim of the study was to ascertain the incidence, circumstances and causes of sudden cardiac death in persons aged 1-40 years in the Czech Republic.: Methods: De-identified autopsy reports of all individuals who died suddenly between ... ...

Abstract	Objectives: The aim of the study was to ascertain the incidence, circumstances and causes of sudden cardiac death in persons aged 1-40 years in the Czech Republic. Methods: De-identified autopsy reports of all individuals who died suddenly between the ages of 1-40 years during the period 2014-2019 inclusive in a selected area of the Czech Republic were analysed retrospectively. Persons with substantial cardiovascular pathology defined by histopathological criteria and those with a negative autopsy were included in the study. The latter were designated as sudden arrhythmic death syndrome. Results: In total, 245 sudden cardiac death cases were identified resulting in an incidence rate of 2.4/100,000 person-years. Among the deceased, we found an enormous gender gap with men representing 81% of cases. More than 80% of deaths occurred during everyday activities or sleep, whereas only 7% were sports-related. The most common cause of death was coronary artery disease detected in 38%, which was followed by cardiomyopathies in 15%, sudden arrhythmic death syndrome in 12%, left ventricular hypertrophy in 10%, and congenital heart defects in 7%. Conclusions: Coronary artery disease is the predominant cause of sudden cardiac death in the young population of the Czech Republic. Hence, effective preventive measures targeted at the reduction of risk factors associated with early coronary artery disease should be reinforced. The second most prevalent cause in our population are potentially heritable heart conditions such as cardiomyopathies and sudden arrhythmic death syndrome. This fact has already prompted the introduction of molecular autopsy and cardiogenetic care for relatives in the Czech Republic.
Mesh-Begriff(e)	Adolescent ; Adult ; Cardiomyopathies/complications ; Cause of Death ; Child ; Child, Preschool ; Coronary Artery Disease/complications ; Czech Republic/epidemiology ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/pathology ; Humans ; Infant ; Male ; Retrospective Studies ; Young Adult
Sprache	Englisch
Erscheinungsdatum	2022-04-11
Erscheinungsland	Czech Republic
Dokumenttyp	Journal Article
ZDB-ID	1176053-9
ISSN	1803-1048 ; 1210-7778 ; 0022-1732
ISSN (online)	1803-1048
ISSN	1210-7778 ; 0022-1732
DOI	10.21101/cejph.a6793
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Suicide or not? Issues in the demonstration of anaphylaxis, a review of the literature.

Králíková, Veronika / Gavronová, Adriana / Hamerlik, Lukáš / Svrchokryl, Václav / Vitovják, Marek / Kim, Hajin / Šidová, Veronika / Bednaříková, Jana / Dobiáš, Martin

Soudni lekarstvi

2022 Band 68, Heft 3, Seite(n) 30–32

Abstract: The authors review the literature on the determination of post-mortem serum tryptase values and present the case of a young man who was hit by a train. However, his family believes he has no motivation to commit suicide. Collision with a train is one of ... ...

Titelübersetzung	Sebevražda nebo nehoda? Problematika anafylaxe s analýzou odborné literatury.
Abstract	The authors review the literature on the determination of post-mortem serum tryptase values and present the case of a young man who was hit by a train. However, his family believes he has no motivation to commit suicide. Collision with a train is one of the most common methods of suicide, especially among young men under 40 years of age. (1). The forensic autopsy showed that the man died due to the collision with the train, with traumatic hemorrhagic shock stated as a cause of death. Following toxicological, biochemical, and immunological tests created a supposition that the incident was not a result of suicidal action but a consequence of a possible allergic or anaphylactic reaction of the organism combined with a state of mild alcohol intoxication.
Mesh-Begriff(e)	Male ; Humans ; Anaphylaxis/etiology ; Tryptases ; Autopsy ; Suicide
Chemische Substanzen	Tryptases (EC 3.4.21.59)
Sprache	Englisch
Erscheinungsdatum	2022-12-02
Erscheinungsland	Czech Republic
Dokumenttyp	Review ; Journal Article
ZDB-ID	138272-x
ISSN	0371-1854
ISSN	0371-1854
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Fatal Hemorrhage from an Arteriovenous Fistula.

Handlos, Petr / Marecová, Klára / Smatanová, Margita / Dvořáček, Igor / Dobiáš, Martin

Journal of forensic sciences

2018 Band 63, Heft 5, Seite(n) 1577–1581

Abstract: In this study, we present two cases of sudden deaths of people with end-stage kidney with arteriovenous fistulas for long-term hemodialysis treatment. This procedure is associated with a number of known complications. While stenosis, thrombosis, and ... ...

Abstract	In this study, we present two cases of sudden deaths of people with end-stage kidney with arteriovenous fistulas for long-term hemodialysis treatment. This procedure is associated with a number of known complications. While stenosis, thrombosis, and infection are well known, lethal hemorrhage from arteriovenous fistula is much less commonly encountered. Inspection of the bodies at the scene of the death by a medical examiner suggested that the deaths were due to exsanguination. Autopsies revealed visible defects on the front wall of the arteriovenous fistulas. Microscopic examination showed wall necrosis with infiltration of various inflammatory cells. Deaths were due to exsanguination from the ulcerated arteriovenous fistulas in patients with chronic renal failure. Further investigation revealed that complications in the area around the arteriovenous fistulas were known and were being treated until a sudden rupture of the vessels and hemorrhage from the arteriovenous fistulas resulted in the deaths.
Mesh-Begriff(e)	Aged ; Aged, 80 and over ; Arteriovenous Shunt, Surgical/adverse effects ; Exsanguination/etiology ; Fatal Outcome ; Female ; Humans ; Kidney Failure, Chronic/therapy ; Renal Dialysis
Sprache	Englisch
Erscheinungsdatum	2018-01-16
Erscheinungsland	United States
Dokumenttyp	Case Reports
ZDB-ID	219216-0
ISSN	1556-4029 ; 0022-1198
ISSN (online)	1556-4029
ISSN	0022-1198
DOI	10.1111/1556-4029.13730
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Význam otoskopie v soudnělékařské diagnostice: prospektivní studie.

Kučerová, Štěpánka / Hejna, Petr / Dobiáš, Martin

Soudni lekarstvi

2016 Band 61, Heft 2, Seite(n) 14–17

Abstract: The otoscopy is an examination of the external auditory canal, the eardrum, and the middle ear with an instrument called an otoscope. It is a simple, inexpensive, and time-saving endoscopic method typically used by general practitioners and ... ...

Titelübersetzung	Benefits of otoscopy in forensic autopsy practice: A prospective study.
Abstract	The otoscopy is an examination of the external auditory canal, the eardrum, and the middle ear with an instrument called an otoscope. It is a simple, inexpensive, and time-saving endoscopic method typically used by general practitioners and otorhinolaryngologists. Authors present a prospective study of otoscopic findings investigated consecutively at autopsy. Of the 250 examined persons, 50 positive findings were identified: 38 cases with petechial hemorrhages and 12 cases with tympanic membrane perforation or hemotympanon. Hemorrhages of the tympanic membrane detected through the otoscopy may serve as evidence of congestion within head and neck potentially associated with asphyxiation either in the death or in the living (similar to periorbital and conjuctival petechial hemorrhages). In our study, hemorrhages of the tympanic membrane were related to heart failure, hanging and asphyxiation. Perforated tympanic membrane and hemotympanum have been sporadically reported in victims of fatal lightning strike and rarely in strangulation. This findings were in our study associated with craniocerebral injuries: traffic accidents, falls from height and gunshot injuries. The otoscopy may help to reveal various traumatic and pathological changes within the outer and the middle ear, and, thus, provide important forensic evidence. The otoscopy is also highly recommended in the investigation of the sudden deaths in the young.
Sprache	Tschechisch
Erscheinungsdatum	2016
Erscheinungsland	Czech Republic
Dokumenttyp	English Abstract ; Journal Article
ZDB-ID	138272-x
ISSN	0371-1854
ISSN	0371-1854
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Artikel ; Online: Circumstances and causes of fatal cycling crashes in the Czech Republic.

Bíl, Michal / Bílová, Martina / Dobiáš, Martin / Andrášik, Richard

Traffic injury prevention

2016 Band 17, Heft 4, Seite(n) 394–399

Abstract: Objectives: The circumstances and causes of death of 129 cyclists registered in the Olomouc and the Zlín regions, the Czech Republic, between 2005 and 2013 were the subject of this study.: Methods: We analyzed the autopsy reports, where the principal ...

Abstract	Objectives: The circumstances and causes of death of 129 cyclists registered in the Olomouc and the Zlín regions, the Czech Republic, between 2005 and 2013 were the subject of this study. Methods: We analyzed the autopsy reports, where the principal cause of death was stated, and obtained a detailed description of the circumstances recorded by the police officers. Results: Eighty-three cases (64.3% of the set) were collisions involving a motor vehicle. The driver was the guilty party in 57 cases (68.7%) and the cyclist in the remaining 26 cases (31.3%). The most frequent cause of the crash was connected with right of way (29 cases). Cars were involved in 52 cases; heavy vehicles, including buses, in 26 cases; and motorcycles in 5 cases. Single-vehicle crashes consisted of 43 (33.3%) cases. We divided this group into 3 subgroups based on whether the particular case could be attributed to a cyclist having lost control of the bicycle (31 cases) or to other particular causes. Sixty-eight cases (52.7%) of fatal outcomes were directly linked to intracranial injuries. Multiple injuries were the principal cause of death in 19 cases (14.7%), followed by hemorrhagic traumatic shock (12 cases, 9.3%). Seventy-two (55.8%) cyclists died immediately after the crash and 23 (17.8%) cyclists died within a day of the accident. Conclusions: Trucks were more dangerous to cyclists than cars at intersections, whereas cars were more dangerous on straight sections. The most important pattern was identified as a motor vehicle hitting a cyclist from behind on a straight road section. We identified a strong underestimation of natural death as a cause of cycling fatalities in the official police reports.
Mesh-Begriff(e)	Accidents, Traffic/mortality ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Automobiles/statistics & numerical data ; Bicycling/injuries ; Child ; Child, Preschool ; Czech Republic/epidemiology ; Female ; Humans ; Infant ; Male ; Middle Aged ; Motor Vehicles/statistics & numerical data ; Police ; Records as Topic ; Risk Factors ; Wounds and Injuries/mortality ; Young Adult
Sprache	Englisch
Erscheinungsdatum	2016--18
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2089818-6
ISSN	1538-957X ; 1538-9588
ISSN (online)	1538-957X
ISSN	1538-9588
DOI	10.1080/15389588.2015.1094183
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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