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  1. Buch ; Dissertation / Habilitation: Potential der Skelettszintigraphie zur Evaluation von Stressfrakturen bei Sportlern

    Dobrindt, Oliver Björn

    Diagnose und Prognose

    2012  

    Verfasserangabe vorgelegt von Oliver Björn Dobrindt
    Sprache Deutsch
    Umfang 62 Bl. : Ill., graph. Darst.
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Magdeburg, Univ., Med. Fak., Diss., 2012
    HBZ-ID HT017590080
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    SignaturLeihstatusStandort
    2013 E 304 bestellbar zur Ausleihe Magazin

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  2. Artikel ; Online: Association between posterior tibial slope and anatomic spinopelvic parameters: a retrospective cross-sectional study.

    Caffard, Thomas / Awan Malik, Hassan / Lutz, Bernd / Dobrindt, Oliver / Dornacher, Daniel / Faschingbauer, Martin / Strube, Patrick / Reichel, Heiko / Fuchs, Michael / Zippelius, Timo

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2023  Band 32, Heft 10, Seite(n) 3616–3623

    Abstract: Purpose: Only a few publications considered the influence of the spinopelvic parameters on below-hip anatomy. There is a lack of evidence about the relationship between the anatomic spinopelvic parameters and the posterior tibial slope (PTS). Therefore, ...

    Abstract Purpose: Only a few publications considered the influence of the spinopelvic parameters on below-hip anatomy. There is a lack of evidence about the relationship between the anatomic spinopelvic parameters and the posterior tibial slope (PTS). Therefore, the aim of this study was to analyze the association between fixed anatomic spinopelvic parameters and PTS.
    Methods: Adult patients presenting with lumbar, thoracic, or cervical complaints together with knee pain at a single hospital between 2017 to 2022 with available standing full-spine lateral radiograph and lateral knee radiograph were retrospectively reviewed. The measured parameters included the pelvic incidence (PI), the sacral kyphosis (SK), the pelvisacral angle, the sacral anatomic orientation (SAO), the sacral table angle, the sacropelvic angle and the PTS. Pearson's correlations and linear regression analyses were conducted.
    Results: A total of 80 patients (44 women), median age 63 years were analyzed. A strong positive correlation was identified between PI and PTS (r = 0.70, p < 0.001). A strong negative correlation was observed between PI and SAO (r = - 0.74, p < 0.001). A strong positive correlation was observed between PI and SK (r = 0.81, p < 0.001). A univariable linear regression analysis showed that PTS can be deduced from PI according to the following formula: PTS = 0.174 × PI - 1.138.
    Conclusion: This study is the first to support a positive correlation between the PI and the PTS. We demonstrate that knee anatomy is individually correlated to pelvic shape and therefore influences spinal posture.
    Mesh-Begriff(e) Adult ; Humans ; Female ; Middle Aged ; Retrospective Studies ; Cross-Sectional Studies ; Sacrum ; Radiography ; Lower Extremity ; Lordosis/diagnostic imaging
    Sprache Englisch
    Erscheinungsdatum 2023-06-27
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-023-07830-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Answer to the Letter to the Editor of Tugba Ozudogru Celik concerning "Association between posterior tibial slope and anatomic spinopelvic parameters: a retrospective cross-sectional study" by Caffard T, et al. (Eur Spine J. 2023; doi: 10.1007/s00586-023-07830-1).

    Caffard, Thomas / Awan Malik, Hassan / Lutz, Bernd / Dobrindt, Oliver / Dornacher, Daniel / Faschingbauer, Martin / Strube, Patrick / Reichel, Heiko / Fuchs, Michael / Zippelius, Timo

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2023  Band 33, Heft 2, Seite(n) 752–753

    Mesh-Begriff(e) Humans ; Cross-Sectional Studies ; Retrospective Studies ; Spine ; Spinal Fusion
    Sprache Englisch
    Erscheinungsdatum 2023-12-06
    Erscheinungsland Germany
    Dokumenttyp Letter
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-023-08061-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Importance of the cervical paraspinal muscles in postoperative patient-reported outcomes and maintenance of sagittal alignment after anterior cervical discectomy and fusion.

    Caffard, Thomas / Arzani, Artine / Verna, Bruno / Tripathi, Vidushi / Chiapparelli, Erika / Schönnagel, Lukas / Zhu, Jiaqi / Medina, Samuel J / Tani, Soji / Camino-Willhuber, Gaston / Guven, Ali E / Amoroso, Krizia / Tan, Ek Tsoon / Carrino, John A / Shue, Jennifer / Dobrindt, Oliver / Zippelius, Timo / Dalton, David / Sama, Andrew A /
    Girardi, Federico P / Cammisa, Frank P / Hughes, Alexander P

    Journal of neurosurgery. Spine

    2024  , Seite(n) 1–10

    Abstract: Objective: The aim of this study was to investigate the influence of preoperatively assessed paraspinal muscle parameters on postoperative patient-reported outcomes and maintenance of cervical sagittal alignment after anterior cervical discectomy and ... ...

    Abstract Objective: The aim of this study was to investigate the influence of preoperatively assessed paraspinal muscle parameters on postoperative patient-reported outcomes and maintenance of cervical sagittal alignment after anterior cervical discectomy and fusion (ACDF).
    Methods: Patients with preoperative and postoperative standing cervical spine lateral radiographs and preoperative cervical MRI who underwent an ACDF between 2015 and 2018 were reviewed. Muscles from C3 to C7 were segmented into 4 functional groups: anterior, posteromedial, posterolateral, and sternocleidomastoid. The functional cross-sectional area and also the percent fat infiltration (FI) were calculated for all groups. Radiographic alignment parameters collected preoperatively and postoperatively included C2-7 lordosis and C2-7 sagittal vertical axis (SVA). Neck Disability Index (NDI) scores were recorded preoperatively and at 2 and 4-6 months postoperatively. To investigate the relationship between muscle parameters and postoperative changes in sagittal alignment, multivariable linear mixed models were used. Multivariable linear regression models were used to analyze the correlations between the changes in NDI scores and the muscles' FI.
    Results: A total of 168 patients with NDI and 157 patients with sagittal alignment measurements with a median follow-up of 364 days were reviewed. The mixed models showed that a greater functional cross-sectional area of the posterolateral muscle group at each subaxial level and less FI at C4-6 were significantly associated with less progression of C2-7 SVA over time. Moreover, there was a significant correlation between greater FI of the posteromedial muscle group measured at the C7 level and less NDI improvement at 4-6 months after ACDF.
    Conclusions: The findings highlight the importance of preoperative assessment of the cervical paraspinal muscle morphology as a predictor for patient-reported outcomes and maintenance of C2-7 SVA after ACDF.
    Sprache Englisch
    Erscheinungsdatum 2024-05-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2158643-3
    ISSN 1547-5646 ; 1547-5654
    ISSN (online) 1547-5646
    ISSN 1547-5654
    DOI 10.3171/2024.2.SPINE23926
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.135 -Spine-: Hefte anzeigen Standort:
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  5. Artikel ; Online: Importance of the lumbar paraspinal muscles on the maintenance of global sagittal alignment after lumbar pedicle subtraction osteotomy.

    Caffard, Thomas / Arzani, Artine / Amoroso, Krizia / Chiapparelli, Erika / Medina, Samuel J / Schönnagel, Lukas / Zhu, Jiaqi / Verna, Bruno / Finos, Kyle / Nathoo, Isaac / Tani, Soji / Camino-Willhuber, Gaston / Guven, Ali E / Zadeh, Arman / Tan, Ek Tsoon / Carrino, John A / Shue, Jennifer / Dobrindt, Oliver / Zippelius, Timo /
    Dalton, David / Sama, Andrew A / Girardi, Federico P / Cammisa, Frank P / Hughes, Alexander P

    Journal of neurosurgery. Spine

    2024  , Seite(n) 1–9

    Abstract: Objective: There are limited data about the influence of the lumbar paraspinal muscles on the maintenance of sagittal alignment after pedicle subtraction osteotomy (PSO) and the risk factors for sagittal realignment failure. The authors aimed to ... ...

    Abstract Objective: There are limited data about the influence of the lumbar paraspinal muscles on the maintenance of sagittal alignment after pedicle subtraction osteotomy (PSO) and the risk factors for sagittal realignment failure. The authors aimed to investigate the influence of preoperative lumbar paraspinal muscle quality on the postoperative maintenance of sagittal alignment after lumbar PSO.
    Methods: Patients who underwent lumbar PSO with preoperative lumbar MRI and pre- and postoperative whole-spine radiography in the standing position were included. Spinopelvic measurements included pelvic incidence, sacral slope, pelvic tilt, L1-S1 lordosis, T4-12 thoracic kyphosis, spinosacral angle, C7-S1 sagittal vertical axis (SVA), T1 pelvic angle, and mismatch between pelvic incidence and L1-S1 lordosis. Validated custom software was used to calculate the percent fat infiltration (FI) of the psoas major, as well as the erector spinae and multifidus (MF). A multivariable linear mixed model was applied to further examine the association between MF FI and the postoperative progression of SVA over time, accounting for repeated measures over time that were adjusted for age, sex, BMI, and length of follow-up.
    Results: Seventy-seven patients were recruited. The authors' results demonstrated significant correlations between MF FI and the maintenance of corrected sagittal alignment after PSO. After adjustment for the aforementioned parameters, the model showed that the MF FI was significantly associated with the postoperative progression of positive SVA over time. A 1% increase from the preoperatively assessed total MF FI was correlated with an increase of 0.92 mm in SVA postoperatively (95% CI 0.42-1.41, p < 0.0001).
    Conclusions: This study included a large patient cohort with midterm follow-up after PSO and emphasized the importance of the lumbar paraspinal muscles in the maintenance of sagittal alignment correction. Surgeons should assess the quality of the MF preoperatively in patients undergoing PSO to identify patients with severe FI, as they may be at higher risk for sagittal decompensation.
    Sprache Englisch
    Erscheinungsdatum 2024-06-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2158643-3
    ISSN 1547-5646 ; 1547-5654
    ISSN (online) 1547-5646
    ISSN 1547-5654
    DOI 10.3171/2024.3.SPINE231052
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: The Use of Iloprost in the Treatment of Bone Marrow Edema Syndrome of the Proximal Femur: A Review and Meta-Analysis.

    Zippelius, Timo / Strube, Patrick / Rohe, Sebastian / Schlattmann, Peter / Dobrindt, Oliver / Caffard, Thomas / Awan Malik, Hassan / Lindemann, Chris / Matziolis, Georg / Böhle, Sabrina

    Journal of personalized medicine

    2022  Band 12, Heft 11

    Abstract: Objective: The aim of this meta-analysis was to investigate the impact of intravenous iloprost therapy on pain, function, edema changes, and follow-up surgery in bone marrow edema syndrome of the proximal femur. Methods: A systematic literature search up ...

    Abstract Objective: The aim of this meta-analysis was to investigate the impact of intravenous iloprost therapy on pain, function, edema changes, and follow-up surgery in bone marrow edema syndrome of the proximal femur. Methods: A systematic literature search up to May 2022 was performed to find relevant papers that made a statement about the outcome of intravenous iloprost therapy alone. Factors such as the Visual Analog Scale (VAS), Harris Hip Score (HHS), edema reduction, and follow-up interventions were considered. These were compared using Forest plots. Results: In 11 studies, 190 proximal femora with bone marrow edema syndrome that received intravenous iloprost therapy without further therapeutic intravenous or surgical intervention such as core decompression were studied. There was a significant mean improvement in VAS by 3.3 cm (2.07−4.5 cm) (p < 0.001) and HHS by 24.36 points (18.23−30.49) (p < 0.001) 3−6 months after receiving iloprost therapy. Only in 9.3% of cases (1.1−24.3%) did no clinical or radiological improvement occur. Conclusions: It could be shown that the existing publications support intravenous therapy with iloprost in patients with bone marrow edema syndrome and result in good clinical outcomes.
    Sprache Englisch
    Erscheinungsdatum 2022-10-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12111757
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Konferenzbeitrag: Die Korrelation des Posterioren Tibial Slope mit den anatomischen Spinopelvinen Parametern: Eine retrospektive Querschnittstudie

    Caffard, Thomas / Awan Malik, Hassan / Lutz, Bernd / Dobrindt, Oliver / Dornacher, Daniel / Faschingbauer, Martin / Strube, Patrick / Reichel, Heiko / Fuchs, Michael / Zippelius, Timo

    2023  , Seite(n) AV62–2944

    Veranstaltung/Kongress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2023); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2023
    Schlagwörter Medizin, Gesundheit ; posterior tibial slope ; pelvic incidence ; sagittal alignment
    Erscheinungsdatum 2023-10-23
    Verlag German Medical Science GMS Publishing House; Düsseldorf
    Dokumenttyp Konferenzbeitrag
    DOI 10.3205/23dkou646
    Datenquelle German Medical Science

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  8. Konferenzbeitrag: Einfluss von multiplen Hüft-TEP Revisionen auf Standzeit und Versagensursachen

    Dobrindt, Oliver / Schmelzer, Lisa / Perka, Carsten-Frank / Müller, Michael

    2015  , Seite(n) WI19–1061

    Veranstaltung/Kongress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2015); Berlin; ; Berufsverband der Fachärzte für Orthopädie; 2015
    Schlagwörter Medizin, Gesundheit ; H-TEP Revisionen
    Erscheinungsdatum 2015-10-05
    Verlag German Medical Science GMS Publishing House; Düsseldorf
    Dokumenttyp Konferenzbeitrag
    DOI 10.3205/15dkou080
    Datenquelle German Medical Science

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  9. Konferenzbeitrag: Geringe diagnostische Wertigkeit des CRP bei low-grade Infektionen von Hüftendoprothesen

    Dobrindt, Oliver / Schmelzer, Lisa / Müller, Michael / Perka, Carsten-Frank

    2014  , Seite(n) WI30–1566

    Veranstaltung/Kongress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2014); Berlin; ; Berufsverband der Fachärzte für Orthopädie; 2014
    Schlagwörter Medizin, Gesundheit
    Erscheinungsdatum 2014-10-13
    Verlag German Medical Science GMS Publishing House; Düsseldorf
    Dokumenttyp Konferenzbeitrag
    DOI 10.3205/14dkou173
    Datenquelle German Medical Science

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  10. Artikel ; Online: Human osteoblast damage after antiseptic treatment.

    Vörös, Pauline / Dobrindt, Oliver / Perka, Carsten / Windisch, Christoph / Matziolis, Georg / Röhner, Eric

    International orthopaedics

    2013  Band 38, Heft 1, Seite(n) 177–182

    Abstract: Purpose: Antiseptics are powerful medical agents used for wound treatment and decontamination and have a high potential for defeating joint infections in septic surgery. Both chlorhexidine and polyhexanide are frequently used in clinical practice and ... ...

    Abstract Purpose: Antiseptics are powerful medical agents used for wound treatment and decontamination and have a high potential for defeating joint infections in septic surgery. Both chlorhexidine and polyhexanide are frequently used in clinical practice and have a broad antimicrobial range, but their effect on human osteoblasts has not been sufficiently studied. Our objective was to investigate the toxic effects of polyhexanide and chlorhexidine on human osteoblasts in vitro to evaluate their clinical applicability in septic surgery.
    Methods: We isolated and cultivated human osteoblasts in vitro and assayed the toxic effects of chlorhexidine 0.1% and polyhexanide 0.04%, concentrations commonly applied in clinical practice. Toxicity analysis was performed by visualisation of cell structure, lactate dehydrogenase (LDH) activity and evaluation of vital cells. Toxicity was evaluated by microscopic inspection of cell morphology, trypan blue staining and determination of LDH release.
    Results: Damaged cell structure could be shown by microscopy. Both antiseptics promoted LDH activity after incubation with osteoblasts. The evaluation of vital osteoblasts showed a significant decrease of vital cells.
    Conclusions: Both antiseptics induced significant cell death of osteoblasts at optimum exposure. We therefore recommend cautious use of polyhexanide and chlorhexidine in septic surgery to avoid severe osteoblast toxicity.
    Mesh-Begriff(e) Anti-Infective Agents, Local/pharmacology ; Biguanides/pharmacology ; Cell Survival/drug effects ; Cells, Cultured ; Chlorhexidine/pharmacology ; Dose-Response Relationship, Drug ; Humans ; In Vitro Techniques ; L-Lactate Dehydrogenase/metabolism ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Osteoblasts/pathology
    Chemische Substanzen Anti-Infective Agents, Local ; Biguanides ; polihexanide (322U039GMF) ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; Chlorhexidine (R4KO0DY52L)
    Sprache Englisch
    Erscheinungsdatum 2013-09-28
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 80384-4
    ISSN 1432-5195 ; 0341-2695
    ISSN (online) 1432-5195
    ISSN 0341-2695
    DOI 10.1007/s00264-013-2107-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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