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  1. Artikel ; Online: Abscisic acid promotes proteasome-mediated degradation of the transcription coactivator NPR1 in Arabidopsis thaliana.

    Ding, Yezhang / Dommel, Matthew / Mou, Zhonglin

    The Plant journal : for cell and molecular biology

    2016  Band 86, Heft 1, Seite(n) 20–34

    Abstract: Proteasome-mediated turnover of the transcription coactivator NPR1 is pivotal for efficient activation of the broad-spectrum plant immune responses known as localized acquired resistance (LAR) and systemic acquired resistance (SAR) in adjacent and ... ...

    Abstract Proteasome-mediated turnover of the transcription coactivator NPR1 is pivotal for efficient activation of the broad-spectrum plant immune responses known as localized acquired resistance (LAR) and systemic acquired resistance (SAR) in adjacent and systemic tissues, respectively, and requires the CUL3-based E3 ligase and its adaptor proteins, NPR3 and NPR4, which are receptors for the signaling molecule salicylic acid (SA). It has been shown that SA prevents NPR1 turnover under non-inducing and LAR/SAR-inducing conditions, but how cellular NPR1 homeostasis is maintained remains unclear. Here, we show that the phytohormone abscisic acid (ABA) and SA antagonistically influence cellular NPR1 protein levels. ABA promotes NPR1 degradation via the CUL3(NPR) (3/) (NPR) (4) complex-mediated proteasome pathway, whereas SA may protect NPR1 from ABA-promoted degradation through phosphorylation. Furthermore, we demonstrate that the timing and strength of SA and ABA signaling are critical in modulating NPR1 accumulation and target gene expression. Perturbing ABA or SA signaling in adjacent tissues alters the temporal dynamic pattern of NPR1 accumulation and target gene transcription. Finally, we show that sequential SA and ABA treatment leads to dynamic changes in NPR1 protein levels and target gene expression. Our results revealed a tight correlation between sequential SA and ABA signaling and dynamic changes in NPR1 protein levels and NPR1-dependent transcription in plant immune responses.
    Mesh-Begriff(e) Abscisic Acid/metabolism ; Arabidopsis/genetics ; Arabidopsis/physiology ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Cell Nucleus/metabolism ; Gene Expression Regulation, Plant ; Homeostasis ; Phosphorylation ; Plant Growth Regulators/metabolism ; Plant Immunity ; Proteasome Endopeptidase Complex/metabolism ; Salicylic Acid/metabolism ; Signal Transduction ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
    Chemische Substanzen Arabidopsis Proteins ; NPR1 protein, Arabidopsis ; NPR3 protein, Arabidopsis ; NPR4 protein, Arabidopsis ; Plant Growth Regulators ; Abscisic Acid (72S9A8J5GW) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Salicylic Acid (O414PZ4LPZ)
    Sprache Englisch
    Erscheinungsdatum 2016-04
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1088037-9
    ISSN 1365-313X ; 0960-7412
    ISSN (online) 1365-313X
    ISSN 0960-7412
    DOI 10.1111/tpj.13141
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Differential Quantitative Requirements for NPR1 Between Basal Immunity and Systemic Acquired Resistance in

    Ding, Yezhang / Dommel, Matthew R / Wang, Chenggang / Li, Qi / Zhao, Qi / Zhang, Xudong / Dai, Shaojun / Mou, Zhonglin

    Frontiers in plant science

    2020  Band 11, Seite(n) 570422

    Abstract: Non-expressor of pathogenesis-related (PR) genes1 (NPR1) is a key transcription coactivator of plant basal immunity and systemic acquired resistance (SAR). Two mutant alleles, ...

    Abstract Non-expressor of pathogenesis-related (PR) genes1 (NPR1) is a key transcription coactivator of plant basal immunity and systemic acquired resistance (SAR). Two mutant alleles,
    Sprache Englisch
    Erscheinungsdatum 2020-09-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2711035-7
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2020.570422
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Big Genes, Small Effectors: Pea Aphid Cassette Effector Families Composed From Miniature Exons.

    Dommel, Matthew / Oh, Jonghee / Huguet-Tapia, Jose Carlos / Guy, Endrick / Boulain, Hélène / Sugio, Akiko / Murugan, Marimuthu / Legeai, Fabrice / Heck, Michelle / Smith, C Michael / White, Frank F

    Frontiers in plant science

    2020  Band 11, Seite(n) 1230

    Abstract: Aphids secrete proteins from their stylets that evidence indicates function similar to pathogen effectors for virulence. Here, we describe two small candidate effector gene families of the pea aphid, ...

    Abstract Aphids secrete proteins from their stylets that evidence indicates function similar to pathogen effectors for virulence. Here, we describe two small candidate effector gene families of the pea aphid,
    Sprache Englisch
    Erscheinungsdatum 2020-09-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2711035-7
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2020.01230
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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