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  1. Artikel ; Online: Epidemiology and prevalence of dementia and Alzheimer's disease in American Indians: Data from the Strong Heart Study.

    Suchy-Dicey, Astrid M / Domoto-Reilly, Kimiko / Nelson, Lonnie / Jayadev, Suman / Buchwald, Dedra S / Grabowski, Thomas J / Rhoads, Kristoffer

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2024  

    Abstract: Introduction: Accurate epidemiologic estimates for dementia are lacking for American Indians, despite substantive social and health disparities.: Methods: The Strong Heart Study, a population-based cohort of 11 American Indian tribes, conducted ... ...

    Abstract Introduction: Accurate epidemiologic estimates for dementia are lacking for American Indians, despite substantive social and health disparities.
    Methods: The Strong Heart Study, a population-based cohort of 11 American Indian tribes, conducted detailed cognitive testing and examinations over two visits approximately 7 years apart. An expert panel reviewed case materials for consensus adjudication of cognitive status (intact; mild cognitive impairment [MCI]; dementia; other impaired/not MCI) and probable etiology (Alzheimer's disease [AD], vascular bain injury [VBI], traumatic brain injury [TBI], other).
    Results: American Indians aged 70-95 years had 54% cognitive impairment including 10% dementia. VBI and AD were primary etiology approximately equal proportions (>40%). Apolipoprotein (APO) Eε4 carriers were more common among those with dementia (p = 0.040). Plasma pTau, glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) were higher among those with cognitive impairment, but not amyloid beta (Aβ). Cognitive intact had mean 3MSE 92.2 (SD 6.4) and mean Montreal Cognitive Assessment (MoCA) score of 21.3 (SD 3.2).
    Discussion: This is the first population-based study to estimate the prevalence of vascular and Alzheimer's dementias in a population-based study of American Indians.
    Highlights: The Strong Heart Study is a population-based cohort of American Indian tribes, conducted over 30+ years and three US geographic regions (Northern Plains, Southern Plains, Southwest). Our teams conducted detailed cognitive testing, neurological examination, and brain imaging over two visits approximately 7 years apart. An expert panel reviewed collected materials for consensus-based adjudication of cognitive status (intact; MCI; dementia; other impaired/not MCI) and probable underlying etiology (AD; VBI; TBI; other). In this cohort of American Indians aged 70-95, 54% were adjudicated with cognitive impairment, including approximately 35% MCI and 10% dementia. These data expand on prior reports from studies using electronic health records, which had suggested prevalence, and incidence of dementia in American Indians to be more comparable to the majority population or non-Hispanic White individuals, perhaps due to latent case undercounts in clinical settings. Vascular and neurodegenerative injuries were approximately equally responsible for cognitive impairment, suggesting that reduction of cardiovascular disease is needed for primary prevention. Traumatic injury was more prevalent than in other populations, and common among those in the "other/not MCI" cognitive impairment category. Mean scores for common dementia screening instruments-even among those adjudicated as unimpaired-were relatively low compared to other populations (mean unimpaired 3MSE 92.2, SD 6.4; mean unimpaired MoCA 21.3, SD 3.2), suggesting the need for cultural and environmental adaptation of common screening and evaluation instruments.
    Sprache Englisch
    Erscheinungsdatum 2024-05-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13849
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  2. Artikel ; Online: Virtual Intervention for Caregivers of Persons With Lewy Body Dementia: Pilot Quasi-Experimental Single-Arm Study.

    Zaslavsky, Oleg / Kaneshiro, Jasmine / Chu, Frances / Teng, Andrew / Domoto-Reilly, Kimiko / Chen, Annie T

    JMIR formative research

    2022  Band 6, Heft 7, Seite(n) e37108

    Abstract: Background: Compared to other types of dementia, family caregivers of people with Lewy body dementia (LBD) report higher stress levels and more severe depressive symptoms. Although several digital support interventions for caregivers of persons with ... ...

    Abstract Background: Compared to other types of dementia, family caregivers of people with Lewy body dementia (LBD) report higher stress levels and more severe depressive symptoms. Although several digital support interventions for caregivers of persons with dementia exist, few target LBD specifically or leverage a fully remote and asynchronous approach suitable for pandemic circumstances.
    Objective: We performed a pilot evaluation of a digital intervention designed to help caregivers of people with LBD address challenges they have experienced, with the end goal of reducing psychological distress in this population.
    Methods: We recruited 15 family caregivers of people with LBD to participate in the quasi-experimental, single-arm, mixed methods study titled Virtual Online Communities for Aging Life Experience-Lewy Body Dementia (VOCALE-LBD). The study offers an 8-week web-based intervention that uses a digital discussion platform and involves moderation, peer-to-peer support, didactic training, and problem-solving skill enactment.
    Results: Participants' baseline characteristics were the following: mean age 66 (SD 8) years; 14 of 15 (93%) of them were female; all (15/15, 100%) were White; and 8 (53%) of them had at least a postgraduate degree. Throughout the intervention, participants engaged in weekly web-based discussions, generating a total of 434 posts (average 4 posts per week). Attrition was 20% (3/15). Upon study exit, participants showed the following average improvements: 3.0 (SD 6.0) in depression, 8.3 (SD 16.7) in burden, 2.9 (SD 6.8) in stress, and 0.3 (SD 0.8) in loneliness. When looking at the proportion of participants with clinically significant improvement versus those with a worsening of ≥0.5 SD for each outcome, we observed net improvements of 50% (6/12), 33% (4/12), 25% (3/12), and 25% (3/12) in depression, loneliness, burden, and stress, respectively. In terms of the benefits of participation, participants reported that participation helped them "a great deal" to (1) improve their understanding of LBD (9/12, 75%), (2) gain confidence in dealing with difficult behaviors of the care recipient (6/12, 50%), and (3) improve in one's abilities to provide care to the care recipient (4/12, 33%).
    Conclusions: The study generated promising feasibility and preliminary efficacy data for a low-cost, web-based intervention designed for caregivers of persons with LBD. Though the study was not powered for significance, we observed nominal average and net improvements in important psychological outcomes. Moreover, many caregivers reported that study participation helped them better understand the disease, feel more confident in dealing with difficult behaviors of the care recipient, and improve their ability to care for the care recipient. If validated in future studies, the intervention could be an accessible, on-demand resource for caregivers, enabling them to engage in moderated remote discussions with peers at their own convenience in terms of location, time of the day, and frequency.
    Sprache Englisch
    Erscheinungsdatum 2022-07-29
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ISSN 2561-326X
    ISSN (online) 2561-326X
    DOI 10.2196/37108
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  3. Artikel: Cerebrospinal fluid soluble insulin receptor levels in Alzheimer's disease.

    Thomas, Peter / Leclerc, Manon / Evitts, Kira / Brown, Caitlin / Miller, Wyatt / Hanson, Angela J / Banks, William A / Gibbons, Laura / Domoto-Reilly, Kimiko / Jayadev, Suman / Li, Ge / Peskind, Elaine / Young, Jessica E / Calon, Frederic / Rhea, Elizabeth M

    Alzheimer's & dementia (Amsterdam, Netherlands)

    2024  Band 16, Heft 2, Seite(n) e12603

    Abstract: Introduction: Brain insulin resistance and deficiency is a consistent feature of Alzheimer's disease (AD). Insulin resistance can be mediated by the surface expression of the insulin receptor (IR). Cleavage of the IR generates the soluble IR (sIR).: ... ...

    Abstract Introduction: Brain insulin resistance and deficiency is a consistent feature of Alzheimer's disease (AD). Insulin resistance can be mediated by the surface expression of the insulin receptor (IR). Cleavage of the IR generates the soluble IR (sIR).
    Methods: We measured the levels of sIR present in cerebrospinal fluid (CSF) from individuals along the AD diagnostic spectrum from two cohorts: Seattle (
    Results: CSF sIR levels were not statistically different in AD. CSF sIR and amyloid beta (Aβ)42 and Aβ40 levels significantly correlated as well as CSF sIR and cognition in the CIMA-Q cohort. Human neurons expressing the amyloid precursor protein "Swedish" mutation generated significantly greater sIR and human astrocytes were also able to release sIR in response to both an inflammatory and insulin stimulus.
    Discussion: These data support further investigation into the generation and role of sIR in AD.
    Highlights: Cerebrospinal fluid (CSF) soluble insulin receptor (sIR) levels positively correlate with amyloid beta (Aβ)42 and Aβ40.CSF sIR levels negatively correlate with cognitive performance (Montreal Cognitive Assessment score).CSF sIR levels in humans remain similar across Alzheimer's disease diagnostic groups.Neurons derived from humans with the "Swedish" mutation in which Aβ42 is increased generate increased levels of sIR.Human astrocytes can also produce sIR and generation is stimulated by tumor necrosis factor α and insulin.
    Sprache Englisch
    Erscheinungsdatum 2024-05-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2832898-X
    ISSN 2352-8729
    ISSN 2352-8729
    DOI 10.1002/dad2.12603
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  4. Artikel ; Online: Adipocyte-Derived Small Extracellular Vesicles from Patients with Alzheimer Disease Carry miRNAs Predicted to Target the CREB Signaling Pathway in Neurons.

    Batabyal, Rachael A / Bansal, Ankush / Cechinel, Laura Reck / Authelet, Kayla / Goldberg, Madeleine / Nadler, Evan / Keene, C Dirk / Jayadev, Suman / Domoto-Reilly, Kimiko / Li, Gail / Peskind, Elaine / Hashimoto-Torii, Kazue / Buchwald, Dedra / Freishtat, Robert J

    International journal of molecular sciences

    2023  Band 24, Heft 18

    Abstract: Alzheimer disease (AD) is characterized by amyloid-β (Aβ) plaques, neurofibrillary tangles, synaptic dysfunction, and progressive dementia. Midlife obesity increases the risk of developing AD. Adipocyte-derived small extracellular vesicles (ad-sEVs) have ...

    Abstract Alzheimer disease (AD) is characterized by amyloid-β (Aβ) plaques, neurofibrillary tangles, synaptic dysfunction, and progressive dementia. Midlife obesity increases the risk of developing AD. Adipocyte-derived small extracellular vesicles (ad-sEVs) have been implicated as a mechanism in several obesity-related diseases. We hypothesized that ad-sEVs from patients with AD would contain miRNAs predicted to downregulate pathways involved in synaptic plasticity and memory formation. We isolated ad-sEVs from the serum and cerebrospinal fluid (CSF) of patients with AD and controls and compared miRNA expression profiles. We performed weighted gene co-expression network analysis (WGCNA) on differentially expressed miRNAs to identify highly interconnected clusters correlating with clinical traits. The WGCNA identified a module of differentially expressed miRNAs, in both the serum and CSF, that was inversely correlated with the Mini-Mental State Examination scores. Within this module, miRNAs that downregulate CREB signaling in neurons were highly represented. These results demonstrate that miRNAs carried by ad-sEVs in patients with AD may downregulate CREB signaling and provide a potential mechanistic link between midlife obesity and increased risk of AD.
    Mesh-Begriff(e) Humans ; Adipocytes ; Alzheimer Disease/genetics ; Extracellular Vesicles/genetics ; MicroRNAs/genetics ; Neurons ; Obesity ; Plaque, Amyloid ; Signal Transduction
    Chemische Substanzen MicroRNAs ; CREB1 protein, human
    Sprache Englisch
    Erscheinungsdatum 2023-09-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241814024
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  5. Artikel ; Online: Regional prefrontal cortical atrophy predicts specific cognitive-behavioral symptoms in ALS-FTD.

    Ratti, Elena / Domoto-Reilly, Kimiko / Caso, Christina / Murphy, Alyssa / Brickhouse, Michael / Hochberg, Daisy / Makris, Nikos / Cudkowicz, Merit E / Dickerson, Bradford C

    Brain imaging and behavior

    2021  Band 15, Heft 5, Seite(n) 2540–2551

    Abstract: Amyotrophic Lateral Sclerosis-Frontotemporal Dementia (ALS-FTD) may present typical behavioral variant FTD symptoms. This study aims to determine whether profile and severity of cognitive-behavioral symptoms in ALS/ALS-FTD are predicted by regional ... ...

    Abstract Amyotrophic Lateral Sclerosis-Frontotemporal Dementia (ALS-FTD) may present typical behavioral variant FTD symptoms. This study aims to determine whether profile and severity of cognitive-behavioral symptoms in ALS/ALS-FTD are predicted by regional cortical atrophy. The hypothesis is that executive dysfunction can be predicted by dorsolateral prefrontal cortical (dlPFC) atrophy, apathy by dorsomedial PFC (dmPFC) and anterior cingulate cortical (ACC) atrophy, disinhibition by orbitofrontal cortical (OFC) atrophy. 3.0 Tesla MRI scans were acquired from 22 people with ALS or ALS-FTD. Quantitative cortical thickness analysis was performed with FreeSurfer. A priori-defined regions of interest (ROI) were used to measure cortical thickness in each participant and calculate magnitude of atrophy in comparison to 115 healthy controls. Spearman correlations were used to evaluate associations between frontal ROI cortical thickness and cognitive-behavioral symptoms, measured by Neuropsychiatric Inventory Questionnaire (NPI-Q) and Clinical Dementia Rating (CDR) scale. ALS-FTD participants exhibited variable degrees of apathy (NPI-Q/apathy: 1.6 ± 1.2), disinhibition (NPI-Q/disinhibition: 1.2 ± 1.2), executive dysfunction (CDR/judgment-problem solving: 1.7 ± 0.8). Within the ALS-FTD group, executive dysfunction correlated with dlPFC atrophy (ρ:-0.65;p < 0.05); similar trends were seen for apathy with ACC (ρ:-0.53;p < 0.10) and dmPFC (ρ:-0.47;p < 0.10) atrophy, for disinhibition with OFC atrophy (ρ:-0.51;p < 0.10). Compared to people with ALS, those with ALS-FTD showed more diffuse atrophy involving precentral gyrus, prefrontal, temporal regions. Profile and severity of cognitive-behavioral symptoms in ALS-FTD are predicted by regional prefrontal atrophy. These findings are consistent with established brain-behavior models and support the role of quantitative MRI in diagnosis, management, counseling, monitoring and prognostication for a neurodegenerative disorder with diverse phenotypes.
    Mesh-Begriff(e) Amyotrophic Lateral Sclerosis/diagnostic imaging ; Atrophy ; Behavioral Symptoms ; Cognition ; Frontotemporal Dementia/diagnostic imaging ; Humans ; Magnetic Resonance Imaging
    Sprache Englisch
    Erscheinungsdatum 2021-02-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2377165-3
    ISSN 1931-7565 ; 1931-7557
    ISSN (online) 1931-7565
    ISSN 1931-7557
    DOI 10.1007/s11682-021-00456-1
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  6. Artikel: Use of the Progressive Aphasia Severity Scale (PASS) in monitoring speech and language status in PPA.

    Sapolsky, Daisy / Domoto-Reilly, Kimiko / Dickerson, Bradford C

    Aphasiology

    2014  Band 28, Heft 8-9, Seite(n) 993–1003

    Abstract: Background: Primary progressive aphasia (PPA) is a devastating neurodegenerative syndrome involving the gradual development of aphasia, slowly impairing the patient's ability to communicate. Pharmaceutical treatments do not currently exist and ... ...

    Abstract Background: Primary progressive aphasia (PPA) is a devastating neurodegenerative syndrome involving the gradual development of aphasia, slowly impairing the patient's ability to communicate. Pharmaceutical treatments do not currently exist and intervention often focuses on speech-language behavioral therapies, although further investigation is warranted to determine how best to harness functional benefits. Efforts to develop pharmaceutical and behavioral treatments have been hindered by a lack of standardized methods to monitor disease progression and treatment efficacy.
    Aims: Here we describe our current approach to monitoring progression of PPA, including the development and applications of a novel clinical instrument for this purpose, the Progressive Aphasia Severity Scale (PASS). We also outline some of the issues related to initial evaluation and longitudinal monitoring of PPA.
    Methods & procedures: In our clinical and research practice we perform initial and follow-up assessments of PPA patients using a multi-faceted approach. In addition to standardized assessment measures, we use the PASS to rate presence and severity of symptoms across distinct domains of speech, language, and functional and pragmatic aspects of communication. Ratings are made using the clinician's best judgment, integrating information from patient test performance in the office as well as a companion's description of routine daily functioning.
    Outcomes & results: Monitoring symptom characteristics and severity with the PASS can assist in developing behavioral therapies, planning treatment goals, and counseling patients and families on clinical status and prognosis. The PASS also has potential to advance the implementation of PPA clinical trials.
    Conclusions: PPA patients display heterogeneous language profiles that change over time given the progressive nature of the disease. The monitoring of symptom progression is therefore crucial to ensure that proposed treatments are appropriate at any given stage, including speech-language therapy and potentially pharmaceutical treatments once these become available. Because of the discrepancy that can exist between a patient's daily functioning and standardized test performance, we believe a comprehensive assessment and monitoring battery must include performance-based instruments, interviews with the patient and partner, questionnaires about functioning in daily life, and measures of clinician judgment. We hope that our clinician judgment-based rating scale described here will be a valuable addition to the PPA assessment and monitoring battery.
    Sprache Englisch
    Erscheinungsdatum 2014-09-25
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 639180-1
    ISSN 1464-5041 ; 0268-7038
    ISSN (online) 1464-5041
    ISSN 0268-7038
    DOI 10.1080/02687038.2014.931563
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  7. Artikel ; Online: Associations of Binge Drinking With Vascular Brain Injury and Atrophy in Older American Indians: The Strong Heart Study.

    Lewis, Jordan P / Suchy-Dicey, Astrid M / Noonan, Carolyn / Blue Bird Jernigan, Valarie / Umans, Jason G / Domoto-Reilly, Kimiko / Buchwald, Dedra S / Manson, Spero M

    Journal of aging and health

    2021  Band 33, Heft 7-8_suppl, Seite(n) 51S–59S

    Abstract: Objectives: ...

    Abstract Objectives:
    Mesh-Begriff(e) Aged ; Alcohol Drinking/adverse effects ; Alcohol Drinking/epidemiology ; Atrophy ; Binge Drinking/epidemiology ; Brain/diagnostic imaging ; Brain/pathology ; Cerebrovascular Trauma/diagnostic imaging ; Cerebrovascular Trauma/ethnology ; Cerebrovascular Trauma/pathology ; Cohort Studies ; Female ; Humans ; Indians, North American/psychology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; American Indian or Alaska Native/psychology
    Sprache Englisch
    Erscheinungsdatum 2021-07-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1045392-1
    ISSN 1552-6887 ; 0898-2643
    ISSN (online) 1552-6887
    ISSN 0898-2643
    DOI 10.1177/08982643211013696
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  8. Artikel ; Online: Unusually long duration and delayed penetrance in a family with FTD and mutation in MAPT (V337M).

    Domoto-Reilly, Kimiko / Davis, Marie Y / Keene, C Dirk / Bird, Thomas D

    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

    2016  Band 174, Heft 1, Seite(n) 70–74

    Abstract: Mutations in the MAPT gene coding for the tau protein are one of the most common causes of familial frontotemporal dementia (FTD). In a previously described family with the V337M mutation in MAPT, we now report an affected woman who died at age 92 with a ...

    Abstract Mutations in the MAPT gene coding for the tau protein are one of the most common causes of familial frontotemporal dementia (FTD). In a previously described family with the V337M mutation in MAPT, we now report an affected woman who died at age 92 with a >40 year duration of symptoms, more than three times the mean disease duration in her family (13.8 years). Neuropathology showed the typical findings of a diffuse tauopathy. Conversely, her 67-year-old son with the same mutation remains asymptomatic more than 15 years beyond the mean age of onset in the family (51.5 years). These two cases demonstrate the marked variability in onset and duration of familial FTD and underscore the difficulties of discussing these issues with patients and families. The presumed genetic and environmental factors influencing these parameters remain largely unknown. © 2016 Wiley Periodicals, Inc.
    Mesh-Begriff(e) Aged ; Dementia/genetics ; Female ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/psychology ; Humans ; Male ; Mutation ; Pedigree ; Penetrance ; tau Proteins/genetics ; tau Proteins/metabolism
    Chemische Substanzen MAPT protein, human ; tau Proteins
    Sprache Englisch
    Erscheinungsdatum 2016-03-16
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2108616-3
    ISSN 1552-485X ; 1552-4841 ; 0148-7299
    ISSN (online) 1552-485X
    ISSN 1552-4841 ; 0148-7299
    DOI 10.1002/ajmg.b.32443
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  9. Artikel ; Online: Plasma inflammation for predicting phenotypic conversion and clinical progression of autosomal dominant frontotemporal lobar degeneration.

    Asken, Breton M / Ljubenkov, Peter A / Staffaroni, Adam M / Casaletto, Kaitlin B / Vandevrede, Lawren / Cobigo, Yann / Rojas-Rodriguez, Julio C / Rankin, Katherine P / Kornak, John / Heuer, Hilary / Shigenaga, Judy / Appleby, Brian S / Bozoki, Andrea C / Domoto-Reilly, Kimiko / Ghoshal, Nupur / Huey, Edward / Litvan, Irene / Masdeu, Joseph C / Mendez, Mario F /
    Pascual, Belen / Pressman, Peter / Tartaglia, Maria Carmela / Kremers, Walter / Forsberg, Leah K / Boeve, Brad F / Boxer, Adam L / Rosen, Howie J / Kramer, Joel H

    Journal of neurology, neurosurgery, and psychiatry

    2023  Band 94, Heft 7, Seite(n) 541–549

    Abstract: Background: Measuring systemic inflammatory markers may improve clinical prognosis and help identify targetable pathways for treatment in patients with autosomal dominant forms of frontotemporal lobar degeneration (FTLD).: Methods: We measured plasma ...

    Abstract Background: Measuring systemic inflammatory markers may improve clinical prognosis and help identify targetable pathways for treatment in patients with autosomal dominant forms of frontotemporal lobar degeneration (FTLD).
    Methods: We measured plasma concentrations of IL-6, TNFα and YKL-40 in pathogenic variant carriers (
    Results: We studied 394 participants (non-carriers=143,
    Conclusions: Systemic proinflammatory protein measurement, particularly TNFα, may improve clinical prognosis in autosomal dominant FTLD pathogenic variant carriers who are not yet exhibiting severe impairment. Integrating TNFα with markers of neuronal dysfunction like NfL could optimise detection of impending symptom conversion in asymptomatic pathogenic variant carriers and may help personalise therapeutic approaches.
    Mesh-Begriff(e) Humans ; C9orf72 Protein/genetics ; Disease Progression ; Frontotemporal Dementia/diagnosis ; Frontotemporal Lobar Degeneration/diagnosis ; Frontotemporal Lobar Degeneration/genetics ; Frontotemporal Lobar Degeneration/pathology ; Inflammation ; Interleukin-6 ; Mutation ; tau Proteins/genetics ; Tumor Necrosis Factor-alpha
    Chemische Substanzen C9orf72 Protein ; Interleukin-6 ; tau Proteins ; Tumor Necrosis Factor-alpha
    Sprache Englisch
    Erscheinungsdatum 2023-03-28
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2022-330866
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  10. Artikel ; Online: Multisite ALLFTD study modeling progressive empathy loss from the earliest stages of behavioral variant frontotemporal dementia.

    Toller, Gianina / Cobigo, Yann / Callahan, Patrick / Appleby, Brian S / Brushaber, Danielle / Domoto-Reilly, Kimiko / Forsberg, Leah K / Ghoshal, Nupur / Graff-Radford, Jonathan / Graff-Radford, Neil R / Grossman, Murray / Heuer, Hilary W / Kornak, John / Kremers, Walter / Lapid, Maria I / Leger, Gabriel / Litvan, Irene / Mackenzie, Ian R / Pascual, Maria B /
    Ramos, Eliana M / Rascovsky, Katya / Rojas, Julio C / Staffaroni, Adam M / Tartaglia, Maria C / Toga, Arthur / Weintraub, Sandra / Wszolek, Zbigniew K / Boeve, Brad F / Boxer, Adam L / Rosen, Howard J / Rankin, Katherine P

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2023  Band 19, Heft 7, Seite(n) 2842–2852

    Abstract: Introduction: Empathy relies on fronto-cingular and temporal networks that are selectively vulnerable in behavioral variant frontotemporal dementia (bvFTD). This study modeled when in the disease process empathy changes begin, and how they progress.: ... ...

    Abstract Introduction: Empathy relies on fronto-cingular and temporal networks that are selectively vulnerable in behavioral variant frontotemporal dementia (bvFTD). This study modeled when in the disease process empathy changes begin, and how they progress.
    Methods: Four hundred thirty-one individuals with asymptomatic genetic FTD (n = 114), genetic and sporadic bvFTD (n = 317), and 163 asymptomatic non-carrier controls were enrolled. In sub-samples, we investigated empathy measured by the informant-based Interpersonal Reactivity Index (IRI) at each disease stage and over time (n = 91), and its correspondence to underlying atrophy (n = 51).
    Results: Empathic concern (estimate = 4.38, 95% confidence interval [CI] = 2.79, 5.97; p < 0.001) and perspective taking (estimate = 5.64, 95% CI = 3.81, 7.48; p < 0.001) scores declined between the asymptomatic and very mild symptomatic stages regardless of pathogenic variant status. More rapid loss of empathy corresponded with subcortical atrophy.
    Discussion: Loss of empathy is an early and progressive symptom of bvFTD that is measurable by IRI informant ratings and can be used to monitor behavior in neuropsychiatry practice and treatment trials.
    Mesh-Begriff(e) Humans ; Empathy ; Frontotemporal Dementia/diagnosis ; Neuropsychological Tests ; Atrophy ; Magnetic Resonance Imaging
    Sprache Englisch
    Erscheinungsdatum 2023-01-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.12898
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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