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  1. Artikel ; Online: The management of cardiovascular risk in psoriatic disease: A bridge over troubled water.

    Alunno, Alessia / Carubbi, Francesco / Rodríguez-Carrio, Javier / Gossec, Laure / Donohoe, Siobhán / Ferri, Claudio

    Seminars in arthritis and rheumatism

    2024  Band 65, Seite(n) 152389

    Abstract: Evidence that psoriatic disease is burdened by an excess cardiovascular (CV) risk has accrued, however many questions remain unanswered. Although an interplay between traditional risk factors inflammation, disease activity and pharmacological therapies, ... ...

    Abstract Evidence that psoriatic disease is burdened by an excess cardiovascular (CV) risk has accrued, however many questions remain unanswered. Although an interplay between traditional risk factors inflammation, disease activity and pharmacological therapies, as observed in rheumatoid arthritis (RA), may account for this increased risk, metabolic comorbidities rather than inflammation seem to have a leading role in psoriatic disease. Therefore, specific approaches, risk factors targeting and the importance of traditional risk factors and inflammation management need to be considered. The purpose of this review article is to discuss current data on CV risk in psoriatic disease, and to outline similarities and differences with RA in the light of international recommendations. Arguments in favour of developing specific guidance for CV prevention in psoriatic disease are discussed.
    Mesh-Begriff(e) Humans ; Risk Factors ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Arthritis, Psoriatic/complications ; Arthritis, Psoriatic/drug therapy ; Arthritis, Rheumatoid/drug therapy ; Inflammation ; Heart Disease Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2024-01-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 120247-9
    ISSN 1532-866X ; 0049-0172
    ISSN (online) 1532-866X
    ISSN 0049-0172
    DOI 10.1016/j.semarthrit.2024.152389
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  2. Artikel: Ontogeny of Beta 2 Glycoprotein I and Annexin V in Villous Placenta of Normal and Antiphospholipid Syndrome Pregnancies

    Donohoe, Siobhán / Kingdom, John C. P. / Mackie, Ian J. / Burrell, Stephen / Quenby, Siobhán / Jauniaux, Eric / Machin, Samuel J.

    Thrombosis and Haemostasis

    2000  Band 83, Heft 01, Seite(n) 32–38

    Abstract: β 2 -glycoprotein I (β 2 GPI) and annexin V (AV) have been implicated in the pathophysiology of the antiphospholipid syndrome (APS). We investigated their placental expression in normal villous tissues throughout gestation; first trimester n = 10, early ... ...

    Abstract β 2 -glycoprotein I (β 2 GPI) and annexin V (AV) have been implicated in the pathophysiology of the antiphospholipid syndrome (APS). We investigated their placental expression in normal villous tissues throughout gestation; first trimester n = 10, early second trimester; n = 4, preterm; n = 5) and term; n = 7 and in APS (2 first trimester, 1 preterm and 8 term deliveries). β 2 GPI and AV were both expressed by the placenta from as early as seven weeks gestation and were colocalised to the syncytiotrophoblast. β 2 GPI staining was also observed in stromal cells, being present in phagocytic Hofbauer cells and surrounding newly formed fetal vessels in a perivascular pattern, from seven to seventeen weeks gestation. An abnormal morphological distribution of AV was noted in one first trimester APS placenta, and for β 2 GPI in a further first trimester placenta. When placental proteins were extracted from villous tissue, the concentration of AV/mg protein in term APS placentas (median, interquartile range) (aPS; 8.16, 7.87-9.72 µg/mg) was significantly higher (p <0.005) than normal term levels (normal; 2.47, 2.28-2.54 µg/mg). β 2 GPI increased with advancing gestation (first trimester; 0.93, 0.64-1.26 µg/mg, term; 3.67, 2.58-4.48 µg/mg) in normal pregnancy. Term APS placentas had a reduced β 2 GPI content (2.31, 1.87-2.49 µg/mg), p <0.05. The placental role of these proteins remains to be identified.
    Schlagwörter β ; -glycoprotein-I ; annexin V ; placenta ; antiphospholipid syndrome (APS)
    Sprache Englisch
    Erscheinungsdatum 2000-01-01
    Verlag Schattauer GmbH
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0037-1613963
    Datenquelle Thieme Verlag

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    Zs.MO 433: Hefte anzeigen

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