Artikel ; Online: Pulmonary vascular disease in Veterans with post-deployment respiratory syndrome.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
2024 Band 71, Seite(n) 107640
Abstract: Exertional dyspnea has been documented in US military personnel after deployment to Iraq and Afghanistan. We studied whether continued exertional dyspnea in this patient population is associated with pulmonary vascular disease (PVD). We performed ... ...
| Abstract | Exertional dyspnea has been documented in US military personnel after deployment to Iraq and Afghanistan. We studied whether continued exertional dyspnea in this patient population is associated with pulmonary vascular disease (PVD). We performed detailed histomorphometry of pulmonary vasculature in 52 Veterans with biopsy-proven post-deployment respiratory syndrome (PDRS) and then recruited five of these same Veterans with continued exertional dyspnea to undergo a follow-up clinical evaluation, including symptom questionnaire, pulmonary function testing, surface echocardiography, and right heart catheterization (RHC). Morphometric evaluation of pulmonary arteries showed significantly increased intima and media thicknesses, along with collagen deposition (fibrosis), in Veterans with PDRS compared to non-diseased (ND) controls. In addition, pulmonary veins in PDRS showed increased intima and adventitia thicknesses with prominent collagen deposition compared to controls. Of the five Veterans involved in our clinical follow-up study, three had borderline or overt right ventricle (RV) enlargement by echocardiography and evidence of pulmonary hypertension (PH) on RHC. Together, our studies suggest that PVD with predominant venular fibrosis is common in PDRS and development of PH may explain exertional dyspnea and exercise limitation in some Veterans with PDRS. |
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| Mesh-Begriff(e) | Humans ; Male ; Pulmonary Artery/pathology ; Pulmonary Artery/physiopathology ; Pulmonary Artery/diagnostic imaging ; Adult ; Hypertension, Pulmonary/pathology ; Hypertension, Pulmonary/physiopathology ; Hypertension, Pulmonary/etiology ; Middle Aged ; Female ; Afghan Campaign 2001- ; Iraq War, 2003-2011 ; Pulmonary Veins/pathology ; Pulmonary Veins/physiopathology ; Pulmonary Veins/diagnostic imaging ; Dyspnea/etiology ; Dyspnea/physiopathology ; Veterans ; Case-Control Studies ; Veterans Health ; Biopsy ; Fibrosis |
| Sprache | Englisch |
| Erscheinungsdatum | 2024-04-09 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article |
| ZDB-ID | 1134600-0 |
| ISSN | 1879-1336 ; 1054-8807 |
| ISSN (online) | 1879-1336 |
| ISSN | 1054-8807 |
| DOI | 10.1016/j.carpath.2024.107640 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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