Artikel ; Online: Cystatin F (
2023 Band 12
Abstract: Microglial endolysosomal (dys)function is strongly implicated in neurodegenerative disease. Transcriptomic studies show that a microglial state characterised by a set of genes involved in endolysosomal function is induced in both mouse Alzheimer's ... ...
| Abstract | Microglial endolysosomal (dys)function is strongly implicated in neurodegenerative disease. Transcriptomic studies show that a microglial state characterised by a set of genes involved in endolysosomal function is induced in both mouse Alzheimer's disease (AD) models and human AD brain, and that the emergence of this state is emphasised in females. |
|---|---|
| Mesh-Begriff(e) | Animals ; Female ; Humans ; Male ; Mice ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Cystatins/metabolism ; Disease Models, Animal ; Mice, Transgenic ; Microglia/metabolism ; Neurodegenerative Diseases/pathology |
| Chemische Substanzen | Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Cystatins ; cystatin F, mouse |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-12-12 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2687154-3 |
| ISSN | 2050-084X ; 2050-084X |
| ISSN (online) | 2050-084X |
| ISSN | 2050-084X |
| DOI | 10.7554/eLife.85279 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Zusatzmaterialien
Kategorien
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.