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  1. Book ; Online ; E-Book: Johns and Cunningham's the physics of radiology

    Bezak, Eva / Beddoe, Alun H. / Marcu, Loredana G. / Ebert, Martin / Price, Roger

    2021  

    Title translation Physics of radiology
    Title variant The physics of radiology
    Author's details Eva Bezak, Alun H Beddoe, Loredana G Marcu, Martin Ebert, Roger Price
    Keywords Medical radiology ; Radiology
    Language English
    Size 1 Online-Ressource (xxvii, 1352 Seiten), Illustrationen, Diagramme
    Edition Fifth edition
    Publisher Charles C. Thomas, Publisher, Ltd
    Publishing place Springfield, Illinois
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020867565
    ISBN 978-0-3980-9295-5 ; 9780398092948 ; 0-3980-9295-8 ; 039809294X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article: Taxonomic status of the caturid genera (Halecomorphi, Caturidae) and their Late Jurassic species.

    López-Arbarello, Adriana / Ebert, Martin

    Royal Society open science

    2023  Volume 10, Issue 1, Page(s) 221318

    Abstract: Caturids are among the best-known predatory ray-finned fishes of the Mesozoic. Although there is consensus about their sister-group relationship to Amiidae (Holostei, Amiiformes), their diversity, ingroup phylogenetic relationships and evolutionary ... ...

    Abstract Caturids are among the best-known predatory ray-finned fishes of the Mesozoic. Although there is consensus about their sister-group relationship to Amiidae (Holostei, Amiiformes), their diversity, ingroup phylogenetic relationships and evolutionary history are still very poorly understood. Caturidae is currently restricted to
    Language English
    Publishing date 2023-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.221318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Development of a 3D printed phantom for commissioning and quality assurance of multiple brain targets stereotactic radiosurgery.

    Mukwada, Godfrey / Hirst, Andrew / Rowshanfarzad, Pejman / Ebert, Martin A

    Physical and engineering sciences in medicine

    2024  

    Abstract: Single plan techniques for multiple brain targets (MBT) stereotactic radiosurgery (SRS) are now routine. Patient specific quality assurance (QA) for MBT poses challenges due to the limited capabilities of existing QA tools which necessitates several plan ...

    Abstract Single plan techniques for multiple brain targets (MBT) stereotactic radiosurgery (SRS) are now routine. Patient specific quality assurance (QA) for MBT poses challenges due to the limited capabilities of existing QA tools which necessitates several plan redeliveries. This study sought to develop an SRS QA phantom that enables flexible MBT patient specific QA in a single delivery, along with complex SRS commissioning. PLA marble and PLA StoneFil materials were selected based on the literature and previous research conducted in our department. The HU numbers were investigated to determine the appropriate percentage infill for skull and soft-tissue equivalence. A Prusa MK3S printer in conjunction with the above-mentioned filaments were used to print the SRS QA phantom. Quality control (QC) was performed on the printed skull, film inserts and plugs for point dose measurements. EBT3 film and point dose measurements were performed using a CC04 ionisation chamber. QC demonstrated that the SRS QA phantom transverse, coronal and sagittal film planes were orthogonal within 0.5°. HU numbers for the skull, film inserts and plugs were 858 ± 20 and 35 ± 12 respectively. Point and EBT3 film dose measurements were within 2.5% and 3%/2 mm 95% gamma pass rate, respectively except one Gross Tumour Volume (GTV) that had a slightly lower gamma pass rate. Dose distributions to five GTVs were measured with EBT3 film in a single plan delivery on CyberKnife. In conclusion, an SRS QA phantom was designed, and 3D printed and its use for performing complex MBT patient specific QA in a single delivery was demonstrated.
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2662-4737
    ISSN (online) 2662-4737
    DOI 10.1007/s13246-023-01374-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction factors for commissioning and patient specific quality assurance of stereotactic fields in a Monte Carlo based treatment planning system : TPS correction factors.

    Goodall, Simon K / Rowshanfarzad, Pejman / Ebert, Martin A

    Physical and engineering sciences in medicine

    2023  Volume 46, Issue 2, Page(s) 735–745

    Abstract: Validation of small field dosimetry is crucial for stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). Accurate and considered measurement of linear accelerator dose must be compared to precise and accurate calculation by the ... ...

    Abstract Validation of small field dosimetry is crucial for stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). Accurate and considered measurement of linear accelerator dose must be compared to precise and accurate calculation by the treatment planning system (TPS). Monte Carlo calculated distributions contain statistical noise, reducing the reliance that should be given to single voxel doses. The average dose to a small volume of interest (VOI) can minimise the influence of noise, but for small fields introduces significant volume averaging. Similar challenges present during measurement of composite dose from clinical plans when a small volume ionisation chamber is used. This study derived correction factors for VOI averaged TPS doses calculated for small fields, allowing correction to an isocentre dose following account for statistical noise. These factors were used to determine an optimal VOI to represent small volume ionisation chambers during patient specific quality assurance (PSQA). A retrospective comparison of 82 SRS and 28 SBRT PSQA measurements to TPS calculated doses from varying VOI was completed to evaluate the determined volumes. Small field commissioning correction factors of under 5% were obtained for field sizes of 8 mm and larger. Optimal spherical VOI with radius between 1.5 and 1.8 mm and 2.5 to 2.9 mm were determined for IBA CC01 and CC04 ionisation chambers respectively. Review of PSQA confirmed an optimal agreement between CC01 measured doses and a volume of 1.5 to 1.8 mm while CC04 measured doses showed no variation with VOI.
    MeSH term(s) Humans ; Radiotherapy Dosage ; Retrospective Studies ; Radiotherapy Planning, Computer-Assisted ; Radiosurgery ; Particle Accelerators
    Language English
    Publishing date 2023-04-06
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2662-4737
    ISSN (online) 2662-4737
    DOI 10.1007/s13246-023-01246-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Thesis: Vergleichende Studie über die Wirksamkeit von Cetrylpyridiniumchlorid-Pinsellösungen

    Ebert, Martin

    1992  

    Author's details vorgelegt von: Martin Ebert
    Size II, 51 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 1993
    HBZ-ID HT004944110
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    93 D 2498 order for loan Magazin

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  6. Article ; Online: Comparison of the accuracy of Monte Carlo and Ray Tracing dose calculation algorithms for multiple target brain treatments on CyberKnife.

    Mukwada, Godfrey / Skorska, Malgorzata / Rowshanfarzad, Pejman / Ebert, Martin A

    Physical and engineering sciences in medicine

    2023  Volume 46, Issue 4, Page(s) 1477–1487

    Abstract: Single plan multiple brain targets (MBT) stereotactic radiosurgery dose difference between Monte Carlo (MC) and Ray Tracing (RT) algorithms has not been studied. A retrospective study and dose measurements were performed to access factors influencing ... ...

    Abstract Single plan multiple brain targets (MBT) stereotactic radiosurgery dose difference between Monte Carlo (MC) and Ray Tracing (RT) algorithms has not been studied. A retrospective study and dose measurements were performed to access factors influencing dose differences. Fifty-three RT treatment plans with a total of 209 brain metastases were extracted from Precision Treatment Planning System (TPS). These plans were generated using fixed cones and were delivered using the CyberKnife M6 system. The same treatment plans were recalculated using MC algorithm and keeping the beam parameters unchanged. MC calculated plan parameters were extracted and dose differences were normalised to MC calculated dose. Correlations were investigated. RT and MC calculated off-centre-ratio (OCR) and tissue-phantom-ratio (TPRs) were exported from the TPS and compared with measured. Plans with 5 gross tumour volumes (GTVs) were created on a phantom and dose measured using a CC04 ionisation chamber and microdiamond detector for comparison with calculated doses. Calculated and measured TPR agreed within ± 1% beyond depth of maximum dose. The OCR showed differences up to 4.3% in the penumbra and out-of-field (OOF) regions. Largest RT and MC calculated GTV mean dose difference was - 5.7%. An increase in the number of GTVs and reduction in the geometric separation of metastases were associated with increased differences between RT and MC calculated doses. In conclusion, calculated dose disagreement in MBT depends on the number of GTVs per plan, number of GTVs within a certain separation distance and plan complexity. MC dose calculation is recommended for complex CyberKnife SRS of MBT.
    MeSH term(s) Humans ; Lung Neoplasms/surgery ; Radiotherapy Dosage ; Retrospective Studies ; Radiotherapy Planning, Computer-Assisted ; Algorithms ; Brain/diagnostic imaging ; Brain/surgery ; Brain/pathology
    Language English
    Publishing date 2023-08-08
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2662-4737
    ISSN (online) 2662-4737
    DOI 10.1007/s13246-023-01312-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Focal Boost in Prostate Cancer Radiotherapy: A Review of Planning Studies and Clinical Trials.

    Zhao, Yutong / Haworth, Annette / Rowshanfarzad, Pejman / Ebert, Martin A

    Cancers

    2023  Volume 15, Issue 19

    Abstract: Background: Focal boost radiotherapy was developed to deliver elevated doses to functional sub-volumes within a target. Such a technique was hypothesized to improve treatment outcomes without increasing toxicity in prostate cancer treatment.: Purpose!# ...

    Abstract Background: Focal boost radiotherapy was developed to deliver elevated doses to functional sub-volumes within a target. Such a technique was hypothesized to improve treatment outcomes without increasing toxicity in prostate cancer treatment.
    Purpose: To summarize and evaluate the efficacy and variability of focal boost radiotherapy by reviewing focal boost planning studies and clinical trials that have been published in the last ten years.
    Methods: Published reports of focal boost radiotherapy, that specifically incorporate dose escalation to intra-prostatic lesions (IPLs), were reviewed and summarized. Correlations between acute/late ≥G2 genitourinary (GU) or gastrointestinal (GI) toxicity and clinical factors were determined by a meta-analysis.
    Results: By reviewing and summarizing 34 planning studies and 35 trials, a significant dose escalation to the GTV and thus higher tumor control of focal boost radiotherapy were reported consistently by all reviewed studies. Reviewed trials reported a not significant difference in toxicity between focal boost and conventional radiotherapy. Acute ≥G2 GU and late ≥G2 GI toxicities were reported the most and least prevalent, respectively, and a negative correlation was found between the rate of toxicity and proportion of low-risk or intermediate-risk patients in the cohort.
    Conclusion: Focal boost prostate cancer radiotherapy has the potential to be a new standard of care.
    Language English
    Publishing date 2023-10-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15194888
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  8. Article ; Online: Recommended dose voxel size and statistical uncertainty parameters for precision of Monte Carlo dose calculation in stereotactic radiotherapy.

    Goodall, Simon K / Ebert, Martin A

    Journal of applied clinical medical physics

    2020  Volume 21, Issue 12, Page(s) 120–130

    Abstract: Monte Carlo (MC)-based treatment planning requires a choice of dose voxel size (DVS) and statistical uncertainty (SU). These parameters effect both the precision of displayed dose distribution and time taken to complete a calculation. For efficient, ... ...

    Abstract Monte Carlo (MC)-based treatment planning requires a choice of dose voxel size (DVS) and statistical uncertainty (SU). These parameters effect both the precision of displayed dose distribution and time taken to complete a calculation. For efficient, accurate, and precise treatment planning in a clinical setting, optimal values should be selected. In this investigation, 30 volumetric modulated arc therapy (VMAT) stereotactic radiotherapy (SRT) treatment plans, 10 brain, 10 lung, and 10 spine were calculated in the Monaco 5.11.02 treatment planning system (TPS). Each plan was calculated with a DVS of 0.1 and 0.2 cm using SU values of 0.50%, 0.75%, 1.00%, 1.50%, and 2.00%, along with a ground truth calculation using a DVS of 0.1 cm and SU of 0.15%. The variance at each relative dose level was calculated for all SU settings to assess their relationship. The variation from the ground truth calculation for each DVS and SU combination was determined for a range of DVH metrics and plan quality indices along with the time taken to complete the calculations. Finally, the effect of defining the maximum dose using a volume of 0.035 cc was compared to 0.100 cc when considering DVS and SU settings. Changes in the DVS produced greater variations from the ground truth calculation than changes in SU across the values tested. Plan quality metrics and mean dose values showed less sensitivity to changes in SU than DVH metrics. From this study, it was concluded that while maintaining an average calculation time of <10 min, 75% of plans could be calculated with variations of <2.0% from their ground truth values when using an SU setting of 1.50% and a DVS of 0.1 cm in the case of brain or spine plans, and a 0.2 cm DVS in the case of lung plans.
    MeSH term(s) Humans ; Monaco ; Monte Carlo Method ; Radiosurgery ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Intensity-Modulated ; Uncertainty
    Language English
    Publishing date 2020-10-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010347-5
    ISSN 1526-9914 ; 1526-9914
    ISSN (online) 1526-9914
    ISSN 1526-9914
    DOI 10.1002/acm2.13077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online ; Thesis: In-situ Messungen von eisnukleierenden Aerosolen mit dem Eiskeimzähler FINCH

    Kohl, Rebecca Martina [Verfasser] / Curtius, Joachim Gutachter] / [Ebert, Martin [Gutachter]

    2023  

    Author's details Rebecca Martina Kohl ; Gutachter: Joachim Curtius, Martin Ebert
    Keywords Geowissenschaften ; Earth Sciences
    Subject code sg550
    Language German
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Article ; Online: Dosimetric evaluation of an intraoperative radiotherapy system: a measurement-based and Monte-Carlo modelling investigation.

    Chin, Marsha / Rowshanfarzad, Pejman / Neveri, Gabor / Ebert, Martin A / Pfefferlé, David

    Physical and engineering sciences in medicine

    2023  Volume 46, Issue 2, Page(s) 687–701

    Abstract: Intraoperative radiotherapy (IORT) is a specialised subset of radiotherapy, where a high radiation dose is delivered to a surgically exposed tumour bed in order to eradicate any remaining cancer cells. The aim of this study was to examine the dose ... ...

    Abstract Intraoperative radiotherapy (IORT) is a specialised subset of radiotherapy, where a high radiation dose is delivered to a surgically exposed tumour bed in order to eradicate any remaining cancer cells. The aim of this study was to examine the dose characteristics of the Zeiss Intrabeam IORT device which provides near-isotropic emission of up to 50 kV X-rays. The EGSnrc Monte Carlo (MC) code system was used to simulate the device and percentage depth dose (PDD) data measured with a soft X-ray parallel-plate ionisation chamber were used for model verification. The model provided energy spectra, isodose curves and mean photon energies. In addition, EBT3 Gafchromic film was used to verify the MC model by examining PDDs and 2D dose distributions for various applicators. The differences between MC model and ionisation chamber measurements were within 3% for most points, with a maximum deviation of ~ 9%. Most of the simulated PDD points were within 5% of the film-measured data, with a maximum deviation of ~ 10%. The mean energy of the bare probe was found to be 21.19 keV. The mean photon energy from applicators ranged from 29.00 to 30.85 keV. Results of this study may be useful for future work on creating a system for treatment planning.
    MeSH term(s) Radiometry ; Radiotherapy Planning, Computer-Assisted/methods ; Photons ; X-Rays ; Monte Carlo Method
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2662-4737
    ISSN (online) 2662-4737
    DOI 10.1007/s13246-023-01243-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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