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  1. Article: Bio-Hacking Better Health-Leveraging Metabolic Biochemistry to Maximise Healthspan.

    Cooper, Isabella D / Kyriakidou, Yvoni / Petagine, Lucy / Edwards, Kurtis / Elliott, Bradley T

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: In the pursuit of longevity and healthspan, we are challenged with first overcoming chronic diseases of ageing: cardiovascular disease, hypertension, cancer, dementias, type 2 diabetes mellitus. These are hyperinsulinaemia diseases presented in different ...

    Abstract In the pursuit of longevity and healthspan, we are challenged with first overcoming chronic diseases of ageing: cardiovascular disease, hypertension, cancer, dementias, type 2 diabetes mellitus. These are hyperinsulinaemia diseases presented in different tissue types. Hyperinsulinaemia reduces endogenous antioxidants, via increased consumption and reduced synthesis. Hyperinsulinaemia enforces glucose fuelling, consuming 4 NAD
    Language English
    Publishing date 2023-09-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12091749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The role of CD180 in hematological malignancies and inflammatory disorders.

    Edwards, Kurtis / Lydyard, Peter M / Kulikova, Nino / Tsertsvadze, Tamar / Volpi, Emanuela V / Chiorazzi, Nicholas / Porakishvili, Nino

    Molecular medicine (Cambridge, Mass.)

    2023  Volume 29, Issue 1, Page(s) 97

    Abstract: Toll-like receptors play a significant role in the innate immune system and are also involved in the pathophysiology of many different diseases. Over the past 35 years, there have been a growing number of publications exploring the role of the orphan ... ...

    Abstract Toll-like receptors play a significant role in the innate immune system and are also involved in the pathophysiology of many different diseases. Over the past 35 years, there have been a growing number of publications exploring the role of the orphan toll-like receptor, CD180. We therefore set out to provide a narrative review of the current evidence surrounding CD180 in both health and disease. We first explore the evidence surrounding the role of CD180 in physiology including its expression, function and signaling in antigen presenting cells (APCs) (dendritic cells, monocytes, and B cells). We particularly focus on the role of CD180 as a modulator of other TLRs including TLR2, TLR4, and TLR9. We then discuss the role of CD180 in inflammatory and autoimmune diseases, as well as in hematological malignancies of B cell origin, including chronic lymphocytic leukemia (CLL). Based on this evidence we produce a current model for CD180 in disease and explore the potential role for CD180 as both a prognostic biomarker and therapeutic target. Throughout, we highlight specific areas of research which should be addressed to further the understanding of CD180 biology and the translational potential of research into CD180 in various diseases.
    MeSH term(s) Humans ; Antigens, CD/metabolism ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; B-Lymphocytes ; Hematologic Neoplasms/metabolism ; Hematologic Neoplasms/pathology ; Monocytes/metabolism
    Chemical Substances Antigens, CD ; CD180 protein, human
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1283676-x
    ISSN 1528-3658 ; 1076-1551
    ISSN (online) 1528-3658
    ISSN 1076-1551
    DOI 10.1186/s10020-023-00682-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4456: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Factors Involved in the onset of infection following bacterially contaminated platelet transfusions.

    Wilson-Nieuwenhuis, Joels / El-Mohtadi, Mohamed / Edwards, Kurtis / Whitehead, Kathryn / Dempsey-Hibbert, Nina

    Platelets

    2020  Volume 32, Issue 7, Page(s) 909–918

    Abstract: Transfusion of platelet concentrates (PCs) is associated with several adverse patient reactions, the most common of which are febrile non-hemolytic transfusion reactions (FNHTRs) and transfusion-associated bacterial-infection/transfusion-associated ... ...

    Abstract Transfusion of platelet concentrates (PCs) is associated with several adverse patient reactions, the most common of which are febrile non-hemolytic transfusion reactions (FNHTRs) and transfusion-associated bacterial-infection/transfusion-associated sepsis (T-ABI/TA-S). Diagnosis of T-ABI/T-AS requires a positive blood culture (BC) result from the transfusion recipient and also a positive identification of bacterial contamination within a test aliquot of the transfused PC. In a significant number of cases, clinical symptoms post-transfusion are reported by the clinician, yet the BCs from the patient and/or PC are negative. The topic of 'missed bacterial detection' has therefore been the focus of several primary research studies and review articles, suggesting that biofilm formation in the blood bag and the presence of viable but non-culturable (VBNC) pathogens are the major causes of this missed detection. However, platelets are emerging as key players in early host responses to infection and as such, the aforementioned biofilm formation could elicit 'platelet priming', which could lead to significant immunological reactions in the host, in the absence of planktonic bacteria in the host bloodstream. This review reflects on what is known about missed detection and relates this to the emerging understanding of the effect of bacterial contamination on the platelets themselves and the significant role played by platelets in exacerbation of an immune response to infection within the transfusion setting.
    MeSH term(s) Bacterial Infections/etiology ; Bacterial Infections/pathology ; Humans ; Platelet Transfusion/adverse effects
    Language English
    Publishing date 2020-08-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2020.1803253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2888: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Ketosis Suppression and Ageing (KetoSAge): The Effects of Suppressing Ketosis in Long Term Keto-Adapted Non-Athletic Females.

    Cooper, Isabella D / Kyriakidou, Yvoni / Edwards, Kurtis / Petagine, Lucy / Seyfried, Thomas N / Duraj, Tomas / Soto-Mota, Adrian / Scarborough, Andrew / Jacome, Sandra L / Brookler, Kenneth / Borgognoni, Valentina / Novaes, Vanusa / Al-Faour, Rima / Elliott, Bradley T

    International journal of molecular sciences

    2023  Volume 24, Issue 21

    Abstract: Most studies on ketosis have focused on short-term effects, male athletes, or weight loss. Hereby, we studied the effects of short-term ketosis suppression in healthy women on long-standing ketosis. Ten lean (BMI 20.5 ± 1.4), metabolically healthy, pre- ... ...

    Abstract Most studies on ketosis have focused on short-term effects, male athletes, or weight loss. Hereby, we studied the effects of short-term ketosis suppression in healthy women on long-standing ketosis. Ten lean (BMI 20.5 ± 1.4), metabolically healthy, pre-menopausal women (age 32.3 ± 8.9) maintaining nutritional ketosis (NK) for > 1 year (3.9 years ± 2.3) underwent three 21-day phases: nutritional ketosis (NK; P1), suppressed ketosis (SuK; P2), and returned to NK (P3). Adherence to each phase was confirmed with daily capillary D-beta-hydroxybutyrate (BHB) tests (P1 = 1.9 ± 0.7; P2 = 0.1 ± 0.1; and P3 = 1.9 ± 0.6 pmol/L). Ageing biomarkers and anthropometrics were evaluated at the end of each phase. Ketosis suppression significantly increased: insulin, 1.78-fold from 33.60 (± 8.63) to 59.80 (± 14.69) pmol/L (
    MeSH term(s) Animals ; Cattle ; Humans ; Male ; Female ; Young Adult ; Adult ; Cattle Diseases/metabolism ; Ketosis ; Diet, Ketogenic ; Insulin/pharmacology ; Hyperinsulinism ; 3-Hydroxybutyric Acid/metabolism
    Chemical Substances Insulin ; 3-Hydroxybutyric Acid (TZP1275679)
    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242115621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a ketogenic diet: experimental support for the lipid energy model.

    Cooper, Isabella D / Sanchez-Pizarro, Claudio / Norwitz, Nicholas G / Feldman, David / Kyriakidou, Yvoni / Edwards, Kurtis / Petagine, Lucy / Elliot, Bradley T / Soto-Mota, Adrian

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1326768

    Abstract: Introduction: There is a large heterogeneity in LDL-cholesterol change among individuals adopting ketogenic diets. Interestingly, lean metabolically healthy individuals seem to be particularly susceptible, with an inverse association between body mass ... ...

    Abstract Introduction: There is a large heterogeneity in LDL-cholesterol change among individuals adopting ketogenic diets. Interestingly, lean metabolically healthy individuals seem to be particularly susceptible, with an inverse association between body mass index and LDL-cholesterol change. The lipid energy model proposes that, in lean healthy individuals, carbohydrate restriction upregulates systemic lipid trafficking to meet energy demands. To test if anthropometric and energy metabolism markers predict LDL-cholesterol change during carbohydrate restriction.
    Methods: Ten lean, healthy, premenopausal women who habitually consumed a ketogenic diet for ≥6 months were engaged in a three-phase crossover study consisting of continued nutritional ketosis, suppression of ketosis with carbohydrate reintroduction, and return to nutritional ketosis. Each phase lasted 21 days. The predictive performance of all available relevant variables was evaluated with the linear mixed-effects models.
    Results: All body composition metrics, free T
    Discussion: Among lean, healthy women undergoing carbohydrate restriction, body composition and energy metabolism markers are major drivers of LDL-cholesterol change, not saturated fat, consistent with the lipid energy model.
    MeSH term(s) Humans ; Female ; Diet, Ketogenic ; Cross-Over Studies ; Thyroid Gland ; Body Composition ; Cholesterol, LDL ; Ketosis ; Carbohydrates
    Chemical Substances Cholesterol, LDL ; Carbohydrates
    Language English
    Publishing date 2023-12-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1326768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Expression patterns of CD180 in the lymph nodes of patients with chronic lymphocytic leukaemia.

    Edwards, Kurtis / Zaitseva, Kristina / Sayed, Uzma / Volpi, Emanuela V / Nathwani, Amit / Gribben, John G / Lydyard, Peter / Krysov, Sergey / Porakishvili, Nino

    British journal of haematology

    2021  Volume 195, Issue 2, Page(s) e131–e134

    MeSH term(s) Antigens, CD/blood ; Antigens, CD/immunology ; B-Lymphocytes/pathology ; Case-Control Studies ; Humans ; Immunohistochemistry/methods ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Lymph Nodes/immunology ; Lymph Nodes/metabolism ; Lymph Nodes/pathology ; Neoplasm Staging/methods ; Toll-Like Receptors/immunology ; Toll-Like Receptors/metabolism ; Tumor Microenvironment/immunology ; p38 Mitogen-Activated Protein Kinases/metabolism
    Chemical Substances Antigens, CD ; CD180 protein, human ; Toll-Like Receptors ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2021-07-05
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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