Article ; Online: Apigetrin-enriched Pulmeria alba extract prevents assault of STZ on pancreatic β-cells and neuronal oxidative stress with concomitant attenuation of tissue damage and suppression of inflammation in the brain of diabetic rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2023 Volume 162, Page(s) 114582
Abstract: In the present study, in vitro, in vivo, and in silico models were used to evaluate the therapeutic potential of Pulmeria alba methanolic (PAm) extract, and we identified the major phytocompound, apigetrin. Our in vitro studies revealed dose-dependent ... ...
| Abstract | In the present study, in vitro, in vivo, and in silico models were used to evaluate the therapeutic potential of Pulmeria alba methanolic (PAm) extract, and we identified the major phytocompound, apigetrin. Our in vitro studies revealed dose-dependent increased glucose uptake and inhibition of α-amylase (50% inhibitory concentration (IC |
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| MeSH term(s) | Rats ; Humans ; Animals ; Diabetes Mellitus, Experimental/drug therapy ; Acetylcholinesterase/metabolism ; Rats, Wistar ; Blood Glucose/metabolism ; Oxidative Stress ; Antioxidants/pharmacology ; Brain/metabolism ; Inflammation/drug therapy ; Streptozocin/therapeutic use ; Plant Extracts/pharmacology | |||||
| Chemical Substances | apigetrin (7OF2S66PCH) ; Acetylcholinesterase (EC 3.1.1.7) ; Blood Glucose ; Antioxidants ; Streptozocin (5W494URQ81) ; Plant Extracts | |||||
| Language | English | |||||
| Publishing date | 2023-03-28 | |||||
| Publishing country | France | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 392415-4 | |||||
| ISSN | 1950-6007 ; 0753-3322 ; 0300-0893 | |||||
| ISSN (online) | 1950-6007 | |||||
| ISSN | 0753-3322 ; 0300-0893 | |||||
| DOI | 10.1016/j.biopha.2023.114582 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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