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  1. Article ; Online: Antioxidant Effects of Argan Oil and Olive Oil against Iron-Induced Oxidative Stress: In Vivo and In Vitro Approaches.

    Bouchab, Habiba / Essadek, Soukaina / El Kamouni, Soufiane / Moustaid, Khadija / Essamadi, Abdelkhalid / Andreoletti, Pierre / Cherkaoui-Malki, Mustapha / El Kebbaj, Riad / Nasser, Boubker

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 15

    Abstract: Recently, the study of the protective powers of medicinal plants has become the focus of several studies. Attention has been focused on the identification of new molecules with antioxidant and chelating properties to counter reactive oxygen species (ROS) ...

    Abstract Recently, the study of the protective powers of medicinal plants has become the focus of several studies. Attention has been focused on the identification of new molecules with antioxidant and chelating properties to counter reactive oxygen species (ROS) involved as key elements in several pathologies. Considerable attention is given to argan oil (AO) and olive oil (OO) due to their particular composition and preventive properties. Our study aimed to determine the content of AO and OO on phenolic compounds, chlorophylls, and carotenoid pigments and their antioxidant potential by FRAP and DPPH tests. Thus, several metallic elements can induce oxidative stress, as a consequence of the formation of ROS. Iron is one of these metal ions, which participates in the generation of free radicals, especially OH from H
    MeSH term(s) Mice ; Animals ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Olive Oil/pharmacology ; Reactive Oxygen Species/metabolism ; Iron/pharmacology ; Hydrogen Peroxide/pharmacology ; Plant Oils/pharmacology ; Plant Oils/chemistry ; Oxidative Stress ; Lipid Peroxidation ; Glutathione/metabolism ; Phenols/pharmacology ; Superoxide Dismutase/metabolism
    Chemical Substances Antioxidants ; argan oil (4V59G5UW9X) ; Olive Oil ; Reactive Oxygen Species ; Iron (E1UOL152H7) ; Hydrogen Peroxide (BBX060AN9V) ; Plant Oils ; Glutathione (GAN16C9B8O) ; Phenols ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2023-08-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28155924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article: Effects of a Short-Term Lipopolysaccharides Challenge on Mouse Brain and Liver Peroxisomal Antioxidant and β-oxidative Functions: Protective Action of Argan Oil.

    Essadek, Soukaina / Bouchab, Habiba / El Kebbaj, Riad / Gondcaille, Catherine / El Kamouni, Soufiane / Savary, Stéphane / Vamecq, Joseph / Essamadi, Abdelkhalid / Cherkaoui-Malki, Mustapha / Nasser, Boubker / Andreoletti, Pierre

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 4

    Abstract: During sepsis, the imbalance between oxidative insult and body antioxidant response causes the dysfunction of organs, including the brain and liver. Exposing mice to bacterial lipopolysaccharides (LPS) results in a similar pathophysiological outcome. The ...

    Abstract During sepsis, the imbalance between oxidative insult and body antioxidant response causes the dysfunction of organs, including the brain and liver. Exposing mice to bacterial lipopolysaccharides (LPS) results in a similar pathophysiological outcome. The protection offered by argan oil was studied against LPS-induced oxidative stress, dysregulation of peroxisomal antioxidants, and β-oxidation activities in the brain and liver. In a short-term LPS treatment, lipid peroxidation (malonaldehyde assay) increased in the brain and liver with upregulations of proinflammatory
    Language English
    Publishing date 2022-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15040465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Protective Effect of Argan and Olive Oils against LPS-Induced Oxidative Stress and Inflammation in Mice Livers.

    El Kamouni, Soufiane / El Kebbaj, Riad / Andreoletti, Pierre / El Ktaibi, Abderrahim / Rharrassi, Issam / Essamadi, Abdelkhalid / El Kebbaj, M'hammed Saïd / Mandard, Stéphane / Latruffe, Norbert / Vamecq, Joseph / Nasser, Boubker / Cherkaoui-Malki, Mustapha

    International journal of molecular sciences

    2017  Volume 18, Issue 10

    Abstract: Sepsis causes severe dysregulation of organ functions, via the development of oxidative stress and inflammation. These pathophysiological mechanisms are mimicked in mice injected with bacterial lipopolysaccharide (LPS). Here, protective properties of ... ...

    Abstract Sepsis causes severe dysregulation of organ functions, via the development of oxidative stress and inflammation. These pathophysiological mechanisms are mimicked in mice injected with bacterial lipopolysaccharide (LPS). Here, protective properties of argan oil against LPS-induced oxidative stress and inflammation are explored in the murine model. Mice received standard chow, supplemented with argan oil (AO) or olive oil (OO) for 25 days, before septic shock was provoked with a single intraperitoneal injection of LPS, 16 hours prior to animal sacrifice. In addition to a rise in oxidative stress and inflammatory markers, injected LPS also caused hepatotoxicity, accompanied by hyperglycemia, hypercholesterolemia and hyperuremia. These LPS-associated toxic effects were blunted by AO pretreatment, as corroborated by normal plasma parameters and cell stress markers (glutathione: GSH) and antioxidant enzymology (catalase, CAT; superoxide dismutase, SOD and glutathione peroxidase, GPx). Hematoxylin-eosin staining revealed that AO can protect against acute liver injury, maintaining a normal status, which is pointed out by absent or reduced LPS-induced hepatic damage markers (i.e., alanine aminotransferase (ALT) and aspartate transaminase (AST)). Our work also indicated that AO displayed anti-inflammatory activity, due to down-regulations of genes encoding pro-inflammatory cytokines Interleukin-6 (IL-6) and Tumor Necrosis Factor-α (TNF-α) and in up-regulations of the expression of anti-inflammatory genes encoding Interleukin-4 (IL-4) and Interleukin-10 (IL-10). OO provided animals with similar, though less extensive, protective changes. Collectively our work adds compelling evidence to the protective mechanisms of AO against LPS-induced liver injury and hence therapeutic potentialities, in regard to the management of human sepsis. Activations of IL-4/Peroxisome Proliferator-Activated Receptors (IL-4/PPARs) signaling and, under LPS, an anti-inflammatory IL-10/Liver X Receptor (IL-10/LXR) route, obviously indicated the high potency and plasticity of the anti-inflammatory properties of argan oil.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Antioxidants/administration & dosage ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Dietary Supplements ; Lipopolysaccharides/toxicity ; Liver/drug effects ; Liver/metabolism ; Liver Diseases/drug therapy ; Liver Diseases/etiology ; Liver Diseases/prevention & control ; Mice ; Olive Oil/administration & dosage ; Olive Oil/pharmacology ; Olive Oil/therapeutic use ; Oxidative Stress ; Plant Oils/administration & dosage ; Plant Oils/pharmacology ; Plant Oils/therapeutic use
    Chemical Substances Anti-Inflammatory Agents ; Antioxidants ; Lipopolysaccharides ; Olive Oil ; Plant Oils ; argan oil (4V59G5UW9X)
    Language English
    Publishing date 2017-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms18102181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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