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  1. Artikel ; Online: Rare liver diseases in Egypt: Clinical and epidemiological characterization.

    Abdelhamed, Walaa / El-Kassas, Mohamed

    Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

    2024  

    Abstract: Illnesses that afflict a tiny number of individuals are referred to as rare diseases (RDs), sometimes called orphan diseases. The local healthcare systems are constantly under financial, psychological, and medical strain due to low incidence rates, ... ...

    Abstract Illnesses that afflict a tiny number of individuals are referred to as rare diseases (RDs), sometimes called orphan diseases. The local healthcare systems are constantly under financial, psychological, and medical strain due to low incidence rates, unusual presentations, flawed diagnostic standards, and a lack of treatment alternatives for these RDs. The effective management of the once widely spread viral hepatitis B and C has altered the spectrum of liver diseases in Egypt during the last several years. The detection of uncommon disorders such as autoimmune, cholestatic, and hereditary liver diseases has also been made easier by the increasing knowledge and greater accessibility of specific laboratory testing. Finally, despite Egypt's large population, there are more uncommon liver disorders than previously thought. This review article discusses the clinical and epidemiological characteristics of a few uncommon liver disorders and the information currently accessible concerning these illnesses in Egypt.
    Sprache Englisch
    Erscheinungsdatum 2024-01-15
    Erscheinungsland Egypt
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2502114-X
    ISSN 2090-2387 ; 1687-1979
    ISSN (online) 2090-2387
    ISSN 1687-1979
    DOI 10.1016/j.ajg.2023.12.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Diagnosis, treatment protocols, and outcomes of liver transplant recipients infected with COVID-19.

    Hashem, Mai / El-Kassas, Mohamed

    World journal of clinical cases

    2023  Band 11, Heft 10, Seite(n) 2140–2159

    Abstract: Several cases of fatal pneumonia during November 2019 were linked initially to severe acute respiratory syndrome coronavirus 2, which the World Health Organization later designated as coronavirus disease 2019 (COVID-19). The World Health Organization ... ...

    Abstract Several cases of fatal pneumonia during November 2019 were linked initially to severe acute respiratory syndrome coronavirus 2, which the World Health Organization later designated as coronavirus disease 2019 (COVID-19). The World Health Organization declared COVID-19 as a pandemic on March 11, 2020. In the general population, COVID-19 severity can range from asymptomatic/mild symptoms to seriously ill. Its mortality rate could be as high as 49%. The Centers for Disease Control and Prevention have acknowledged that people with specific underlying medical conditions, among those who need immunosuppression after solid organ transplantation (SOT), are at an increased risk of developing severe illness from COVID-19. Liver transplantation is the second most prevalent SOT globally. Due to their immunosuppressed state, liver transplant (LT) recipients are more susceptible to serious infections. Therefore, comorbidities and prolonged immunosuppression among SOT recipients enhance the likelihood of severe COVID-19. It is crucial to comprehend the clinical picture, immunosuppressive management, prognosis, and prophylaxis of COVID-19 infection because it may pose a danger to transplant recipients. This review described the clinical and laboratory findings of COVID-19 in LT recipients and the risk factors for severe disease in this population group. In the following sections, we discussed current COVID-19 therapy choices, reviewed standard practice in modifying immunosuppressant regimens, and outlined the safety and efficacy of currently licensed drugs for inpatient and outpatient management. Additionally, we explored the clinical outcomes of COVID-19 in LT recipients and mentioned the efficacy and safety of vaccination use.
    Sprache Englisch
    Erscheinungsdatum 2023-04-12
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v11.i10.2140
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Anesthesia in patients with chronic liver disease: An updated review.

    Bedewy, Ahmed / El-Kassas, Mohamed

    Clinics and research in hepatology and gastroenterology

    2023  Band 47, Heft 8, Seite(n) 102205

    Abstract: Anesthesia in chronic liver disease patients can be challenging because of the medications given or interventions performed and their effects on liver physiology. Also, the effects of liver disease on coagulation and metabolism should be considered ... ...

    Abstract Anesthesia in chronic liver disease patients can be challenging because of the medications given or interventions performed and their effects on liver physiology. Also, the effects of liver disease on coagulation and metabolism should be considered carefully. This review focuses on anesthesia in patients with different chronic liver disease stages. A literature search was performed for Scopus and PubMed databases for articles discussing different types of anesthesia in patients with chronic liver disease, their safety, usage, and risks. The choice of anesthesia is of crucial importance. Regional anesthesia, especially neuroaxial anesthesia, may benefit some patients with liver disease, but coagulopathy should be considered. Regional anesthesia provides optimum intraoperative relaxation and analgesia that extends to the postoperative period while avoiding the side effects of intravenous anesthetics and opioids. Pharmacodynamics and pharmacokinetics of anesthetic medications must guard against complications related to overdose or decreased metabolism. The choice of anesthesia in chronic liver disease patients is crucial and could be tailored according to the degree of liver compensation and the magnitude of the surgical procedure.
    Sprache Englisch
    Erscheinungsdatum 2023-09-05
    Erscheinungsland France
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2023.102205
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  4. Artikel ; Online: Steatotic liver disease as a new nomenclature for NAFLD from the perspectives of the MENA region: One size fits all this time.

    El-Kassas, Mohamed / Alswat, Khalid

    Journal of hepatology

    2023  Band 80, Heft 2, Seite(n) e66–e68

    Mesh-Begriff(e) Humans ; Non-alcoholic Fatty Liver Disease ; Terminology as Topic
    Sprache Englisch
    Erscheinungsdatum 2023-08-22
    Erscheinungsland Netherlands
    Dokumenttyp Letter
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2023.08.012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2027: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Artikel ; Online: Artificial Intelligence in endoscopy: A future poll.

    Elshaarawy, Omar / Alboraie, Mohamed / El-Kassas, Mohamed

    Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

    2024  Band 25, Heft 1, Seite(n) 13–17

    Abstract: Artificial Intelligence [AI] has been a trendy topic in recent years, with many developed medical applications. In gastrointestinal endoscopy, AI systems include computer-assisted detection [CADe] for lesion detection as bleedings and polyps and computer- ...

    Abstract Artificial Intelligence [AI] has been a trendy topic in recent years, with many developed medical applications. In gastrointestinal endoscopy, AI systems include computer-assisted detection [CADe] for lesion detection as bleedings and polyps and computer-assisted diagnosis [CADx] for optical biopsy and lesion characterization. The technology behind these systems is based on a computer algorithm that is trained for a specific function. This function could be to recognize or characterize target lesions such as colonic polyps. Moreover, AI systems can offer technical assistance to improve endoscopic performance as scope insertion guidance. Currently, we believe that such technologies still lack legal and regulatory validations as a large sector of doctors and patients have concerns. However, there is no doubt that these technologies will bring significant improvement in the endoscopic management of patients as well as save money and time.
    Mesh-Begriff(e) Humans ; Artificial Intelligence ; Endoscopy, Gastrointestinal ; Polyps
    Sprache Englisch
    Erscheinungsdatum 2024-01-13
    Erscheinungsland Egypt
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2502114-X
    ISSN 2090-2387 ; 1687-1979
    ISSN (online) 2090-2387
    ISSN 1687-1979
    DOI 10.1016/j.ajg.2023.11.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Shedding lights on diagnostic challenges in Wilson's disease: The positive impact of introducing steatotic liver disease new nomenclature umbrella.

    Hassan, Marwa Khalaf / Alswat, Khalid / El-Kassas, Mohamed

    Liver international : official journal of the International Association for the Study of the Liver

    2024  Band 44, Heft 5, Seite(n) 1267–1268

    Mesh-Begriff(e) Humans ; Hepatolenticular Degeneration/diagnosis ; Liver ; Copper ; Fatty Liver
    Chemische Substanzen Copper (789U1901C5)
    Sprache Englisch
    Erscheinungsdatum 2024-02-12
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15868
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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1632: Hefte anzeigen Standort:
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  7. Artikel: Barrett's esophagus in a patient with bulimia nervosa: A case report.

    Gouda, Ahmed / El-Kassas, Mohamed

    World journal of clinical cases

    2022  Band 10, Heft 17, Seite(n) 5841–5845

    Abstract: Background: Barrett's esophagus is a known complication of long-standing gastroesophageal reflux disease, and it is a potential risk factor of developing esophageal adenocarcinoma.: Case summary: Here, we present a case of a 47-year-old male patient ... ...

    Abstract Background: Barrett's esophagus is a known complication of long-standing gastroesophageal reflux disease, and it is a potential risk factor of developing esophageal adenocarcinoma.
    Case summary: Here, we present a case of a 47-year-old male patient referred to the gastroenterology clinic for upper endoscopy because he has a long-standing history of heartburn and vomiting after meals. On examination, he had characteristic findings of self-induced vomiting as abrasions and callosities on the dorsum of the right hand and dental erosions. A detailed history revealed that he had 17 years of binge eating with self-induced vomiting. His upper endoscopy showed gastroesophageal reflux grade D with salmon-red mucosal projections, and the biopsy revealed intestinal mucosal metaplasia.
    Conclusion: This case emphasized the importance of considering upper endoscopy screening for Barrett's esophagus in patients with eating disorders, especially those with self-induced vomiting, as in bulimia nervosa.
    Sprache Englisch
    Erscheinungsdatum 2022-08-01
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v10.i17.5841
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Fibrolamellar hepatocellular carcinoma: A rare but unpleasant event.

    Abdelhamed, Walaa / El-Kassas, Mohamed

    World journal of gastrointestinal oncology

    2022  Band 14, Heft 6, Seite(n) 1103–1114

    Abstract: Fibrolamellar carcinoma (FLC) is a rare variant of hepatocellular carcinoma (HCC), comprising 1%-9% of all HCCs. FLC is a poorly understood malignancy, which seems to be more prevalent in young patients with no underlying liver diseases. The term " ... ...

    Abstract Fibrolamellar carcinoma (FLC) is a rare variant of hepatocellular carcinoma (HCC), comprising 1%-9% of all HCCs. FLC is a poorly understood malignancy, which seems to be more prevalent in young patients with no underlying liver diseases. The term "fibrolamellar" is derived from thick fibrous collagen bands surrounding the tumor cells. Unlike HCC, cirrhosis and viral hepatitis infection are not predisposing to FLC, and it is not associated with elevations in serum alpha-fetoprotein. FLC patients often present with vague abdominal pain, nausea, malaise, and weight loss. Most cases present are at an advanced stage at the time of initial diagnosis. However, curative treatment options can still be offered to up to 70% of patients. Surgery (resection/liver transplantation) is the mainstay of treatment and the only potentially curative option. FLCs have been less chemo-responsive than the conventional HCC, however, in advanced cases, multimodality treatments can be effective. Recent advances in molecular studies of FLC have found a unique DNAJB1-PRKACA fusion transcript in most of the cases studied. The review aims to describe clinical characteristics, diagnostic methods, and therapeutic modalities for this rare tumor to raise awareness among clinicians and surgeons.
    Sprache Englisch
    Erscheinungsdatum 2022-06-24
    Erscheinungsland China
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2573696-6
    ISSN 1948-5204
    ISSN 1948-5204
    DOI 10.4251/wjgo.v14.i6.1103
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Tailored treatment strategies for cancer patients during COVID-19 pandemic.

    Abdelkader, Haytham / El-Kassas, Mohamed

    Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

    2022  Band 27, Heft 2, Seite(n) 318–330

    Abstract: The global pandemic of respiratory disease caused by the novel human coronavirus (SARS-CoV-2) has caused indefinite global distress, uncertainty, and disturbance. This pandemic has had direct and indirect impacts for the healthcare systems across the ... ...

    Abstract The global pandemic of respiratory disease caused by the novel human coronavirus (SARS-CoV-2) has caused indefinite global distress, uncertainty, and disturbance. This pandemic has had direct and indirect impacts for the healthcare systems across the world, but certain subgroups of patients have been particularly affected. Among these groups are patients with cancer, who as a result of their immunosuppressed status either from the disease itself or as a consequence of treatment, are at increased risk of severe COVID-19 infection and complications. The pandemic has also led to limited resources as medical services have been primarily directed to emergency care. In this context, physicians and healthcare providers have had to balance the importance of continuing treatment of cancer patients with the risk of virus infection. In this review, we outline the treatment strategies for cancer patients during this pandemic, focusing on tailored treatment in this challenging situation of varying risks and benefits.
    Sprache Englisch
    Erscheinungsdatum 2022-05-19
    Erscheinungsland Poland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2188087-6
    ISSN 1507-1367
    ISSN 1507-1367
    DOI 10.5603/RPOR.a2022.0024
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6108: Hefte anzeigen Standort:
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  10. Artikel: Hepatocellular Carcinoma in Africa: Challenges and Opportunities.

    El-Kassas, Mohamed / Elbadry, Mohamed

    Frontiers in medicine

    2022  Band 9, Seite(n) 899420

    Sprache Englisch
    Erscheinungsdatum 2022-06-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.899420
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