Artikel ; Online: Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis.
2020 Band 345, Seite(n) 577279
Abstract: A detailed understanding of the role of Tfh cells in MuSK-antibody positive myasthenia gravis (MuSK-MG) is lacking. We characterized phenotype and function of Tfh cells in MuSK-MG patients and controls. We found similar overall Tfh and follicular ... ...
Abstract | A detailed understanding of the role of Tfh cells in MuSK-antibody positive myasthenia gravis (MuSK-MG) is lacking. We characterized phenotype and function of Tfh cells in MuSK-MG patients and controls. We found similar overall Tfh and follicular regulatory (Tfr) T cell frequencies in MuSK-MG and healthy controls, but MuSK-MG patients exhibited higher frequencies of Tfh17 cells and a higher ratio of Tfh:Tfr cells. These results suggest imbalanced Tfh cell regulation, further supported by increased frequencies of CD4 T cells co-producing IL-21/IL-17 and IL-17/IFN-γ, and increased Tfh-supported IgG production. These results support a role for Tfh cell dysregulation in MuSK-MG immunopathology. |
---|---|
Mesh-Begriff(e) | Adult ; Aged ; Autoantibodies/blood ; Autoantibodies/immunology ; Coculture Techniques ; Female ; Humans ; Inflammation Mediators/blood ; Inflammation Mediators/immunology ; Interleukin-17/blood ; Interleukin-17/immunology ; Male ; Middle Aged ; Myasthenia Gravis/blood ; Myasthenia Gravis/immunology ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/metabolism ; Young Adult |
Chemische Substanzen | Autoantibodies ; IL17A protein, human ; Inflammation Mediators ; Interleukin-17 |
Sprache | Englisch |
Erscheinungsdatum | 2020-05-27 |
Erscheinungsland | Netherlands |
Dokumenttyp | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
ZDB-ID | 8335-5 |
ISSN | 1872-8421 ; 0165-5728 |
ISSN (online) | 1872-8421 |
ISSN | 0165-5728 |
DOI | 10.1016/j.jneuroim.2020.577279 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Zs.A 1646: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.