Artikel: Oral enzyme combination with bromelain, trypsin and the flavonoid rutoside reduces systemic inflammation and pain when used pre- and post-operatively in elective total hip replacement: a randomized exploratory placebo-controlled trial.
Therapeutic advances in musculoskeletal disease
2023 Band 15, Seite(n) 1759720X231186875
Abstract: Background: Early mobilization after total hip replacement (THR) is key for fast recovery but is often limited by pain. Oral enzyme combinations (OECs) have demonstrated anti-inflammatory and pain-relieving effects.: Objectives and design: This ... ...
| Abstract | Background: Early mobilization after total hip replacement (THR) is key for fast recovery but is often limited by pain. Oral enzyme combinations (OECs) have demonstrated anti-inflammatory and pain-relieving effects. Objectives and design: This prospective, randomized, double-blind, placebo-controlled exploratory trial evaluated the effects of pre- and post-operative use of OEC (90 mg bromelain, 48 mg trypsin, 100 mg rutoside) following elective THR, on post-operative recovery. Methods: Candidates for primary elective cementless THR owing to osteoarthritis were eligible for participation [age ⩾50 years, body mass index 25-35 kg/m Results: Patients ( Conclusions: Pre- and post-operative use of OEC significantly reduced CRP levels and patient self-reported pain. OEC may be an efficacious and safe treatment option to facilitate post-operative recovery following THR. Trial registration: EudraCT number 2016-003078-41. |
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| Sprache | Englisch |
| Erscheinungsdatum | 2023-07-29 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2516075-8 |
| ISSN | 1759-7218 ; 1759-720X |
| ISSN (online) | 1759-7218 |
| ISSN | 1759-720X |
| DOI | 10.1177/1759720X231186875 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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