LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 10 von insgesamt 212

Suchoptionen

  1. Buch: Oral cancer

    Fakhry, Carole / Pitman, Karen T. / Kiess, Ana P. / Eisele, David W.

    evaluation, therapy, and rehabilitation

    2020  

    Verfasserangabe Carole Fakhry,Karen T. Pitman, Ana P. Kiess, David W Eisele
    Schlagwörter premalignant oral lesions ; squamous cell cancer ; oral cancer reconstruction ; salivary gland malignancies ; oral cancer surgery ; 807
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Umfang xx, 441 Seiten, Illustrationen, 28 cm x 21.6 cm, 1633 g
    Ausgabenhinweis 1. Auflage
    Verlag Thieme
    Erscheinungsort New York
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    Anmerkung Zugang zur Online-Ausgabe über Code
    HBZ-ID HT020588102
    ISBN 978-1-62623-968-5 ; 1-62623-968-1 ; 9781626239692 ; 162623969X
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Zusatzmaterialien

    Kategorien

  2. Buch: HPV and head and neck cancers

    Fakhry, Carole / D’Souza, Gypsyamber

    (Head and neck cancer clinics)

    2015  

    Verfasserangabe Carole Fakhry ; Gypsyamver D'Souza ed
    Serientitel Head and neck cancer clinics
    Schlagwörter Oropharyngeal ; Squamous cell carcinoma ; Cancer screening ; Behavioral aspects
    Sprache Englisch
    Umfang XXI, 127 S. : Ill., graph. Darst., 235 mm x 155 mm
    Verlag Springer
    Erscheinungsort New Dehli u.a.
    Erscheinungsland Indien
    Dokumenttyp Buch
    HBZ-ID HT018711040
    ISBN 978-81-322-2412-9 ; 81-322-2412-4 ; 9788132224136 ; 8132224132
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Zusatzmaterialien

    Kategorien

  3. Artikel ; Online: Plasma Circulating Tumor HPV DNA and HPV-Related Oropharynx Cancer-A Caution-Reply.

    D'Souza, Gypsyamber / Fakhry, Carole

    JAMA otolaryngology-- head & neck surgery

    2022  Band 148, Heft 10, Seite(n) 993–994

    Mesh-Begriff(e) Circulating Tumor DNA ; DNA, Viral ; Humans ; Oropharyngeal Neoplasms/pathology ; Oropharynx/pathology ; Papillomaviridae/genetics ; Papillomavirus Infections
    Chemische Substanzen Circulating Tumor DNA ; DNA, Viral
    Sprache Englisch
    Erscheinungsdatum 2022-08-25
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2022.2455
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  4. Artikel ; Online: Epidemiologic Trends in Human Papillomavirus-Associated Sinonasal Squamous Cell Carcinoma.

    Amanian, Ameen / Ishii, Masaru / Fakhry, Carole / London, Nyall R

    JAMA otolaryngology-- head & neck surgery

    2024  

    Abstract: Importance: Sinonasal squamous cell carcinoma (SNSCC) is the most commonly encountered cancer within the sinonasal cavity. Ongoing research has sought to ascertain the potential role of human papillomavirus (HPV) in the pathogenesis of SNSCC.: ... ...

    Abstract Importance: Sinonasal squamous cell carcinoma (SNSCC) is the most commonly encountered cancer within the sinonasal cavity. Ongoing research has sought to ascertain the potential role of human papillomavirus (HPV) in the pathogenesis of SNSCC.
    Objective: To assess trends in HPV-associated and HPV-independent SNSCC over time, including assessment of clinical demographics, treatment patterns, and survival.
    Design, setting, and participants: This cohort study used patient data from the National Cancer Institute's Surveillance, Epidemiology, and End Results Program database between 1975 and 2018. Anatomic sites with a greater predilection for HPV positivity (ie, nasal cavity, ethmoid sinus) were used as a surrogate for HPV-associated SNSCC; meanwhile, patients with SNSCC in the other subsites were classified into the HPV-independent group. Data were analyzed from August 2022 to May 2023.
    Main outcomes and measures: Clinical demographics and mortality trends over time were described for the HPV-associated and HPV-independent groups and further stratified according to stage on presentation.
    Results: The study population consisted of 3752 patients with SNSCC (mean [SD] age at diagnosis, 65.7 [13.3] years; 2417 [64.4%] male), with 1983 (52.9%) having HPV-associated SNSCC and 1769 (47.1%) with HPV-independent SNSCC. Patients with HPV-associated subsites compared with patients with HPV-independent SNSCC were more likely to present with localized disease (838 [42.3%] vs 162 [9.2%]), whereas more patients in the HPV-independent group than HPV-associated group presented with regional disease (1018 [57.5%] vs 480 [24.2%]). Incidence-based mortality was stable over time within the HPV-associated group (0.32%) and, conversely, showed a significant decrease within the HPV-independent group (-2.29%). Patients with HPV-associated SNSCC had a higher 5-year overall survival when compared with the HPV-independent group (62% vs 35% [difference, 27 percentage points; 95% CI, 23-31 percentage points]). The better 5-year overall survival in the HPV-associated group vs HPV-independent group was present across all disease stages (localized: hazard ratio [HR], 2.67; 95% CI, 1.96-3.65; regional: HR, 1.53; 95% CI, 1.29-1.82; and distant: HR, 1.97; 95% CI, 1.52-2.55).
    Conclusions and relevance: This cohort study showed that the proportion of HPV-associated SNSCC rose over time associated with both a rise in the proportion of nasal cavity SNSCC and a decrease in HPV-independent maxillary sinus SNSCC. These data suggest that HPV-associated SNSCC has a distinct demographic and prognostic profile, given the improved survival seen in patients with HPV-associated SNSCC.
    Sprache Englisch
    Erscheinungsdatum 2024-06-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2024.1311
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  5. Artikel ; Online: Novel Oral Cancer Survival Calculator-Do We Have a Crystal Ball?

    Mady, Leila J / Koch, Wayne M / Fakhry, Carole

    JAMA otolaryngology-- head & neck surgery

    2023  Band 149, Heft 11, Seite(n) 1000–1002

    Mesh-Begriff(e) Humans ; Mouth Neoplasms ; Risk Assessment
    Sprache Englisch
    Erscheinungsdatum 2023-07-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2023.1976
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  6. Artikel ; Online: The evolving landscape of oropharyngeal cancer: a window of opportunity for primary prevention.

    Windon, Melina J / D'Souza, Gypsyamber / Fakhry, Carole

    Journal of the National Cancer Institute

    2023  Band 115, Heft 12, Seite(n) 1454–1456

    Mesh-Begriff(e) Humans ; Incidence ; Oropharyngeal Neoplasms/epidemiology ; Oropharyngeal Neoplasms/prevention & control ; Papillomaviridae ; Primary Prevention
    Sprache Englisch
    Erscheinungsdatum 2023-10-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djad171
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  7. Artikel ; Online: Epidemiology of HPV Related Malignancies.

    Scott-Wittenborn, Nicholas / Fakhry, Carole

    Seminars in radiation oncology

    2021  Band 31, Heft 4, Seite(n) 286–296

    Abstract: Human papillomavirus is the most common sexually transmitted infection in the world and had been linked to both anogenital and oropharyngeal cancers. It causes nearly 100% of cervical cancers and an increasing portion of oropharyngeal cancers. The ... ...

    Abstract Human papillomavirus is the most common sexually transmitted infection in the world and had been linked to both anogenital and oropharyngeal cancers. It causes nearly 100% of cervical cancers and an increasing portion of oropharyngeal cancers. The geographical burden of cervical HPV infection and associated cancers is not uniform and is mainly found in low middle income countries in South America, Africa, and Asia. However, HPV-positive oropharyngeal cancer is rapidly becoming more prevalent in high middle income countries. With the development of vaccines which prevent HPV infection, the World Health Organization has designated the extirpation of HPV and its associated cancers a priority. Countries that have implemented adequate vaccine programs have shown a decrease in HPV prevalence. Understanding the epidemiology of HPV and its associated cancers is fundamental in improving vaccine programs and other health programs.
    Mesh-Begriff(e) Female ; Humans ; Oropharyngeal Neoplasms/epidemiology ; Oropharyngeal Neoplasms/prevention & control ; Papillomaviridae ; Papillomavirus Infections/complications ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/prevention & control ; Prevalence ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/prevention & control
    Sprache Englisch
    Erscheinungsdatum 2021-08-28
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2021.04.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  8. Artikel: Radiomics Features in Predicting Human Papillomavirus Status in Oropharyngeal Squamous Cell Carcinoma: A Systematic Review, Quality Appraisal, and Meta-Analysis.

    Ansari, Golnoosh / Mirza-Aghazadeh-Attari, Mohammad / Mosier, Kristine M / Fakhry, Carole / Yousem, David M

    Diagnostics (Basel, Switzerland)

    2024  Band 14, Heft 7

    Abstract: We sought to determine the diagnostic accuracy of radiomics features in predicting HPV status in oropharyngeal squamous cell carcinoma (SCC) compared to routine paraclinical measures used in clinical practice. Twenty-six articles were included in the ... ...

    Abstract We sought to determine the diagnostic accuracy of radiomics features in predicting HPV status in oropharyngeal squamous cell carcinoma (SCC) compared to routine paraclinical measures used in clinical practice. Twenty-six articles were included in the systematic review, and thirteen were used for the meta-analysis. The overall sensitivity of the included studies was 0.78, the overall specificity was 0.76, and the overall area under the ROC curve was 0.84. The diagnostic odds ratio (DOR) equaled 12 (8, 17). Subgroup analysis showed no significant difference between radiomics features extracted from CT or MR images. Overall, the studies were of low quality in regard to radiomics quality score, although most had a low risk of bias based on the QUADAS-2 tool. Radiomics features showed good overall sensitivity and specificity in determining HPV status in OPSCC, though the low quality of the included studies poses problems for generalizability.
    Sprache Englisch
    Erscheinungsdatum 2024-03-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14070737
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  9. Artikel ; Online: Is 2045 Optimistic?-Concerns Regarding Rising Vaccine Hesitancy-Reply.

    Zhang, Yuehan / Fakhry, Carole / D'Souza, Gypsyamber

    JAMA oncology

    2022  Band 8, Heft 3, Seite(n) 482–483

    Mesh-Begriff(e) Humans ; Vaccination Hesitancy
    Sprache Englisch
    Erscheinungsdatum 2022-01-20
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2021.7166
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  10. Artikel ; Online: Spontaneous regression of an human papillomavirus-positive oropharyngeal squamous cell carcinoma.

    Seo, Stefanie / Rooper, Lisa / Seiwert, Tanguy Y / Fakhry, Carole

    Head & neck

    2022  Band 45, Heft 1, Seite(n) E1–E4

    Abstract: Background: Spontaneous regression (SR) of cancer is an exceedingly rare phenomenon. While SR is well-documented for some cancers, very few reports exist in oropharyngeal squamous cell carcinomas (OPSCCs) and none in human papillomavirus (HPV)-positive ... ...

    Abstract Background: Spontaneous regression (SR) of cancer is an exceedingly rare phenomenon. While SR is well-documented for some cancers, very few reports exist in oropharyngeal squamous cell carcinomas (OPSCCs) and none in human papillomavirus (HPV)-positive OPSCCs.
    Methods: A 67-year old man presented with a left-sided neck mass. Neck CT, PET, and biopsies showed a SCC in a left-sided lymph node without a primary lesion. Immunohistochemistry confirmed HPV16. Six weeks after biopsy, the patient underwent left selective tonsillectomy and neck dissection.
    Results: Surgery revealed a left tonsillar SCC and no lymph nodes with tumor. Histology revealed homogenous fibrosis and intermixed immune cells indicative of tumor regression analogous to reports of immune-related pathologic responses. AE1/AE3 immunostain was also negative for tumor. All lymph nodes remained negative at 1 year follow-up.
    Conclusion: We described a spontaneously regressed lymph node in a tonsillar HPV-positive SCC. The unique immune environment of HPV-positive OPSCCs, and unknown environmental or host factors, may have played a role in our patient's SR which requires future studies to elucidate.
    Sprache Englisch
    Erscheinungsdatum 2022-10-18
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27226
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang