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  1. Artikel: Monsoon Floods: A Challenge To Pakistan's Already Fragile Healthcare Infrastructure.

    Nasir, Muhammad Moiz / Khan, Adam Bilal / Farhan, Syed Husain

    JPMA. The Journal of the Pakistan Medical Association

    2023  Band 73, Heft 8, Seite(n) 1765–1766

    Mesh-Begriff(e) Humans ; Floods ; Pakistan
    Sprache Englisch
    Erscheinungsdatum 2023-09-12
    Erscheinungsland Pakistan
    Dokumenttyp Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.7982
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Virtual reality-based rehabilitation: A favourable treatment plan for stroke patients in Pakistan.

    Mushahid, Hasan / Ahmed, Huda / Farhan, Syed Husain

    JPMA. The Journal of the Pakistan Medical Association

    2023  Band 73, Heft 6, Seite(n) 1364

    Mesh-Begriff(e) Humans ; Pakistan ; Stroke/therapy ; Stroke Rehabilitation ; Virtual Reality ; Upper Extremity
    Sprache Englisch
    Erscheinungsdatum 2023-04-30
    Erscheinungsland Pakistan
    Dokumenttyp Letter
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.7859
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Disparities in the renal cancer mortality between Black and White adults in the United States, 1999-2020.

    Nusrat, Khushboo / Khan, Rafay / Farhan, Syed Husain / Malik, Shanza / Paryani, Neha Saleem / Siddiq, Mohammad Arham / Memon, Roha Saeed / Jawaid, Hafsa / Hameed, Ishaque

    Journal of geriatric oncology

    2024  , Seite(n) 101797

    Sprache Englisch
    Erscheinungsdatum 2024-05-23
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2024.101797
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Comparative Safety and Efficacy of Low/Moderate-Intensity Statin plus Ezetimibe Combination Therapy vs. High-Intensity Statin Monotherapy in Patients with Atherosclerotic Cardiovascular Disease: An Updated Meta-Analysis.

    Hameed, Ishaque / Shah, Syeda Ayesha / Aijaz, Ashnah / Mushahid, Hasan / Farhan, Syed Husain / Dada, Muhammad / Khan, Adam Bilal / Amjad, Reeha / Alvi, Fawad / Murtaza, Mustafa / Zuberi, Zaid / Hamza, Mohammad

    American journal of cardiovascular drugs : drugs, devices, and other interventions

    2024  Band 24, Heft 3, Seite(n) 419–431

    Abstract: Aim: Statin therapy is considered the gold standard for treating hypercholesterolemia. This updated meta-analysis aims to compare the efficacy and safety of a low/moderate-intensity statin in combination with ezetimibe compared with high-intensity ... ...

    Abstract Aim: Statin therapy is considered the gold standard for treating hypercholesterolemia. This updated meta-analysis aims to compare the efficacy and safety of a low/moderate-intensity statin in combination with ezetimibe compared with high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease (ASCVD).
    Methods: A systematic search of two databases (PubMed and Cochrane CENTRAL) was conducted from inception to January 2023 and a total of 21 randomized clinical trials (RCTs) were identified and included in the analysis. Data were pooled using Hedges's g and a Mantel-Haenszel random-effects model to derive standard mean differences (SMDs) and 95% confidence intervals (Cis). The primary outcome studied was the effect of these treatments on lipid parameters and safety events.
    Results: The results revealed that combination therapy was more effective in reducing low-density lipoprotein cholesterol (LDL-C) levels (SMD= - 0.41; CI - 0.63 to - 0.19; P = 0.0002). There was no significant change in the levels of high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglyceride (TG), high-sensitivity C-reactive protein (hs-CRP), Apo A1, or Apo B. The safety of these treatments was assessed by the following markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatine phosphokinase (CK), and a significant difference was only observed in CK (SMD: - 0.81; CI - 1.52 to - 0.10; P = 0.02).
    Conclusion: This meta-analysis demonstrated that the use of low/moderate-intensity statin combination therapy significantly reduced LDL-C levels compared with high-intensity statin monotherapy, making it preferable for patients with related risks. However, further trials are encouraged to evaluate potential adverse effects associated with combined therapy.
    Mesh-Begriff(e) Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Ezetimibe/administration & dosage ; Ezetimibe/therapeutic use ; Ezetimibe/adverse effects ; Drug Therapy, Combination ; Atherosclerosis/drug therapy ; Anticholesteremic Agents/administration & dosage ; Anticholesteremic Agents/adverse effects ; Anticholesteremic Agents/therapeutic use ; Cholesterol, LDL/blood ; Randomized Controlled Trials as Topic ; Cardiovascular Diseases ; Hypercholesterolemia/drug therapy ; Cholesterol, HDL/blood
    Sprache Englisch
    Erscheinungsdatum 2024-04-05
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2052547-3
    ISSN 1179-187X ; 1175-3277
    ISSN (online) 1179-187X
    ISSN 1175-3277
    DOI 10.1007/s40256-024-00642-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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  5. Artikel ; Online: Differential Use of Glycoprotein IIb/IIIa Inhibitors with Bivalirudin in Patients with STEMI Undergoing PCI: A Systematic Review and Meta-Analysis.

    Mushahid, Hasan / Shah, Syeda Ayesha / Farhan, Syed Husain / Shuja, Muhammad Hamza / Balasingam, Kyle / Siddiqui, Asad Ali / Hameed, Ishaque / Akram, Kamran / Mushahid, Shayan / Usman, Muhammad Shariq

    American journal of cardiovascular drugs : drugs, devices, and other interventions

    2024  Band 24, Heft 3, Seite(n) 385–398

    Abstract: Aim: The efficacy and safety of bivalirudin when used concurrently with glycoprotein IIb/IIIa inhibitors (GPI) is uncertain. In this systematic review and meta-analysis, we aimed to evaluate the efficacy and safety of bivalirudin versus heparin in ... ...

    Abstract Aim: The efficacy and safety of bivalirudin when used concurrently with glycoprotein IIb/IIIa inhibitors (GPI) is uncertain. In this systematic review and meta-analysis, we aimed to evaluate the efficacy and safety of bivalirudin versus heparin in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) and to explore the impact of differential use (greater and balanced) of GPI.
    Methods: Online databases were queried from inception to March 2023 to identify eight randomized controlled trials (n = 22,483) for inclusion. The primary outcomes included all-cause mortality, major bleeding, major adverse cardiovascular events (MACE), and net adverse clinical events (NACE). Secondary efficacy endpoints included cardiac death, reinfarction, stent thrombosis (ST), and stroke. Data were pooled using a random-effects model to derive risk ratios (RRs) and 95% confidence intervals (CIs).
    Results: When compared to heparin, bivalirudin was associated with a significant reduction in all-cause mortality (RR 0.83; 95% CI 0.72-0.97; P = 0.02), major bleeding (RR 0.73; 95% CI 0.57-0.93; P = 0.01), cardiac death (RR 0.79; 95% CI 0.66-0.94; P = 0.01), and NACE (RR 0.80; 95% CI 0.72-0.89; P < 0.0001). However, while the bivalirudin arm showed an increased likelihood of ST in the greater GPI subgroup (RR 1.70; 95% CI 1.13-2.56; P = 0.01), it was associated with a decreased likelihood of ST in the balanced GPI subgroup (RR 0.40; 95% CI 0.24-0.65; P = 0.0003).
    Conclusion: Overall, our findings suggest that bivalirudin may be a more efficacious intervention than heparin for reducing certain adverse events in patients with STEMI undergoing primary PCI.
    Mesh-Begriff(e) Humans ; Hirudins/adverse effects ; Hirudins/administration & dosage ; ST Elevation Myocardial Infarction/drug therapy ; ST Elevation Myocardial Infarction/therapy ; Peptide Fragments/therapeutic use ; Peptide Fragments/adverse effects ; Percutaneous Coronary Intervention/methods ; Percutaneous Coronary Intervention/adverse effects ; Recombinant Proteins/therapeutic use ; Recombinant Proteins/adverse effects ; Recombinant Proteins/administration & dosage ; Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors ; Heparin/adverse effects ; Heparin/therapeutic use ; Heparin/administration & dosage ; Antithrombins/therapeutic use ; Antithrombins/adverse effects ; Hemorrhage/chemically induced ; Platelet Aggregation Inhibitors/therapeutic use ; Platelet Aggregation Inhibitors/adverse effects ; Randomized Controlled Trials as Topic
    Sprache Englisch
    Erscheinungsdatum 2024-04-29
    Erscheinungsland New Zealand
    Dokumenttyp Systematic Review ; Journal Article ; Meta-Analysis
    ZDB-ID 2052547-3
    ISSN 1179-187X ; 1175-3277
    ISSN (online) 1179-187X
    ISSN 1175-3277
    DOI 10.1007/s40256-024-00636-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: The effect of oral anticoagulants on the incidence of dementia in patients with atrial fibrillation: A systematic review and meta-analysis.

    Latif, Fakhar / Nasir, Muhammad Moiz / Meer, Komail K / Farhan, Syed Husain / Cheema, Huzaifa Ahmad / Khan, Adam Bilal / Umer, Mohammad / Rehman, Wajeeh Ur / Ahmad, Adeel / Khan, Muhammad Aslam / Almas, Talal / Mactaggart, Sebastian / Nashwan, Abdulqadir J / Ahmed, Raheel / Dani, Sourbha S

    International journal of cardiology. Cardiovascular risk and prevention

    2024  Band 21, Seite(n) 200282

    Abstract: Background: Dementia is a recognized complication of atrial fibrillation (AF). Oral anticoagulant (OAC) therapy can potentially be protective against this complication.: Methods: A comprehensive search of MEDLINE and Embase for comparative ... ...

    Abstract Background: Dementia is a recognized complication of atrial fibrillation (AF). Oral anticoagulant (OAC) therapy can potentially be protective against this complication.
    Methods: A comprehensive search of MEDLINE and Embase for comparative observational studies reporting the efficacy of OAC therapy for the incidence of dementia in patients with AF was conducted from its inception until March 2023. Studies that had patients with prior use of OAC or with a previous history of dementia were excluded.
    Results: A total of 22 studies were included in this review involving 617,204 participants. The pooled analysis revealed that OAC therapy, including direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs), was associated with a reduced incidence of dementia in AF patients. Specifically, compared to non-OAC treatment, OACs demonstrated a significant reduction in dementia incidence (HR 0.68, 95 % CI [0.58, 0.80], p < 0.00001), with similar findings observed for DOACs (HR 0.69, 95 % CI [0.51, 0.94], p = 0.02) and VKAs (HR 0.73, 95 % CI [0.56, 0.95], p = 0.02). The comparison of DOAC vs VKA revealed that DOACs are associated with reduced risk of dementia (HR 0.87, 95 % CI [0.79, 0.96], p = 0.004).
    Conclusion: Our SR and meta-analysis showed that the use of OAC therapy is associated with a reduced risk of dementia in individuals with AF. However, our results are limited by the potential influence of confounding bias and significant heterogeneity in the analyses.
    Sprache Englisch
    Erscheinungsdatum 2024-05-07
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ISSN 2772-4875
    ISSN (online) 2772-4875
    DOI 10.1016/j.ijcrp.2024.200282
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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