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  1. Artikel ; Online: Performance of the UroVysion

    Rosolen, Débora C B / Faria, Daniel K / Faria, Caroline S / Antonangelo, Leila

    Cancer medicine

    2018  Band 7, Heft 5, Seite(n) 1967–1977

    Abstract: The cytological examination of cavity fluids has limited sensitivity in the diagnosis of malignancy. Aneuploidy, which is commonly observed in neoplastic cells, could potentially be used as an ancillary diagnostic tool. To evaluate the detection of ... ...

    Abstract The cytological examination of cavity fluids has limited sensitivity in the diagnosis of malignancy. Aneuploidy, which is commonly observed in neoplastic cells, could potentially be used as an ancillary diagnostic tool. To evaluate the detection of aneuploid cells in cavitary effusion samples using the fluorescence in situ hybridization (FISH) assay UroVysion
    Mesh-Begriff(e) Aged ; Aneuploidy ; Chromosome Aberrations ; Cytogenetic Analysis ; Female ; Humans ; In Situ Hybridization, Fluorescence/methods ; Male ; Middle Aged ; Pleural Effusion, Malignant/diagnosis ; Pleural Effusion, Malignant/genetics ; Sensitivity and Specificity
    Sprache Englisch
    Erscheinungsdatum 2018-03-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.1442
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Hybrid panel of biomarkers can be useful in the diagnosis of pleural and peritoneal effusions.

    Faria, Daniel K / Faria, Caroline S / Doi, Dimitria / Acencio, Milena M P / Antonangelo, Leila

    Clinica chimica acta; international journal of clinical chemistry

    2019  Band 497, Seite(n) 48–53

    Abstract: Background: In clinical practice, pleural and peritoneal effusions are usual diagnosis. We evaluated the performance of a hybrid panel of biomarkers in the diagnosis of the main diseases affecting pleura and/or peritoneum.: Methods: Samples of ... ...

    Abstract Background: In clinical practice, pleural and peritoneal effusions are usual diagnosis. We evaluated the performance of a hybrid panel of biomarkers in the diagnosis of the main diseases affecting pleura and/or peritoneum.
    Methods: Samples of pleural/ peritoneal fluid from 120 patients were evaluated for: CEA (carcinoembryonic antigen), VEGF-A (vascular endothelial growth factor A), PD-L1/B7-H1 (programmed death-ligand 1), NGAL (neutrophil gelatinase-associated lipocalin), TREM-1 (triggering receptor expressed in myeloid cells type-1) and IFNγ (gamma-interferon) by Luminex®; CALP (Calprotectin) by ELISA, and ADA (adenosine deaminase) by enzymatic deamination.
    Results: For malignant effusion (ME) diagnosis, CEA and NGAL presented superior performance than VEGF-A, PD-L1 and CALP. A CEA-NGAL association showed good sensitivity (86.6%) and accuracy (79.2%). For non-tuberculous infectious effusion (NTBIE), NGAL presented the best performance with sensitivity (75.0%), specificity (62.0%) and accuracy (65.0%) higher than TREM-1 and CALP; however, when associated, although with good sensitivity, there was important decrease in specificity. For tuberculous pleural effusion (TPE), IFNy-ADA presented excellent sensitivity (100%), specificity (87.6%), NPV (100%) and accuracies (~90%).
    Conclusions: CEA, NGAL, ADA and IFNy were useful in discriminating ME and TPE. However, for NTBIE diagnosis, the hybrid panel did not demonstrate advantages over the classic parameters.
    Mesh-Begriff(e) Adenosine Deaminase/analysis ; Adenosine Deaminase/metabolism ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers/analysis ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Interferon-gamma/analysis ; Interferon-gamma/metabolism ; Male ; Middle Aged ; Paracentesis ; Pleural Effusion, Malignant/diagnosis ; Young Adult
    Chemische Substanzen Biomarkers ; Interferon-gamma (82115-62-6) ; Adenosine Deaminase (EC 3.5.4.4)
    Sprache Englisch
    Erscheinungsdatum 2019-07-13
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2019.07.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Improving serum calcium test ordering according to a decision algorithm.

    Faria, Daniel K / Taniguchi, Leandro U / Fonseca, Luiz A M / Ferreira-Junior, Mario / Aguiar, Francisco J B / Lichtenstein, Arnaldo / Sumita, Nairo M / Duarte, Alberto J S / Sales, Maria M

    Journal of clinical pathology

    2018  Band 72, Heft 3, Seite(n) 232–236

    Abstract: Aim: To detect differences in the pattern of serum calcium tests ordering before and after the implementation of a decision algorithm.: Methods: We studied patients admitted to an internal medicine ward of a university hospital on April 2013 and ... ...

    Abstract Aim: To detect differences in the pattern of serum calcium tests ordering before and after the implementation of a decision algorithm.
    Methods: We studied patients admitted to an internal medicine ward of a university hospital on April 2013 and April 2016. Patients were classified as critical or non-critical on the day when each test was performed. Adequacy of ordering was defined according to adherence to a decision algorithm implemented in 2014.
    Results: Total and ionised calcium tests per patient-day of hospitalisation significantly decreased after the algorithm implementation; and duplication of tests (total and ionised calcium measured in the same blood sample) was reduced by 49%. Overall adequacy of ionised calcium determinations increased by 23% (P=0.0001) due to the increase in the adequacy of ionised calcium ordering in non-critical conditions.
    Conclusions: A decision algorithm can be a useful educational tool to improve adequacy of the process of ordering serum calcium tests.
    Mesh-Begriff(e) Algorithms ; Blood Chemical Analysis/methods ; Calcium/blood ; Decision Making, Computer-Assisted ; Humans ; Practice Patterns, Physicians'
    Chemische Substanzen Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2018-05-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jclinpath-2018-205026
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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