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  1. Artikel ; Online: Searching for Signs of Plastic Surgery on the Face: Tracking the Eyes of Where Observers Look.

    Fearington, Forrest W / Pumford, Andrew D / Awadallah, Andrew S / Dey, Jacob K

    Facial plastic surgery & aesthetic medicine

    2024  

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2024-03-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3006458-2
    ISSN 2689-3622 ; 2689-3614
    ISSN (online) 2689-3622
    ISSN 2689-3614
    DOI 10.1089/fpsam.2023.0260
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Konferenzbeitrag: Preoperative Risk Factors Influencing Orbital Decompression Surgery Outcomes for Thyroid Eye Disease

    Peraza, Lazaro R. / Fearington, Forrest W. / Stokken, Janalee K.

    Journal of Neurological Surgery Part B: Skull Base

    2024  Band 85, Heft S 01

    Veranstaltung/Kongress 33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
    Sprache Englisch
    Erscheinungsdatum 2024-02-01
    Verlag Georg Thieme Verlag KG
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel ; Konferenzbeitrag
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0044-1779915
    Datenquelle Thieme Verlag

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  3. Artikel ; Online: Platelet-Rich Plasma Versus Alternative Injections for Osteoarthritis of the Knee: A Systematic Review and Statistical Fragility Index-Based Meta-analysis of Randomized Controlled Trials.

    Oeding, Jacob F / Varady, Nathan H / Fearington, Forrest W / Pareek, Ayoosh / Strickland, Sabrina M / Nwachukwu, Benedict U / Camp, Christopher L / Krych, Aaron J

    The American journal of sports medicine

    2024  , Seite(n) 3635465231224463

    Abstract: Background: Based in part on the results of randomized controlled trials (RCTs) that suggest a beneficial effect over alternative treatment options, the use of platelet-rich plasma (PRP) for the management of knee osteoarthritis (OA) is widespread and ... ...

    Abstract Background: Based in part on the results of randomized controlled trials (RCTs) that suggest a beneficial effect over alternative treatment options, the use of platelet-rich plasma (PRP) for the management of knee osteoarthritis (OA) is widespread and increasing. However, the extent to which these studies are vulnerable to slight variations in the outcomes of patients remains unknown.
    Purpose: To evaluate the statistical fragility of conclusions from RCTs that reported outcomes of patients with knee OA who were treated with PRP versus alternative nonoperative management strategies.
    Study design: Systematic review and meta-analysis; Level of evidence, 2.
    Methods: All RCTs comparing PRP with alternative nonoperative treatment options for knee OA were identified. The fragility index (FI) and reverse FI were applied to assess the robustness of conclusions regarding the efficacy of PRP for knee OA. Meta-analyses were performed to determine the minimum number of patients from ≥1 trials included in the meta-analysis for which a modification on the event status would change the statistical significance of the pooled treatment effect.
    Results: In total, this analysis included outcomes from 1993 patients with a mean ± SD age of 58.0 ± 3.8 years. The mean number of events required to reverse significance of individual RCTs (FI) was 4.57 ± 5.85. Based on random-effects meta-analyses, PRP demonstrated a significantly higher rate of successful outcomes when compared with hyaluronic acid (
    Conclusion: Conclusions drawn from individual RCTs evaluating PRP for knee OA demonstrated slight robustness. On meta-analysis, PRP demonstrated a significant advantage over hyaluronic acid as well as improved symptom relief, lower rates of reintervention, and more frequent achievement of the MCID for pain improvement when compared with alternative nonoperative treatment options. Statistically significant pooled treatment effects evaluating PRP for knee OA are more robust than approximately half of all comparable meta-analyses in medicine and health care. Future RCTs and meta-analyses should consider reporting FIs and fragility quotients to facilitate interpretation of results in their proper context.
    Sprache Englisch
    Erscheinungsdatum 2024-02-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 197482-8
    ISSN 1552-3365 ; 0363-5465
    ISSN (online) 1552-3365
    ISSN 0363-5465
    DOI 10.1177/03635465231224463
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Long-Term Outcomes of Septoplasty With or Without Turbinoplasty: A Systematic Review.

    Fearington, Forrest W / Awadallah, Andrew S / Hamilton, Grant S / Olson, Michael D / Dey, Jacob K

    The Laryngoscope

    2023  Band 134, Heft 6, Seite(n) 2525–2537

    Abstract: Background: Septoplasty is used to correct nasal obstruction from nasal septum deviation. However, the long-term efficacy of septoplasty is unclear, and no literature reviews have examined long-term outcomes of septoplasty with or without turbinate ... ...

    Abstract Background: Septoplasty is used to correct nasal obstruction from nasal septum deviation. However, the long-term efficacy of septoplasty is unclear, and no literature reviews have examined long-term outcomes of septoplasty with or without turbinate modification. This systematic review aimed to evaluate the long-term efficacy of septoplasty with or without turbinate modification in improving nasal obstruction.
    Data sources: PubMed, EMBASE, Cochrane CENTRAL.
    Methods: A systematic review of the literature was conducted using the aforementioned databases. Studies reporting outcomes 12+ months after functional septoplasty with or without turbinate surgery for nasal obstruction were included. Septorhinoplasties, concurrent sinus surgery, pediatric studies, and studies where septoplasty was performed for indications other than nasal obstruction were excluded.
    Results: After screening, 35 studies with 4,432 patients were included. Mean weighted post-operative follow-up time was 29.1 months (range 12-120 months). All studies reported significant improvement in subjective and objective outcomes at long-term follow-up compared to baseline. When comparing short-term (<12 months) to long-term (≥12 months) outcomes, four studies noticed that subjective outcomes worsened slightly over time, but no study found a significant change in objective outcomes over time. In addition, 23 studies reported patient satisfaction and/or improvement rates, with 75.4% (2,348/3,113) of patients expressing satisfaction/improvement at an average of 27.0 months after surgery.
    Conclusions: Overall, septoplasty with or without turbinate modification shows significant improvement in obstructive symptoms at long-term follow-up per both objective and subjective measures. Whether outcomes may worsen slightly over time remains indeterminate based on mixed results in the literature.
    Level of evidence: N/A Laryngoscope, 134:2525-2537, 2024.
    Mesh-Begriff(e) Humans ; Nasal Septum/surgery ; Nasal Obstruction/surgery ; Turbinates/surgery ; Rhinoplasty/methods ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2023-11-22
    Erscheinungsland United States
    Dokumenttyp Systematic Review ; Journal Article ; Review
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31193
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Addressing positive multi-cancer early detection tests in head and neck Surgery: Experience with head and neck work up for high-risk referrals.

    Fearington, Forrest W / Zhao, Conan Y / Romero-Brufau, Santiago / Moore, Eric J / Price, Daniel L / Tasche, Kendall K / Yin, Linda X / Kunkel, Elizabeth T / Kisiel, John B / Giridhar, Karthik V / Routman, David M / Van Abel, Kathryn M

    Oral oncology

    2024  Band 152, Seite(n) 106809

    Abstract: Objectives: Blood-based multi-cancer early detection (MCED) tests are now commercially available. However, there are currently no consensus guidelines available for head and neck cancer (HNC) providers to direct work up or surveillance for patients with ...

    Abstract Objectives: Blood-based multi-cancer early detection (MCED) tests are now commercially available. However, there are currently no consensus guidelines available for head and neck cancer (HNC) providers to direct work up or surveillance for patients with a positive MCED test. We seek to describe cases of patients with positive MCED tests suggesting HNC and provide insights for their evaluation.
    Methods: Retrospective chart review of patients referred to Otolaryngology with an MCED result suggesting HNC. Patients enrolled in prospective MCED clinical trials were excluded. Cancer diagnoses were confirmed via frozen-section pathology.
    Results: Five patients were included (mean age: 69.2 years, range 50-87; 4 male) with MCED-identified-high-risk for HNC or lymphoma. Only patient was symptomatic. After physical exam and follow-up head and neck imaging, circulating tumor HPV DNA testing, two patients were diagnosed with p16 + oropharyngeal squamous cell carcinomas and underwent appropriate therapy. A third patient had no evidence of head and neck cancer but was diagnosed with sarcoma of the thigh. The remaining two patients had no evidence of malignancy after in-depth workup.
    Conclusions: In this retrospective study, 2 of 5 patients referred to Otolaryngology with a positive MCED result were diagnosed with HPV + oropharyngeal squamous cell carcinoma. We recommend that positive HNC MCED work up include thorough head and neck examination with flexible laryngoscopy and focused CT or MRI imaging. Given the potential for inaccurate MCED tissue of origin classification, PET/CT may be useful in specific situations. For a patient with no cancer identified, development of clear guidelines is warranted.
    Mesh-Begriff(e) Humans ; Male ; Aged ; Middle Aged ; Female ; Early Detection of Cancer/methods ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/surgery ; Head and Neck Neoplasms/pathology ; Aged, 80 and over ; Retrospective Studies ; Referral and Consultation
    Sprache Englisch
    Erscheinungsdatum 2024-04-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2024.106809
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Autologous Osteochondral Transfer of the Knee Demonstrates Continued High Rates of Return to Sport and Low Rates of Conversion to Arthroplasty at Long-Term Follow-Up: A Systematic Review.

    Oeding, Jacob F / Dancy, Malik E / Fearington, Forrest W / Pruneski, James A / Pareek, Ayoosh / Hevesi, Mario / Hangody, Laszlo / Camp, Christopher L / Krych, Aaron J

    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

    2023  Band 40, Heft 6, Seite(n) 1938–1949

    Abstract: Purpose: To perform a systematic review of the literature to evaluate (1) activity level and knee function, (2) reoperation and failure rates, and (3) risk factors for reoperation and failure of autologous osteochondral transfer (AOT) at long-term ... ...

    Abstract Purpose: To perform a systematic review of the literature to evaluate (1) activity level and knee function, (2) reoperation and failure rates, and (3) risk factors for reoperation and failure of autologous osteochondral transfer (AOT) at long-term follow-up.
    Methods: A comprehensive review of the long-term outcomes of AOT was performed. Studies reported on activity-based outcomes (Tegner Activity Scale) and clinical outcomes (Lysholm score and International Knee Documentation Committee score). Reoperation and failure rates as defined by the publishing authors were recorded for each study. Modified Coleman Methodology Scores were calculated to assess study methodological quality.
    Results: Twelve studies with a total of 495 patients and an average age of 32.5 years at the time of surgery and a mean follow-up of 15.1 years (range, 10.4-18.0 years) were included. The mean defect size was 3.2 cm
    Conclusions: AOT of the knee resulted in high rates of return to sport with correspondingly low rates of conversion to arthroplasty at long-term follow-up. In addition, AOT demonstrated significant improvements in long-term patient-reported outcomes from baseline.
    Level of evidence: Level IV, systematic review of Level I-IV studies.
    Mesh-Begriff(e) Humans ; Return to Sport/statistics & numerical data ; Transplantation, Autologous ; Reoperation/statistics & numerical data ; Follow-Up Studies ; Knee Joint/surgery ; Treatment Outcome ; Adult ; Bone Transplantation ; Cartilage, Articular/surgery ; Female ; Male
    Sprache Englisch
    Erscheinungsdatum 2023-12-05
    Erscheinungsland United States
    Dokumenttyp Systematic Review ; Journal Article ; Review
    ZDB-ID 632528-2
    ISSN 1526-3231 ; 0749-8063
    ISSN (online) 1526-3231
    ISSN 0749-8063
    DOI 10.1016/j.arthro.2023.11.026
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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