Artikel ; Online: Occurrence and distribution of extended-spectrum β-lactamase in clinical
2022 Band 55, Heft 4, Seite(n) 298–307
Abstract: Objective: This study determined the occurrence and distribution of Extended Spectrum β-Lactamase (ESBL) genotypes of : Design: A cross-sectional study.: Setting: A single centre study was conducted at Ho Teaching Hospital of Ghana.: ... ...
Abstract | Objective: This study determined the occurrence and distribution of Extended Spectrum β-Lactamase (ESBL) genotypes of Design: A cross-sectional study. Setting: A single centre study was conducted at Ho Teaching Hospital of Ghana. Participants: Patients who visited Ho Teaching Hospital Laboratory with the request for culture and susceptibility testing. Main outcome measure: Escherichia coli Results: Of the 135 isolates, 56(41.5%,95% CI: 33.1% - 50.3%) were ESBL producers. More males, 14(58.3%), produced ESBL than females, 42(37.8%). The ESBL prevalence was highest among the elderly who were 80 years and above 3(100.0%), with the least prevalence among patients within 50-59 years and 0-9 years age bracket, representing 4(25.0%) and 3(27.3%), respectively. The total prevalence of ESBL was marginally higher among out-patients (41.8% 95% CI: 31.9% - 52.2%) compared to in-patients [40.5% 95% CI: 24.8% - 57.9]. BlaTEM-1 was the predominant ESBL genotype obtained from 83.9% (47/56) of the confirmed ESBL producing isolates, with the least being TOHO-1 4(7.1%). The co-existence of 2 different ESBL genes occurred in 19(33.9%) of the isolates. The single and quadruple carriage were 16(28.6%) and 3(5.4%), respectively. The highest co-existence of the ESBL genotypes was recorded for blaTEM-1 and blaCTXM-1 15(26.8%), followed by blaTEM-1, blaCTXM-1 and blaSHV-73 [12(21.4%)]. Conclusion: The high prevalence of ESBL-producing Funding: This research received no external funding. |
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Mesh-Begriff(e) | Aged ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cross-Sectional Studies ; Escherichia coli/genetics ; Escherichia coli Infections/epidemiology ; Female ; Ghana/epidemiology ; Hospitals, Teaching ; Humans ; Male ; beta-Lactamases/genetics |
Chemische Substanzen | Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6) |
Sprache | Englisch |
Erscheinungsdatum | 2022-07-31 |
Erscheinungsland | Ghana |
Dokumenttyp | Journal Article |
ZDB-ID | 2259233-7 |
ISSN | 2616-163X ; 2616-163X |
ISSN (online) | 2616-163X |
ISSN | 2616-163X |
DOI | 10.4314/gmj.v55i4.11 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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