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  1. Article ; Online: How does colpocleisis for pelvic organ prolapse in older women affect quality of life, body image, and sexuality? A critical review of the literature.

    Felder, Laetitia / Heinzelmann-Schwarz, Viola / Kavvadias, Tilemachos

    Women's health (London, England)

    2022  Volume 18, Page(s) 17455057221111067

    Abstract: Colpocleisis is a surgical treatment for pelvic organ prolapse that results in vaginal obliteration. This review aims to systematically evaluate the quality of life, changes in body image, regret, and impact on sexual activity in women after colpocleisis. ...

    Abstract Colpocleisis is a surgical treatment for pelvic organ prolapse that results in vaginal obliteration. This review aims to systematically evaluate the quality of life, changes in body image, regret, and impact on sexual activity in women after colpocleisis. A review was conducted using the PubMed and Scopus databases with search criteria specifying pelvic organ prolapse, colpocleisis, quality of life, body image, regret, sexuality, and their synonyms. For the selection of the eligible articles, we used the PRISMA reporting system. A total of 1285 articles were found. After removing duplicates and applying the inclusion and exclusion criteria, 30 articles were reviewed in full length. Quality of life after colpocleisis was evaluated in 22 articles, and 20 authors used validated questionnaires. All concluded that quality of life improved after surgical treatment. Twenty-one articles studied regret after obliterative treatment for pelvic organ prolapse. Most of the patients reported no regret. Regret was often due to bowel and bladder symptoms. A few patients reported regret because of loss of coital function. Body image was highlighted in six studies. Three articles assessed body image using the modified Body Image scale. The body image scores demonstrated a significant improvement after surgery. Women tended to remain sexually active and some also regained sexual activities after surgery. Colpocleisis remains a viable option for pelvic organ prolapse, without compromising quality of life, body image, or sexuality, but diligent patient selection is needed. Particular concern should be given to bladder and bowel symptoms since these are the main reason for dissatisfaction after colpocleisis.
    MeSH term(s) Aged ; Body Image ; Female ; Gynecologic Surgical Procedures ; Humans ; Pelvic Organ Prolapse/surgery ; Quality of Life ; Sexual Behavior ; Sexuality ; Treatment Outcome ; Vagina/surgery
    Language English
    Publishing date 2022-07-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2274503-8
    ISSN 1745-5065 ; 1745-5057
    ISSN (online) 1745-5065
    ISSN 1745-5057
    DOI 10.1177/17455057221111067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A high C-reactive protein/procalcitonin ratio predicts Mycoplasma pneumoniae infection.

    Neeser, Olivia L / Vukajlovic, Tanja / Felder, Laetitia / Haubitz, Sebastian / Hammerer-Lercher, Angelika / Ottiger, Cornelia / Mueller, Beat / Schuetz, Philipp / Fux, Christoph A

    Clinical chemistry and laboratory medicine

    2019  Volume 57, Issue 10, Page(s) 1638–1646

    Abstract: Background Discriminating Mycoplasma pneumoniae (MP) from Streptococcus pneumoniae (SP) and viral etiologies of community-acquired pneumonia (CAP) is challenging but has important implications regarding empiric antibiotic therapy. We investigated patient ...

    Abstract Background Discriminating Mycoplasma pneumoniae (MP) from Streptococcus pneumoniae (SP) and viral etiologies of community-acquired pneumonia (CAP) is challenging but has important implications regarding empiric antibiotic therapy. We investigated patient parameters upon hospital admission to predict MP infection. Methods All patients hospitalized in a tertiary care hospital between 2013 and 2017 for CAP with a confirmed etiology were analyzed using logistic regression analyses and area under the receiver operator characteristics (ROC) curves (AUC) for associations between demographic, clinical and laboratory features and the causative pathogen. Results We analyzed 568 patients with CAP, including 47 (8%) with MP; 152 (27%) with SP and 369 (65%) with influenza or other viruses. Comparing MP and SP by multivariate logistic regression analysis, younger age (odds ration [OR] 0.56 per 10 years, 95% CI 0.42-0.73), a lower neutrophil/lymphocyte ratio (OR 0.9, 0.82-0.99) and an elevated C-reactive protein/procalcitonin (CRP/PCT) ratio (OR 15.04 [5.23-43.26] for a 400 mg/μg cut-off) independently predicted MP. With a ROC curve AUC of 0.91 (0.80 for the >400 mg/μg cutoff), the CRP/PCT ratio was the strongest predictor of MP vs. SP. The discriminatory value resulted from significantly lower PCT values (p < 0.001) for MP, while CRP was high in both groups (p = 0.057). Comparing MP and viral infections showed similar results with again the CRP/PCT ratio providing the best information (AUC 0.83; OR 5.55 for the >400 mg/μg cutoff, 2.26-13.64). Conclusions In patients hospitalized with CAP, a high admission CRP/PCT ratio predicts M. pneumoniae infection and may improve empiric management.
    MeSH term(s) Adult ; Aged ; Biomarkers ; C-Reactive Protein/analysis ; Calcitonin/analysis ; Calcitonin Gene-Related Peptide/analysis ; Community-Acquired Infections ; Female ; Hospitalization ; Humans ; Lymphocytes ; Male ; Middle Aged ; Mycoplasma pneumoniae/metabolism ; Mycoplasma pneumoniae/pathogenicity ; Neutrophils ; Pneumonia, Mycoplasma/blood ; Pneumonia, Mycoplasma/diagnosis ; Pneumonia, Mycoplasma/metabolism ; Procalcitonin/analysis ; Procalcitonin/blood ; Prognosis ; Protein Precursors ; ROC Curve ; Streptococcus pneumoniae/pathogenicity
    Chemical Substances Biomarkers ; Procalcitonin ; Protein Precursors ; Calcitonin (9007-12-9) ; C-Reactive Protein (9007-41-4) ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
    Keywords covid19
    Language English
    Publishing date 2019-05-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2019-0194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Validation of a Prediction Rule for

    Bolliger, Rebekka / Neeser, Olivia / Merker, Meret / Vukajlovic, Tanja / Felder, Laetitia / Fiumefreddo, Rico / Haubitz, Sebastian / Koch, Daniel / Hammerer-Lercher, Angelika / Ottiger, Cornelia / Fux, Christoph A / Mueller, Beat / Schuetz, Philipp

    Open forum infectious diseases

    2019  Volume 6, Issue 7, Page(s) ofz268

    Abstract: We validated a clinical prediction rule ... ...

    Abstract We validated a clinical prediction rule for
    Language English
    Publishing date 2019-06-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofz268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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