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  1. Artikel: Examination of Fas-Induced Apoptosis of Murine Thymocytes in Thymic Tissue Slices Reveals That Fas Is Dispensable for Negative Selection.

    Chu, Chang-Feng / Feng, Hsing-Kai / Sun, Kuang-Hui / Hsu, Chia-Lin / Dzhagalov, Ivan L

    Frontiers in cell and developmental biology

    2020  Band 8, Seite(n) 586807

    Abstract: The death receptor Fas can induce cell death through the extrinsic pathway of apoptosis in a variety of cells, including developing thymocytes. Although Fas-induced cell death has been researched and modeled extensively, most of the studies have been ... ...

    Abstract The death receptor Fas can induce cell death through the extrinsic pathway of apoptosis in a variety of cells, including developing thymocytes. Although Fas-induced cell death has been researched and modeled extensively, most of the studies have been done
    Sprache Englisch
    Erscheinungsdatum 2020-10-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2020.586807
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Multiomics reveal the central role of pentose phosphate pathway in resident thymic macrophages to cope with efferocytosis-associated stress.

    Tsai, Tsung-Lin / Zhou, Tyng-An / Hsieh, Yu-Ting / Wang, Ju-Chu / Cheng, Hui-Kuei / Huang, Chen-Hua / Tsai, Pei-Yuan / Fan, Hsiu-Han / Feng, Hsing-Kai / Huang, Yu-Chia / Lin, Chen-Ching / Lin, Chao-Hsiung / Lin, Chih-Yu / Dzhagalov, Ivan L / Hsu, Chia-Lin

    Cell reports

    2022  Band 40, Heft 2, Seite(n) 111065

    Abstract: Tissue-resident macrophages (TRMs) are heterogeneous cell populations found throughout the body. Depending on their location, they perform diverse functions maintaining tissue homeostasis and providing immune surveillance. To survive and function within, ...

    Abstract Tissue-resident macrophages (TRMs) are heterogeneous cell populations found throughout the body. Depending on their location, they perform diverse functions maintaining tissue homeostasis and providing immune surveillance. To survive and function within, TRMs adapt metabolically to the distinct microenvironments. However, little is known about the metabolic signatures of TRMs. The thymus provides a nurturing milieu for developing thymocytes yet efficiently removes those that fail the selection, relying on the resident thymic macrophages (TMφs). This study harnesses multiomics analyses to characterize TMφs and unveils their metabolic features. We find that the pentose phosphate pathway (PPP) is preferentially activated in TMφs, responding to the reduction-oxidation demands associated with the efferocytosis of dying thymocytes. The blockade of PPP in Mφs leads to decreased efferocytosis, which can be rescued by reactive oxygen species (ROS) scavengers. Our study reveals the key role of the PPP in TMφs and underscores the importance of metabolic adaptation in supporting Mφ efferocytosis.
    Mesh-Begriff(e) Macrophages/metabolism ; Pentose Phosphate Pathway ; Phagocytosis ; Reactive Oxygen Species/metabolism
    Chemische Substanzen Reactive Oxygen Species
    Sprache Englisch
    Erscheinungsdatum 2022-07-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.111065
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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