Artikel ; Online: Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination.
2023 Band 96, Heft 1, Seite(n) e29317
Abstract: People living with human immunodeficiency virus (HIV) are the individuals most affected by the current Monkeypox virus outbreak that was first announced in May 2022. Here we report Pan-pox-specific T-cell responses in a cohort of HIV-1-infected ... ...
| Abstract | People living with human immunodeficiency virus (HIV) are the individuals most affected by the current Monkeypox virus outbreak that was first announced in May 2022. Here we report Pan-pox-specific T-cell responses in a cohort of HIV-1-infected individuals after receiving the nonreplicative, attenuated smallpox vaccine JYNNEOS from Bavarian Nordic. Intradermal (i.d.) and subcutaneous (s.c.) vaccination was safe without major side effects. Dose-sparing i.d. vaccination was superior to s.c. vaccination and promoted T-cell polyfunctionality, and the expression of the gut-homing marker α4β7 integrin on lymphocytes. HIV-1-infected individuals with CD4 T-cell counts ≤500/mm |
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| Mesh-Begriff(e) | Humans ; HIV-1 ; HIV Infections ; CD4-Positive T-Lymphocytes ; Vaccination | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2023-12-27 | |||||
| Erscheinungsland | United States | |||||
| Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 752392-0 | |||||
| ISSN | 1096-9071 ; 0146-6615 | |||||
| ISSN (online) | 1096-9071 | |||||
| ISSN | 0146-6615 | |||||
| DOI | 10.1002/jmv.29317 | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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