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  1. Artikel: Treatment of Cholera.

    Finley, C A

    Medical examiner (Philadelphia, Pa.)

    2023  Band 5, Heft 57, Seite(n) 524

    Sprache Englisch
    Erscheinungsdatum 2023-12-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: A Case, Illustrative of the Beneficial Effects of Cold Water, as an External Application.

    Finley, C A

    Medical examiner (Philadelphia, Pa.)

    2023  Band 2, Heft 42, Seite(n) 661–662

    Sprache Englisch
    Erscheinungsdatum 2023-12-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Confronting the Negative Impact of Cigarette Smoking on Cancer Surgery.

    Choe, Se-In / Finley, Christian

    Current oncology (Toronto, Ont.)

    2022  Band 29, Heft 8, Seite(n) 5869–5874

    Abstract: Smoking is a common health risk behavior that has substantial effects on perioperative risk and postoperative surgical outcomes. Current smoking is clearly linked to an increased risk of perioperative cardiovascular, pulmonary and wound healing ... ...

    Abstract Smoking is a common health risk behavior that has substantial effects on perioperative risk and postoperative surgical outcomes. Current smoking is clearly linked to an increased risk of perioperative cardiovascular, pulmonary and wound healing complications. Accumulating evidence indicates that smoking cessation can reduce the higher perioperative complication risk that is observed in current smokers. In addition, continued smoking has a negative impact on the overall prognosis of cancer patients. Smoking cessation, on the other hand, can improve long-term outcomes after surgery. Smoking cessation services should be implemented in a comprehensive programmatic manner to ensure that all patients gain access to evidence-based care. Although the benefits of abstinence increase in proportion to the length of cessation, cessation should be recommended regardless of timing prior to surgery.
    Mesh-Begriff(e) Cigarette Smoking ; Humans ; Neoplasms/etiology ; Neoplasms/surgery ; Postoperative Period ; Prognosis ; Smoking Cessation
    Sprache Englisch
    Erscheinungsdatum 2022-08-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol29080463
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: The effect of surgeon volume on procedure selection in non-small cell lung cancer surgeries.

    Finley, Christian

    The Journal of thoracic and cardiovascular surgery

    2016  Band 151, Heft 4, Seite(n) 1219

    Mesh-Begriff(e) Carcinoma, Non-Small-Cell Lung/surgery ; Delivery of Health Care/trends ; Female ; Hospitals, High-Volume/trends ; Hospitals, Low-Volume/trends ; Humans ; Lung Neoplasms/surgery ; Male ; Patient Selection ; Pneumonectomy/trends ; Surgeons/trends
    Sprache Englisch
    Erscheinungsdatum 2016-04
    Erscheinungsland United States
    Dokumenttyp Comment ; Letter
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2016.01.014
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Mirizzi Syndrome Type I: A Case Presentation.

    Won, Michelle N / Collins, Dylon P / Bouchard, Stephanie / Finley, Christopher

    Cureus

    2023  Band 15, Heft 4, Seite(n) e37029

    Abstract: Mirizzi syndrome (MS) is a rare complication of chronic cholelithiasis. The syndrome describes gallstone obstruction of Hartmann's pouch or the cystic duct that extrinsically compresses the common hepatic duct, causing obstructive jaundice. In advanced ... ...

    Abstract Mirizzi syndrome (MS) is a rare complication of chronic cholelithiasis. The syndrome describes gallstone obstruction of Hartmann's pouch or the cystic duct that extrinsically compresses the common hepatic duct, causing obstructive jaundice. In advanced cases, the gallstones may erode into the biliary tree creating a fistula, requiring prompt diagnosis and careful surgical management. We present a case of an 82-year-old female who presented with upper abdominal pain and jaundice, later diagnosed with suspected MS type I, and managed surgically. We aim to highlight MS type I because of the potential progression and damage to the bile duct, creating complications that may affect overall patient outcome.
    Sprache Englisch
    Erscheinungsdatum 2023-04-02
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.37029
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Current and Future Treatment Options in the Management of Stage III NSCLC.

    Li, Yuchen / Juergens, Rosalyn Anne / Finley, Christian / Swaminath, Anand

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2023  Band 18, Heft 11, Seite(n) 1478–1491

    Abstract: For much of the past two decades, the treatment options for patients with stage III NSCLC were mostly stagnant. In the past 5 years, ongoing innovations have dovetailed alongside advances in biomarker testing, novel therapeutics, precision surgery, and ... ...

    Abstract For much of the past two decades, the treatment options for patients with stage III NSCLC were mostly stagnant. In the past 5 years, ongoing innovations have dovetailed alongside advances in biomarker testing, novel therapeutics, precision surgery, and radiotherapy, all of which are leading to an increase in more personalized option for the treatment. This review article will focus on several completed and ongoing initiatives involving treatment of patients with stage III NSCLC. First, it will tackle the progress made in curative treatment of unresectable stage III NSCLC, starting with PACIFIC, and branching out into topics such as concurrent immunotherapy and chemoradiation, intensification of consolidative immunotherapy, dual immunotherapy consolidation, and a reflection on those subpopulations that may not benefit from consolidative immunotherapy. Second, there will be discussion of novel strategies in the setting of resectable stage III disease, most notably neoadjuvant therapy using combined chemoimmunotherapy and immunotherapy alone before surgical resection. Third, it will delve into recent data evaluating adjuvant immunotherapy for resectable stage III NSCLC, including adjuvant targeted therapy (for those harboring driver mutations) and postoperative radiotherapy. Finally, a look to future trials/initiatives will be interspersed throughout the review, to reveal the ongoing efforts being made to continue to improve outcomes in this group of patients.
    Mesh-Begriff(e) Humans ; Lung Neoplasms/pathology ; Neoplasm Staging ; Carcinoma, Non-Small-Cell Lung/pathology ; Combined Modality Therapy ; Neoadjuvant Therapy ; Immunotherapy
    Sprache Englisch
    Erscheinungsdatum 2023-08-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2023.08.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Buch: All the boats on the ocean

    Finley, Carmel

    how government subsidies led to global overfishing

    2017  

    Abstract: Introduction: political roles for fish populations -- The fishing empires of the Pacific: the Americans, the Japanese, and the Soviets -- Islands and war -- Manifest destiny and fishing -- Tariffs -- Industrialization -- Treaties -- Imperialism -- ... ...

    Verfasserangabe Carmel Finley
    Abstract Introduction: political roles for fish populations -- The fishing empires of the Pacific: the Americans, the Japanese, and the Soviets -- Islands and war -- Manifest destiny and fishing -- Tariffs -- Industrialization -- Treaties -- Imperialism -- Enclosure -- Conclusions: updating the best available science
    Schlagwörter Fisheries/History ; Fishery management/Political aspects ; Fishery management/History ; Fishery policy ; Overfishing ; Sea-power/Economic aspects ; Fischschutz ; Fischereipolitik ; Subvention ; Nachhaltigkeit ; Fischwirtschaft ; Fischereiressourcen ; Welt
    Sprache Englisch
    Umfang viii, 211 Seiten, Illustrationen
    Verlag The University of Chicago Press
    Erscheinungsort Chicago
    Dokumenttyp Buch
    Anmerkung Includes bibliographical references and index
    ISBN 9780226443379 ; 9780226443409 ; 022644337X ; 022644340X
    Datenquelle ECONomics Information System

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  8. Artikel ; Online: Pan-Canadian colorectal cancer surgery data: an opportunity for reflection and improvement.

    Moloo, Husein / Lacaille-Ranger, Ariane / MacLean, Anthony / Finley, Christian

    Canadian journal of surgery. Journal canadien de chirurgie

    2022  Band 65, Heft 6, Seite(n) E735–E738

    Abstract: Variation in data provides an opportunity for health care providers to assess how patient care can be improved. Pan-Canadian colorectal cancer data show that, although long-term survival is similar among provinces, differences exist in other important ... ...

    Abstract Variation in data provides an opportunity for health care providers to assess how patient care can be improved. Pan-Canadian colorectal cancer data show that, although long-term survival is similar among provinces, differences exist in other important aspects of care: length of stay, minimally invasive approach, readmission, and short-term mortality. Examining variation among stakeholders involved with colorectal cancer allows the opportunity to reflect on and optimize care.
    Mesh-Begriff(e) Humans ; Canada ; Digestive System Surgical Procedures ; Colorectal Neoplasms/surgery ; Length of Stay ; Minimally Invasive Surgical Procedures ; Retrospective Studies ; Postoperative Complications
    Sprache Englisch
    Erscheinungsdatum 2022-11-02
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ZDB-ID 410651-9
    ISSN 1488-2310 ; 0008-428X
    ISSN (online) 1488-2310
    ISSN 0008-428X
    DOI 10.1503/cjs.000621
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: A trans-Canadian positive deviance seminar for paraesophageal hernia surgery: Reporting national postoperative outcomes and consensus recommendations.

    Tankel, James / Safieddine, Najib / Malthaner, Rick / French, Danny / Johnston, Brian / Finley, Christian / Darling, Gail / Ferri, Lorenzo / Seely, Andrew / Gowing, Stephen

    World journal of surgery

    2024  Band 48, Heft 3, Seite(n) 673–680

    Abstract: Background: The incidence of adverse events (AEs) and length of stay (LOS) varies significantly following paraesophageal hernia surgery. We performed a Canadian multicenter positive deviance (PD) seminar to review individual center and national level ... ...

    Abstract Background: The incidence of adverse events (AEs) and length of stay (LOS) varies significantly following paraesophageal hernia surgery. We performed a Canadian multicenter positive deviance (PD) seminar to review individual center and national level data and establish holistic perioperative practice recommendations.
    Methods: A national virtual PD seminar was performed in October 2021. Recent best evidence focusing on AEs and LOS was presented. Subsequently, anonymized center-level AE and LOS data collected between 01/2017 and 01/2021 from a prospective, web-based database that tracks postoperative outcomes was presented. The top two performing centers with regards to these metrics were chosen and surgeons from these hospitals discussed elements of their treatment pathways that contributed to these outcomes. Consensus recommendations were then identified with participants independently rating their level of agreement.
    Results: Twenty-eight surgeons form 8 centers took part in the seminar across 5 Canadian provinces. Of the 680 included patients included, Clavien-Dindo grade I and II/III/IV/V complications occurred in 121/39/12/2 patients (17.8%/5.7%/1.8%/0.3%). Respiratory complications were the most common (effusion 12/680, 1.7% and pneumonia 9/680, 1.3%). Esophageal and gastric perforation occurred in 7 and 4/680, (1.0% and 0.6% respectively). Median LOS varied significantly between institutions (1 day, range 1-3 vs. 7 days, 3-8, p < 0.001). A strong level of agreement was achieved for 10/12 of the consensus statements generated.
    Conclusion: PD seminars provide a supportive forum for centers to review best evidence and experience and generate recommendations based on expert opinion. Further research is ongoing to determine if this approach effectively accomplishes this objective.
    Mesh-Begriff(e) Humans ; Hernia, Hiatal/surgery ; Hernia, Hiatal/complications ; Prospective Studies ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Canada ; Length of Stay ; Laparoscopy/adverse effects
    Sprache Englisch
    Erscheinungsdatum 2024-02-15
    Erscheinungsland United States
    Dokumenttyp Multicenter Study ; Journal Article
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1002/wjs.12087
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Overview of AlphaFold2 and breakthroughs in overcoming its limitations.

    Wang, Lei / Wen, Zehua / Liu, Shi-Wei / Zhang, Lihong / Finley, Cierra / Lee, Ho-Jin / Fan, Hua-Jun Shawn

    Computers in biology and medicine

    2024  Band 176, Seite(n) 108620

    Abstract: Predicting three-dimensional (3D) protein structures has been challenging for decades. The emergence of AlphaFold2 (AF2), a deep learning-based machine learning method developed by DeepMind, became a game changer in the protein folding community. AF2 can ...

    Abstract Predicting three-dimensional (3D) protein structures has been challenging for decades. The emergence of AlphaFold2 (AF2), a deep learning-based machine learning method developed by DeepMind, became a game changer in the protein folding community. AF2 can predict a protein's three-dimensional structure with high confidence based on its amino acid sequence. Accurate prediction of protein structures can dramatically accelerate our understanding of biological mechanisms and provide a solid foundation for reliable drug design. Although AF2 breaks through the barriers in predicting protein structures, many rooms remain to be further studied. This review provides a brief historical overview of the development of protein structure prediction, covering template-based, template-free, and machine learning-based methods. In addition to reviewing the potential benefits (Pros) and considerations (Cons) of using AF2, this review summarizes the diverse applications, including protein structure predictions, dynamic changes, point mutation, integration of language model and experimental data, protein complex, and protein-peptide interaction. It underscores recent advancements in efficiency, reliability, and broad application of AF2. This comprehensive review offers valuable insights into the applications of AF2 and AF2-inspired AI methods in structural biology and its potential for clinically significant drug target discovery.
    Mesh-Begriff(e) Proteins/chemistry ; Proteins/metabolism ; Proteins/genetics ; Humans ; Protein Folding ; Deep Learning ; Protein Conformation ; Models, Molecular ; Computational Biology/methods ; Machine Learning
    Chemische Substanzen Proteins
    Sprache Englisch
    Erscheinungsdatum 2024-05-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2024.108620
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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