Artikel ; Online: Generation of post-surgical minimal residual disease models to investigate metastasis in soft tissue sarcoma patient-derived orthotopic xenografts.
STAR protocols
2024 Band 5, Heft 1, Seite(n) 102863
Abstract: Despite optimal multimodal treatment including surgical resection, 50%-80% of high-grade soft tissue sarcoma (STS) patients metastasize. Here, we present a protocol for the generation and use of post-surgical minimal residual disease models to ... ...
Abstract | Despite optimal multimodal treatment including surgical resection, 50%-80% of high-grade soft tissue sarcoma (STS) patients metastasize. Here, we present a protocol for the generation and use of post-surgical minimal residual disease models to investigate metastatic relapse in STS patient-derived xenografts. We describe steps for orthotopic engraftment of high-grade STS patient-derived tumor tissue. We then detail procedures for primary tumor resection with broad, negative resection margins and follow-up until metastases using MRI. For complete details on the use and execution of this protocol, please refer to Fischer et al. (2023). |
---|---|
Mesh-Begriff(e) | Humans ; Neoplasm, Residual ; Heterografts ; Sarcoma/diagnostic imaging ; Sarcoma/surgery ; Sarcoma/pathology ; Soft Tissue Neoplasms/diagnostic imaging ; Soft Tissue Neoplasms/surgery ; Soft Tissue Neoplasms/pathology ; Magnetic Resonance Imaging |
Sprache | Englisch |
Erscheinungsdatum | 2024-02-28 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article |
ISSN | 2666-1667 |
ISSN (online) | 2666-1667 |
DOI | 10.1016/j.xpro.2024.102863 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Zusatzmaterialien
Kategorien
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.
Fernleihe an ZB MED
Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.