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  1. Artikel: Out-of-hospital cardiac arrest: stay and play or scoop and run (to an ECMO centre).

    Fisher, Caleb M

    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

    2023  Band 24, Heft 1, Seite(n) 5–6

    Sprache Englisch
    Erscheinungsdatum 2023-10-18
    Erscheinungsland Netherlands
    Dokumenttyp Editorial
    ZDB-ID 2401976-8
    ISSN 1441-2772
    ISSN 1441-2772
    DOI 10.51893/2022.1.E
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  2. Artikel ; Online: Further Exploration of MARS.

    Warrillow, Stephen / Fisher, Caleb

    Critical care medicine

    2022  Band 50, Heft 2, Seite(n) 346–348

    Sprache Englisch
    Erscheinungsdatum 2022-01-31
    Erscheinungsland United States
    Dokumenttyp Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005202
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  3. Artikel ; Online: Ceremonial purification: which rite is right in liver failure?

    Fisher, Caleb / Warrillow, Stephen / Bellomo, Rinaldo

    Intensive care medicine

    2022  Band 49, Heft 3, Seite(n) 366

    Mesh-Begriff(e) Humans ; Liver Failure/therapy
    Sprache Englisch
    Erscheinungsdatum 2022-11-09
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06923-7
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  4. Artikel ; Online: The Impact of Early Positive Studies on the Evolution of Extracorporeal Albumin Dialysis Literature: A Bibliometric Analysis.

    Chaba, Anis / Warrillow, Stephen / Fisher, Caleb / Maeda, Akinori / Spano, Sofia / Bellomo, Rinaldo

    Blood purification

    2023  Band 53, Heft 4, Seite(n) 279–287

    Abstract: Introduction: Liver failure is a life-threatening condition characterized by the accumulation of metabolic toxins. Extracorporeal albumin dialysis (ECAD) has been promoted as a possible therapy.: Methods: We employed bibliometric analysis to ... ...

    Abstract Introduction: Liver failure is a life-threatening condition characterized by the accumulation of metabolic toxins. Extracorporeal albumin dialysis (ECAD) has been promoted as a possible therapy.
    Methods: We employed bibliometric analysis to scrutinize the conceptual, intellectual, and social structure of the ECAD literature including its co-citation network and thematic analysis to explore its evolution and organization.
    Results: We identified 784 documents with a mean of 30.25 citations per document in a corpus of 15,191 references. The average citation rate peaked in 1998 at 280.75 citations/year before a second 2013 peak of 54.81 citations/year and then progressively decreased to its nadir in 2022 (1.48 yearly citations). We identified four primary co-citation clusters, with the most impactful publications being small "positive" manuscripts by Mitzner et al. (2000) and Heemann et al. (2002) (Cluster 1). This first cluster had several relational citations with clusters 2 and 3, but almost no citation link with cluster 4 represented by Bañares et al. (2013), Saliba et al. (2013), and Larsen et al. (2016), with their three negative randomized controlled trials. Finally, the thematic map revealed a shift in focus over time, with inflammation and ammonia as recent emergent themes.
    Conclusions: This bibliometric analysis provided a transparent and reproducible longitudinal assessment of ECAD literature and demonstrated how positive studies with low levels of evidence can dominate a research field and overshadow negative findings from higher quality studies. These insights hold significant implications for future research and clinical practice within this domain.
    Mesh-Begriff(e) Humans ; Renal Dialysis ; Bibliometrics ; Albumins ; Liver Failure
    Chemische Substanzen Albumins
    Sprache Englisch
    Erscheinungsdatum 2023-10-31
    Erscheinungsland Switzerland
    Dokumenttyp Systematic Review
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000534915
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Ammonia Clearance with Different Continuous Renal Replacement Therapy Techniques in Patients with Liver Failure.

    Fisher, Caleb / Baldwin, Ian / Fealy, Nigel / Naorungroj, Thummaporn / Bellomo, Rinaldo

    Blood purification

    2022  Band 51, Heft 10, Seite(n) 840–846

    Abstract: Introduction: Continuous renal replacement therapy (CRRT) can be used to treat hyperammonaemia. However, no study has assessed the effect of different CRRT techniques on ammonia clearance.: Methods: We compared 3 different CRRT techniques in adult ... ...

    Abstract Introduction: Continuous renal replacement therapy (CRRT) can be used to treat hyperammonaemia. However, no study has assessed the effect of different CRRT techniques on ammonia clearance.
    Methods: We compared 3 different CRRT techniques in adult patients with hyperammonaemia, liver failure, and acute kidney injury. We protocolized CRRT to progressively deliver continuous veno-venous haemofiltration (CVVH), haemodialysis (CVVHD) or haemodiafiltration (CVVHDF). Ammonia was simultaneously sampled from the patient's arterial blood and effluent fluid for each technique. We applied accepted equations to calculate clearance.
    Results: We studied 12 patients with a median age of 47 years (interquartile range [IQR] 25-79). Acute liver failure was present in 4 (25%) and acute-on-chronic liver failure in 8 (75%). There was no significant difference in median ammonia clearance between CRRT technique; CVVH: 27 (IQR 23-32) mL/min versus CVVHD: 21 (IQR 17-28) mL/min versus CVVHDF: 20 (IQR 14-28) mL/min, p = 0.32. Moreover, for all techniques, ammonia clearance was significantly less than urea and creatinine clearance; urea 50 (47-54) mL/min versus creatinine 42 (IQR 38-46) mL/min versus ammonia 25 (IQR 18-29) mL/min, p = 0.0001.
    Conclusion: We found no significant difference in ammonia clearance according to CRRT technique and demonstrated that ammonia clearance is significantly less than urea or creatinine clearance.
    Mesh-Begriff(e) Acute Kidney Injury/therapy ; Adult ; Ammonia ; Continuous Renal Replacement Therapy ; Creatinine ; Humans ; Hyperammonemia/therapy ; Liver Failure/therapy ; Middle Aged ; Renal Replacement Therapy/methods ; Urea
    Chemische Substanzen Ammonia (7664-41-7) ; Urea (8W8T17847W) ; Creatinine (AYI8EX34EU)
    Sprache Englisch
    Erscheinungsdatum 2022-01-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000521312
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  6. Artikel ; Online: Correction and Control of Hyperammonemia in Acute Liver Failure: The Impact of Continuous Renal Replacement Timing, Intensity, and Duration.

    Warrillow, Stephen / Fisher, Caleb / Bellomo, Rinaldo

    Critical care medicine

    2020  Band 48, Heft 2, Seite(n) 218–224

    Abstract: Objectives: Hyperammonemia is a key contributing factor for cerebral edema in acute liver failure. Continuous renal replacement therapy may help reduce ammonia levels. However, the optimal timing, mode, intensity, and duration of continuous renal ... ...

    Abstract Objectives: Hyperammonemia is a key contributing factor for cerebral edema in acute liver failure. Continuous renal replacement therapy may help reduce ammonia levels. However, the optimal timing, mode, intensity, and duration of continuous renal replacement therapy in this setting are unknown. We aimed to study continuous renal replacement therapy use in acute liver failure patients and to assess its impact on hyperammonemia.
    Design: Retrospective observational study.
    Setting: ICU within a specialized liver transplant hospital.
    Patients: Fifty-four patients with acute liver failure.
    Interventions: Data were obtained from medical records and analyzed for patient characteristics, continuous renal replacement therapy use, ammonia dynamics, and outcomes.
    Main results: Forty-five patients (83%) had high grade encephalopathy. Median time to continuous renal replacement therapy commencement was 4 hours (interquartile range, 2-4.5) with 35 (78%) treated with continuous venovenous hemodiafiltration and 10 (22%) with continuous venovenous hemofiltration. Median hourly effluent flow rate was 43 mL/kg (interquartile range, 37-62). The median ammonia concentration decreased every day during treatment from 151 µmol/L (interquartile range, 110-204) to 107 µmol/L (interquartile range, 84-133) on day 2, 75 µmol/L (interquartile range, 63-95) on day 3, and 52 µmol/L (interquartile range, 42-70) (p < 0.0001) on day 5. The number of patients with an ammonia level greater than 150 µmol/L decreased on the same days from 26, to nine, then two, and finally none. Reductions in ammonia levels correlated best with the cumulative duration of therapy hours (p = 0.03), rather than hourly treatment intensity.
    Conclusions: Continuous renal replacement therapy is associated with reduced ammonia concentrations in acute liver failure patients. This effect is related to greater cumulative dose. These findings suggest that continuous renal replacement therapy initiated early and continued or longer may represent a useful approach to hyperammonemia control in acute liver failure patients.
    Mesh-Begriff(e) APACHE ; Adult ; Age Factors ; Ammonia/metabolism ; Body Weight ; Continuous Renal Replacement Therapy/methods ; Female ; Humans ; Hyperammonemia/etiology ; Hyperammonemia/physiopathology ; Hyperammonemia/therapy ; Intensive Care Units ; Liver Failure, Acute/complications ; Male ; Middle Aged ; Retrospective Studies ; Sex Factors ; Time Factors
    Chemische Substanzen Ammonia (7664-41-7)
    Sprache Englisch
    Erscheinungsdatum 2020-01-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000004153
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Early and prolonged continuous hypertonic saline infusion in patients with acute liver failure.

    Michel, Claire / Warming, Scott / Neto, Ary Serpa / Abeygunawardana, Vihangi / Fisher, Caleb / Kishore, Kartik / Warrillow, Stephen / Bellomo, Rinaldo

    Journal of critical care

    2023  Band 76, Seite(n) 154289

    Abstract: Purpose: To study patient characteristics, physiological changes, and outcomes associated with prolonged continuous hypertonic saline (HTS) infusion in acute liver failure (ALF).: Materials and methods: Retrospective observational cohort study of ... ...

    Abstract Purpose: To study patient characteristics, physiological changes, and outcomes associated with prolonged continuous hypertonic saline (HTS) infusion in acute liver failure (ALF).
    Materials and methods: Retrospective observational cohort study of adult patients with ALF. We collected clinical, biochemical, and physiological data six hourly for the first week, daily until day 30 or hospital discharge, and weekly, when documented, until day 180.
    Results: Of 127 patients, 85 received continuous HTS. Compared with non-HTS patients they were more likely to receive continuous renal replacement therapy (CRRT) (p < 0.001) and mechanical ventilation (p < 0.001). Median HTS duration was 150 (Interquartile range (IQR): 84-168) hours, delivering a median 2244 (IQR: 979-4610) mmol sodium load. Median peak sodium concentration was 149 mmol/L vs 138 mmol/L in non-HTS patients (p < 0.001). The median rate of sodium increase with infusion was 0.1 mmol/L/h and median rate of decrease during weaning was 0.1 mmol/L every 6 h. Median lowest pH value was 7.29 vs. 7.35 in non-HTS patients. Survival of HTS patients was 72.9% overall and 72.2% without transplantation.
    Conclusions: In ALF patients, the prolonged administration of HTS infusion was not associated with severe hypernatremia or rapid shifts in serum sodium upon commencement, delivery, or weaning.
    Mesh-Begriff(e) Adult ; Humans ; Retrospective Studies ; Treatment Outcome ; Saline Solution, Hypertonic/therapeutic use ; Sodium ; Liver Failure, Acute/therapy
    Chemische Substanzen Saline Solution, Hypertonic ; Sodium (9NEZ333N27)
    Sprache Englisch
    Erscheinungsdatum 2023-03-16
    Erscheinungsland United States
    Dokumenttyp Observational Study ; Journal Article
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2023.154289
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  8. Artikel ; Online: Medical students as interpreters in health care situations: "… it's a grey area".

    Ryan, Anna Therese / Fisher, Caleb / Chiavaroli, Neville

    The Medical journal of Australia

    2019  Band 211, Heft 4, Seite(n) 170–174

    Abstract: Objective: To examine the extent to which medical students in Australia are acting as interpreters in medical settings, and their perceptions of this activity.: Design, setting, participants: Anonymous online survey of final year students in the ... ...

    Abstract Objective: To examine the extent to which medical students in Australia are acting as interpreters in medical settings, and their perceptions of this activity.
    Design, setting, participants: Anonymous online survey of final year students in the graduate medical program of the University of Melbourne, undertaken in 2014.
    Main outcome measures: Numbers of students who had acted or who had been asked to act as ad hoc interpreters in health care situations during their clinical rotations and outside the medical education context.
    Results: 146 of 319 final year medical students completed the survey (46% response). 106 students (73%) reported they could speak at least one language in addition to English; none had formal interpreting qualifications, but 40 (36%) had been asked to interpret during clinical rotations, and 36 (34%) had done so. The students described a diverse range of experiences, including complex interactions regarding informed consent and the breaking of bad news.
    Conclusion: Medical students frequently acted as interpreters during their clinical training. Most did not feel appropriately qualified to interpret in clinical situations, and some felt pressured to do so, but many found the experience positive. Our study highlights the lack of clear guidelines regarding medical student interpreters in Australian health care settings.
    Mesh-Begriff(e) Australia ; Communication Barriers ; Humans ; Language ; Physician-Patient Relations ; Students, Medical ; Surveys and Questionnaires ; Translating
    Sprache Englisch
    Erscheinungsdatum 2019-06-12
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.50235
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Improved Thyreostatic Drug Detection in Animal Tissues Using Liquid Chromatography-High-Field Asymmetric Waveform Ion Mobility Spectrometry-Mass Spectrometry.

    Purves, Randy W / Souster, Kim / West, Michelle / Huda, Azhar M / Fisher, Caleb M E / Belford, Michael W / Shurmer, Bryn O

    Journal of agricultural and food chemistry

    2022  Band 70, Heft 16, Seite(n) 4785–4791

    Abstract: Thyreostatic drugs (thyreostats) interfere with thyroid function and have been used illegally in animals slaughtered for food. Thyreostat use leads to poorer quality meat, and the drug residues can cause adverse effects in humans. These drugs, with the ... ...

    Abstract Thyreostatic drugs (thyreostats) interfere with thyroid function and have been used illegally in animals slaughtered for food. Thyreostat use leads to poorer quality meat, and the drug residues can cause adverse effects in humans. These drugs, with the exception of thiouracil, do not occur naturally and require sensitive methodologies for their detection in animal tissues. Because thyreostats are low-molecular-weight polar analytes, liquid chromatography-mass spectrometry (LC-MS) is typically used for detection and, in particular, triple quadrupole mass spectrometry with selective reaction monitoring (i.e., LC-SRM). However, LC-SRM thyreostat methods suffer from chemical background noise and endogenous interferences arising from the complex tissue matrix. An improved high-field asymmetric waveform ion mobility spectrometry interface (FAIMS Pro), which separates ions based on differential ion mobility, was combined with LC-SRM to minimize these interferences. Using the same samples and conditions, LC-FAIMS-SRM showed improvements in the signal-to-noise ratio (S/N) of up to 50 times compared with our validated LC-SRM method. In addition, wider linear ranges, including substantial improvements in the lower limit of quantification (approximately an order of magnitude for tapazole and methylthiouracil), were observed with LC-FAIMS-SRM.
    Mesh-Begriff(e) Animals ; Chromatography, Liquid ; Drug Residues ; Ion Mobility Spectrometry/methods ; Ions/chemistry ; Tandem Mass Spectrometry/methods
    Chemische Substanzen Ions
    Sprache Englisch
    Erscheinungsdatum 2022-01-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.1c06937
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Improved Thyreostatic Drug Detection in Animal Tissues Using Liquid Chromatography–High-Field Asymmetric Waveform Ion Mobility Spectrometry–Mass Spectrometry

    Purves, Randy W. / Souster, Kim / West, Michelle / Huda, Azhar M. / Fisher, Caleb M. E. / Belford, Michael W. / Shurmer, Bryn O.

    Journal of agricultural and food chemistry. 2022 Jan. 21, v. 70, no. 16

    2022  

    Abstract: Thyreostatic drugs (thyreostats) interfere with thyroid function and have been used illegally in animals slaughtered for food. Thyreostat use leads to poorer quality meat, and the drug residues can cause adverse effects in humans. These drugs, with the ... ...

    Abstract Thyreostatic drugs (thyreostats) interfere with thyroid function and have been used illegally in animals slaughtered for food. Thyreostat use leads to poorer quality meat, and the drug residues can cause adverse effects in humans. These drugs, with the exception of thiouracil, do not occur naturally and require sensitive methodologies for their detection in animal tissues. Because thyreostats are low-molecular-weight polar analytes, liquid chromatography–mass spectrometry (LC–MS) is typically used for detection and, in particular, triple quadrupole mass spectrometry with selective reaction monitoring (i.e., LC–SRM). However, LC–SRM thyreostat methods suffer from chemical background noise and endogenous interferences arising from the complex tissue matrix. An improved high-field asymmetric waveform ion mobility spectrometry interface (FAIMS Pro), which separates ions based on differential ion mobility, was combined with LC–SRM to minimize these interferences. Using the same samples and conditions, LC–FAIMS–SRM showed improvements in the signal-to-noise ratio (S/N) of up to 50 times compared with our validated LC–SRM method. In addition, wider linear ranges, including substantial improvements in the lower limit of quantification (approximately an order of magnitude for tapazole and methylthiouracil), were observed with LC–FAIMS–SRM.
    Schlagwörter chemical species ; food chemistry ; liquid chromatography ; mass spectrometry ; meat ; methimazole ; methylthiouracil ; signal-to-noise ratio ; thiouracil ; thyroid function
    Sprache Englisch
    Erscheinungsverlauf 2022-0121
    Umfang p. 4785-4791.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.1c06937
    Datenquelle NAL Katalog (AGRICOLA)

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