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  1. Artikel: Impact of transcription factors KLF1 and GATA1 on red blood cell antigen expression: a review.

    Lopez, Genghis H / Sarri, Mia E / Flower, Robert L / Hyland, Catherine A

    Immunohematology

    2024  Band 40, Heft 1, Seite(n) 1–9

    Abstract: KLF transcription factor 1 (KLF1) and GATA binding protein 1 (GATA1) are transcription factors (TFs) that initiate and regulate transcription of the genes involved in erythropoiesis. These TFs possess DNA-binding domains that recognize specific ... ...

    Abstract KLF transcription factor 1 (KLF1) and GATA binding protein 1 (GATA1) are transcription factors (TFs) that initiate and regulate transcription of the genes involved in erythropoiesis. These TFs possess DNA-binding domains that recognize specific nucleotide sequences in genes, to which they bind and regulate transcription. Variants in the genes that encode either KLF1 or GATA1 can result in a range of hematologic phenotypes-from benign to severe forms of thrombocytopenia and anemia; they can also weaken the expression of blood group antigens. The Lutheran (LU) blood group system is susceptible to TF gene variations, particularly
    Mesh-Begriff(e) Humans ; Kruppel-Like Transcription Factors/genetics ; GATA1 Transcription Factor/genetics ; Erythrocytes/metabolism ; Erythrocytes/immunology ; Blood Group Antigens/genetics ; Blood Group Antigens/immunology ; Lutheran Blood-Group System/genetics ; Gene Expression Regulation ; Erythropoiesis/genetics
    Chemische Substanzen Kruppel-Like Transcription Factors ; GATA1 Transcription Factor ; erythroid Kruppel-like factor ; GATA1 protein, human ; Blood Group Antigens ; Lutheran Blood-Group System
    Sprache Englisch
    Erscheinungsdatum 2024-05-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1146978-x
    ISSN 0894-203X
    ISSN 0894-203X
    DOI 10.2478/immunohematology-2024-002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Tired and stressed: direct holographic quasi-static stretching of aging echinocytes and discocytes in plasma using optical tweezers [Invited].

    Stilgoe, Alexander B / Kashchuk, Anatolii V / Balanant, Marie-Anne / Santangelo, Deborah / Nieminen, Timo A / Sauret, Emilie / Flower, Robert / Rubinsztein-Dunlop, Halina

    Biomedical optics express

    2024  Band 15, Heft 2, Seite(n) 656–671

    Abstract: Red blood cells (RBCs) undergo a progressive morphological transformation from smooth biconcave discocytes into rounder echinocytes with spicules on their surface during cold storage. The echinocytic morphology impacts RBCs' ability to flow through ... ...

    Abstract Red blood cells (RBCs) undergo a progressive morphological transformation from smooth biconcave discocytes into rounder echinocytes with spicules on their surface during cold storage. The echinocytic morphology impacts RBCs' ability to flow through narrow sections of the circulation and therefore transfusion of RBC units with a high echinocytic content are thought to have a reduced efficiency. We use an optical tweezers-based technique where we directly trap and measure linear stiffness of RBCs under stress without the use of attached spherical probe particles or microfluidic flow to induce shear. We study RBC deformability with over 50 days of storage performing multiple stretches in blood plasma (serum with cold agglutinins removed to eliminate clotting). In particular, we find that discocytes and echinocytes do not show significant changes in linear stiffness in the small strain limit (
    Sprache Englisch
    Erscheinungsdatum 2024-01-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.504779
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Neonatal Outcomes From Arboviruses in the Perinatal Period: A State-of-the-Art Review.

    Ginige, Shamila / Flower, Robert / Viennet, Elvina

    Pediatrics

    2021  Band 147, Heft 4

    Abstract: Since the 2016 Zika outbreak and the understanding of the teratogenic effect of this infection, there has been a newfound interest in arbovirus infections and their effects on pregnancy, resulting in numerous publications in the last 5 years. However, ... ...

    Abstract Since the 2016 Zika outbreak and the understanding of the teratogenic effect of this infection, there has been a newfound interest in arbovirus infections and their effects on pregnancy, resulting in numerous publications in the last 5 years. However, limited literature focuses on arbovirus infection in different stages of pregnancy and their effect on the neonate. There is currently no consensus management of perinatal acquisition of arboviruses, and current evidence is largely anecdotal observational reports. Teratogens can have different effects on the developing fetus depending on the time of infection, so infections during pregnancy should be analyzed by trimester. A better understanding of arbovirus infection in the perinatal period is required to assist obstetric, neonatal, and pediatric clinicians in making decisions about the management of mother and neonate. Our objective was to assess the evidence of adverse neonatal outcomes for several arboviral infections when contracted during the perinatal period to guide clinicians in managing these patients. There are 8 arboviruses for which neonatal outcomes from maternal acquisition in the perinatal period have been reported, with the most data for dengue and Chikungunya virus infections. The evidence reviewed in this article supports the adoption of preventive strategies to avoid ticks and mosquitoes close to the date of delivery. For the other arbovirus infections, further community-based cohort studies during outbreaks are required to evaluate whether these infections have a similar teratogenic impact.
    Mesh-Begriff(e) Arbovirus Infections/complications ; Arbovirus Infections/transmission ; Congenital Abnormalities/virology ; Encephalitis, Viral/etiology ; Female ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Newborn, Diseases/virology ; Infectious Disease Transmission, Vertical ; Pregnancy ; Pregnancy Complications, Infectious/virology ; Premature Birth/virology ; Skin Diseases, Infectious/virology ; Stillbirth
    Sprache Englisch
    Erscheinungsdatum 2021-03-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2020-009720
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Investigation of the effect of pre-analytical factors on particle concentration and size in cryoprecipitate using nanoparticle tracking analysis.

    Hwang, Ji Hui / Tung, John-Paul / Harkin, Damien G / Flower, Robert L / Pecheniuk, Natalie M

    Transfusion medicine (Oxford, England)

    2023  Band 33, Heft 5, Seite(n) 398–402

    Abstract: Background: Cryoprecipitate is used primarily to replenish fibrinogen levels in patients. Little is known about the presence of micro- or nano-sized particles in cryoprecipitate. Therefore, we aimed to quantify these particles and investigate some pre- ... ...

    Abstract Background: Cryoprecipitate is used primarily to replenish fibrinogen levels in patients. Little is known about the presence of micro- or nano-sized particles in cryoprecipitate. Therefore, we aimed to quantify these particles and investigate some pre-analytical considerations.
    Materials and methods: Particle concentration and size distribution were determined in 10 cryoprecipitate units by nanoparticle tracking analysis (NTA). The effects of freeze-thawing cryoprecipitate and 0.45 μm filtration with either regenerated cellulose (RC) or polytetrafluoroethylene (PTFE) filters before sample analysis were examined.
    Results: Neither the size nor concentration of particles were affected by two freeze/thaw cycles. PTFE filtration, but not RC filtration, significantly reduced particle mean and mode size compared to RC filtration and mode size compared to unfiltered cryoprecipitate. The 10 cryoprecipitate units had an average particle concentration of 2.50 × 10
    Conclusion: This study demonstrated that preanalytical filtration of cryoprecipitate units using RC filters was suitable for NTA. An additional freeze/thaw cycle did not impact NTA parameters, suggesting that aliquoting cryoprecipitate units prior to laboratory investigations is suitable for downstream analyses.
    Mesh-Begriff(e) Humans ; Nanoparticles/analysis ; Particle Size ; Polytetrafluoroethylene ; Factor VIII/chemistry ; Fibrinogen/chemistry ; Filtration
    Chemische Substanzen Polytetrafluoroethylene (9002-84-0) ; cryoprecipitate coagulum ; Factor VIII (9001-27-8) ; Fibrinogen (9001-32-5)
    Sprache Englisch
    Erscheinungsdatum 2023-07-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.12986
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Inverse Relationship Between Lipopolysaccharide Concentration and Monocyte and Dendritic Cells Inflammatory Response.

    Perros, Alexis J / Flower, Robert L / Dean, Melinda M

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2020  Band 40, Heft 7, Seite(n) 349–356

    Abstract: Dendritic cells (DCs) and monocytes are key immunoregulatory cells that link the innate and adaptive immune response. However, understanding of human cell-specific responses to different doses of stimuli including lipopolysaccharide (LPS) is limited. ... ...

    Abstract Dendritic cells (DCs) and monocytes are key immunoregulatory cells that link the innate and adaptive immune response. However, understanding of human cell-specific responses to different doses of stimuli including lipopolysaccharide (LPS) is limited. This study investigated the monocyte and classical DC (cDC)-specific, as well as the overall inflammatory response after exposure to varying doses of LPS. Fresh peripheral whole blood (
    Mesh-Begriff(e) Cells, Cultured ; Cytokines/biosynthesis ; Cytokines/blood ; Cytokines/immunology ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Dose-Response Relationship, Drug ; Humans ; Inflammation/immunology ; Lipopolysaccharides/pharmacology ; Monocytes/drug effects ; Monocytes/immunology
    Chemische Substanzen Cytokines ; Lipopolysaccharides
    Sprache Englisch
    Erscheinungsdatum 2020-05-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2019.0244
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Buch: Indocyanine green angiography

    Yannuzzi, Lawrence A. / Flower, Robert W. / Slakter, Jason S.

    1997  

    Verfasserangabe Lawrence A. Yannuzzi ; Robert W. Flower ; Jason S. Slakter
    Schlagwörter Indocyanine Green / diagnostic use ; Fluorescein Angiography ; Choroid Diseases ; Retinal Diseases ; Auge ; Angiographie ; Indocyaningrün
    Schlagwörter Angioradiographie ; Vasographie ; Gefäßdarstellung ; Sehorgan
    Sprache Englisch
    Umfang XVI, 359 S. : zahlr. Ill., graph. Darst.
    Verlag Mosby
    Erscheinungsort St. Louis u.a.
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    HBZ-ID HT007710228
    ISBN 0-8151-9774-8 ; 978-0-8151-9774-4
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    1997 A 6841 bestellbar zur Ausleihe Magazin

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  7. Artikel ; Online: Intraoperative cell salvage: The impact on immune cell numbers.

    Roets, Michelle / Sturgess, David / Tran, Thu / Obeysekera, Maheshi / Perros, Alexis / Tung, John-Paul / Flower, Robert / van Zundert, Andre / Dean, Melinda

    PloS one

    2023  Band 18, Heft 8, Seite(n) e0289177

    Abstract: Background: Patient outcomes are influenced by many confounding factors peri-operatively, including the type of surgery, anaesthesia, transfusion, and immune competence. We have previously demonstrated (in-vitro) that compared to allogeneic blood ... ...

    Abstract Background: Patient outcomes are influenced by many confounding factors peri-operatively, including the type of surgery, anaesthesia, transfusion, and immune competence. We have previously demonstrated (in-vitro) that compared to allogeneic blood transfusion (ABT), intraoperative cell salvage (ICS) improves immune competence. The peri-operative immune response is complex. Altered or impaired immune responses may predispose patients to develop adverse outcomes (i.e., post-operative wound infection, pneumonia, urinary tract infection etc.) Surgical patients may develop infection, even without the confirmed presence of a definite microbiological pathogen. With all these factors in mind it is important to consider changes in immune cell numbers (and sub-populations) and functional capacity during peri-operative transfusion.
    Methods: In this TRIMICS-Cell (Transfusion Related Immune Modulation and Intraoperative Cell Salvage-Cell numbers) study (n = 17, October 2018-November 2019) we prioritized and analysed peri-operative changes in the number and proportions of immune cell populations and sub-populations (B cells (CD20+), NK (natural killer) cells (CD56+), monocytes (CD14+), T cells (total CD3+ and sub-populations: T helper cells (CD4+), cytotoxic T cells (CD8+), effector T cells (CD4+ CD127+), activated effector T cells (CD4+ CD25+ CD127+) and regulatory T cells (CD4+ CD25+ CD127-)), plasmacytoid dendritic cells (pDC; Lineage-, HLA-DR+, CD11c-, CD123+), classical dendritic cell (cDC) (Lineage-, HLA-DR+, CD11c+), and cDC activation (Lineage-, HLA-DR+, CD11c+), co-stimulatory/adhesion molecules and pDC (CD9+, CD38+, CD80+, CD83+, CD86+, CD123+). Firstly we analysed the whole cohort of study patients and secondly according to the relevant transfusion modality (i.e., three study groups: those who received no transfusion, received ICS only (ICS), or both ICS and allogeneic packed red blood cells (pRBC) (ICS&RBC)), during major orthopaedic surgery.
    Results: For the whole study cohort (all patients), changes in immune cell populations were significant: leucocytes and specifically neutrophils increased post-operatively, returning towards pre-operative numbers by 48h post-operatively (48h), and lymphocytes reduced post-operatively returning to pre-operative numbers by 48h. When considering transfusion modalities, there were no significant peri-operative changes in the no transfusion group for all immune cell populations studied (cell numbers and proportions (%)). Significant changes in cell population numbers (i.e., leucocytes, neutrophils and lymphocytes) were identified in both transfused groups (ICS and ICS&RBC). Considering all patients, changes in immune cell sub-populations (NK cells, monocytes, B cells, T cells and DCs) and functional characteristics (e.g., co-stimulation markers, adhesion, activation, and regulation) were significant peri-operatively and when considering transfusion modalities. Interestingly DC numbers and functional capacity were specifically altered following ICS compared to ICS&RBC and pDCs were relatively preserved post-operatively following ICS.
    Conclusion: A transient peri-operative alteration with recovery towards pre-operative numbers by 48h post-surgery was demonstrated for many immune cell populations and sub-populations throughout. Immune cell sub-populations and functional characteristics were similar peri-operatively in those who received no transfusion but changed significantly following ICS and ICS&RBC. Interesting changes that require future study are a post-operative monocyte increase in the ICS&RBC group, changes in cDC considering transfusion modalities, and possibly preserved pDC numbers post-operatively following ICS. Future studies to assess changes in immune cell sub-populations, especially during peri-operative transfusion, while considering post-operative adverse outcomes, is recommended.
    Mesh-Begriff(e) Humans ; Interleukin-3 Receptor alpha Subunit ; HLA-DR Antigens ; T-Lymphocytes, Regulatory ; Blood Transfusion ; Cell Count ; Dendritic Cells
    Chemische Substanzen Interleukin-3 Receptor alpha Subunit ; HLA-DR Antigens
    Sprache Englisch
    Erscheinungsdatum 2023-08-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0289177
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Observation and characterization of microvascular vasomotion using erythrocyte mediated ICG angiography (EM-ICG-A).

    Flower, Robert W / Kling, Ronn

    Microvascular research

    2017  Band 113, Seite(n) 78–87

    Abstract: A clinical method for characterizing the state of micro-vasculature vasomotion is demonstrated, based on observing in capillaries the dynamics of autologously re-injected erythrocytes containing ICG dye. Since a manifestation of vasomotion is transient ... ...

    Abstract A clinical method for characterizing the state of micro-vasculature vasomotion is demonstrated, based on observing in capillaries the dynamics of autologously re-injected erythrocytes containing ICG dye. Since a manifestation of vasomotion is transient erythrocyte pausing, vasomotion state within a field of capillaries is characterized by an histogram plot of the number of paused erythrocytes as a function of pause duration during a fixed period of observation, then the ratio of long-pausing to short-pausing erythrocytes was calculated. The method was first applied to the posterior pole retinal vasculatures of anesthetized-monkey eyes, and normal vasomotion state during air-breathing was compared to the state induced by O
    Sprache Englisch
    Erscheinungsdatum 2017-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80307-8
    ISSN 1095-9319 ; 0026-2862
    ISSN (online) 1095-9319
    ISSN 0026-2862
    DOI 10.1016/j.mvr.2017.02.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: A clinical method for quantification of tissue microvascular blood perfusion in absolute terms [blood-volume/(time·tissue-area)].

    Flower, Robert W / Kling, Ronn

    Microvascular research

    2017  Band 114, Seite(n) 92–100

    Abstract: Fluorescence-mediated photoplethysmography (FM-PPG) was developed to facilitate determination of tissue microvascular (capillary) blood perfusion, requiring intra-venous injection of a small bolus (~0.33mL) of dye (25mg/mL ICG) and acquisition of high- ... ...

    Abstract Fluorescence-mediated photoplethysmography (FM-PPG) was developed to facilitate determination of tissue microvascular (capillary) blood perfusion, requiring intra-venous injection of a small bolus (~0.33mL) of dye (25mg/mL ICG) and acquisition of high-speed angiogram images (>15images/s). The methodology is applicable to microvascular capillary beds of tissues that can be optically imaged, directly or laparoscopically. Proof of concept of the methodology and feasibility of its implementation are demonstrated in human forearm skin and in the choroid of a monkey eye, determined to have blood perfusion rates on the order of 1e-5mL/(s·mm
    Mesh-Begriff(e) Algorithms ; Angiography/methods ; Animals ; Blood Flow Velocity ; Blood Volume ; Choroid/blood supply ; Feasibility Studies ; Fluorescent Dyes/administration & dosage ; Forearm ; Humans ; Image Processing, Computer-Assisted ; Indocyanine Green/administration & dosage ; Macaca fascicularis ; Microcirculation ; Models, Cardiovascular ; Optical Imaging/methods ; Perfusion Imaging/methods ; Photoplethysmography/methods ; Predictive Value of Tests ; Regional Blood Flow ; Skin/blood supply ; Time Factors
    Chemische Substanzen Fluorescent Dyes ; Indocyanine Green (IX6J1063HV)
    Sprache Englisch
    Erscheinungsdatum 2017
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80307-8
    ISSN 1095-9319 ; 0026-2862
    ISSN (online) 1095-9319
    ISSN 0026-2862
    DOI 10.1016/j.mvr.2017.05.009
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  10. Artikel ; Online: Genomic characterisation of clinically significant blood group variants in Aboriginal Australians.

    Jadhao, Sudhir / Davison, Candice / Roulis, Eileen / Lee, Simon / Campbell, Tamika / Griffin, Reece / Toombs, Maree / Brown, Alex / Perry, Maree / Nasir, Bushra / Irving, David O / Hyland, Catherine A / Flower, Robert L / Nagaraj, Shivashankar H

    Blood transfusion = Trasfusione del sangue

    2024  

    Abstract: Background: Hematological disorders are often treated with blood transfusions. Many blood group antigens and variants are population-specific, and for patients with rare blood types, extensive donor screening is required to find suitable matches for ... ...

    Abstract Background: Hematological disorders are often treated with blood transfusions. Many blood group antigens and variants are population-specific, and for patients with rare blood types, extensive donor screening is required to find suitable matches for transfusion. There is a scarcity of knowledge regarding blood group variants in Aboriginal Australian populations, despite a higher need for transfusion due to the higher prevalence of renal diseases and anaemia.
    Materials and methods: In this study, we applied next-generation sequencing and analysis to 245 samples obtained from Aboriginal Australians from South-East Queensland, to predict antigen phenotypes for 36 blood group systems.
    Results: We report potential weak antigens in blood group systems RH, FY and JR that have potential clinical implications in transfusion and pregnancy settings. These include partial DIII type 4, weak D type 33, and Del RHD (IVS2-2delA). The rare Rh phenotypes D+ C+ E+ c- e+ and D+ C+ E+ c+ e- were also detected.
    Discussion: The comprehensive analyses of blood group genetic variant profiles identified in this study will provide insight and an opportunity to improve Aboriginal health by aiding in the identification of appropriate blood products for population-specific transfusion needs.
    Sprache Englisch
    Erscheinungsdatum 2024-03-11
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 2135732-8
    ISSN 2385-2070 ; 0041-1787 ; 1723-2007
    ISSN (online) 2385-2070
    ISSN 0041-1787 ; 1723-2007
    DOI 10.2450/BloodTransfus.664
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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