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  1. Artikel ; Online: The molecular cytoarchitecture of the adult mouse brain.

    Langlieb, Jonah / Sachdev, Nina S / Balderrama, Karol S / Nadaf, Naeem M / Raj, Mukund / Murray, Evan / Webber, James T / Vanderburg, Charles / Gazestani, Vahid / Tward, Daniel / Mezias, Chris / Li, Xu / Flowers, Katelyn / Cable, Dylan M / Norton, Tabitha / Mitra, Partha / Chen, Fei / Macosko, Evan Z

    Nature

    2023  Band 624, Heft 7991, Seite(n) 333–342

    Abstract: The function of the mammalian brain relies upon the specification and spatial positioning of diversely specialized cell types. Yet, the molecular identities of the cell types and their positions within individual anatomical structures remain incompletely ...

    Abstract The function of the mammalian brain relies upon the specification and spatial positioning of diversely specialized cell types. Yet, the molecular identities of the cell types and their positions within individual anatomical structures remain incompletely known. To construct a comprehensive atlas of cell types in each brain structure, we paired high-throughput single-nucleus RNA sequencing with Slide-seq
    Mesh-Begriff(e) Animals ; Mice ; Brain/anatomy & histology ; Brain/cytology ; Brain/metabolism ; Gene Expression Profiling/methods ; High-Throughput Nucleotide Sequencing ; Hypothalamus/cytology ; Hypothalamus/metabolism ; Mesencephalon/cytology ; Mesencephalon/metabolism ; Neuropeptides/metabolism ; Neurotransmitter Agents/metabolism ; Phenotype ; Rhombencephalon/cytology ; Rhombencephalon/metabolism ; Single-Cell Gene Expression Analysis ; Transcriptome/genetics
    Chemische Substanzen Neuropeptides ; Neurotransmitter Agents
    Sprache Englisch
    Erscheinungsdatum 2023-12-13
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06818-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Increasing diversity in genomics requires investment in equitable partnerships and capacity building.

    Martin, Alicia R / Stroud, Rocky E / Abebe, Tamrat / Akena, Dickens / Alemayehu, Melkam / Atwoli, Lukoye / Chapman, Sinéad B / Flowers, Katelyn / Gelaye, Bizu / Gichuru, Stella / Kariuki, Symon M / Kinyanjui, Sam / Korte, Kristina J / Koen, Nastassja / Koenen, Karestan C / Newton, Charles R J C / Olivares, Ana Maria / Pollock, Sam / Post, Kristianna /
    Singh, Ilina / Stein, Dan J / Teferra, Solomon / Zingela, Zukiswa / Chibnik, Lori B

    Nature genetics

    2022  Band 54, Heft 6, Seite(n) 740–745

    Mesh-Begriff(e) Capacity Building ; Genomics
    Sprache Englisch
    Erscheinungsdatum 2022-05-30
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-022-01095-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Phylogenetic analysis of SARS-CoV-2 in the Boston area highlights the role of recurrent importation and superspreading events.

    Lemieux, Jacob E / Siddle, Katherine J / Shaw, Bennett M / Loreth, Christine / Schaffner, Stephen F / Gladden-Young, Adrianne / Adams, Gordon / Fink, Timelia / Tomkins-Tinch, Christopher H / Krasilnikova, Lydia A / DeRuff, Katherine C / Rudy, Melissa / Bauer, Matthew R / Lagerborg, Kim A / Normandin, Erica / Chapman, Sinead B / Reilly, Steven K / Anahtar, Melis N / Lin, Aaron E /
    Carter, Amber / Myhrvold, Cameron / Kemball, Molly E / Chaluvadi, Sushma / Cusick, Caroline / Flowers, Katelyn / Neumann, Anna / Cerrato, Felecia / Farhat, Maha / Slater, Damien / Harris, Jason B / Branda, John / Hooper, David / Gaeta, Jessie M / Baggett, Travis P / O'Connell, James / Gnirke, Andreas / Lieberman, Tami D / Philippakis, Anthony / Burns, Meagan / Brown, Catherine M / Luban, Jeremy / Ryan, Edward T / Turbett, Sarah E / LaRocque, Regina C / Hanage, William P / Gallagher, Glen R / Madoff, Lawrence C / Smole, Sandra / Pierce, Virginia M / Rosenberg, Eric / Sabeti, Pardis C / Park, Daniel J / Maclnnis, Bronwyn L

    medRxiv : the preprint server for health sciences

    2020  

    Abstract: SARS-CoV-2 has caused a severe, ongoing outbreak of COVID-19 in Massachusetts with 111,070 confirmed cases and 8,433 deaths as of August 1, 2020. To investigate the introduction, spread, and epidemiology of COVID-19 in the Boston area, we sequenced and ... ...

    Abstract SARS-CoV-2 has caused a severe, ongoing outbreak of COVID-19 in Massachusetts with 111,070 confirmed cases and 8,433 deaths as of August 1, 2020. To investigate the introduction, spread, and epidemiology of COVID-19 in the Boston area, we sequenced and analyzed 772 complete SARS-CoV-2 genomes from the region, including nearly all confirmed cases within the first week of the epidemic and hundreds of cases from major outbreaks at a conference, a nursing facility, and among homeless shelter guests and staff. The data reveal over 80 introductions into the Boston area, predominantly from elsewhere in the United States and Europe. We studied two superspreading events covered by the data, events that led to very different outcomes because of the timing and populations involved. One produced rapid spread in a vulnerable population but little onward transmission, while the other was a major contributor to sustained community transmission, including outbreaks in homeless populations, and was exported to several other domestic and international sites. The same two events differed significantly in the number of new mutations seen, raising the possibility that SARS-CoV-2 superspreading might encompass disparate transmission dynamics. Our results highlight the failure of measures to prevent importation into MA early in the outbreak, underscore the role of superspreading in amplifying an outbreak in a major urban area, and lay a foundation for contact tracing informed by genetic data.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-25
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2020.08.23.20178236
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events.

    Lemieux, Jacob E / Siddle, Katherine J / Shaw, Bennett M / Loreth, Christine / Schaffner, Stephen F / Gladden-Young, Adrianne / Adams, Gordon / Fink, Timelia / Tomkins-Tinch, Christopher H / Krasilnikova, Lydia A / DeRuff, Katherine C / Rudy, Melissa / Bauer, Matthew R / Lagerborg, Kim A / Normandin, Erica / Chapman, Sinéad B / Reilly, Steven K / Anahtar, Melis N / Lin, Aaron E /
    Carter, Amber / Myhrvold, Cameron / Kemball, Molly E / Chaluvadi, Sushma / Cusick, Caroline / Flowers, Katelyn / Neumann, Anna / Cerrato, Felecia / Farhat, Maha / Slater, Damien / Harris, Jason B / Branda, John A / Hooper, David / Gaeta, Jessie M / Baggett, Travis P / O'Connell, James / Gnirke, Andreas / Lieberman, Tami D / Philippakis, Anthony / Burns, Meagan / Brown, Catherine M / Luban, Jeremy / Ryan, Edward T / Turbett, Sarah E / LaRocque, Regina C / Hanage, William P / Gallagher, Glen R / Madoff, Lawrence C / Smole, Sandra / Pierce, Virginia M / Rosenberg, Eric / Sabeti, Pardis C / Park, Daniel J / MacInnis, Bronwyn L

    Science (New York, N.Y.)

    2020  Band 371, Heft 6529

    Abstract: Analysis of 772 complete severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from early in the Boston-area epidemic revealed numerous introductions of the virus, a small number of which led to most cases. The data revealed two ... ...

    Abstract Analysis of 772 complete severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from early in the Boston-area epidemic revealed numerous introductions of the virus, a small number of which led to most cases. The data revealed two superspreading events. One, in a skilled nursing facility, led to rapid transmission and significant mortality in this vulnerable population but little broader spread, whereas other introductions into the facility had little effect. The second, at an international business conference, produced sustained community transmission and was exported, resulting in extensive regional, national, and international spread. The two events also differed substantially in the genetic variation they generated, suggesting varying transmission dynamics in superspreading events. Our results show how genomic epidemiology can help to understand the link between individual clusters and wider community spread.
    Mesh-Begriff(e) Boston/epidemiology ; COVID-19/epidemiology ; COVID-19/transmission ; Disease Outbreaks ; Epidemiological Monitoring ; Genome, Viral ; Humans ; Phylogeny ; SARS-CoV-2/genetics
    Sprache Englisch
    Erscheinungsdatum 2020-12-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abe3261
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Phylogenetic analysis of SARS-CoV-2 in the Boston area highlights the role of recurrent importation and superspreading events

    Lemieux, Jacob / Siddle, Katherine J / Shaw, Bennett M. / Loreth, Christine / Schaffner, Stephen / Gladden-Young, Adrianne / Adams, Gordon / Fink, Timelia / Tomkins-Tinch, Chris H / Krasilnikova, Lydia A / Deruff, Katherine C / Rudy, Melissa / Bauer, Matthew R / Lagerborg, Kim A / Normandin, Erica / Chapman, Sinead B / Reilly, Steven K / Anahtar, Melis N / Lin, Aaron E /
    Carter, Amber / Myhrvold, Cameron / Kemball, Molly / Chaluvadi, Suschma / Cusick, Caroline / Flowers, Katelyn / Neumann, Anna / Cerrato, Felecia / Farhat, Maha / Slater, Damien / Harris, Jason B / Branda, John / Hooper, David / Gaeta, Jessie M / Baggett, Travis P. / O'Connell, James / Gnirke, Andreas / Lieberman, Tami D / Philippakis, Anthony / Burns, Meagan / Brown, Catherine / Luban, Jeremy / Ryan, Edward T / Turbett, Sarah E / LaRocque, Regina C / Hanage, William P. / Gallagher, Glen / Madoff, Lawrence C / Smole, Sandra / Pierce, Virginia M. / Rosenberg, Eric S / Sabeti, Pardis / Park, Daniel J / MacInnis, Bronwyn L

    medRxiv

    Abstract: SARS-CoV-2 has caused a severe, ongoing outbreak of COVID-19 in Massachusetts with 111,070 confirmed cases and 8,433 deaths as of August 1, 2020. To investigate the introduction, spread, and epidemiology of COVID-19 in the Boston area, we sequenced and ... ...

    Abstract SARS-CoV-2 has caused a severe, ongoing outbreak of COVID-19 in Massachusetts with 111,070 confirmed cases and 8,433 deaths as of August 1, 2020. To investigate the introduction, spread, and epidemiology of COVID-19 in the Boston area, we sequenced and analyzed 772 complete SARS-CoV-2 genomes from the region, including nearly all confirmed cases within the first week of the epidemic and hundreds of cases from major outbreaks at a conference, a nursing facility, and among homeless shelter guests and staff. The data reveal over 80 introductions into the Boston area, predominantly from elsewhere in the United States and Europe. We studied two superspreading events covered by the data, events that led to very different outcomes because of the timing and populations involved. One produced rapid spread in a vulnerable population but little onward transmission, while the other was a major contributor to sustained community transmission, including outbreaks in homeless populations, and was exported to several other domestic and international sites. The same two events differed significantly in the number of new mutations seen, raising the possibility that SARS-CoV-2 superspreading might encompass disparate transmission dynamics. Our results highlight the failure of measures to prevent importation into MA early in the outbreak, underscore the role of superspreading in amplifying an outbreak in a major urban area, and lay a foundation for contact tracing informed by genetic data.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-25
    Verlag Cold Spring Harbor Laboratory Press
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2020.08.23.20178236
    Datenquelle COVID19

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