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  1. Artikel ; Online: Robustness of tissue oxygenation estimates by continuous wave space-resolved near infrared spectroscopy.

    Amendola, Caterina / Contini, Davide / Re, Rebecca / Spinelli, Lorenzo / Frabasile, Lorenzo / Levoni, Pietro / Torricelli, Alessandro

    Journal of biomedical optics

    2023  Band 28, Heft 7, Seite(n) 75002

    Abstract: Significance: Continuous wave near infrared spectroscopy (CW-NIRS) is widely exploited in clinics to estimate skeletal muscles and brain cortex oxygenation. Spatially resolved spectroscopy (SRS) is generally implemented in commercial devices. However, ... ...

    Abstract Significance: Continuous wave near infrared spectroscopy (CW-NIRS) is widely exploited in clinics to estimate skeletal muscles and brain cortex oxygenation. Spatially resolved spectroscopy (SRS) is generally implemented in commercial devices. However, SRS suffers from two main limitations: the
    Aim: We studied the accuracy and robustness of SRS NIRS. We investigated the errors in retrieving hemodynamic parameters, in particular tissue oxygen saturation (
    Approach: We simulated hemodynamic variations mimicking real-life scenarios for skeletal muscles. Simulations were performed by exploiting the analytical solutions of the photon diffusion equation in different geometries: (1) semi-infinite homogeneous medium and constant
    Results: Variations in
    Conclusions: These results highlight the need for more sophisticated strategies (e.g., the use of multiple short and long distances) to reduce the influence of superficial tissues in retrieving hemodynamic parameters and warn the SRS users to be aware of the intrinsic limitation of this approach, particularly when exploited in the clinical environment.
    Mesh-Begriff(e) Oxygen ; Spectroscopy, Near-Infrared/methods ; Brain/diagnostic imaging ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/chemistry ; Hemoglobins/analysis
    Chemische Substanzen Oxygen (S88TT14065) ; Hemoglobins
    Sprache Englisch
    Erscheinungsdatum 2023-07-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1309154-2
    ISSN 1560-2281 ; 1083-3668
    ISSN (online) 1560-2281
    ISSN 1083-3668
    DOI 10.1117/1.JBO.28.7.075002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Motor cortex hemodynamic response to goal-oriented and non-goal-oriented tasks in healthy subjects.

    Lacerenza, Michele / Frabasile, Lorenzo / Buttafava, Mauro / Spinelli, Lorenzo / Bassani, Elisa / Micheloni, Francesco / Amendola, Caterina / Torricelli, Alessandro / Contini, Davide

    Frontiers in neuroscience

    2023  Band 17, Seite(n) 1202705

    Abstract: Background: Motor disorders are one of the world's major scourges, and neuromotor rehabilitation is paramount for prevention and monitoring plans. In this scenario, exercises and motor tasks to be performed by patients are crucial to follow and assess ... ...

    Abstract Background: Motor disorders are one of the world's major scourges, and neuromotor rehabilitation is paramount for prevention and monitoring plans. In this scenario, exercises and motor tasks to be performed by patients are crucial to follow and assess treatments' progression and efficacy. Nowadays, in clinical environments, quantitative assessment of motor cortex activities during task execution is rare, due to the bulkiness of instrumentation and the need for immobility during measurements [e.g., functional magnetic resonance imaging (MRI)]. Functional near-infrared spectroscopy (fNIRS) can contribute to a better understanding of how neuromotor processes work by measuring motor cortex activity non-invasively in freely moving subjects.
    Aim: Exploit fNIRS to measure functional activation of the motor cortex area during arm-raising actions.
    Design: All subjects performed three different upper limbs motor tasks: arm raising (non-goal-oriented), arm raising and grasping (goal oriented), and assisted arm raising (passive task). Each task was repeated ten times. The block design for each task was divided into 5 seconds of baseline, 5 seconds of activity, and 15 seconds of recovery.
    Population: Sixteen healthy subjects (11 males and 5 females) with an average (+/- standard deviation) of 37.9 (+/- 13.0) years old.
    Methods: Cerebral hemodynamic responses have been recorded in two locations, motor cortex (activation area) and prefrontal cortex (control location) exploiting commercial time-domain fNIRS devices. Haemodynamic signals were analyzed, separating the brain cortex hemodynamic response from extracerebral hemodynamic variations.
    Results: The hemodynamic response was recorded in the cortical motor area for goal-oriented and not-goaloriented tasks, while no response was noticed in the control location (prefrontal cortex position).
    Conclusions: This study provides a basis for canonical upper limb motor cortex activations that can be potentially compared to pathological cerebral responses in patients. It also highlights the potential use of TD-fNIRS to study goal-oriented versus non-goaloriented motor tasks. Impact: the findings of this study may have implications for clinical rehabilitation by providing a better understanding of the neural mechanisms underlying goal-oriented versus non-goal-oriented motor tasks. This may lead to more effective rehabilitation strategies for individuals with motor disorders and a more effective diagnosis of motor dysfunction supported by objective and quantitative neurophysiological readings.
    Sprache Englisch
    Erscheinungsdatum 2023-07-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1202705
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Reproducibility of identical solid phantoms.

    Zhao, Fangzhou / Levoni, Pietro / Frabasile, Lorenzo / Qi, Hong / Lacerenza, Michele / Lanka, Pranav / Torricelli, Alessandro / Pifferi, Antonio / Cubeddu, Rinaldo / Spinelli, Lorenzo

    Journal of biomedical optics

    2022  Band 27, Heft 7

    Abstract: Significance: Tissue-like solid phantoms with identical optical properties, known within tolerant uncertainty, are of crucial importance in diffuse optics for instrumentation assessment, interlaboratory comparison studies, industrial standards, and ... ...

    Abstract Significance: Tissue-like solid phantoms with identical optical properties, known within tolerant uncertainty, are of crucial importance in diffuse optics for instrumentation assessment, interlaboratory comparison studies, industrial standards, and multicentric clinical trials.
    Aim: The reproducibility in fabrication of homogeneous solid phantoms is focused based on spectra measurements by instrument comparisons grounded on the time-resolved diffuse optics.
    Approach: Epoxy-resin and silicone phantoms are considered as matrices and both employ three different instruments for time-resolved diffuse spectroscopy within the spectral range of 540 to 1100 nm. In particular, we fabricated two batches of five phantoms each in epoxy resin and silicone. Then, we evaluated the intra- and interbatch variability with respect to the instrument precision, by considering the coefficient of variation (CV) of absorption and reduced scattering coefficients.
    Results: We observed a similar precision for the three instruments, within 2% for repeated measurements on the same phantom. For epoxy-resin phantoms, the intra- and the interbatch variability reached the instrument precision limit, demonstrating a very good phantom reproducibility. For the silicone phantoms, we observed larger values for intra- and interbatch variability. In particular, at worst, for reduced scattering coefficient interbatch CV was about 5%.
    Conclusions: Results suggest that the fabrication of solid phantoms, especially considering epoxy-resin matrix, is highly reproducible, even if they come from different batch fabrications and are measured using different instruments.
    Mesh-Begriff(e) Optics and Photonics ; Phantoms, Imaging ; Reproducibility of Results ; Silicones ; Spectrum Analysis
    Chemische Substanzen Silicones
    Sprache Englisch
    Erscheinungsdatum 2022-02-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1309154-2
    ISSN 1560-2281 ; 1083-3668
    ISSN (online) 1560-2281
    ISSN 1083-3668
    DOI 10.1117/1.JBO.27.7.074713
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  4. Artikel: Assessment of power spectral density of microvascular hemodynamics in skeletal muscles at very low and low-frequency via near-infrared diffuse optical spectroscopies.

    Amendola, Caterina / Buttafava, Mauro / Carteano, Talyta / Contini, Letizia / Cortese, Lorenzo / Durduran, Turgut / Frabasile, Lorenzo / Guadagno, Claudia Nunzia / Karadeinz, Umut / Lacerenza, Michele / Mesquida, Jaume / Parsa, Shahrzad / Re, Rebecca / Sanoja Garcia, Diego / Konugolu Venkata Sekar, Sanathana / Spinelli, Lorenzo / Torricelli, Alessandro / Tosi, Alberto / Weigel, Udo M /
    Yaqub, M Atif / Zanoletti, Marta / Contini, Davide

    Biomedical optics express

    2023  Band 14, Heft 11, Seite(n) 5994–6015

    Abstract: In this work, we used a hybrid time domain near-infrared spectroscopy (TD-NIRS) and diffuse correlation spectroscopy (DCS) device to retrieve hemoglobin and blood flow oscillations of skeletal muscle microvasculature. We focused on very low (VLF) and low- ...

    Abstract In this work, we used a hybrid time domain near-infrared spectroscopy (TD-NIRS) and diffuse correlation spectroscopy (DCS) device to retrieve hemoglobin and blood flow oscillations of skeletal muscle microvasculature. We focused on very low (VLF) and low-frequency (LF) oscillations (
    Sprache Englisch
    Erscheinungsdatum 2023-10-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.502618
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  5. Artikel: Non-invasive estimation of

    Frabasile, Lorenzo / Amendola, Caterina / Buttafava, Mauro / Chincarini, Matteo / Contini, Davide / Cozzi, Bruno / De Zani, Donatella / Guerri, Giulia / Lacerenza, Michele / Minero, Michela / Petrizzi, Lucio / Qiu, Lina / Rabbogliatti, Vanessa / Rossi, Emanuela / Spinelli, Lorenzo / Straticò, Paola / Vignola, Giorgio / Zani, Davide Danilo / Dalla Costa, Emanuela /
    Torricelli, Alessandro

    Frontiers in veterinary science

    2023  Band 10, Seite(n) 1243325

    Abstract: Biosensors applied in veterinary medicine serve as a noninvasive method to determine the health status of animals and, indirectly, their level of welfare. Near infrared spectroscopy (NIRS) has been suggested as a technology with this application. This ... ...

    Abstract Biosensors applied in veterinary medicine serve as a noninvasive method to determine the health status of animals and, indirectly, their level of welfare. Near infrared spectroscopy (NIRS) has been suggested as a technology with this application. This study presents preliminary
    Sprache Englisch
    Erscheinungsdatum 2023-09-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2023.1243325
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  6. Artikel ; Online: Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care.

    Yaqub, M Atif / Zanoletti, Marta / Cortese, Lorenzo / Sánchez, Daniel Senciales / Amendola, Caterina / Frabasile, Lorenzo / Karadeniz, Umut / Garcia, Jacqueline Martinez / Martin, Marta / Cortes-Picas, Jordi / Caballer, Alba / Cortes, Edgar / Nogales, Sara / Tosi, Alberto / Carteano, Talyta / Garcia, Diego Sanoja / Tomanik, Jakub / Wagenaar, Tessa / Mui, Hsiao /
    Guadagno, Claudia Nunzia / Parsa, Shahrzad / Venkata Sekar, Sanathana Konugolu / Demarteau, Luc / Houtbeckers, Tijl / Weigel, Udo M / Lacerenza, Michele / Buttafava, Mauro / Torricelli, Alessandro / Contini, Davide / Mesquida, Jaume / Durduran, Turgut

    Journal of visualized experiments : JoVE

    2024  , Heft 207

    Abstract: The detection of levels of impairment in microvascular oxygen consumption and reactive hyperemia is vital in critical care. However, there are no practical means for a robust and quantitative evaluation. This paper describes a protocol to evaluate these ... ...

    Abstract The detection of levels of impairment in microvascular oxygen consumption and reactive hyperemia is vital in critical care. However, there are no practical means for a robust and quantitative evaluation. This paper describes a protocol to evaluate these impairments using a hybrid near-infrared diffuse optical device. The device contains modules for near-infrared time-resolved and diffuse correlation spectroscopies and pulse-oximetry. These modules allow the non-invasive, continuous, and real-time measurement of the absolute, microvascular blood/tissue oxygen saturation (StO2) and the blood flow index (BFI) along with the peripheral arterial oxygen saturation (SpO2). This device uses an integrated, computer-controlled tourniquet system to execute a standardized protocol with optical data acquisition from the brachioradialis muscle. The standardized vascular occlusion test (VOT) takes care of the variations in the occlusion duration and pressure reported in the literature, while the automation minimizes inter-operator differences. The protocol we describe focuses on a 3-min occlusion period but the details described in this paper can readily be adapted to other durations and cuff pressures, as well as other muscles. The inclusion of an extended baseline and post-occlusion recovery period measurement allows the quantification of the baseline values for all the parameters and the blood/tissue deoxygenation rate that corresponds to the metabolic rate of oxygen consumption. Once the cuff is released, we characterize the tissue reoxygenation rate, magnitude, and duration of the hyperemic response in BFI and StO2. These latter parameters correspond to the quantification of the reactive hyperemia, which provides information about the endothelial function. Furthermore, the above-mentioned measurements of the absolute concentration of oxygenated and deoxygenated hemoglobin, BFI, the derived metabolic rate of oxygen consumption, StO2, and SpO2 provide a yet-to-be-explored rich data set that can exhibit disease severity, personalized therapeutics, and management interventions.
    Mesh-Begriff(e) Spectroscopy, Near-Infrared/methods ; Hyperemia/metabolism ; Humans ; Critical Care/methods ; Oxygen/metabolism ; Oxygen/blood ; Oxygen Consumption/physiology ; Oximetry/methods ; Oximetry/instrumentation ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/blood supply ; Microcirculation/physiology ; Microvessels/metabolism ; Oxygen Saturation/physiology
    Chemische Substanzen Oxygen (S88TT14065)
    Sprache Englisch
    Erscheinungsdatum 2024-05-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/66062
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise.

    Lanka, Pranav / Yang, Lin / Orive-Miguel, David / Veesa, Joshua Deepak / Tagliabue, Susanna / Sudakou, Aleh / Samaei, Saeed / Forcione, Mario / Kovacsova, Zuzana / Behera, Anurag / Gladytz, Thomas / Grosenick, Dirk / Hervé, Lionel / Durduran, Turgut / Bejm, Karolina / Morawiec, Magdalena / Kacprzak, Michał / Sawosz, Piotr / Gerega, Anna /
    Liebert, Adam / Belli, Antonio / Tachtsidis, Ilias / Lange, Frédéric / Bale, Gemma / Baratelli, Luca / Gioux, Sylvain / Alexander, Kalyanov / Wolf, Martin / Sekar, Sanathana Konugolu Venkata / Zanoletti, Marta / Pirovano, Ileana / Lacerenza, Michele / Qiu, Lina / Ferocino, Edoardo / Maffeis, Giulia / Amendola, Caterina / Colombo, Lorenzo / Frabasile, Lorenzo / Levoni, Pietro / Buttafava, Mauro / Renna, Marco / Di Sieno, Laura / Re, Rebecca / Farina, Andrea / Spinelli, Lorenzo / Dalla Mora, Alberto / Contini, Davide / Taroni, Paola / Tosi, Alberto / Torricelli, Alessandro / Dehghani, Hamid / Wabnitz, Heidrun / Pifferi, Antonio

    Journal of biomedical optics

    2022  Band 27, Heft 7

    Abstract: Significance: Multi-laboratory initiatives are essential in performance assessment and standardization-crucial for bringing biophotonics to mature clinical use-to establish protocols and develop reference tissue phantoms that all will allow universal ... ...

    Abstract Significance: Multi-laboratory initiatives are essential in performance assessment and standardization-crucial for bringing biophotonics to mature clinical use-to establish protocols and develop reference tissue phantoms that all will allow universal instrument comparison.
    Aim: The largest multi-laboratory comparison of performance assessment in near-infrared diffuse optics is presented, involving 28 instruments and 12 institutions on a total of eight experiments based on three consolidated protocols (BIP, MEDPHOT, and NEUROPT) as implemented on three kits of tissue phantoms. A total of 20 synthetic indicators were extracted from the dataset, some of them defined here anew.
    Approach: The exercise stems from the Innovative Training Network BitMap funded by the European Commission and expanded to include other European laboratories. A large variety of diffuse optics instruments were considered, based on different approaches (time domain/frequency domain/continuous wave), at various stages of maturity and designed for different applications (e.g., oximetry, spectroscopy, and imaging).
    Results: This study highlights a substantial difference in hardware performances (e.g., nine decades in responsivity, four decades in dark count rate, and one decade in temporal resolution). Agreement in the estimates of homogeneous optical properties was within 12% of the median value for half of the systems, with a temporal stability of <5  %   over 1 h, and day-to-day reproducibility of <3  %  . Other tests encompassed linearity, crosstalk, uncertainty, and detection of optical inhomogeneities.
    Conclusions: This extensive multi-laboratory exercise provides a detailed assessment of near-infrared Diffuse optical instruments and can be used for reference grading. The dataset-available soon in an open data repository-can be evaluated in multiple ways, for instance, to compare different analysis tools or study the impact of hardware implementations.
    Mesh-Begriff(e) Laboratories ; Optics and Photonics ; Phantoms, Imaging ; Reproducibility of Results ; Spectrum Analysis
    Sprache Englisch
    Erscheinungsdatum 2022-06-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1309154-2
    ISSN 1560-2281 ; 1083-3668
    ISSN (online) 1560-2281
    ISSN 1083-3668
    DOI 10.1117/1.JBO.27.7.074716
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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