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  1. Artikel ; Online: Correction: Metagenomic sequencing reveals time, host, and body compartment-specific viral dynamics after lung transplantation.

    Widder, Stefanie / Görzer, Irene / Friedel, Benjamin / Rahimi, Nina / Schwarz, Stefan / Jaksch, Peter / Knapp, Sylvia / Puchhammer-Stöckl, Elisabeth

    Microbiome

    2022  Band 10, Heft 1, Seite(n) 81

    Sprache Englisch
    Erscheinungsdatum 2022-05-30
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 2697425-3
    ISSN 2049-2618 ; 2049-2618
    ISSN (online) 2049-2618
    ISSN 2049-2618
    DOI 10.1186/s40168-022-01285-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Metagenomic sequencing reveals time, host, and body compartment-specific viral dynamics after lung transplantation.

    Widder, Stefanie / Görzer, Irene / Friedel, Benjamin / Rahimi, Nina / Schwarz, Stefan / Jaksch, Peter / Knapp, Sylvia / Puchhammer-Stöckl, Elisabeth

    Microbiome

    2022  Band 10, Heft 1, Seite(n) 66

    Abstract: Background: The virome of lung transplant recipients (LTRs) under immunosuppressive therapy is dominated by non-pathogenic Anelloviridae and further includes several pathogenic viruses such as Herpesviruses or respiratory viruses. It is unclear whether ... ...

    Abstract Background: The virome of lung transplant recipients (LTRs) under immunosuppressive therapy is dominated by non-pathogenic Anelloviridae and further includes several pathogenic viruses such as Herpesviruses or respiratory viruses. It is unclear whether the donor-derived virome in the transplanted lung influences recipient virome dynamics in other body compartments and if so, to which degree. Likewise, it is unknown whether dependencies exist among virus populations that mutually shape viral loads and kinetics.
    Results: To address these questions, we characterized viral communities in airways and plasma of 49 LTRs and analyzed their abundance patterns in a data modeling approach. We found distinct viral clusters that were specific for body compartments and displayed independent dynamics. These clusters robustly gathered specific viral species across the patient cohort. In the lung, viral cluster abundance associated with time after transplantation and we detected mutual exclusion of viral species within the same human host. In plasma, viral cluster dynamics were associated with the indication for transplantation lacking significant short-time changes. Interestingly, pathogenic viruses in the plasma co-occurred specifically with Alpha torque virus genogroup 4 and Gamma torque virus strains suggesting shared functional or ecological requirements.
    Conclusions: In summary, the detailed analysis of virome dynamics after lung transplantation revealed host, body compartment, and time-specific dependency patterns among viruses. Furthermore, our results suggested genetic adaptation to the host microenvironment at the level of the virome and support the hypothesis of functional complementarity between Anellovirus groups and other persistent viruses. Video abstract.
    Mesh-Begriff(e) Humans ; Lung ; Lung Transplantation ; Metagenome ; Metagenomics/methods ; Transplant Recipients
    Sprache Englisch
    Erscheinungsdatum 2022-04-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697425-3
    ISSN 2049-2618 ; 2049-2618
    ISSN (online) 2049-2618
    ISSN 2049-2618
    DOI 10.1186/s40168-022-01244-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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