LIVIVO - Suchergebnisse -

Suchergebnis

Treffer 1 - 10 von insgesamt 144

Suchoptionen

Artikel ; Online: Tricuspid stenosis due to pectus excavatum in a paediatric patient with trisomy 21.

Fujita, Yuya / Chida-Nagai, Ayako / Takeda, Atsuhito

European heart journal. Case reports

2024 Band 8, Heft 3, Seite(n) ytae104

Sprache	Englisch
Erscheinungsdatum	2024-02-19
Erscheinungsland	England
Dokumenttyp	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytae104
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Details ▾
- Kostenpflichtig bestellen

Artikel ; Online: The Expanding Spectrum of Autoinflammatory Diseases.

Migita, Kiyoshi / Fujita, Yuya / Asano, Tomoyuki / Sato, Shuzo

Internal medicine (Tokyo, Japan)

2023 Band 62, Heft 1, Seite(n) 43–50

Abstract: Autoinflammatory diseases are systemic disorders caused by genetic or acquired abnormalities in certain signaling pathways of the innate immune system. Dysregulated activation of the inflammasome, i.e. molecular platforms responsible for the activation ... ...

Abstract	Autoinflammatory diseases are systemic disorders caused by genetic or acquired abnormalities in certain signaling pathways of the innate immune system. Dysregulated activation of the inflammasome, i.e. molecular platforms responsible for the activation of caspase-1 and production of interleukin-1β, causes autoinflammation. Familial Mediterranean fever (FMF), the most common genetic autoinflammatory disease, is characterized by a periodic fever and serositis. The complex and heterogeneous genetic background of Japanese FMF patients, accompanied by potential overlap with other rheumatic diseases, suggests crosstalk between genetic and environmental factors. Recently, FMF has been recognized as being part of a spectrum of autoinflammatory syndromes named pyrin-associated autoinflammatory diseases. The discovery of a new monogenic autoinflammatory disease, A20 haploinsufficiency, may provide novel insights into early-onset Behçet's-like diseases. In contrast, adult-onset Still's disease and Schnitzler's syndrome are acquired autoinflammatory diseases without a monogenic abnormality. Although the concept of autoinflammatory diseases originally applied to monogenic hereditary recurrent fevers, it has been expanded to include non-genetic complex autoinflammatory diseases. Information concerning monogenic autoinflammatory diseases may prove useful for elucidating the molecular mechanisms underlying non-genetic autoinflammatory diseases.
Mesh-Begriff(e)	Adult ; Humans ; Hereditary Autoinflammatory Diseases/diagnosis ; Hereditary Autoinflammatory Diseases/genetics ; Familial Mediterranean Fever/diagnosis ; Familial Mediterranean Fever/genetics ; Inflammasomes ; Fever ; Behcet Syndrome/genetics
Chemische Substanzen	Inflammasomes
Sprache	Englisch
Erscheinungsdatum	2023-01-01
Erscheinungsland	Japan
Dokumenttyp	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.09279-21
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 240: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾
- Im ZB MED-Bestand
- Kostenpflichtig bestellen

Artikel ; Online: The Expanding Spectrum of Autoinflammatory Diseases.

Migita, Kiyoshi / Fujita, Yuya / Asano, Tomoyuki / Sato, Shuzo

Internal medicine (Tokyo, Japan)

2022

Abstract	Autoinflammatory diseases are systemic disorders caused by genetic or acquired abnormalities in certain signaling pathways of the innate immune system. Dysregulated activation of the inflammasome, i.e. molecular platforms responsible for the activation of caspase-1 and production of interleukin-1β, causes autoinflammation. Familial Mediterranean fever (FMF), the most common genetic autoinflammatory disease, is characterized by a periodic fever and serositis. The complex and heterogeneous genetic background of Japanese FMF patients, accompanied by potential overlap with other rheumatic diseases, suggests crosstalk between genetic and environmental factors. Recently, FMF has been recognized as being part of a spectrum of autoinflammatory syndromes named pyrin-associated autoinflammatory diseases. The discovery of a new monogenic autoinflammatory disease, A20 haploinsufficiency, may provide novel insights into early-onset Behçet's-like diseases. In contrast, adult-onset Still's disease and Schnitzler's syndrome are acquired autoinflammatory diseases without a monogenic abnormality. Although the concept of autoinflammatory diseases originally applied to monogenic hereditary recurrent fevers, it has been expanded to include non-genetic complex autoinflammatory diseases. Information concerning monogenic autoinflammatory diseases may prove useful for elucidating the molecular mechanisms underlying non-genetic autoinflammatory diseases.
Sprache	Englisch
Erscheinungsdatum	2022-03-19
Erscheinungsland	Japan
Dokumenttyp	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.9279-21
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 240: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾
- Im ZB MED-Bestand
- Kostenpflichtig bestellen

Artikel ; Online: Bacterial Meningitis Caused by Haemophilus influenzae Type F Diagnosed Using Next-Generation Sequencing.

Fujita, Yuya / Moriya, Kunihiko / Kitazawa, Taichi / Mabuchi, Haruna / Matsumoto, Hiroshi / Fujikura, Yuji / Imai, Kohsuke

Indian journal of pediatrics

2023 Band 91, Heft 5, Seite(n) 520

Mesh-Begriff(e)	Humans ; Infant ; Meningitis, Bacterial/diagnosis ; Haemophilus influenzae ; High-Throughput Nucleotide Sequencing ; Meningitis, Haemophilus/diagnosis ; Meningitis, Haemophilus/microbiology ; Haemophilus Vaccines
Chemische Substanzen	Haemophilus Vaccines
Sprache	Englisch
Erscheinungsdatum	2023-12-28
Erscheinungsland	India
Dokumenttyp	Letter
ZDB-ID	218231-2
ISSN	0973-7693 ; 0019-5456
ISSN (online)	0973-7693
ISSN	0019-5456
DOI	10.1007/s12098-023-05006-9
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Volltext online

Zugriff für angemeldete ZB MED Nutzerinnen und Nutzer

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 826: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾

Artikel ; Online: Clinical features of flare in Japanese patients with new-onset SLE and risk factors for SLE flare in daily clinical practice: a single-center cohort study.

Sato, Shuzo / Yoshida, Shuhei / Sumichika, Yuya / Saito, Kenji / Matsumoto, Haruki / Temmoku, Jumpei / Fujita, Yuya / Matsuoka, Naoki / Asano, Tomoyuki / Migita, Kiyoshi

Immunological medicine

2024 , Seite(n) 1–8

Abstract: This study aimed to elucidate the clinical features, outcomes and risk factors of flares in patients with systemic lupus erythematosus (SLE). Data were collected from patients with newly diagnosed SLE at the Fukushima Medical University Hospital between ... ...

Abstract	This study aimed to elucidate the clinical features, outcomes and risk factors of flares in patients with systemic lupus erythematosus (SLE). Data were collected from patients with newly diagnosed SLE at the Fukushima Medical University Hospital between 2011 and 2022. Patients who experienced a flare during the study period constituted the flare group, and their clinical features were compared with those of the no-flare group. The cumulative flare-free survival regarding several clinical items was compared between the two groups using Kaplan-Meier's curves. Among 387 patients with SLE, 83 patients with newly diagnosed SLE were included. Their mean age was 37.9 years, and 29 patients experienced flares during the study period. The general characteristics were similar between the two groups, with the exception of the observation period and anti-SS-A antibody positivity. Regarding therapy, a significantly increased frequency of hydroxychloroquine intake and combination with immunosuppressive agents were observed in the no-flare group. The Kaplan-Meier analysis revealed a significantly higher cumulative flare-free survival in the anti-SS-A negative group and combination immunosuppressive therapy group. In conclusion, anti-SS-A positivity may be a risk factor for SLE flare. In turn, combination immunosuppressive therapy may be beneficial for SLE treatment in daily clinical practice.
Sprache	Englisch
Erscheinungsdatum	2024-06-03
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	2578-5826
ISSN (online)	2578-5826
DOI	10.1080/25785826.2024.2360664
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Details ▾
- Kostenpflichtig bestellen

Artikel ; Online: Colchicine-resistant sacroiliitis in a Japanese patient with familial Mediterranean fever.

Matsumoto, Haruki / Sumichika, Yuya / Saito, Kenji / Yoshida, Shuhei / Temmoku, Jumpei / Fujita, Yuya / Matsuoka, Naoki / Asano, Tomoyuki / Sato, Shuzo / Migita, Kiyoshi

Modern rheumatology case reports

2024 Band 8, Heft 1, Seite(n) 215–218

Abstract: The articular involvement in patients with familial Mediterranean fever (FMF) represents a clinical characteristic of acute monoarthritis with pain and hydrarthrosis, which always resolves spontaneously. Colchicine prevents painful arthritis attacks in ... ...

Abstract	The articular involvement in patients with familial Mediterranean fever (FMF) represents a clinical characteristic of acute monoarthritis with pain and hydrarthrosis, which always resolves spontaneously. Colchicine prevents painful arthritis attacks in most FMF cases. Spondyloarthritis is rarely associated with Japanese patients with FMF. Here, we report a Japanese male patient with FMF-related axial joint involvement. A 43-year-old male Japanese patient who presented with recurrent febrile episodes with hip joint and back pain was referred to our hospital. He carried heterozygous variants in exon 2 (L110P/E148Q) of the MEFV gene. FMF was suspected, and oral administration of colchicine (1 mg/day) was initiated. Colchicine treatment improved his febrile attack with hip joint pain. He was diagnosed as having FMF based on the Tel-Hashomer diagnostic criteria for FMF since he fulfilled one major criterion (repeated febrile attack accompanied by hip joint pain) and one minor criterion (improvement with colchicine treatment). Although the human leucocyte antigen-B27 allele was not detected, sacroiliitis-related symptoms progressed despite the ongoing colchicine treatment. Salazosulphapyridine and methotrexate were administered in addition to colchicine; however, these treatments were not effective. Canakinumab treatment successfully resolved this unique aspect of sacroiliitis, and the patient was finally diagnosed with FMF-associated axial joint involvement.
Mesh-Begriff(e)	Humans ; Male ; Adult ; Familial Mediterranean Fever/complications ; Familial Mediterranean Fever/diagnosis ; Familial Mediterranean Fever/drug therapy ; Colchicine/therapeutic use ; Sacroiliitis/diagnosis ; Sacroiliitis/drug therapy ; Sacroiliitis/etiology ; Japan ; Fever ; Arthralgia ; Pyrin/genetics
Chemische Substanzen	Colchicine (SML2Y3J35T) ; MEFV protein, human ; Pyrin
Sprache	Englisch
Erscheinungsdatum	2024-01-02
Erscheinungsland	England
Dokumenttyp	Case Reports ; Journal Article
ISSN	2472-5625
ISSN (online)	2472-5625
DOI	10.1093/mrcr/rxad050
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Details ▾
- Kostenpflichtig bestellen

Artikel ; Online: Post-renal acute kidney injury complicated by urinary tract obstruction due to massive blood clots and severe thrombocytopenia in a patient with systemic lupus erythematosus: A case report.

Fujita, Yuya / Sato, Shuzo / Yoshida, Shuhei / Asano, Tomoyuki / Matsumoto, Haruki / Temmoku, Jumpei / Matsuoka, Naoki / Ohkawara, Hiroshi / Shakespear, Norshalena / Migita, Kiyoshi

Modern rheumatology case reports

2024

Abstract: Systemic lupus erythematosus (SLE) is often seen with antiphospholipid antibody syndrome (APS), and these conditions may occur concurrently with severe immune thrombocytopenia and even acute kidney injury (AKI); however, post-renal AKI due to bleeding is ...

Abstract	Systemic lupus erythematosus (SLE) is often seen with antiphospholipid antibody syndrome (APS), and these conditions may occur concurrently with severe immune thrombocytopenia and even acute kidney injury (AKI); however, post-renal AKI due to bleeding is uncommon. Here, we describe a case of post-renal AKI and anuria in a patient with SLE and APS, which were attributable to urinary tract obstruction due to massive blood clots caused by secondary immune thrombocytopenia. A 50-year-old Japanese woman was admitted to our hospital with anuria, abdominal tenderness, purpura in the trunk and in both legs, and severe thrombocytopenia. She had been receiving medical treatment for APS and SLE till the age of 45 years. Computed tomography revealed a blood clot without extravasation in both urinary tracts and she was diagnosed with post-renal AKI due to complete obstruction of the urinary system. Additionally, based on her medical history, elevated platelet-associated IgG levels, and increased megakaryocyte count, she was diagnosed with secondary immune thrombocytopenia complicated by SLE and APS. She also had elevated APS-related autoantibodies, including antiphosphatidylserine/prothrombin IgM, and IgG. However, concomitant serositis such as lupus enteritis or cystitis was not seen. She was treated with a combination of glucocorticoids, intravenous immunoglobulin, and continuous hemodialysis/hemofiltration, which resulted in rapid improvement of her symptoms and renal dysfunction. Secondary immune thrombocytopenia-induced massive bleeding of urinary tract can cause post-renal AKI. Appropriate diagnosis and aggressive treatment are necessary to improve prognosis in such patients.
Sprache	Englisch
Erscheinungsdatum	2024-03-14
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	2472-5625
ISSN (online)	2472-5625
DOI	10.1093/mrcr/rxae014
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Details ▾
- Kostenpflichtig bestellen

Buch ; Online: Exploration of Efficient End-to-End ASR using Discretized Input from Self-Supervised Learning

Chang, Xuankai / Yan, Brian / Fujita, Yuya / Maekaku, Takashi / Watanabe, Shinji

2023

Abstract: Self-supervised learning (SSL) of speech has shown impressive results in speech-related tasks, particularly in automatic speech recognition (ASR). While most methods employ the output of intermediate layers of the SSL model as real-valued features for ... ...

Abstract	Self-supervised learning (SSL) of speech has shown impressive results in speech-related tasks, particularly in automatic speech recognition (ASR). While most methods employ the output of intermediate layers of the SSL model as real-valued features for downstream tasks, there is potential in exploring alternative approaches that use discretized token sequences. This approach offers benefits such as lower storage requirements and the ability to apply techniques from natural language processing. In this paper, we propose a new protocol that utilizes discretized token sequences in ASR tasks, which includes de-duplication and sub-word modeling to enhance the input sequence. It reduces computational cost by decreasing the length of the sequence. Our experiments on the LibriSpeech dataset demonstrate that our proposed protocol performs competitively with conventional ASR systems using continuous input features, while reducing computational and storage costs. Comment: Accepted at INTERSPEECH 2023
Schlagwörter	Computer Science - Sound ; Electrical Engineering and Systems Science - Audio and Speech Processing
Thema/Rubrik (Code)	006
Erscheinungsdatum	2023-05-29
Erscheinungsland	us
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

Volltext online

Volltext online

Zusatzmaterialien

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Buch ; Online: Cross-Modal Multi-Tasking for Speech-to-Text Translation via Hard Parameter Sharing

Yan, Brian / Chang, Xuankai / Anastasopoulos, Antonios / Fujita, Yuya / Watanabe, Shinji

2023

Abstract: Recent works in end-to-end speech-to-text translation (ST) have proposed multi-tasking methods with soft parameter sharing which leverage machine translation (MT) data via secondary encoders that map text inputs to an eventual cross-modal representation. ...

Abstract	Recent works in end-to-end speech-to-text translation (ST) have proposed multi-tasking methods with soft parameter sharing which leverage machine translation (MT) data via secondary encoders that map text inputs to an eventual cross-modal representation. In this work, we instead propose a ST/MT multi-tasking framework with hard parameter sharing in which all model parameters are shared cross-modally. Our method reduces the speech-text modality gap via a pre-processing stage which converts speech and text inputs into two discrete token sequences of similar length -- this allows models to indiscriminately process both modalities simply using a joint vocabulary. With experiments on MuST-C, we demonstrate that our multi-tasking framework improves attentional encoder-decoder, Connectionist Temporal Classification (CTC), transducer, and joint CTC/attention models by an average of +0.5 BLEU without any external MT data. Further, we show that this framework incorporates external MT data, yielding +0.8 BLEU, and also improves transfer learning from pre-trained textual models, yielding +1.8 BLEU.
Schlagwörter	Computer Science - Computation and Language ; Computer Science - Sound ; Electrical Engineering and Systems Science - Audio and Speech Processing
Thema/Rubrik (Code)	410 ; 006
Erscheinungsdatum	2023-09-27
Erscheinungsland	us
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

Volltext online

Volltext online

Zusatzmaterialien

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Buch ; Online: HuBERTopic

Maekaku, Takashi / Shi, Jiatong / Chang, Xuankai / Fujita, Yuya / Watanabe, Shinji

Enhancing Semantic Representation of HuBERT through Self-supervision Utilizing Topic Model

2023

Abstract: Recently, the usefulness of self-supervised representation learning (SSRL) methods has been confirmed in various downstream tasks. Many of these models, as exemplified by HuBERT and WavLM, use pseudo-labels generated from spectral features or the model's ...

Abstract	Recently, the usefulness of self-supervised representation learning (SSRL) methods has been confirmed in various downstream tasks. Many of these models, as exemplified by HuBERT and WavLM, use pseudo-labels generated from spectral features or the model's own representation features. From previous studies, it is known that the pseudo-labels contain semantic information. However, the masked prediction task, the learning criterion of HuBERT, focuses on local contextual information and may not make effective use of global semantic information such as speaker, theme of speech, and so on. In this paper, we propose a new approach to enrich the semantic representation of HuBERT. We apply topic model to pseudo-labels to generate a topic label for each utterance. An auxiliary topic classification task is added to HuBERT by using topic labels as teachers. This allows additional global semantic information to be incorporated in an unsupervised manner. Experimental results demonstrate that our method achieves comparable or better performance than the baseline in most tasks, including automatic speech recognition and five out of the eight SUPERB tasks. Moreover, we find that topic labels include various information about utterance, such as gender, speaker, and its theme. This highlights the effectiveness of our approach in capturing multifaceted semantic nuances. Comment: Submitted to IEEE ICASSP 2024
Schlagwörter	Computer Science - Sound ; Computer Science - Computation and Language
Thema/Rubrik (Code)	006
Erscheinungsdatum	2023-10-05
Erscheinungsland	us
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

Volltext online

Volltext online

Zusatzmaterialien

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang

Zusatzmaterialien

Kategorien

Über subito bestellen

Fernleihe an ZB MED

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Volltext online

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen

Fernleihe an ZB MED

Zusatzmaterialien

Kategorien

Über subito bestellen

Fernleihe an ZB MED

Zusatzmaterialien

Kategorien

Über subito bestellen

Fernleihe an ZB MED

Volltext online

Zusatzmaterialien

Kategorien

Fernleihe an ZB MED

Volltext online

Zusatzmaterialien

Kategorien

Fernleihe an ZB MED

Volltext online

Zusatzmaterialien

Kategorien

Fernleihe an ZB MED