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  1. Artikel: Bilateral Intertrochanteric Femur Fractures in a Paraplegic Patient: A Case Report.

    Forrest, Anthony / Eaddy, Samuel G / Fulton, Zachary W / Boothby, Benjamin

    Cureus

    2024  Band 16, Heft 2, Seite(n) e54883

    Abstract: Bilateral intertrochanteric (IT) femur fractures are rare, and appropriate evaluation and treatment can vary depending on concurrent patient comorbidities. Even less has been described for patients with bilateral IT fractures with pre-existing paraplegia. ...

    Abstract Bilateral intertrochanteric (IT) femur fractures are rare, and appropriate evaluation and treatment can vary depending on concurrent patient comorbidities. Even less has been described for patients with bilateral IT fractures with pre-existing paraplegia. This case report describes the unique case of a 72-year-old paraplegic female who presented with bilateral IT femur fractures due to a wheelchair accident. The patient was treated with single-stage bilateral cephalomedullary nail fixation so she could effectively transfer to and from the wheelchair with less pain and a greater chance of fracture union. At the last follow-up, the patient's pain had resolved and she was able to transfer as effectively and safely as her pre-injury baseline. Single-stage cephalomedullary fixation of bilateral IT femur fractures is indicated in the paraplegic population to relieve pain and improve effective safe transfers for daily activities.
    Sprache Englisch
    Erscheinungsdatum 2024-02-25
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54883
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Targeted Muscle Reinnervation for Trauma-Related Amputees: A Systematic Review.

    Fulton, Zachary W / Boothby, Benjamin C / Phillips, Seth A

    Cureus

    2022  Band 14, Heft 8, Seite(n) e28474

    Abstract: While amputation techniques have improved over time, questions remain around how to best treat neuromas and severed nerves in the amputee population, specifically for trauma-related amputees. This systematic review investigates and summarizes outcomes ... ...

    Abstract While amputation techniques have improved over time, questions remain around how to best treat neuromas and severed nerves in the amputee population, specifically for trauma-related amputees. This systematic review investigates and summarizes outcomes following targeted muscle reinnervation (TMR) for the trauma-related amputee population. Studies were classified based on primary or secondary TMR and relevant outcomes, including the ability to use a prosthesis, post-TMR opioid use, Patient-Reported Outcomes Measurement Information System (PROMIS) scores for phantom limb pain and residual limb pain, and overall pain resolution/reduction. Following TMR for trauma-related amputation, most patients experienced neuroma pain resolution (86.2%, 95% confidence interval [CI]: 67.2-95.0%) and overall pain reduction/resolution (90.7%, 95% CI: 82.2-95.4%). No differences were seen between primary and secondary TMR. Preliminary evidence indicates that TMR is effective for preventing or treating pain in patients with trauma-related amputation, whether used in the acute or delayed setting.
    Sprache Englisch
    Erscheinungsdatum 2022-08-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.28474
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Acute Femoropopliteal Bypass Graft Occlusion After Knee Manipulation Under Anesthesia: A Case Report and Review of Current Literature.

    Fulton, Zachary W / Singleton, Amy / Davis, Kirk R

    Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews

    2022  Band 6, Heft 2

    Abstract: Bilateral tibiofemoral knee dislocations are a relatively rare injury, and there is a scarcity of literature on its appropriate evaluation and treatment. Even less knee dislocations with concomitant popliteal artery injury have been described. ... ...

    Abstract Bilateral tibiofemoral knee dislocations are a relatively rare injury, and there is a scarcity of literature on its appropriate evaluation and treatment. Even less knee dislocations with concomitant popliteal artery injury have been described. Postoperative graft occlusion accounts for approximately half of the overall complication rate, occurring in up to 18% of the patients undergoing femoropopliteal bypass grafting. Furthermore, anticoagulation and antiplatelet therapy after graft placement is a point of contention. Here, we describe a case of a knee dislocation with associated popliteal artery transection treated initially with successful knee-spanning external fixation and arterial grafting, respectively. At 6 weeks after injury, the patient underwent external fixation removal and closed manipulation of the knee for arthrofibrosis. After manipulation, yet still under anesthesia, distal pulses were acutely diminished and subsequent CTA demonstrated femoropopliteal graft thrombosis. This case demonstrates successful recognition, thrombectomy, and restoration of arterial blood flow, which has since been maintained. Written consent by the patient involved in this case report was obtained.
    Mesh-Begriff(e) Anesthesia/adverse effects ; Femoral Artery/surgery ; Graft Occlusion, Vascular/etiology ; Graft Occlusion, Vascular/surgery ; Humans ; Popliteal Artery/diagnostic imaging ; Popliteal Artery/surgery ; Vascular Patency
    Sprache Englisch
    Erscheinungsdatum 2022-02-02
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2898328-2
    ISSN 2474-7661 ; 1067-151X
    ISSN (online) 2474-7661
    ISSN 1067-151X
    DOI 10.5435/JAAOSGlobal-D-21-00197
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Coracoclavicular Ligament Reconstruction Using TightRope for Delayed Grade III Acromioclavicular Joint Injury After Ipsilateral Diaphyseal Clavicle Fracture Fixation: Surgical Technique and Review of Current Literature.

    Fulton, Zachary W / Singleton, Amy / Miller, Richard M

    Techniques in hand & upper extremity surgery

    2022  Band 26, Heft 3, Seite(n) 208–211

    Abstract: Athletes commonly sustain high-energy direct impact injuries to the shoulder, with acromioclavicular joint (ACJ) injuries accounting for over half. Ipsilateral ACJ injury and diaphyseal clavicle fracture occur nearly 7% of the time. There is limited ... ...

    Abstract Athletes commonly sustain high-energy direct impact injuries to the shoulder, with acromioclavicular joint (ACJ) injuries accounting for over half. Ipsilateral ACJ injury and diaphyseal clavicle fracture occur nearly 7% of the time. There is limited literature offering treatment suggestions for this unique injury pattern and limited evidence providing guidance to suggest which injury patterns should be treated operatively or nonoperatively. Here, we present successful treatment of a high-level athlete utilizing a Knotless TightRope XP placed through a superior clavicle plate with successful return to full activity at 6 months postoperation. The TightRope technique offers the ability to augment through a preexisting superior clavicular plate in a low-profile manner and promote easy suture tensioning to obtain and maintain reduction of the injured ACJ.
    Mesh-Begriff(e) Acromioclavicular Joint/injuries ; Acromioclavicular Joint/surgery ; Clavicle/injuries ; Clavicle/surgery ; Fracture Fixation ; Fractures, Bone/surgery ; Humans ; Joint Dislocations/surgery ; Ligaments, Articular/injuries ; Ligaments, Articular/surgery ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2022-09-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2075789-X
    ISSN 1531-6572 ; 1089-3393
    ISSN (online) 1531-6572
    ISSN 1089-3393
    DOI 10.1097/BTH.0000000000000386
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Novel autophosphorylation sites of Src family kinases regulate kinase activity and SH2 domain-binding capacity.

    Weir, Marion E / Mann, Jacqueline E / Corwin, Thomas / Fulton, Zachary W / Hao, Jennifer M / Maniscalco, Jeanine F / Kenney, Marie C / Roman Roque, Kristal M / Chapdelaine, Elizabeth F / Stelzl, Ulrich / Deming, Paula B / Ballif, Bryan A / Hinkle, Karen L

    FEBS letters

    2016  Band 590, Heft 8, Seite(n) 1042–1052

    Abstract: Src family tyrosine kinases (SFKs) are critical players in normal and aberrant biological processes. While phosphorylation importantly regulates SFKs at two known tyrosines, large-scale phosphoproteomics have revealed four additional tyrosines commonly ... ...

    Abstract Src family tyrosine kinases (SFKs) are critical players in normal and aberrant biological processes. While phosphorylation importantly regulates SFKs at two known tyrosines, large-scale phosphoproteomics have revealed four additional tyrosines commonly phosphorylated in SFKs. We found these novel tyrosines to be autophosphorylation sites. Mimicking phosphorylation at the C-terminal site to the activation loop decreased Fyn activity. Phosphomimetics and direct phosphorylation at the three SH2 domain sites increased Fyn activity while reducing phosphotyrosine-dependent interactions. While 68% of human SH2 domains exhibit conservation of at least one of these tyrosines, few have been found phosphorylated except when found in cis to a kinase domain.
    Mesh-Begriff(e) Amino Acids/genetics ; Conserved Sequence ; HEK293 Cells ; Humans ; Mass Spectrometry ; Phosphorylation ; Phosphotyrosine ; Protein Binding ; Proto-Oncogene Proteins c-fyn/chemistry ; Proto-Oncogene Proteins c-fyn/metabolism ; Saccharomyces cerevisiae/metabolism ; Structure-Activity Relationship ; src Homology Domains ; src-Family Kinases/chemistry ; src-Family Kinases/metabolism
    Chemische Substanzen Amino Acids ; Phosphotyrosine (21820-51-9) ; Proto-Oncogene Proteins c-fyn (EC 2.7.10.2) ; src-Family Kinases (EC 2.7.10.2)
    Sprache Englisch
    Erscheinungsdatum 2016
    Erscheinungsland England
    Dokumenttyp Letter ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.12144
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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