Artikel ; Online: Characterization of a triple-recombinant, reassortant rotavirus strain from the Dominican Republic.
The Journal of general virology
2017 Band 98, Heft 2, Seite(n) 134–142
Abstract: We report the genome of a novel human triple-recombinant G4P[6-8_R] mono-reassortant strain identified in a stool sample from the Dominican Republic during routine facility-based rotavirus strain surveillance. The strain was designated as RVA/Human-wt/ ... ...
Abstract | We report the genome of a novel human triple-recombinant G4P[6-8_R] mono-reassortant strain identified in a stool sample from the Dominican Republic during routine facility-based rotavirus strain surveillance. The strain was designated as RVA/Human-wt/DOM/2013840364/2013/G4P[6-8_R], with a genomic constellation of G4-P[6-8_R]-I1-R1-C1-M1-(A1-A8_R)-N1-(T1-T7_R)-E1-H1. Recombinant gene segments NSP1 and NSP3 were generated as a result of recombination between genogroup 1 rotavirus A1 human strain and a genotype A8 porcine strain and between genogroup 1 rotavirus T1 human strain and a genotype T7 bovine strain, respectively. Analyses of the RNA secondary structures of gene segment VP4, NSP1 and NSP3 showed that all the recombinant regions appear to start in a loop (single-stranded) region and terminate in a stem (double-stranded) structure. Also, the VP7 gene occupied lineage VII within the G4 genotypes consisting of mostly porcine or porcine-like G4 strains, suggesting the occurrence of reassortment. The remaining gene segments clustered phylogenetically with genogroup 1 strains. This exchange of whole or partial genetic materials between rotaviruses by recombination and reassortment contributes directly to their diversification, adaptation and evolution. |
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Mesh-Begriff(e) | Adaptation, Physiological/genetics ; Animals ; Cattle/virology ; Dominican Republic ; Epidemiological Monitoring ; Evolution, Molecular ; Feces/virology ; Gastroenteritis/veterinary ; Gastroenteritis/virology ; Genetic Variation ; Genome, Viral ; Genomics ; Genotype ; Humans ; Multigene Family ; Nucleic Acid Conformation ; Phylogeny ; RNA, Viral/chemistry ; RNA, Viral/genetics ; Reassortant Viruses/classification ; Reassortant Viruses/genetics ; Recombination, Genetic ; Rotavirus/classification ; Rotavirus/genetics ; Rotavirus/isolation & purification ; Rotavirus Infections/virology ; Sequence Analysis, DNA ; Swine/virology ; Viral Nonstructural Proteins/genetics |
Chemische Substanzen | NSP3 protein, Rotavirus ; RNA, Viral ; Viral Nonstructural Proteins ; nsp1 protein, Rotavirus |
Sprache | Englisch |
Erscheinungsdatum | 2017-02-24 |
Erscheinungsland | England |
Dokumenttyp | Journal Article |
ZDB-ID | 219316-4 |
ISSN | 1465-2099 ; 0022-1317 |
ISSN (online) | 1465-2099 |
ISSN | 0022-1317 |
DOI | 10.1099/jgv.0.000688 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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