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  1. Artikel ; Online: In vitro

    Miller-Holt, Jacqueline / Baskerville-Abraham, Irene / Sakimura, Masanori / Fukushima, Toshiro / Puglisi, Andrea / Gafner, Jeremie

    Toxicology reports

    2022  Band 9, Seite(n) 1316–1324

    Abstract: Non-clinical in vitro studies were conducted to investigate the characteristics of extracts from tobacco free nicotine pouches alongside a reference snus product and/or 1R6F reference cigarette. ...

    Abstract Non-clinical in vitro studies were conducted to investigate the characteristics of extracts from tobacco free nicotine pouches alongside a reference snus product and/or 1R6F reference cigarette.
    Sprache Englisch
    Erscheinungsdatum 2022-06-15
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2022.06.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: In vitro evaluation of mutagenic, cytotoxic, genotoxic and oral irritation potential of nicotine pouch products

    Miller-Holt, Jacqueline / Baskerville-Abraham, Irene / Sakimura, Masanori / Fukushima, Toshiro / Puglisi, Andrea / Gafner, Jeremie

    Toxicology Reports. 2022, v. 9 p.1316-1324

    2022  

    Abstract: Non-clinical in vitro studies were conducted to investigate the characteristics of extracts from tobacco free nicotine pouches alongside a reference snus product and/or 1R6F reference cigarette. In vitro investigations were conducted in the Neutral Red ... ...

    Abstract Non-clinical in vitro studies were conducted to investigate the characteristics of extracts from tobacco free nicotine pouches alongside a reference snus product and/or 1R6F reference cigarette. In vitro investigations were conducted in the Neutral Red Uptake (NRU) cytotoxicity assay, Bacterial Reverse Mutation (Ames) assay, and in vitro Mammalian Cell Micronucleus (ivMN) assay. These products were also investigated for their oral irritation potential in the EpiGingival™ 3D tissue model. Results from the Ames, in vitro Micronucleus and NRU assays indicated that the tested products were non-mutagenic, non-genotoxic and non-cytotoxic in contrast to results obtained for the 1R6F reference cigarette. Results from Complete Artificial Saliva (CAS) extracts from these products also failed to be classified as irritants (as measured using the MTT assay), in the EpiGingival™ 3D tissue model
    Schlagwörter cigarettes ; cytotoxicity ; mammals ; models ; mutagens ; mutation ; nicotine ; saliva ; toxicity testing ; Smokeless ; Nicotine pouch ; In vitro ; EpiGingival™ ; 3D tissue ; Micronucleus ; Ames
    Sprache Englisch
    Umfang p. 1316-1324.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel ; Online
    Anmerkung Use and reproduction
    ZDB-ID 2805786-7
    ISSN 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2022.06.008
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel ; Online: Key challenges for in vitro testing of tobacco products for regulatory applications: Recommendations for dosimetry.

    Miller-Holt, Jacqueline / Behrsing, Holger / Crooks, Ian / Curren, Rodger / Demir, Kubilay / Gafner, Jeremie / Gillman, Gene / Hollings, Michael / Leverette, Robert / Oldham, Michael / Simms, Liam / Stankowski, Leon F / Thorne, David / Wieczorek, Roman / Moore, Martha M

    Drug testing and analysis

    2022  Band 15, Heft 10, Seite(n) 1175–1188

    Abstract: The Institute for In Vitro Sciences (IIVS) is sponsoring a series of workshops to develop recommendations for optimal scientific and technical approaches for conducting in vitro assays to assess potential toxicity within and across tobacco and various ... ...

    Abstract The Institute for In Vitro Sciences (IIVS) is sponsoring a series of workshops to develop recommendations for optimal scientific and technical approaches for conducting in vitro assays to assess potential toxicity within and across tobacco and various next-generation products (NGPs) including heated tobacco products (HTPs) and electronic nicotine delivery systems (ENDSs). This publication was developed by a working group of the workshop members in conjunction with the sixth workshop in that series entitled "Dosimetry for conducting in vitro evaluations" and focuses on aerosol dosimetry for aerosol exposure to combustible cigarettes, HTP, and ENDS aerosolized tobacco products and summarizes the key challenges as well as documenting areas for future research.
    Mesh-Begriff(e) Nicotiana ; Tobacco Products ; Electronic Nicotine Delivery Systems ; Aerosols ; In Vitro Techniques
    Chemische Substanzen Aerosols
    Sprache Englisch
    Erscheinungsdatum 2022-08-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2462336-2
    ISSN 1942-7611 ; 1942-7603
    ISSN (online) 1942-7611
    ISSN 1942-7603
    DOI 10.1002/dta.3344
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Genetic association of the Phosphoinositide-3 kinase in schizophrenia and bipolar disorder and interaction with a BDNF gene polymorphism.

    Carrard, Anthony / Salzmann, Annick / Perroud, Nader / Gafner, Jérémie / Malafosse, Alain / Karege, Félicien

    Brain and behavior

    2012  Band 1, Heft 2, Seite(n) 119–124

    Abstract: Phosphoinositide-3-kinase, class III (PIK3C3) is a member of the phosphoinosite-3-kinases family, involved in cell signaling, membrane trafficking, and neurodevelopment. Previous studies have indeed shown an association between PIK3C3 gene variants and ... ...

    Abstract Phosphoinositide-3-kinase, class III (PIK3C3) is a member of the phosphoinosite-3-kinases family, involved in cell signaling, membrane trafficking, and neurodevelopment. Previous studies have indeed shown an association between PIK3C3 gene variants and both bipolar disorder (BD) and schizophrenia (SZ). Brain-derived neurotrophic factor (BDNF) is a neurodevelopmental factor, which can regulate the PI3K signaling pathway. Associations have been reported between BDNF gene polymorphisms and affective and psychotic disorders. The aim of the present study was to replicate an association between PIK3C3 and BDNF gene variants in SZ and BD and a putative epistasis between the two genes. Patients meeting the DSM-IV criteria of BD and SZ were included in this study (98 BD and 79 SZ) as well as 158 healthy controls. Blood DNA was extracted and genotyping was performed either by the polymerase chain reaction (PCR) technique followed by enzymatic digestion or by the high-resolution melt (HRM) method. Genotype and haplotype association was assessed with the UNPHASED statistical program.The results showed one nominal association with BD (P < 0.02) and two risk haplotypes in both SZ (P < 0.001) and BP (P < 0.0005), which survived multiple testing correction. A modest interaction between a BDNF variant and PI3KC3 polymorphism was observed (P < 0.04).These preliminary results confirm the genetic association of PI3K gene variants with both SZ and BD, and support the hypothesis that SZ and BD share a genetic background.
    Sprache Englisch
    Erscheinungsdatum 2012-03-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2623587-0
    ISSN 2162-3279 ; 2162-3279
    ISSN (online) 2162-3279
    ISSN 2162-3279
    DOI 10.1002/brb3.23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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