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  1. Artikel ; Online: A thermometer circuit for hot temperature adjusts Drosophila behavior to persistent heat.

    Alpert, Michael H / Gil, Hamin / Para, Alessia / Gallio, Marco

    Current biology : CB

    2022  Band 32, Heft 18, Seite(n) 4079–4087.e4

    Abstract: Small poikilotherms such as the fruit fly Drosophila depend on absolute temperature measurements to identify external conditions that are above (hot) or below (cold) their preferred range and to react accordingly. Hot and cold temperatures have a ... ...

    Abstract Small poikilotherms such as the fruit fly Drosophila depend on absolute temperature measurements to identify external conditions that are above (hot) or below (cold) their preferred range and to react accordingly. Hot and cold temperatures have a different impact on fly activity and sleep, but the circuits and mechanisms that adjust behavior to specific thermal conditions are not well understood. Here, we use patch-clamp electrophysiology to show that internal thermosensory neurons located within the fly head capsule (the AC neurons
    Mesh-Begriff(e) Animals ; Circadian Rhythm ; Drosophila/physiology ; Drosophila Proteins/metabolism ; Drosophila melanogaster/physiology ; Hot Temperature ; Temperature ; Thermometers
    Chemische Substanzen Drosophila Proteins
    Sprache Englisch
    Erscheinungsdatum 2022-08-17
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2022.07.060
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Sensory biology: The bitter aftertaste.

    Lee, Hojoon / Alpert, Michael H / Gallio, Marco

    Current biology : CB

    2021  Band 31, Heft 24, Seite(n) R1570–R1573

    Abstract: Bitter taste signals a potentially toxic food that should be avoided. A new study shows that taste neurons in Drosophila produce distinct responses after a bitter sip. A bitter aftertaste may help the fly make wise food choices. ...

    Abstract Bitter taste signals a potentially toxic food that should be avoided. A new study shows that taste neurons in Drosophila produce distinct responses after a bitter sip. A bitter aftertaste may help the fly make wise food choices.
    Mesh-Begriff(e) Animals ; Biology ; Drosophila/physiology ; Food Preferences ; Taste/physiology ; Taste Perception
    Sprache Englisch
    Erscheinungsdatum 2021-12-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2021.11.021
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  3. Artikel ; Online: Catching more flies with vinegar.

    Jouandet, Genevieve C / Gallio, Marco

    eLife

    2015  Band 4

    Abstract: Two signalling pathways work together to reshape olfactory responses so that hungry flies are attracted to food sources they would otherwise ignore. ...

    Abstract Two signalling pathways work together to reshape olfactory responses so that hungry flies are attracted to food sources they would otherwise ignore.
    Mesh-Begriff(e) Animals ; Appetitive Behavior ; Drosophila melanogaster/physiology ; Olfactory Perception ; Starvation
    Sprache Englisch
    Erscheinungsdatum 2015-09-09
    Erscheinungsland England
    Dokumenttyp Comment ; Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.10535
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Recovery from cold-induced reproductive dormancy is regulated by temperature-dependent AstC signaling.

    Meiselman, Matthew R / Alpert, Michael H / Cui, Xinyue / Shea, Jamien / Gregg, Ian / Gallio, Marco / Yapici, Nilay

    Current biology : CB

    2022  Band 32, Heft 6, Seite(n) 1362–1375.e8

    Abstract: Animals have evolved a variety of behaviors to cope with adverse environmental conditions. Similar to other insects, the fly, Drosophila melanogaster, responds to sustained cold by reducing its metabolic rate and arresting its reproduction. Here, we show ...

    Abstract Animals have evolved a variety of behaviors to cope with adverse environmental conditions. Similar to other insects, the fly, Drosophila melanogaster, responds to sustained cold by reducing its metabolic rate and arresting its reproduction. Here, we show that a subset of dorsal neurons (DN3s) that express the neuropeptide allatostatin C (AstC) facilitates recovery from cold-induced reproductive dormancy. The activity of AstC-expressing DN3s, as well as AstC peptide levels, are suppressed by cold. Cold temperature also impacts AstC levels in other Drosophila species and mosquitoes, Aedes aegypti, and Anopheles stephensi. The stimulatory effect of AstC on egg production is mediated by cholinergic AstC-R2 neurons. Our results demonstrate that DN3s coordinate female reproductive capacity with environmental temperature via AstC signaling. AstC/AstC-R2 is conserved across many insect species and their role in regulating female reproductive capacity makes them an ideal target for controlling the population of agricultural pests and human disease vectors.
    Mesh-Begriff(e) Animals ; Cold Temperature ; Drosophila melanogaster/physiology ; Female ; Mosquito Vectors ; Neuropeptides/genetics ; Neuropeptides/metabolism ; Reproduction ; Temperature
    Chemische Substanzen Neuropeptides ; allatostatin (110119-33-0)
    Sprache Englisch
    Erscheinungsdatum 2022-02-16
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2022.01.061
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  5. Artikel ; Online: Rapid threat assessment in the Drosophila thermosensory system.

    Jouandet, Genevieve C / Alpert, Michael H / Simões, José Miguel / Suhendra, Richard / Frank, Dominic D / Levy, Joshua I / Para, Alessia / Kath, William L / Gallio, Marco

    Nature communications

    2023  Band 14, Heft 1, Seite(n) 7067

    Abstract: Neurons that participate in sensory processing often display "ON" responses, i.e., fire transiently at the onset of a stimulus. ON transients are widespread, perhaps universal to sensory coding, yet their function is not always well-understood. Here, we ... ...

    Abstract Neurons that participate in sensory processing often display "ON" responses, i.e., fire transiently at the onset of a stimulus. ON transients are widespread, perhaps universal to sensory coding, yet their function is not always well-understood. Here, we show that ON responses in the Drosophila thermosensory system extrapolate the trajectory of temperature change, priming escape behavior if unsafe thermal conditions are imminent. First, we show that second-order thermosensory projection neurons (TPN-IIIs) and their Lateral Horn targets (TLHONs), display ON responses to thermal stimuli, independent of direction of change (heating or cooling) and of absolute temperature. Instead, they track the rate of temperature change, with TLHONs firing exclusively to rapid changes (>0.2 °C/s). Next, we use connectomics to track TLHONs' output to descending neurons that control walking and escape, and modeling and genetic silencing to demonstrate how ON transients can flexibly amplify aversive responses to small thermal change. Our results suggest that, across sensory systems, ON transients may represent a general mechanism to systematically anticipate and respond to salient or dangerous conditions.
    Mesh-Begriff(e) Animals ; Drosophila ; Neurons/physiology ; Sensation/physiology ; Temperature ; Cold Temperature
    Sprache Englisch
    Erscheinungsdatum 2023-11-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42864-5
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  6. Artikel ; Online: A Circuit Encoding Absolute Cold Temperature in Drosophila.

    Alpert, Michael H / Frank, Dominic D / Kaspi, Evan / Flourakis, Matthieu / Zaharieva, Emanuela E / Allada, Ravi / Para, Alessia / Gallio, Marco

    Current biology : CB

    2020  Band 30, Heft 12, Seite(n) 2275–2288.e5

    Abstract: Animals react to environmental changes over timescales ranging from seconds to days and weeks. An important question is how sensory stimuli are parsed into neural signals operating over such diverse temporal scales. Here, we uncover a specialized circuit, ...

    Abstract Animals react to environmental changes over timescales ranging from seconds to days and weeks. An important question is how sensory stimuli are parsed into neural signals operating over such diverse temporal scales. Here, we uncover a specialized circuit, from sensory neurons to higher brain centers, that processes information about long-lasting, absolute cold temperature in Drosophila. We identify second-order thermosensory projection neurons (TPN-IIs) exhibiting sustained firing that scales with absolute temperature. Strikingly, this activity only appears below the species-specific, preferred temperature for D. melanogaster (∼25°C). We trace the inputs and outputs of TPN-IIs and find that they are embedded in a cold "thermometer" circuit that provides powerful and persistent inhibition to brain centers involved in regulating sleep and activity. Our results demonstrate that the fly nervous system selectively encodes and relays absolute temperature information and illustrate a sensory mechanism that allows animals to adapt behavior specifically to cold conditions on the timescale of hours to days.
    Mesh-Begriff(e) Animals ; Brain/physiology ; Cold Temperature ; Drosophila melanogaster/physiology ; Motor Activity/physiology ; Sensory Receptor Cells/physiology ; Sleep/physiology ; Thermosensing/physiology
    Sprache Englisch
    Erscheinungsdatum 2020-05-21
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2020.04.038
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  7. Artikel ; Online: Robustness and plasticity in Drosophila heat avoidance.

    Simões, José Miguel / Levy, Joshua I / Zaharieva, Emanuela E / Vinson, Leah T / Zhao, Peixiong / Alpert, Michael H / Kath, William L / Para, Alessia / Gallio, Marco

    Nature communications

    2021  Band 12, Heft 1, Seite(n) 2044

    Abstract: Simple innate behavior is often described as hard-wired and largely inflexible. Here, we show that the avoidance of hot temperature, a simple innate behavior, contains unexpected plasticity in Drosophila. First, we demonstrate that hot receptor neurons ... ...

    Abstract Simple innate behavior is often described as hard-wired and largely inflexible. Here, we show that the avoidance of hot temperature, a simple innate behavior, contains unexpected plasticity in Drosophila. First, we demonstrate that hot receptor neurons of the antenna and their molecular heat sensor, Gr28B.d, are essential for flies to produce escape turns away from heat. High-resolution fly tracking combined with a 3D simulation of the thermal environment shows that, in steep thermal gradients, the direction of escape turns is determined by minute temperature differences between the antennae (0.1°-1 °C). In parallel, live calcium imaging confirms that such small stimuli reliably activate both peripheral thermosensory neurons and central circuits. Next, based on our measurements, we evolve a fly/vehicle model with two symmetrical sensors and motors (a "Braitenberg vehicle") which closely approximates basic fly thermotaxis. Critical differences between real flies and the hard-wired vehicle reveal that fly heat avoidance involves decision-making, relies on rapid learning, and is robust to new conditions, features generally associated with more complex behavior.
    Mesh-Begriff(e) Animals ; Behavior, Animal ; Choice Behavior ; Drosophila melanogaster/genetics ; Drosophila melanogaster/physiology ; Imaging, Three-Dimensional ; Taxis Response/physiology ; Thermosensing/physiology
    Sprache Englisch
    Erscheinungsdatum 2021-04-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-22322-w
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  8. Artikel ; Online: The irritant receptor TRPA1 mediates the mosquito repellent effect of catnip.

    Melo, Nadia / Capek, Matthew / Arenas, Oscar M / Afify, Ali / Yilmaz, Ayse / Potter, Christopher J / Laminette, Peter J / Para, Alessia / Gallio, Marco / Stensmyr, Marcus C

    Current biology : CB

    2021  Band 31, Heft 9, Seite(n) 1988–1994.e5

    Abstract: Catnip (Nepeta cataria) is a common garden herb well known for its euphoric and hallucinogenic effects on domestic cats, ...

    Abstract Catnip (Nepeta cataria) is a common garden herb well known for its euphoric and hallucinogenic effects on domestic cats,
    Mesh-Begriff(e) Aedes/genetics ; Animals ; Cats ; DEET/pharmacology ; Drosophila melanogaster/genetics ; Insect Repellents/pharmacology ; Irritants ; Nepeta
    Chemische Substanzen Insect Repellents ; Irritants ; DEET (134-62-3)
    Sprache Englisch
    Erscheinungsdatum 2021-03-04
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2021.02.010
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  9. Artikel: Providencia may help find a function for a novel, widespread protein family.

    Gallio, M / Kylsten, P

    Current biology : CB

    2000  Band 10, Heft 19, Seite(n) R693–4

    Mesh-Begriff(e) Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Humans ; Phylogeny ; Providencia/metabolism
    Chemische Substanzen Bacterial Proteins
    Sprache Englisch
    Erscheinungsdatum 2000-10-05
    Erscheinungsland England
    Dokumenttyp Letter
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/s0960-9822(00)00722-3
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  10. Artikel ; Online: Temperature representation in the Drosophila brain.

    Frank, Dominic D / Jouandet, Genevieve C / Kearney, Patrick J / Macpherson, Lindsey J / Gallio, Marco

    Nature

    2015  Band 519, Heft 7543, Seite(n) 358–361

    Abstract: In Drosophila, rapid temperature changes are detected at the periphery by dedicated receptors forming a simple sensory map for hot and cold in the brain. However, flies show a host of complex innate and learned responses to temperature, indicating that ... ...

    Abstract In Drosophila, rapid temperature changes are detected at the periphery by dedicated receptors forming a simple sensory map for hot and cold in the brain. However, flies show a host of complex innate and learned responses to temperature, indicating that they are able to extract a range of information from this simple input. Here we define the anatomical and physiological repertoire for temperature representation in the Drosophila brain. First, we use a photolabelling strategy to trace the connections that relay peripheral thermosensory information to higher brain centres, and show that they largely converge onto three target regions: the mushroom body, the lateral horn (both of which are well known centres for sensory processing) and the posterior lateral protocerebrum, a region we now define as a major site of thermosensory representation. Next, using in vivo calcium imaging, we describe the thermosensory projection neurons selectively activated by hot or cold stimuli. Fast-adapting neurons display transient ON and OFF responses and track rapid temperature shifts remarkably well, while slow-adapting cell responses better reflect the magnitude of simple thermal changes. Unexpectedly, we also find a population of broadly tuned cells that respond to both heating and cooling, and show that they are required for normal behavioural avoidance of both hot and cold in a simple two-choice temperature preference assay. Taken together, our results uncover a coordinated ensemble of neural responses to temperature in the Drosophila brain, demonstrate that a broadly tuned thermal line contributes to rapid avoidance behaviour, and illustrate how stimulus quality, temporal structure, and intensity can be extracted from a simple glomerular map at a single synaptic station.
    Mesh-Begriff(e) Animals ; Brain/anatomy & histology ; Brain/cytology ; Brain/physiology ; Brain Mapping ; Calcium/analysis ; Calcium/metabolism ; Drosophila melanogaster/cytology ; Drosophila melanogaster/physiology ; Mushroom Bodies/innervation ; Neural Pathways ; Neurons/metabolism ; Synapses/metabolism ; Temperature ; Thermoreceptors/metabolism ; Thermosensing/physiology ; Time Factors
    Chemische Substanzen Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2015-03-19
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature14284
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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