Artikel ; Online: Laparoscopic ovarian transposition prior to pelvic radiation in young women with anorectal malignancies: a systematic review and meta-analysis of prevalence.
2023 Band 25, Heft 7, Seite(n) 1336–1348
Abstract: Aim: Young women undergoing radiotherapy (RT) for pelvic malignancies are at risk of developing premature ovarian insufficiency. Ovarian transposition (OT) aims to preserve ovarian function in these patients. However, its role in anorectal malignancy ... ...
| Abstract | Aim: Young women undergoing radiotherapy (RT) for pelvic malignancies are at risk of developing premature ovarian insufficiency. Ovarian transposition (OT) aims to preserve ovarian function in these patients. However, its role in anorectal malignancy has yet to be firmly established. The aim of this review was to determine the effectiveness of laparoscopic OT in preserving ovarian function in premenopausal women undergoing neoadjuvant pelvic RT for anorectal malignancies. Methods: MEDLINE, Embase and CENTRAL were systematically searched from inception through to May 2022. Articles were included if they evaluated ovarian function after OT in women with anorectal malignancies undergoing pelvic RT. The primary outcome was ovarian function preservation. The secondary outcome was 30-day postoperative morbidity following OT. Results: From 207 citations, 10 studies with 133 patients with rectal or anal cancer who underwent OT prior to RT were included. Meta-analysis of pooled proportions of preserved ovarian function demonstrated an incidence of 66.9% (95% CI 55.0-79.0%, I Conclusions: Laparoscopic OT in premenopausal patients undergoing pelvic radiation for anorectal malignancies might be an effective technique at reducing ovarian exposure to RT. The meta-analyses must be interpreted within the context of clinical heterogeneity of the included studies. Further studies are required to fully investigate the outcomes of OT in patients undergoing pelvic radiation for anorectal malignancies. |
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| Mesh-Begriff(e) | Humans ; Female ; Prevalence ; Fertility Preservation/methods ; Ovary/surgery ; Pelvic Neoplasms/radiotherapy ; Pelvic Neoplasms/surgery ; Pelvic Neoplasms/pathology ; Laparoscopy |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-04-08 |
| Erscheinungsland | England |
| Dokumenttyp | Meta-Analysis ; Systematic Review ; Journal Article ; Review |
| ZDB-ID | 1440017-0 |
| ISSN | 1463-1318 ; 1462-8910 |
| ISSN (online) | 1463-1318 |
| ISSN | 1462-8910 |
| DOI | 10.1111/codi.16571 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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