LIVIVO - Suchergebnisse -

Verfasserangabe	Katharina Gastberger ; Gutachter: Torsten Blunk
Schlagwörter	Medizin, Gesundheit ; Medicine, Health
Thema/Rubrik (Code)	sg610
Sprache	Deutsch
Verlag	Universität Würzburg
Erscheinungsort	Würzburg
Dokumenttyp	Buch ; Online ; Dissertation / Habilitation
Datenquelle	Digitale Dissertationen im Internet

Abstract	ATRT is a highly aggressive and rare pediatric CNS tumor of very young children. Its genetic hallmark is bi-allelic inactivation of
Sprache	Englisch
Erscheinungsdatum	2023-12-07
Erscheinungsland	New Zealand
Dokumenttyp	Journal Article ; Review
ZDB-ID	2508013-1
ISSN	1179-1322
ISSN	1179-1322
DOI	10.2147/CMAR.S379451
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Artikel ; Online: Survivors of infant atypical teratoid/rhabdoid tumors present with severely impaired cognitive functions especially for fluid intelligence and visual processing: data from the German brain tumor studies.

Traunwieser, Thomas / Loos, Elena / Ottensmeier, Holger / Gastberger, Katharina / Nemes, Karolina / Mynarek, Martin / Bison, Brigitte / Kandels, Daniela / Neumayer, Petra / Neumann-Holbeck, Anne / Lüttich, Peggy / Baust, Katja / Faulstich-Ritter, Kristin / John, Rainer / Kreisch, Andrea / Landmann, Judyta / Manteufel, Eva / Nest, Alexandra / Prüfe, Jenny /

Schubert, Lisa / Stamm, Walther / Timmermann, Beate / Gerss, Joachim / Rutkowski, Stefan / Schlegel, Paul-Gerhardt / Eyrich, Matthias / Gnekow, Astrid K / Frühwald, Michael C

Pediatric blood & cancer

2024 Band 71, Heft 5, Seite(n) e30910

Abstract: Background: The contribution of tumor type, multimodal treatment, and other patient-related factors upon long-term cognitive sequelae in infant brain tumor survivors remains undefined. We add our retrospective analysis of neuropsychological and quality ... ...

Abstract	Background: The contribution of tumor type, multimodal treatment, and other patient-related factors upon long-term cognitive sequelae in infant brain tumor survivors remains undefined. We add our retrospective analysis of neuropsychological and quality of survival (QoS) outcome data of survivors of atypical teratoid/rhabdoid tumors (ATRT) and extracranial malignant rhabdoid tumors of the soft tissues (eMRT) and kidneys (RTK) treated within the same framework. Neuropsychological data from children with ATRT were compared to data from children with non-irradiated low-grade glioma (LGG). Patients and methods: Following surgery, patients (0-36 months at diagnosis) had received radio-chemotherapy (up to 54 Gy; ATRT: n = 13; eMRT/RTK: n = 7), chemotherapy only (LGG: n = 4; eMRT/RTK: n = 1) or had been observed (LGG: n = 11). Neuropsychological evaluation employing comparable tests was performed at median 6.8 years (ATRT), 6.6 years (eMRT/RTK), and 5.2 years (LGG) post diagnosis. Results: We detected sequelae in various domains for all tumor types. Group comparison showed impairments, specifically in fluid intelligence (p = .041; d = 1.11) and visual processing (p = .001; d = 2.09) in ATRT patients when compared to LGG patients. Results for psychomotor speed and attention abilities were significantly below the norm for both groups (p < .001-.019; d = 0.79-1.90). Diagnosis predicted impairments of cognitive outcome, while sex- and age-related variables did not. QoS outcome for all rhabdoid patients displayed impairments mainly in social (p = .008; d = 0.74) and school functioning (p = .048; d = 0.67), as well as lower overall scores in psychosocial functioning (p = .023; d = 0.78) and quality of life (p = .006; d = 0.79) compared to healthy controls. Conclusion: Survivors of infant ATRT experience various late effects in cognition and QoS following multimodal treatment, while infant LGG patients without radiotherapy demonstrated comparable impairments in psychomotor and attention abilities. Early onset and multimodal treatment of rhabdoid tumors require close monitoring of neuropsychological and QoS sequelae.
Mesh-Begriff(e)	Child ; Infant ; Humans ; Rhabdoid Tumor/complications ; Rhabdoid Tumor/therapy ; Retrospective Studies ; Quality of Life ; Teratoma/complications ; Teratoma/therapy ; Brain Neoplasms/complications ; Brain Neoplasms/therapy ; Central Nervous System Neoplasms/pathology ; Glioma ; Disease Progression ; Visual Perception ; Cognition ; Neoplasms, Neuroepithelial ; Survivors
Sprache	Englisch
Erscheinungsdatum	2024-02-11
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30910
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Volltext online

Zugriff für angemeldete ZB MED Nutzerinnen und Nutzer

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 1131: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Suchergebnis

Suchoptionen

Buch ; Online ; Dissertation / Habilitation: Einfluss der perizellulären Matrix auf die Produktion extrazellulärer Matrix von nativen porcinen Chondrozyten im 3D-Bioprinting in Agarose-Hydrogelen \(in\) \(vitro\)

Volltext online

Zusatzmaterialien

Kategorien

Fernleihe an ZB MED

Artikel: Current Molecular and Clinical Landscape of ATRT - The Link to Future Therapies.

Zusatzmaterialien

Kategorien

Über subito bestellen

Artikel ; Online: Survivors of infant atypical teratoid/rhabdoid tumors present with severely impaired cognitive functions especially for fluid intelligence and visual processing: data from the German brain tumor studies.

Volltext online

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen