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  1. Buch: Functional visual behavior

    Gentile, Michele

    a therapist's guide to evaluation and treatment options

    1997  

    Verfasserangabe Michele Gentile, ed
    Sprache Englisch
    Umfang XX, 551 S. : Ill.
    Verlag American Occupational Therapist Organisation
    Erscheinungsort Bethesda, Md
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    HBZ-ID HT012830764
    ISBN 1-56900-071-9 ; 978-1-56900-071-7
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Artikel ; Online: Eukaryotic-driven directed evolution of Cas9 nucleases.

    Ruta, Giulia Vittoria / Ciciani, Matteo / Kheir, Eyemen / Gentile, Michele Domenico / Amistadi, Simone / Casini, Antonio / Cereseto, Anna

    Genome biology

    2024  Band 25, Heft 1, Seite(n) 79

    Abstract: Background: Further advancement of genome editing highly depends on the development of tools with higher compatibility with eukaryotes. A multitude of described Cas9s have great potential but require optimization for genome editing purposes. Among these, ...

    Abstract Background: Further advancement of genome editing highly depends on the development of tools with higher compatibility with eukaryotes. A multitude of described Cas9s have great potential but require optimization for genome editing purposes. Among these, the Cas9 from Campylobacter jejuni, CjCas9, has a favorable small size, facilitating delivery in mammalian cells. Nonetheless, its full exploitation is limited by its poor editing activity.
    Results: Here, we develop a Eukaryotic Platform to Improve Cas Activity (EPICA) to steer weakly active Cas9 nucleases into highly active enzymes by directed evolution. The EPICA platform is obtained by coupling Cas nuclease activity with yeast auxotrophic selection followed by mammalian cell selection through a sensitive reporter system. EPICA is validated with CjCas9, generating an enhanced variant, UltraCjCas9, following directed evolution rounds. UltraCjCas9 is up to 12-fold more active in mammalian endogenous genomic loci, while preserving high genome-wide specificity.
    Conclusions: We report a eukaryotic pipeline allowing enhancement of Cas9 systems, setting the ground to unlock the multitude of RNA-guided nucleases existing in nature.
    Mesh-Begriff(e) Animals ; CRISPR-Cas Systems ; Gene Editing ; Genome ; Mammals/genetics
    Sprache Englisch
    Erscheinungsdatum 2024-03-25
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1474-760X
    ISSN (online) 1474-760X
    ISSN 1474-760X
    DOI 10.1186/s13059-024-03215-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Micropulse Laser Trabeculoplasty with 577 nm Wavelength at 1500 or 1000 mW for Primary Open-Angle Glaucoma: A Pilot Study.

    Verdina, Tommaso / Gironi, Matteo / Battaglia, Bruno / Gentile, Michele / Chester, Johanna / Kaleci, Shaniko / Scatigna, Gianluca / Mastropasqua, Rodolfo / Cavallini, Gian Maria

    Life (Basel, Switzerland)

    2023  Band 13, Heft 4

    Abstract: ... ...

    Abstract Aim
    Sprache Englisch
    Erscheinungsdatum 2023-04-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13040982
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Buch: Functional visual behavior

    Gentile, Michele

    a therapist's guide to evaluation and treatment options

    1997  

    Verfasserangabe Michele Gentile, editor
    Mesh-Begriff(e) Vision Disorders/rehabilitation ; Visual Perception ; Occupational Therapy
    Sprache Englisch
    Umfang xx, 551 p. :, ill.
    Verlag American Occupational Therapy Association
    Erscheinungsort Bethesda, MD
    Dokumenttyp Buch
    ISBN 9781569000717 ; 1569000719
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  5. Buch ; Online: AI-based Data Preparation and Data Analytics in Healthcare

    Maranghi, Marianna / Anagnostopoulos, Aris / Cannistraci, Irene / Chatzigiannakis, Ioannis / Croce, Federico / Di Teodoro, Giulia / Gentile, Michele / Grani, Giorgio / Lenzerini, Maurizio / Leonardi, Stefano / Mastropietro, Andrea / Palagi, Laura / Pappa, Massimiliano / Rosati, Riccardo / Valentini, Riccardo / Velardi, Paola

    The Case of Diabetes

    2022  

    Abstract: The Associazione Medici Diabetologi (AMD) collects and manages one of the largest worldwide-available collections of diabetic patient records, also known as the AMD database. This paper presents the initial results of an ongoing project whose focus is ... ...

    Abstract The Associazione Medici Diabetologi (AMD) collects and manages one of the largest worldwide-available collections of diabetic patient records, also known as the AMD database. This paper presents the initial results of an ongoing project whose focus is the application of Artificial Intelligence and Machine Learning techniques for conceptualizing, cleaning, and analyzing such an important and valuable dataset, with the goal of providing predictive insights to better support diabetologists in their diagnostic and therapeutic choices.

    Comment: The work has been presented at the conference Ital-IA 2022 (https://www.ital-ia2022.it/)
    Schlagwörter Computer Science - Machine Learning ; Computer Science - Databases
    Erscheinungsdatum 2022-06-13
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Buch: Il Regesto del Codice Pelavicino

    Lupo Gentile, Michele

    (Atti della Società ligure di storia patria ; 44)

    1912  

    Verfasserangabe con 2 facs. e note ill. del Prof. Michele Lupo Gentile
    Serientitel Atti della Società ligure di storia patria ; 44
    Sprache Italienisch
    Umfang XII, 734 S, 4"(8")
    Verlag Soc
    Erscheinungsort Genova
    Dokumenttyp Buch
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  7. Buch: Gli Annales Pisani

    Maragone, Bernardo / Carducci, Giosue / Lupo Gentile, Michele Lupo / Muratori, Lodovico Antonio

    (Rerum Italicarum scriptores ; : raccolta degli storici italiani dal cinquecento al millecinquecento / ordinata da L. A. Muratori ; T. 6, Pt. 2)

    1936  

    Titelvarianten Chronicon Pisanum seu fragmentum auctoris incerti ; Chronicon aliud breve Pisanum incerti auctoris ab anno MCI usque ad annum MCCLXVIII ; Gesta triumphalia per Pisanos facta de captione Hierusalem et civitatis Maioricarum et aliarum civitatum et de triumpho habito contra Ianuenses
    Verfasserangabe di Bernardo Maragone. A cura di Michele Lupo Gentile. Seguono in Appendice: 1. Gesta triumphalia per Pisanos facta de captione Hierusalem et civitatis Maioricarum et aliarum civitatum et de triumpho habito contra Ianuenses. 2. Chronicon Pisanum seu fragmentum auctoris incerti. 3. Chronicon aliud breve Pisanum incerti auctoris ab anno MCI usque ad annum MCCLXVIII
    Serientitel Rerum Italicarum scriptores
    : raccolta degli storici italiani dal cinquecento al millecinquecento / ordinata da L. A. Muratori ; T. 6, Pt. 2
    Sprache Latein ; Italienisch
    Umfang XX, 223 S, 2 Abb
    Ausgabenhinweis Nuova ed. riv., ampliata e corr. con la dir. di Giosue Carducci ...
    Verlag Zanichelli
    Erscheinungsort Bologna
    Dokumenttyp Buch
    Anmerkung Erscheinungsbeginn: 1930
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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