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  1. Artikel ; Online: Prediction of transition metal-binding sites from apo protein structures.

    Babor, Mariana / Gerzon, Sergey / Raveh, Barak / Sobolev, Vladimir / Edelman, Marvin

    Proteins

    2008  Band 70, Heft 1, Seite(n) 208–217

    Abstract: Metal ions are crucial for protein function. They participate in enzyme catalysis, play regulatory roles, and help maintain protein structure. Current tools for predicting metal-protein interactions are based on proteins crystallized with their metal ... ...

    Abstract Metal ions are crucial for protein function. They participate in enzyme catalysis, play regulatory roles, and help maintain protein structure. Current tools for predicting metal-protein interactions are based on proteins crystallized with their metal ions present (holo forms). However, a majority of resolved structures are free of metal ions (apo forms). Moreover, metal binding is a dynamic process, often involving conformational rearrangement of the binding pocket. Thus, effective predictions need to be based on the structure of the apo state. Here, we report an approach that identifies transition metal-binding sites in apo forms with a resulting selectivity >95%. Applying the approach to apo forms in the Protein Data Bank and structural genomics initiative identifies a large number of previously unknown, putative metal-binding sites, and their amino acid residues, in some cases providing a first clue to the function of the protein.
    Mesh-Begriff(e) Apoproteins/chemistry ; Apoproteins/metabolism ; Binding Sites ; Metals/metabolism ; Protein Conformation
    Chemische Substanzen Apoproteins ; Metals
    Sprache Englisch
    Erscheinungsdatum 2008-01-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 806683-8
    ISSN 1097-0134 ; 0887-3585
    ISSN (online) 1097-0134
    ISSN 0887-3585
    DOI 10.1002/prot.21587
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: The limit of accuracy of protein modeling: influence of crystal packing on protein structure.

    Eyal, Eran / Gerzon, Sergey / Potapov, Vladimir / Edelman, Marvin / Sobolev, Vladimir

    Journal of molecular biology

    2005  Band 351, Heft 2, Seite(n) 431–442

    Abstract: The size of the protein database (PDB) makes it now feasible to arrive at statistical conclusions regarding structural effects of crystal packing. These effects are relevant for setting upper practical limits of accuracy on protein modeling. Proteins ... ...

    Abstract The size of the protein database (PDB) makes it now feasible to arrive at statistical conclusions regarding structural effects of crystal packing. These effects are relevant for setting upper practical limits of accuracy on protein modeling. Proteins whose crystals have more than one molecule in the asymmetric unit or whose structures were determined at least twice by X-ray crystallography were paired and their differences analyzed. We demonstrate a clear influence of crystal environment on protein structure, including backbone conformations, hinge-like motions and side-chain conformations. The positions of surface water molecules tend to be variable in different crystal environments while those of ligands are not. Structures determined by independent groups vary more than structures determined by the same authors. The use of different refinement methods is a major source for this effect. Our pair-wise analysis derives a practical limit to the accuracy of protein modeling. For different crystal forms, the limit of accuracy (C(alpha), root-mean-square deviation (RMSD)) is approximately 0.8A for the entire protein, which includes approximately 0.3A due to crystal packing. For organized secondary elements, the upper limit of C(alpha) RMSD is 0.5-0.6A while for loops or protein surface it reaches 1.0A. Twenty percent of exposed side- chains exhibit different chi(1+2) conformations with approximately half of the effect also resulting from crystal packing. A web based tool for analysis and graphic presentation of surface areas of crystal contacts is available (http://ligin.weizmann.ac.il/cryco).
    Mesh-Begriff(e) Computational Biology/methods ; Crystallography, X-Ray/methods ; Databases, Protein ; Ligands ; Models, Molecular ; Molecular Conformation ; Protein Conformation ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Proteins/chemistry ; Proteomics/methods ; Software ; Solvents ; Water/chemistry
    Chemische Substanzen Ligands ; Proteins ; Solvents ; Water (059QF0KO0R)
    Sprache Englisch
    Erscheinungsdatum 2005-08-12
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/j.jmb.2005.05.066
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Buch: Information processing on the basis of processes with competition of modes

    Gerzon, S. A

    (ITEP ; 1985,177)

    1985  

    Titelvarianten Pererabotka informacii na osnove processov s konkurenciej mod
    Verfasserangabe S. A. Gerzon
    Serientitel ITEP ; 1985,177
    Sprache Englisch
    Umfang 8 S
    Erscheinungsort Moscow
    Dokumenttyp Buch
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  4. Artikel ; Online: SPACE: a suite of tools for protein structure prediction and analysis based on complementarity and environment.

    Sobolev, Vladimir / Eyal, Eran / Gerzon, Sergey / Potapov, Vladimir / Babor, Mariana / Prilusky, Jaime / Edelman, Marvin

    Nucleic acids research

    2005  Band 33, Heft Web Server issue, Seite(n) W39–43

    Abstract: We describe a suite of SPACE tools for analysis and prediction of structures of biomolecules and their complexes. LPC/CSU software provides a common definition of inter-atomic contacts and complementarity of contacting surfaces to analyze protein ... ...

    Abstract We describe a suite of SPACE tools for analysis and prediction of structures of biomolecules and their complexes. LPC/CSU software provides a common definition of inter-atomic contacts and complementarity of contacting surfaces to analyze protein structure and complexes. In the current version of LPC/CSU, analyses of water molecules and nucleic acids have been added, together with improved and expanded visualization options using Chime or Java based Jmol. The SPACE suite includes servers and programs for: structural analysis of point mutations (MutaProt); side chain modeling based on surface complementarity (SCCOMP); building a crystal environment and analysis of crystal contacts (CryCo); construction and analysis of protein contact maps (CMA) and molecular docking software (LIGIN). The SPACE suite is accessed at http://ligin.weizmann.ac.il/space.
    Mesh-Begriff(e) Amino Acids/chemistry ; Crystallography, X-Ray ; Databases, Protein ; Internet ; Models, Molecular ; Molecular Structure ; Nucleic Acids/chemistry ; Point Mutation ; Protein Conformation ; Proteins/chemistry ; Proteins/genetics ; Software ; Water/chemistry
    Chemische Substanzen Amino Acids ; Nucleic Acids ; Proteins ; Water (059QF0KO0R)
    Sprache Englisch
    Erscheinungsdatum 2005-07-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2205588-5
    ISSN 1362-4962 ; 1746-8272 ; 0305-1048 ; 0261-3166
    ISSN (online) 1362-4962 ; 1746-8272
    ISSN 0305-1048 ; 0261-3166
    DOI 10.1093/nar/gki398
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Avtomatizirovannoe rabochee mesto ékonomista.

    Gerzon, S S / Gerzon, E I / Norkina, D I / Chermoshentseva, N V / Bochkova, I V

    Meditsinskaia tekhnika

    1987  , Heft 4, Seite(n) 45–47

    Titelübersetzung Automated work station for an economist.
    Mesh-Begriff(e) Computers ; Economics ; Humans ; Medical Laboratory Science/manpower ; Office Automation ; USSR
    Sprache Russisch
    Erscheinungsdatum 1987-07
    Erscheinungsland Russia (Federation)
    Dokumenttyp Journal Article
    ZDB-ID 390691-7
    ISSN 0025-8075 ; 0047-6617
    ISSN 0025-8075 ; 0047-6617
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Buch: Advokat v sovetskom graždanskom processe

    Antimonov, Boris Sergeevič / Gerzon, S. L

    posobie dlja advokatov

    1954  

    Körperschaft Vsesojuznyj Institut juridičeskich nauk Ministerstva justicii SSSR
    Verfasserangabe B. S. Antimonov i S. L. Gerzon. Vsesojuznyj Institut juridičeskich nauk Ministerstva justicii SSSR
    Sprache Russisch
    Umfang 258 S
    Verlag Gosjurizdat
    Erscheinungsort Moskva
    Dokumenttyp Buch
    Anmerkung In kyrill. Schr. ; Der Advokat im sowjetischen Zivilprozess. Handbuch für Advokaten
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  7. Buch: Advokat v sovetskom graždanskom processe

    Antimonov, Boris Sergeevič / Gerzon, S. L

    posobie dlja advokatov

    1954  

    Körperschaft Vsesojuznyj Institut juridičeskich nauk Ministerstva justicii SSSR
    Verfasserangabe B. S. Antimonov i S. L. Gerzon. Vsesojuznyj Institut juridičeskich nauk Ministerstva justicii SSSR
    Schlagwörter Rechtsbeistand ; Russland
    Sprache Russisch
    Umfang 258 S
    Verlag Gosjurizdat
    Erscheinungsort Moskva
    Dokumenttyp Buch
    Anmerkung In kyrill. Schr. ; Der Advokat im sowjetischen Zivilprozess. Handbuch für Advokaten
    Datenquelle ECONomics Information System

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  8. Artikel: Direct measurement of the pion valence-quark momentum distribution, the pion light-cone wave function squared.

    Aitala, E M / Amato, S / Anjos, J C / Appel, J A / Ashery, D / Banerjee, S / Bediaga, I / Blaylock, G / Bracker, S B / Burchat, P R / Burnstein, R A / Carter, T / Carvalho, H S / Copty, N K / Cremaldi, L M / Darling, C / Denisenko, K / Deval, S / Fernandez, A /
    Fox, G F / Gagnon, P / Gerzon, S / Gobel, C / Gounder, K / Halling, A M / Herrera, G / Hurvits, G / James, C / Kasper, P A / Kwan, S / Langs, D C / Leslie, J / Lichtenstadt, J / Lundberg, B / MayTal-Beck, S / Meadows, B / de Mello Neto, J R / Mihalcea, D / Milburn, R H / de Miranda, J M / Napier, A / Nguyen, A / d'Oliveira, A B / O'Shaughnessy, K / Peng, K C / Perera, L P / Purohit, M V / Quinn, B / Radeztsky, S / Rafatian, A / Reay, N W / Reidy, J J / dos Reis, A C / Rubin, H A / Sanders, D A / Santha, A K / Santoro, A F / Schwartz, A J / Sheaff, M / Sidwell, R A / Slaughter, A J / Sokoloff, M D / Solano, J / Stanton, N R / Stefanski, R J / Stenson, K / Summers, D J / Takach, S / Thorne, K / Tripathi, A K / Watanabe, S / Weiss-Babai, R / Wiener, J / Witchey, N / Wolin, E / Yang, S M / Yi, D / Yoshida, S / Zaliznyak, R / Zhang, C

    Physical review letters

    2001  Band 86, Heft 21, Seite(n) 4768–4772

    Abstract: We present the first direct measurements of the pion valence-quark momentum distribution which is related to the square of the pion light-cone wave function. The measurements were carried out using data on diffractive dissociation of 500 GeV/c pi(-) into ...

    Abstract We present the first direct measurements of the pion valence-quark momentum distribution which is related to the square of the pion light-cone wave function. The measurements were carried out using data on diffractive dissociation of 500 GeV/c pi(-) into dijets from a platinum target at Fermilab experiment E791. The results show that the /q&q> light-cone asymptotic wave function describes the data well for Q2 approximately 10 (GeV/c)(2) or more. We also measured the transverse momentum distribution of the diffractive dijets.
    Sprache Englisch
    Erscheinungsdatum 2001-05-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.86.4768
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Observation of color-transparency in diffractive dissociation of pions.

    Aitala, E M / Amato, S / Anjos, J C / Appel, J A / Ashery, D / Banerjee, S / Bediaga, I / Blaylock, G / Bracker, S B / Burchat, P R / Burnstein, R A / Carter, T / Carvalho, H S / Copty, N K / Cremaldi, L M / Darling, C / Denisenko, K / Devmal, S / Fernandez, A /
    Fox, G F / Gagnon, P / Gerzon, S / Gobel, C / Gounder, K / Halling, A M / Herrera, G / Hurvits, G / James, C / Kasper, P A / Kwan, S / Langs, D C / Leslie, J / Lichtenstadt, J / Lundberg, B / MayTal-Beck, S / Meadows, B / de Mello Neto, J R / Mihalcea, D / Milburn, R H / de Miranda, J M / Napier, A / Nguyen, A / d'Oliveira, A B / O'Shaughnessy, K / Peng, K C / Perera, L P / Purohit, M V / Quinn, B / Radeztsky, S / Rafatian, A / Reay, N W / Reidy, J J / dos Reis, A C / Rubin, H A / Sanders, D A / Santha, A K / Santoro, A F / Schwartz, A J / Sheaff, M / Sidwell, R A / Slaughter, A J / Sokoloff, M D / Solano, J / Stanton, N R / Stefanski, R J / Stenson, K / Summers, D J / Takach, S / Thorne, K / Tripathi, A K / Watanabe, S / Weiss-Babai, R / Wiener, J / Witchey, N / Wolin, E / Yang, S M / Yi, D / Yoshida, S / Zaliznyak, R / Zhang, C

    Physical review letters

    2001  Band 86, Heft 21, Seite(n) 4773–4777

    Abstract: We have studied the diffractive dissociation into dijets of 500 GeV/c pions scattering coherently from carbon and platinum targets. Extrapolating to asymptotically high energies (where t(min)-->0), we find that when the per-nucleus cross section for this ...

    Abstract We have studied the diffractive dissociation into dijets of 500 GeV/c pions scattering coherently from carbon and platinum targets. Extrapolating to asymptotically high energies (where t(min)-->0), we find that when the per-nucleus cross section for this process is parametrized as sigma = sigma0Aalpha, alpha has values near 1.6, the exact result depending on jet transverse momentum. These values are in agreement with those predicted by theoretical calculations of color-transparency.
    Sprache Englisch
    Erscheinungsdatum 2001-05-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.86.4773
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Observation of the Cabibbo-Suppressed Decay Ξ_{c}^{+} → pK^{-}π^{+}.

    Jun, S Y / Akchurin, N / Andreev, V A / Atamantchouk, A G / Aykac, M / Balatz, M Y / Bondar, N F / Bravar, A / Cooper, P S / Dauwe, L J / Davidenko, G V / Dersch, U / Dolgolenko, A G / Dreossi, D / Dzyubenko, G B / Edelstein, R / Emediato, L / Endler, A M / Engelfried, J /
    Eschrich, I / Escobar, C O / Evdokimov, A V / Filimonov, I S / Garcia, F G / Gaspero, M / Gerzon, S / Giller, I / Golovtsov, V L / Goncharenko, Y M / Gottschalk, E / Gouffon, P / Grachov, O A / Gülmez, E / Iori, M / Kamenski, A D / Kangling, H / Kaya, M / Kilmer, J / Kim, V T / Kochenda, L M / Königsmann, K / Konorov, I / Kozhevnikov, A A / Krivshich, A G / Krüger, H / Kubantsev, M A / Kubarovsky, V P / Kulyavtsev, A I / Kuropatkin, N P / Kurshetsov, V F / Kushnirenko, A / Kwan, S / Lach, J / Lamberto, A / Landsberg, L G / Larin, I / Leikin, E M / Luksys, M / Lungov, T / Magarrel, D / Maleev, V P / Mao, D / Masciocchi, S / Mathew, P / Mattson, M / Matveev, V / McCliment, E / McKenna, S L / Moinester, M A / Molchanov, V V / Morelos, A / Mukhin, V A / Nelson, K D / Nemitkin, A V / Neoustroev, P V / Newsom, C / Nilov, A P / Nurushev, S B / Ocherashvili, A / Oleynik, G / Onel, Y / Ozel, E / Ozkorucuklu, S / Patrichev, S / Penzo, A / Petrenko, S I / Pogodin, P / Povh, B / Procario, M / Prutskoi, V A / Ramberg, E / Rappazzo, G F / Razmyslovich, B V / Rud, V I / Russ, J / Schiavon, P / Semyatchkin, V K / Simon, J / Sitnikov, A I / Skow, D / Smith, V J / Srivastava, M / Steiner, V / Stepanov, V / Stutte, L / Svoiski, M / Terentyev, N K / Thomas, G P / Uvarov, L N / Vasiliev, A N / Vavilov, D V / Verebryusov, V S / Victorov, V A / Vishnyakov, V E / Vorobyov, A A / Vorwalter, K / Wenheng, Z / You, J / Yunshan, L / Zhenlin, M / Zhigang, L / Zukanovich Funchal, R

    Physical review letters

    2000  Band 84, Heft 9, Seite(n) 1857–1861

    Abstract: We report the first observation of the Cabibbo-suppressed charm baryon decay Ξ_{c}^{+}→pK^{-}π^{+}. We observe 150±22±5 events for the signal. The data were accumulated using the SELEX spectrometer during the 1996-1997 fixed target run at Fermilab, ... ...

    Abstract We report the first observation of the Cabibbo-suppressed charm baryon decay Ξ_{c}^{+}→pK^{-}π^{+}. We observe 150±22±5 events for the signal. The data were accumulated using the SELEX spectrometer during the 1996-1997 fixed target run at Fermilab, chiefly from a 600 GeV/c Σ^{-} beam. The branching fractions of the decay relative to the Cabibbo-favored Ξ_{c}^{+}→Σ^{+}K^{-}π^{+} and Ξ_{c}^{+}→Ξ^{-}π^{+}π^{+} are measured to be B(Ξ_{c}^{+}→pK^{-}π^{+})/B(Ξ_{c}^{+}→Σ^{+}K^{-}π^{+})=0.22±0.06±0.03 and B(Ξ_{c}^{+}→pK^{-}π^{+})/B(Ξ_{c}^{+}→Ξ^{-}π^{+}π^{+})=0.20±0.04±0.02, respectively.
    Sprache Englisch
    Erscheinungsdatum 2000-02-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.84.1857
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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