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  1. Artikel: Pre-Learning Stress That Is Temporally Removed from Acquisition Impairs Fear Learning.

    Zoladz, Phillip R / Cordes, Chloe N / Weiser, Jordan N / Reneau, Kassidy E / Boaz, Kayla M / Helwig, Sara J / Virden, Emma M / Thebeault, Caitlin K / Pfister, Cassidy L / Getnet, Bruktawit A / Niese, Taylor D / Parker, Sydney L / Stanek, Mercedes L / Long, Kristen E / Norrholm, Seth D / Rorabaugh, Boyd R

    Biology

    2023  Band 12, Heft 6

    Abstract: Few studies have examined the time-dependent effects of stress on fear learning. Previously, we found that stress immediately before fear conditioning enhanced fear learning. Here, we aimed to extend these findings by assessing the effects of stress 30 ... ...

    Abstract Few studies have examined the time-dependent effects of stress on fear learning. Previously, we found that stress immediately before fear conditioning enhanced fear learning. Here, we aimed to extend these findings by assessing the effects of stress 30 min prior to fear conditioning on fear learning and fear generalization. Two hundred and twenty-one healthy adults underwent stress (socially evaluated cold pressor test) or a control manipulation 30 min before completing differential fear conditioning in a fear-potentiated startle paradigm. One visual stimulus (CS+), but not another (CS-), was associated with an aversive airblast to the throat (US) during acquisition. The next day, participants were tested for their fear responses to the CS+, CS-, and several generalization stimuli. Stress impaired the acquisition of fear on Day 1 but had no significant impact on fear generalization. The stress-induced impairment of fear learning was particularly evident in participants who exhibited a robust cortisol response to the stressor. These findings are consistent with the notion that stress administered 30 min before learning impairs memory formation via corticosteroid-related mechanisms and may help us understand how fear memories are altered in stress-related psychological disorders.
    Sprache Englisch
    Erscheinungsdatum 2023-05-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12060775
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Pre-Learning Stress That Is Temporally Removed from Acquisition Impairs Fear Learning

    Zoladz, Phillip R. / Cordes, Chloe N. / Weiser, Jordan N. / Reneau, Kassidy E. / Boaz, Kayla M. / Helwig, Sara J. / Virden, Emma M. / Thebeault, Caitlin K. / Pfister, Cassidy L. / Getnet, Bruktawit A. / Niese, Taylor D. / Parker, Sydney L. / Stanek, Mercedes L. / Long, Kristen E. / Norrholm, Seth D. / Rorabaugh, Boyd R.

    Biology (Basel). 2023 May 26, v. 12, no. 6

    2023  

    Abstract: Few studies have examined the time-dependent effects of stress on fear learning. Previously, we found that stress immediately before fear conditioning enhanced fear learning. Here, we aimed to extend these findings by assessing the effects of stress 30 ... ...

    Abstract Few studies have examined the time-dependent effects of stress on fear learning. Previously, we found that stress immediately before fear conditioning enhanced fear learning. Here, we aimed to extend these findings by assessing the effects of stress 30 min prior to fear conditioning on fear learning and fear generalization. Two hundred and twenty-one healthy adults underwent stress (socially evaluated cold pressor test) or a control manipulation 30 min before completing differential fear conditioning in a fear-potentiated startle paradigm. One visual stimulus (CS+), but not another (CS−), was associated with an aversive airblast to the throat (US) during acquisition. The next day, participants were tested for their fear responses to the CS+, CS−, and several generalization stimuli. Stress impaired the acquisition of fear on Day 1 but had no significant impact on fear generalization. The stress-induced impairment of fear learning was particularly evident in participants who exhibited a robust cortisol response to the stressor. These findings are consistent with the notion that stress administered 30 min before learning impairs memory formation via corticosteroid-related mechanisms and may help us understand how fear memories are altered in stress-related psychological disorders.
    Schlagwörter cold ; cortisol ; fearfulness ; memory ; throat
    Sprache Englisch
    Erscheinungsverlauf 2023-0526
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel ; Online
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12060775
    Datenquelle NAL Katalog (AGRICOLA)

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    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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