LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 3 von insgesamt 3

Suchoptionen

  1. Artikel ; Online: Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole for treatment of vaginal candidiasis.

    Gupta, Naresh Vishal / Natasha, Shirodker / Getyala, Anil / Bhat, Ramnath Sudeendra

    Acta pharmaceutica (Zagreb, Croatia)

    2013  Band 63, Heft 3, Seite(n) 359–372

    Abstract: The aim of the present investigation was to prepare and evaluate novel bioadhesive vaginal tablets containing clotrimazole loaded microspheres in order to provide long-term therapeutic activity at the site of infection. Tablets were prepared by ... ...

    Abstract The aim of the present investigation was to prepare and evaluate novel bioadhesive vaginal tablets containing clotrimazole loaded microspheres in order to provide long-term therapeutic activity at the site of infection. Tablets were prepared by incorporating drug loaded microspheres and using bioadhesive polymers hydroxypropylmethylcellulose, sodium carboxymethylcellulose and Carbopol. Microspheres were prepared by the spray drying technique using Eudragit RS-100 and Eudragit RL-100. Microspheres were characterized by SEM, DSC, FTIR, particle size analysis and evaluated for percentage yield, drug loading, encapsulation efficiency and in vitro drug release. To achieve bioadhesion to the mucosal tissue, optimized microspheres were incorporated into bioadhesive tablets and were evaluated for in vitro drug release, in vitro and in vivo mucoadhesion. FTIR and DSC studies showed that no chemical interaction occurred between the drug and polymers. The sphericity factor indicated that the prepared microspheres were spherical. Formulation Mt6 indicated a controlled in vitro drug release and good bioadhesive strength. The in vivo images confirmed the bioadhesion and retention property of tablets up to 24 h. The results indicated that this drug delivery system can be explored for controlled intravaginal drug release.
    Mesh-Begriff(e) Acrylic Resins/administration & dosage ; Acrylic Resins/chemistry ; Acrylic Resins/metabolism ; Administration, Intravaginal ; Animals ; Antifungal Agents/administration & dosage ; Antifungal Agents/chemistry ; Antifungal Agents/metabolism ; Candidiasis, Vulvovaginal/drug therapy ; Candidiasis, Vulvovaginal/metabolism ; Clotrimazole/administration & dosage ; Clotrimazole/chemistry ; Clotrimazole/metabolism ; Drug Carriers/administration & dosage ; Drug Carriers/chemistry ; Drug Carriers/metabolism ; Drug Delivery Systems/methods ; Female ; Microspheres ; Rabbits ; Sheep ; Tissue Adhesives/administration & dosage ; Tissue Adhesives/chemistry ; Tissue Adhesives/metabolism ; Treatment Outcome ; Vaginal Creams, Foams, and Jellies
    Chemische Substanzen Acrylic Resins ; Antifungal Agents ; Drug Carriers ; Tissue Adhesives ; Vaginal Creams, Foams, and Jellies ; Eudragit RS (33434-24-1) ; Clotrimazole (G07GZ97H65)
    Sprache Englisch
    Erscheinungsdatum 2013-09
    Erscheinungsland Croatia
    Dokumenttyp Journal Article
    ZDB-ID 1111806-4
    ISSN 1846-9558 ; 1330-0075
    ISSN (online) 1846-9558
    ISSN 1330-0075
    DOI 10.2478/acph-2013-0027
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 1904: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: ENHANCING SOLUBILITY AND DISSOLUTION OF INDOMETHACIN BY FREEZE DRYING

    Getyala Anil / Dixit Mudit / Kulkarni Parthasarathi Keshavarao / Naga Vamsi Krishna / Devabhaktuni Lavanya

    International Research Journal of Pharmacy, Vol 2, Iss 6, Pp 69-

    2011  Band 74

    Abstract: Indomethacin, an anti-inflammatory drug, exhibits poor water solubility and flow properties. Freeze dried crystals were prepared by freeze drying method. Solvent composition for freeze drying chosen were isopropyl 10 ml of alcohol: water (50:50 %) ... ...

    Abstract Indomethacin, an anti-inflammatory drug, exhibits poor water solubility and flow properties. Freeze dried crystals were prepared by freeze drying method. Solvent composition for freeze drying chosen were isopropyl 10 ml of alcohol: water (50:50 %) mixture. Crystallization medium used for freeze drying of indomethacin consisted of isopropyl alcohol: water in the ratio of 50:50, respectively. Spherical agglomerates were characterized by DSC, IR, XRD AND SEM. Micromeritic, mechanical property, solubility study and dissolution behavior studies were carried out. Dissolution profile of the freeze drying was compared with commercial sample and recrystallized sample. Freeze drying exhibited decreased crystallinity and improved micromeritic properties. The solubility and dissolution of the freeze drying was improved compared with commercial sample. Hence this freeze drying technique can be used for formulation of tablets of indomethacin by direct compression with directly compressible tablet excipients.
    Schlagwörter freeze drying ; indomethacin ; crystallinity ; solubility dissolution. ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Thema/Rubrik (Code) 660 ; 500
    Sprache Englisch
    Erscheinungsdatum 2011-06-01T00:00:00Z
    Verlag International Research Journal of Pharmacy
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  3. Artikel ; Online: Formulation and evaluation of non-effervescent floating tablets of losartan potassium.

    Getyala, Anil / Gangadharappa, H V / Prasad, M Sarat Chandra / Reddy, M Praveen Kumar / Kumar, T M Pramod

    Current drug delivery

    2013  Band 10, Heft 5, Seite(n) 620–629

    Abstract: The aim of the work is to modify the solubility and bioavailability of Losartan potassium, by employing noneffervescent floating drug delivery (tablet dosage forms). Non-effervescent systems are a type of floating drug delivery systems, that have been ... ...

    Abstract The aim of the work is to modify the solubility and bioavailability of Losartan potassium, by employing noneffervescent floating drug delivery (tablet dosage forms). Non-effervescent systems are a type of floating drug delivery systems, that have been used to boost the gastric residence and the floatation time in the gastro intestinal tract. The study included formulation of floating tablets using polymers like Chitosan and Karaya gum as matrix forming agents. Accurel(®) MP 1000 was used as floating agent. The tablets were prepared by direct compression technique. FTIR, DSC studies conformed that there was no incompatibility between the polymer and the drug. Tablet preformulation parameters were within the Pharmacopoeial limit. Tablet showed zero lag time, contisnuance of buoyancy for >12 h. The tablet showed good in vitro release. Drug release was through swelling and abided by the gellation mechanism. In vivo X-ray studies depicted that tablets continued to float in the GIT for 12 h. Accelerated stability showed that, tablets were stable for over 6 month. Thus the prepared non-effervescent floating tablet of Losartan potassium can be used for the treatment of hypertension for more than 12 h with single dose administration.
    Mesh-Begriff(e) Animals ; Antihypertensive Agents/administration & dosage ; Antihypertensive Agents/chemistry ; Calorimetry, Differential Scanning ; Chemistry, Pharmaceutical ; Chitosan/chemistry ; Delayed-Action Preparations/administration & dosage ; Delayed-Action Preparations/chemistry ; Drug Stability ; Gastric Mucosa/metabolism ; Hardness ; Karaya Gum/chemistry ; Losartan/administration & dosage ; Losartan/chemistry ; Polypropylenes/chemistry ; Rabbits ; Spectroscopy, Fourier Transform Infrared ; Tablets
    Chemische Substanzen Antihypertensive Agents ; Delayed-Action Preparations ; Polypropylenes ; Tablets ; Karaya Gum (9000-36-6) ; Chitosan (9012-76-4) ; Losartan (JMS50MPO89)
    Sprache Englisch
    Erscheinungsdatum 2013-01-02
    Erscheinungsland United Arab Emirates
    Dokumenttyp Journal Article
    ZDB-ID 2185284-4
    ISSN 1875-5704 ; 1567-2018
    ISSN (online) 1875-5704
    ISSN 1567-2018
    DOI 10.2174/1567201811310050013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6415: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang