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  1. Artikel ; Online: Corrigendum to "The prophylaxis and treatment potential of supplements for COVID-19" [Eur. J. Pharmacol. 887 (15 November 2020) 173530].

    Sahebnasagh, Adeleh / Saghafi, Fatemeh / Avan, Razieh / Khoshi, Amirhosein / Khataminia, Masoud / Safdari, Mohammadreza / Habtemariam, Solomon / Ghaleno, Hassan Rezai / Nabavi, Seyed Mohammad

    European journal of pharmacology

    2024  Band 972, Seite(n) 176571

    Sprache Englisch
    Erscheinungsdatum 2024-04-12
    Erscheinungsland Netherlands
    Dokumenttyp Published Erratum
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2024.176571
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Aloe vera for Prevention of Acute Radiation Proctitis in Colorectal Cancer a Preliminary Randomized, Placebo-Controlled Clinical Trial.

    Sahebnasagh, Adeleh / Saghafi, Fatemeh / Ghasemi, Arash / Akbari, Jafar / Alipour, Abbas / Habtemariam, Solomon / Safdari, Mohammadreza / Ghaleno, Hassan Rezai / Salehifar, Ebrahim

    Journal of gastrointestinal cancer

    2021  Band 53, Heft 2, Seite(n) 318–325

    Abstract: Objective: To examine the preventive effects of Aloe vera in colorectal cancer patients undergoing radiotherapy.: Material and method: Twenty colorectal cancer patients, who received radiation, were randomized to receive Aloe vera 3% or placebo ... ...

    Abstract Objective: To examine the preventive effects of Aloe vera in colorectal cancer patients undergoing radiotherapy.
    Material and method: Twenty colorectal cancer patients, who received radiation, were randomized to receive Aloe vera 3% or placebo ointment, 1 g twice daily for 6 weeks. At weekly visits, acute radiation proctitis (ARP) was evaluated by Radiation Therapy Oncology Group and clinical presentation criteria as the primary endpoint. We also evaluated secondary endpoints of quality of life, psychosocial status, by applying Hospital Anxiety-Depression (HAD) Scale and laboratory measures of quantitative measurement of C-reactive protein (CRP) as a marker for systemic inflammation.
    Results: There was a significant improvement in the symptom index (before treatment vs. after treatment with Aloe vera) for diarrhea (p = 0.029, median score: 0.5 vs. 0.001). The overall primary and secondary outcomes favored Aloe group, while the measures of toxicity did not achieve a statistical significant difference. The lifestyle score improved significantly with A. vera (p = 004), and they also had a lower depression score in HAD scale (p = 0.008). Furthermore, quantitative CRP decreased significantly during the course of treatment with Aloe vera.
    Conclusion: The use of topical formulation of Aloe vera 3% diminishes the severity of ARP in colorectal cancer patients.
    Mesh-Begriff(e) Aloe ; Colorectal Neoplasms/radiotherapy ; Humans ; Phytotherapy ; Proctitis/etiology ; Proctitis/prevention & control ; Quality of Life
    Sprache Englisch
    Erscheinungsdatum 2021-02-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Randomized Controlled Trial
    ZDB-ID 2452514-5
    ISSN 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
    ISSN (online) 1941-6636 ; 1559-0739
    ISSN 1941-6628 ; 1537-3649
    DOI 10.1007/s12029-021-00597-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: The prophylaxis and treatment potential of supplements for COVID-19.

    Sahebnasagh, Adeleh / Saghafi, Fatemeh / Avan, Razieh / Khoshi, Amirhosein / Khataminia, Masoud / Safdari, Mohammadreza / Habtemariam, Solomon / Ghaleno, Hassan Rezai / Nabavi, Seyed Mohammad

    European journal of pharmacology

    2020  Band 887, Seite(n) 173530

    Abstract: The global impact of the new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), infection that caused COVID-19 has been evident in the last few months from the unprecedented socioeconomic disruption to more than 600,000 deaths. ... ...

    Abstract The global impact of the new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), infection that caused COVID-19 has been evident in the last few months from the unprecedented socioeconomic disruption to more than 600,000 deaths. The lack of vaccine and effective therapeutic agents for the disease prompted world-wide effort to test those antiviral therapeutics already in use for other diseases. Another interesting approach has been based on the pathological sequel of the disease that involve severe inflammatory reaction (or the cytokine storm) associated with pneumonia in critically ill patients. This article outlines the prophylaxis therapeutic potential of supplements vitamins and micronutrients in COVID-19. By ameliorating the inflammatory and oxidative stress associated with the disease and some direct antiviral effects, the application of these agents as adjuvants and other alternative approaches are discussed. Available clinical trials including those currently registered on these supplements are scrutinized.
    Mesh-Begriff(e) Animals ; Antioxidants/therapeutic use ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Dietary Supplements ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; Vitamins/therapeutic use
    Chemische Substanzen Antioxidants ; Vitamins
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-09-01
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2020.173530
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: The prophylaxis and treatment potential of supplements for COVID-19

    Sahebnasagh, Adeleh / Saghafi, Fatemeh / Avan, Razieh / Khoshi, Amirhosein / Khataminia, Masoud / Safdari, Mohammadreza / Habtemariam, Solomon / Ghaleno, Hassan Rezai / Nabavi, Seyed Mohammad

    Eur J Pharmacol

    Abstract: The global impact of the new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), infection that caused COVID-19 has been evident in the last few months from the unprecedented socioeconomic disruption to more than 600,000 deaths. ... ...

    Abstract The global impact of the new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), infection that caused COVID-19 has been evident in the last few months from the unprecedented socioeconomic disruption to more than 600,000 deaths. The lack of vaccine and effective therapeutic agents for the disease prompted world-wide effort to test those antiviral therapeutics already in use for other diseases. Another interesting approach has been based on the pathological sequel of the disease that involve severe inflammatory reaction (or the cytokine storm) associated with pneumonia in critically ill patients. This article outlines the prophylaxis therapeutic potential of supplements vitamins and micronutrients in COVID-19. By ameliorating the inflammatory and oxidative stress associated with the disease and some direct antiviral effects, the application of these agents as adjuvants and other alternative approaches are discussed. Available clinical trials including those currently registered on these supplements are scrutinized.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #738842
    Datenquelle COVID19

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  5. Artikel ; Online: The prophylaxis and treatment potential of supplements for COVID-19

    Sahebnasagh, Adeleh / Saghafi, Fatemeh / Avan, Razieh / Khoshi, Amirhosein / Khataminia, Masoud / Safdari, Mohammadreza / Habtemariam, Solomon / Ghaleno, Hassan Rezai / Nabavi, Seyed Mohammad

    European Journal of Pharmacology

    2020  Band 887, Seite(n) 173530

    Schlagwörter Pharmacology ; covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2020.173530
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Nitric Oxide and Immune Responses in Cancer: Searching for New Therapeutic Strategies.

    Sahebnasagh, Adeleh / Saghafi, Fatemeh / Negintaji, Sina / Hu, Tingyan / Shabani-Borujeni, Mojtaba / Safdari, Mohammadreza / Ghaleno, Hassan Rezai / Miao, Lingchao / Qi, Yaping / Wang, Mingfu / Liao, Pan / Sureda, Antoni / Simal-Gándara, Jesus / Nabavi, Seyed Mohammad / Xiao, Jianbo

    Current medicinal chemistry

    2021  Band 29, Heft 9, Seite(n) 1561–1595

    Abstract: In recent years, there has been an increasing interest in understanding the mysterious functions of nitric oxide (NO) and how this pleiotropic signaling molecule contributes to tumorigenesis. This review attempts to expose and discuss the information ... ...

    Abstract In recent years, there has been an increasing interest in understanding the mysterious functions of nitric oxide (NO) and how this pleiotropic signaling molecule contributes to tumorigenesis. This review attempts to expose and discuss the information available on the immunomodulatory role of NO in cancer and recent approaches to the role of NO donors in the area of immunotherapy. To address the goal, the following databases were searched to identify relevant literature concerning empirical evidence: The Cochrane Library, Pubmed, Medline, and EMBASE from 1980 through March 2020. Valuable attempts have been made to develop distinctive NO-based cancer therapy. Although the data do not allow generalization, the evidence seems to indicate that low/moderate levels may favor tumorigenesis, while higher levels would exert antitumor effects. In this sense, the use of NO donors could have an important therapeutic potential within immunotherapy, although there are still no clinical trials. The emerging understanding of NO-regulated immune responses in cancer may help unravel the recent features of this "doubleedged sword" in cancer physiological and pathologic processes and its potential use as a therapeutic agent for cancer treatment. In short, in this review, we discuss the complex cellular mechanism in which NO, as a pleiotropic signaling molecule, participates in cancer pathophysiology. We also debate the dual role of NO in cancer and tumor progression and clinical approaches for inducible nitric oxide synthase (iNOS) based therapy against cancer.
    Mesh-Begriff(e) Carcinogenesis ; Humans ; Immunity ; Immunotherapy ; Neoplasms/drug therapy ; Nitric Oxide/metabolism ; Nitric Oxide Donors ; Nitric Oxide Synthase Type II/metabolism
    Chemische Substanzen Nitric Oxide Donors ; Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase Type II (EC 1.14.13.39)
    Sprache Englisch
    Erscheinungsdatum 2021-07-08
    Erscheinungsland United Arab Emirates
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867328666210707194543
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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