Artikel ; Online: Targeting c-Myc with decoy oligodeoxynucleotide-loaded polycationic nanoparticles inhibits cell growth and induces apoptosis in cancer stem-like cells (NTERA-2).
2024 Band 51, Heft 1, Seite(n) 623
Abstract: Background: An increase in cancer stem cell (CSC) populations and their resistance to common treatments could be a result of c-Myc dysregulations in certain cancer cells. In the current study, we investigated anticancer effects of c-Myc decoy ODNs ... ...
Abstract | Background: An increase in cancer stem cell (CSC) populations and their resistance to common treatments could be a result of c-Myc dysregulations in certain cancer cells. In the current study, we investigated anticancer effects of c-Myc decoy ODNs loaded-poly (methacrylic acid-co-diallyl dimethyl ammonium chloride) (PMA-DDA)-coated silica nanoparticles as carriers on cancer-like stem cells (NTERA-2). Methods and results: The physicochemical characteristics of the synthesized nanocomposites (SiO Conclusions: The conclusion drawn from this study is that c-Myc decoy ODN-loaded SiO |
---|---|
Mesh-Begriff(e) | Humans ; Apoptosis/drug effects ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Proto-Oncogene Proteins c-myc/metabolism ; Proto-Oncogene Proteins c-myc/genetics ; Cell Proliferation/drug effects ; Nanoparticles/chemistry ; Cell Line, Tumor ; Nanocomposites/chemistry ; Polyelectrolytes/chemistry ; Oligodeoxyribonucleotides/pharmacology ; Oligodeoxyribonucleotides/chemistry ; Cell Survival/drug effects ; Silicon Dioxide/chemistry ; Polyamines/chemistry ; Polyamines/pharmacology ; Cell Cycle/drug effects |
Chemische Substanzen | Proto-Oncogene Proteins c-myc ; Polyelectrolytes ; Oligodeoxyribonucleotides ; polycations ; Silicon Dioxide (7631-86-9) ; Polyamines ; MYC protein, human |
Sprache | Englisch |
Erscheinungsdatum | 2024-05-06 |
Erscheinungsland | Netherlands |
Dokumenttyp | Journal Article |
ZDB-ID | 186544-4 |
ISSN | 1573-4978 ; 0301-4851 |
ISSN (online) | 1573-4978 |
ISSN | 0301-4851 |
DOI | 10.1007/s11033-024-09559-6 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Zs.A 1140: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.