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  1. Book ; Online ; E-Book: Atlas of hepatocellular carcinoma pathology

    Kim, Haeryoung / Leow, Wei-Qiang / Lo, Regina / Mendoza, Paulo Giovanni L. / Chan, Anthony Wing-Hung

    2022  

    Author's details Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
    Keywords Oncology ; Pathology
    Language English
    Size 1 Online-Ressource(xi, 193 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021226741
    ISBN 978-981-16-8500-2 ; 9789811684999 ; 981-16-8500-2 ; 9811684995
    DOI 10.1007/978-981-16-8500-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Ferroptosis-induced Cardiotoxicity and Antitumor Drugs.

    Beretta, Giovanni L

    Current medicinal chemistry

    2023  

    Abstract: The induction of regulated cell death ferroptosis in tumors is emerging as an intriguing strategy for cancer treatment. Numerous antitumor drugs (e.g., doxorubicin, etoposide, tyrosine kinase inhibitors, trastuzumab, arsenic trioxide, 5-fluorouracil) ... ...

    Abstract The induction of regulated cell death ferroptosis in tumors is emerging as an intriguing strategy for cancer treatment. Numerous antitumor drugs (e.g., doxorubicin, etoposide, tyrosine kinase inhibitors, trastuzumab, arsenic trioxide, 5-fluorouracil) induce ferroptosis. Although this mechanism of action is interesting for fighting tumors, the clinical use of drugs that induce ferroptosis is hampered by cardiotoxicity. Besides in cancer cells, ferroptosis induced by chemotherapeutics can occur in cardiomyocytes, and this feature represents an important drawback of antitumor therapy. This inconvenience has been tackled by developing less or no cardiotoxic antitumor drugs or by discovering cardioprotective agents (e.g., berberine, propofol, fisetin, salidroside, melatonin, epigallocatechin-3gallate, resveratrol) to use in combination with conventional chemotherapeutics. This review briefly summarizes the molecular mechanisms of Fer and describes the Fer-dependent mechanisms responsible for cardiac toxicity developed by cancer-suffering patients following the administration of some chemotherapeutics. Additionally, the pharmacological strategies very recently proposed for potentially preventing this inconvenience are considered.
    Language English
    Publishing date 2023-07-19
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867331666230719124453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Radiotherapy-induced ferroptosis for cancer treatment

    Giovanni L. Beretta / Nadia Zaffaroni

    Frontiers in Molecular Biosciences, Vol

    2023  Volume 10

    Abstract: Ferroptosis is a regulated cell death mechanism controlled by iron, amino acid and reactive oxygen species metabolisms, which is very relevant for cancer therapy. Radiotherapy-induced ferroptosis is critical for tumor suppression and several preclinical ... ...

    Abstract Ferroptosis is a regulated cell death mechanism controlled by iron, amino acid and reactive oxygen species metabolisms, which is very relevant for cancer therapy. Radiotherapy-induced ferroptosis is critical for tumor suppression and several preclinical studies have demonstrated that the combination of ionizing radiation with small molecules or nano-systems is effective in combating cancer growth and overcoming drug or ionizing radiation resistance. Here, we briefly overview the mechanisms of ferroptosis and the cross-talk existing between the cellular pathways activated by ferroptosis and those induced by radiotherapy. Lastly, we discuss the recently reported combinational studies involving radiotherapy, small molecules as well as nano-systems and report the recent findings achieved in this field for the treatment of tumors.
    Keywords ferroptosis ; radiotherapy ; reactive oxygen species ; nanomedicine ; drug combinations ; gene signatures ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The Therapeutic Potential of Pyroptosis in Melanoma.

    Zaffaroni, Nadia / Beretta, Giovanni L

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: Pyroptosis is a programmed cell death characterized by the rupture of the plasma membranes and release of cellular content leading to inflammatory reaction. Four cellular mechanisms inducing pyroptosis have been reported thus far, including the (i) ... ...

    Abstract Pyroptosis is a programmed cell death characterized by the rupture of the plasma membranes and release of cellular content leading to inflammatory reaction. Four cellular mechanisms inducing pyroptosis have been reported thus far, including the (i) caspase 1-mediated canonical, (ii) caspase 4/5/11-mediated non-canonical, (iii) caspase 3/8-mediated and (iv) caspase-independent pathways. Although discovered as a defense mechanism protecting cells from infections of intracellular pathogens, pyroptosis plays roles in tumor initiation, progression and metastasis of tumors, as well as in treatment response to antitumor drugs and, consequently, patient outcome. Pyroptosis induction following antitumor therapies has been reported in several tumor types, including lung, colorectal and gastric cancer, hepatocellular carcinoma and melanoma. This review provides an overview of the cellular pathways of pyroptosis and discusses the therapeutic potential of pyroptosis induction in cancer, particularly in melanoma.
    MeSH term(s) Humans ; Pyroptosis ; Apoptosis ; Caspase 1/metabolism ; Caspases/metabolism ; Melanoma/drug therapy
    Chemical Substances Caspase 1 (EC 3.4.22.36) ; Caspases (EC 3.4.22.-)
    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Radiotherapy-induced ferroptosis for cancer treatment.

    Beretta, Giovanni L / Zaffaroni, Nadia

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1216733

    Abstract: Ferroptosis is a regulated cell death mechanism controlled by iron, amino acid and reactive oxygen species metabolisms, which is very relevant for cancer therapy. Radiotherapy-induced ferroptosis is critical for tumor suppression and several preclinical ... ...

    Abstract Ferroptosis is a regulated cell death mechanism controlled by iron, amino acid and reactive oxygen species metabolisms, which is very relevant for cancer therapy. Radiotherapy-induced ferroptosis is critical for tumor suppression and several preclinical studies have demonstrated that the combination of ionizing radiation with small molecules or nano-systems is effective in combating cancer growth and overcoming drug or ionizing radiation resistance. Here, we briefly overview the mechanisms of ferroptosis and the cross-talk existing between the cellular pathways activated by ferroptosis and those induced by radiotherapy. Lastly, we discuss the recently reported combinational studies involving radiotherapy, small molecules as well as nano-systems and report the recent findings achieved in this field for the treatment of tumors.
    Language English
    Publishing date 2023-06-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1216733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Stereotactic body radiation therapy for pleural mesothelioma: Which goal, which patients: Comment to "Clinical outcomes of stereotactic body radiation therapy for malignant pleural mesothelioma" by Shin et al.

    Ceresoli, Giovanni L / Ghirardelli, Paolo / Vavassori, Vittorio

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2024  Volume 193, Page(s) 110137

    MeSH term(s) Humans ; Mesothelioma, Malignant ; Goals ; Mesothelioma/radiotherapy ; Mesothelioma/surgery ; Pleural Neoplasms/radiotherapy ; Pleural Neoplasms/surgery
    Language English
    Publishing date 2024-02-09
    Publishing country Ireland
    Document type Letter
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2024.110137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1926: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Adult hepatoblastoma

    Allison Kaye L. Pagarigan / Paulo Giovanni L. Mendoza

    Journal of Liver Cancer, Vol 23, Iss 1, Pp 219-

    making the challenging distinction from hepatocellular carcinoma

    2023  Volume 224

    Abstract: Hepatoblastoma is an exceptionally rare malignancy in adults with just over 70 non-pediatric cases reported in literature. Recounted is a case of a 49-year-old female who presented with acute right upper quadrant abdominal pain, elevated serum alpha ... ...

    Abstract Hepatoblastoma is an exceptionally rare malignancy in adults with just over 70 non-pediatric cases reported in literature. Recounted is a case of a 49-year-old female who presented with acute right upper quadrant abdominal pain, elevated serum alpha fetoprotein and a large liver mass on imaging. Hepatectomy was performed under clinical suspicion of hepatocellular carcinoma. Immunomorphologic characteristics of the tumor proved consistent with hepatoblastoma of mixed epithelial and mesenchymal type. Hepatocellular carcinoma remains to be the primary differential diagnosis for adult hepatoblastoma, however, distinguishing between these two neoplasms requires close histomorphologic assessment and immunohistochemical profiling as clinical, radiologic and gross pathologic findings typically overlap. Making this distinction is highly crucial in the timely initiation of surgical and chemotherapeutic interventions for this inherently aggressive and rapidly fatal disease.
    Keywords hepatoblastoma ; carcinoma ; hepatocellular ; pathology ; surgical ; immunohistochemistry ; liver cancer ; Internal medicine ; RC31-1245
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Korean Liver Cancer Association
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Episodic aphthous stomatitis with fever, arthralgias and lymphadenopathy following multiple upper respiratory infections and pertussis in an adult: a reactive mimicker of PFAPA syndrome?

    Capella, Giovanni L

    Italian journal of dermatology and venereology

    2019  Volume 157, Issue 6, Page(s) 536–538

    MeSH term(s) Humans ; Adult ; Stomatitis, Aphthous/diagnosis ; Stomatitis, Aphthous/etiology ; Whooping Cough ; Lymphadenopathy ; Fever/diagnosis ; Fever/etiology ; Pharyngitis ; Syndrome ; Arthralgia ; Lymphadenitis/diagnosis
    Language English
    Publishing date 2019-07-26
    Publishing country Italy
    Document type Letter
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.19.06352-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 119: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Adult hepatoblastoma: making the challenging distinction from hepatocellular carcinoma.

    Pagarigan, Allison Kaye L / Mendoza, Paulo Giovanni L

    Journal of liver cancer

    2023  Volume 23, Issue 1, Page(s) 219–224

    Abstract: Hepatoblastoma is an exceptionally rare malignancy in adults with just over 70 non-pediatric cases reported in literature. Recounted is a case of a 49-year-old female who presented with acute right upper quadrant abdominal pain, elevated serum alpha ... ...

    Abstract Hepatoblastoma is an exceptionally rare malignancy in adults with just over 70 non-pediatric cases reported in literature. Recounted is a case of a 49-year-old female who presented with acute right upper quadrant abdominal pain, elevated serum alpha fetoprotein and a large liver mass on imaging. Hepatectomy was performed under clinical suspicion of hepatocellular carcinoma. Immunomorphologic characteristics of the tumor proved consistent with hepatoblastoma of mixed epithelial and mesenchymal type. Hepatocellular carcinoma remains to be the primary differential diagnosis for adult hepatoblastoma, however, distinguishing between these two neoplasms requires close histomorphologic assessment and immunohistochemical profiling as clinical, radiologic and gross pathologic findings typically overlap. Making this distinction is highly crucial in the timely initiation of surgical and chemotherapeutic interventions for this inherently aggressive and rapidly fatal disease.
    Language English
    Publishing date 2023-03-13
    Publishing country Korea (South)
    Document type Case Reports
    ISSN 2383-5001
    ISSN (online) 2383-5001
    DOI 10.17998/jlc.2023.02.24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: HRV Features as Viable Physiological Markers for Stress Detection Using Wearable Devices.

    Dalmeida, Kayisan M / Masala, Giovanni L

    Sensors (Basel, Switzerland)

    2021  Volume 21, Issue 8

    Abstract: Stress has been identified as one of the major causes of automobile crashes which then lead to high rates of fatalities and injuries each year. Stress can be measured via physiological measurements and in this study the focus will be based on the ... ...

    Abstract Stress has been identified as one of the major causes of automobile crashes which then lead to high rates of fatalities and injuries each year. Stress can be measured via physiological measurements and in this study the focus will be based on the features that can be extracted by common wearable devices. Hence, the study will be mainly focusing on heart rate variability (HRV). This study is aimed at investigating the role of HRV-derived features as stress markers. This is achieved by developing a good predictive model that can accurately classify stress levels from ECG-derived HRV features, obtained from automobile drivers, by testing different machine learning methodologies such as K-Nearest Neighbor (KNN), Support Vector Machines (SVM), Multilayer Perceptron (MLP), Random Forest (RF) and Gradient Boosting (GB). Moreover, the models obtained with highest predictive power will be used as reference for the development of a machine learning model that would be used to classify stress from HRV features derived from heart rate measurements obtained from wearable devices. We demonstrate that HRV features constitute good markers for stress detection as the best machine learning model developed achieved a Recall of 80%. Furthermore, this study indicates that HRV metrics such as the Average of normal-to-normal (NN) intervals (AVNN), Standard deviation of the average NN intervals (SDNN) and the Root mean square differences of successive NN intervals (RMSSD) were important features for stress detection. The proposed method can be also used on all applications in which is important to monitor the stress levels in a non-invasive manner, e.g., in physical rehabilitation, anxiety relief or mental wellbeing.
    MeSH term(s) Biomarkers ; Heart Rate ; Monitoring, Physiologic ; Support Vector Machine ; Wearable Electronic Devices
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-04-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21082873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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