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Artikel ; Online: No fitness cost entailed by type VI secretion system synthesis, assembly, contraction, or disassembly in enteroaggregative

Taillefer, Boris / Giraud, Julien F / Cascales, Eric

Journal of bacteriology

2023  Band 205, Heft 12, Seite(n) e0035723

Abstract: Importance: Bacteria use weapons to deliver effectors into target cells. One of these weapons, the type VI secretion system (T6SS), assembles a contractile tail acting as a spring to propel a toxin-loaded needle. Due to its size and mechanism of action, ...

Abstract Importance: Bacteria use weapons to deliver effectors into target cells. One of these weapons, the type VI secretion system (T6SS), assembles a contractile tail acting as a spring to propel a toxin-loaded needle. Due to its size and mechanism of action, the T6SS was intuitively thought to be energetically costly. Here, using a combination of mutants and growth measurements in liquid medium, on plates, and in competition experiments, we show that the T6SS does not entail a growth cost to enteroaggregative
Mesh-Begriff(e) Escherichia coli/genetics ; Type VI Secretion Systems/genetics ; Escherichia coli Proteins/genetics ; Bacterial Proteins
Chemische Substanzen Type VI Secretion Systems ; Escherichia coli Proteins ; Bacterial Proteins
Sprache Englisch
Erscheinungsdatum 2023-11-16
Erscheinungsland United States
Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID 2968-3
ISSN 1098-5530 ; 0021-9193
ISSN (online) 1098-5530
ISSN 0021-9193
DOI 10.1128/jb.00357-23
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