Artikel ; Online: Left ventricular global longitudinal strain and acute myocardial injury in patients with sickle cell disease admitted to the intensive care unit for vaso-occlusive crisis.
British journal of haematology
2024 Band 204, Heft 5, Seite(n) 2007–2015
Abstract: In patients with sickle cell disease (SCD), SCD-related cardiomyopathy may be partly due to repeated ischaemic events related to sickling during vaso-occlusive crises, but few clinical studies support this hypothesis. We evaluated the incidence of acute ... ...
Abstract | In patients with sickle cell disease (SCD), SCD-related cardiomyopathy may be partly due to repeated ischaemic events related to sickling during vaso-occlusive crises, but few clinical studies support this hypothesis. We evaluated the incidence of acute myocardial ischaemia during vaso-occlusive crises as assessed by the left ventricular global longitudinal strain (LVGLS) and high-sensitive cardiac troponin T (hs-cTnT). We included adult patients with SCD admitted to the intensive care unit (ICU) for vaso-occlusive crisis. We collected hs-cTnT and measured LVGLS with echocardiography at admission (day 1), day 2, day 3 and ICU discharge. Among 55 patients included, considering only the first hospitalization of patients admitted several times, 3 (5%) had elevated hs-cTnT at ≥1 time point of the ICU stay. It was ≤2 times the upper limit of normal in two of these patients. LVGLS was altered at ≥1 time point of the ICU stay in 13 (24%) patients. Both hs-cTnT and LVGLS were abnormal at ≥1 time point of the hospital stay in 2 (4%) patients. Acute myocardial injury as assessed by troponin elevation and LVGLS impairment was a rare event during vaso-occlusive crises. |
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Mesh-Begriff(e) | Humans ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/blood ; Male ; Female ; Adult ; Intensive Care Units ; Troponin T/blood ; Middle Aged ; Echocardiography ; Myocardial Ischemia/etiology ; Myocardial Ischemia/blood ; Global Longitudinal Strain |
Chemische Substanzen | Troponin T |
Sprache | Englisch |
Erscheinungsdatum | 2024-03-12 |
Erscheinungsland | England |
Dokumenttyp | Journal Article |
ZDB-ID | 80077-6 |
ISSN | 1365-2141 ; 0007-1048 |
ISSN (online) | 1365-2141 |
ISSN | 0007-1048 |
DOI | 10.1111/bjh.19394 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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