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  1. Artikel ; Online: Prevalence of

    Loras, Cristina / Pérez-Vázquez, María / González Prieto, Andrea / Oteo-Iglesias, Jesús / Alós, Juan-Ignacio

    Microbial drug resistance (Larchmont, N.Y.)

    2023  Band 29, Heft 10, Seite(n) 444–447

    Abstract: Plasmid-mediated resistance to fosfomycin has been seldom described ... ...

    Abstract Plasmid-mediated resistance to fosfomycin has been seldom described in
    Sprache Englisch
    Erscheinungsdatum 2023-04-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1290490-9
    ISSN 1931-8448 ; 1076-6294
    ISSN (online) 1931-8448
    ISSN 1076-6294
    DOI 10.1089/mdr.2022.0269
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4435: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Artikel: Community Emergence of Cefixime-Resistant

    Zaragoza, Gloria / Pérez-Vázquez, María / Villar-Gómara, Laura / González-Prieto, Andrea / Oteo-Iglesias, Jesús / Alós, Juan-Ignacio

    Antibiotics (Basel, Switzerland)

    2024  Band 13, Heft 3

    Abstract: Escherichia ... ...

    Abstract Escherichia coli
    Sprache Englisch
    Erscheinungsdatum 2024-02-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics13030218
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Physicochemical and Microbiological Stability of Two Oral Solutions of Methadone Hydrochloride 10 mg/mL.

    Álvaro-Alonso, Elena Alba / Lorenzo, Ma Paz / Gonzalez-Prieto, Andrea / Izquierdo-García, Elsa / Escobar-Rodríguez, Ismael / Aguilar-Ros, Antonio

    Molecules (Basel, Switzerland)

    2022  Band 27, Heft 9

    Abstract: In this article, we studied physicochemical and microbiological stability and determined the beyond-use date of two oral solutions of methadone in three storage conditions. For this, two oral solutions of methadone (10 mg/mL) were prepared, with and ... ...

    Abstract In this article, we studied physicochemical and microbiological stability and determined the beyond-use date of two oral solutions of methadone in three storage conditions. For this, two oral solutions of methadone (10 mg/mL) were prepared, with and without parabens, as preservatives. They were packed in amber glass vials kept unopened until the day of the test, and in a multi-dose umber glass bottle opened daily. They were stored at 5 ± 3 °C, 25 ± 2 °C and 40 ± 2 °C. pH, clarity, and organoleptic characteristics were obtained. A stability-indicating high-performance liquid chromatography method was used to determine methadone. Microbiological quality was studied and antimicrobial effectiveness testing was also determined following European Pharmacopoeia guidelines. Samples were analyzed at days 0, 7, 14, 21, 28, 42, 56, 70, and 91 in triplicate. After 91 days of storage, pH remained stable at about 6.5-7 in the two solutions, ensuring no risk of methadone precipitation. The organoleptic characteristics remained stable (colorless, odorless, and bitter taste). The absence of particles was confirmed. No differences were found with the use of preservatives. Methadone concentration remained within 95-105% in all samples. No microbial growth was observed. Hence, the two oral methadone solutions were physically and microbiologically stable at 5 ± 3 °C, 25 ± 2 °C, and 40 ± 2 °C for 91 days in closed and opened amber glass bottles.
    Mesh-Begriff(e) Amber ; Chromatography, High Pressure Liquid ; Drug Compounding ; Drug Stability ; Drug Storage ; Methadone ; Solutions
    Chemische Substanzen Amber ; Solutions ; Methadone (UC6VBE7V1Z)
    Sprache Englisch
    Erscheinungsdatum 2022-04-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27092812
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.MO 81: Hefte anzeigen

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  4. Artikel ; Online: Prevalence, detection and characterisation of fosfomycin-resistant Escherichia coli strains carrying fosA genes in Community of Madrid, Spain.

    Loras, Cristina / González-Prieto, Andrea / Pérez-Vázquez, María / Bautista, Verónica / Ávila, Alicia / Campoy, Pedro Sola / Oteo-Iglesias, Jesús / Alós, Juan-Ignacio

    Journal of global antimicrobial resistance

    2021  Band 25, Seite(n) 137–141

    Abstract: Objectives: The aim of this this study was to describe the presence of different variants of the fosA gene in fosfomycin-resistant Escherichia coli strains in Madrid, Spain.: Methods: fos genes were searched for in 55 E. coli strains collected from ... ...

    Abstract Objectives: The aim of this this study was to describe the presence of different variants of the fosA gene in fosfomycin-resistant Escherichia coli strains in Madrid, Spain.
    Methods: fos genes were searched for in 55 E. coli strains collected from seven representative hospitals located in Madrid. A phenotypic screening test was performed following the disk diffusion method with sodium phosphonoformate added as described by Nakamura et al. Additionally, a molecular study based on PCR was used to confirm the screening results. Positive strains for fos genes were further subjected to whole-genome sequencing (WGS).
    Results: Phenotypic screening was positive in 9/55 strains (16.4%), although genotypic detection was positive in only 3 (fosA3, fosA4 and fosA6). Thus, the prevalence of fos genes in Madrid was 5.5% (3/55). WGS data were not available for the fosA6-positive strain. One isolate with fosA3 (ST69) carried a bla
    Conclusion: We detected the presence of different variants of plasmid-mediated fosA genes in fosfomycin-resistant E. coli strains in Madrid, Spain. Despite the few reports in Europe, it would be of interest to monitor the spread of these acquired resistance genes.
    Mesh-Begriff(e) Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial ; Escherichia coli/genetics ; Escherichia coli Infections/epidemiology ; Europe ; Fosfomycin/pharmacology ; Humans ; Prevalence ; Spain/epidemiology
    Chemische Substanzen Anti-Bacterial Agents ; Fosfomycin (2N81MY12TE)
    Sprache Englisch
    Erscheinungsdatum 2021-03-21
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7165
    ISSN (online) 2213-7173
    ISSN 2213-7165
    DOI 10.1016/j.jgar.2021.02.032
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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