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  1. Article ; Online: Psychosocial Well-Being: An Exploratory Cross-Sectional Evaluation of Loneliness, Anxiety, Depression, Self-Compassion, and Professional Quality of Life in Oncology Nurses.

    Phillips, Carolyn S / Becker, Heather / Gonzalez, Emily

    Clinical journal of oncology nursing

    2021  Volume 25, Issue 5, Page(s) 530–538

    Abstract: Background: In addition to heavy workloads, oncology nurses are confronted with emotionally demanding caregiving moments with little training or institutional support for coping and emotional well-being.: Objectives: The aim of this study was to ... ...

    Abstract Background: In addition to heavy workloads, oncology nurses are confronted with emotionally demanding caregiving moments with little training or institutional support for coping and emotional well-being.
    Objectives: The aim of this study was to explore the associations and potential predictors among self-compassion, loneliness, anxiety, depression, and professional quality of life in oncology nurses.
    Methods: Participants were recruited throughout central Texas. Descriptive statistics, bivariate correlations, and multivariate regression analyses were conducted on survey data.
    Findings: Burnout and compassion satisfaction were strongly related to loneliness, self-compassion, and depression. Compassion fatigue was most highly related to anxiety and depression. Loneliness made the strongest unique contribution to burnout and compassion satisfaction, and depression was the only statistically significant predictor of compassion fatigue.
    MeSH term(s) Anxiety ; Burnout, Professional ; Compassion Fatigue ; Cross-Sectional Studies ; Depression ; Empathy ; Humans ; Job Satisfaction ; Loneliness ; Nurse Clinicians ; Nurses ; Quality of Life ; Surveys and Questionnaires
    Language English
    Publishing date 2021-09-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2014665-6
    ISSN 1538-067X ; 1092-1095
    ISSN (online) 1538-067X
    ISSN 1092-1095
    DOI 10.1188/21.CJON.530-538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Interferon-Gamma-Induced Nitric Oxide Inhibits the Proliferation of Murine Renal Cell Carcinoma Cells

    David J. Tate Jr., John R. Patterson, Cruz Velasco-Gonzalez, Emily N. Carroll, Janie Trinh, Daniel Edwards, Ashok Aiyar, Beatriz Finkel-Jimenez, Arnold H. Zea

    International Journal of Biological Sciences, Vol 8, Iss 8, Pp 1109-

    2012  Volume 1120

    Abstract: Renal cell carcinoma (RCC) remains one of the most resistant tumors to systemic chemotherapy, radiotherapy, and immunotherapy. Despite great progress in understanding the basic biology of RCC, the rate of responses in animal models and clinical trials ... ...

    Abstract Renal cell carcinoma (RCC) remains one of the most resistant tumors to systemic chemotherapy, radiotherapy, and immunotherapy. Despite great progress in understanding the basic biology of RCC, the rate of responses in animal models and clinical trials using interferons (IFNs) has not improved significantly. It is likely that the lack of responses can be due to the tumor's ability to develop tumor escape strategies. Currently, the use of targeted therapies has improved the clinical outcomes of patients with RCC and is associated with an increase of Th1-cytokine responses (IFNγ), indicating the importance of IFNγ in inhibiting tumor proliferation. Thus, the present study was designed to investigate a new mechanism by which IFNγ mediates direct anti-proliferative effects against murine renal cell carcinoma cell lines. When cultured RCC cell lines were exposed to murine recombinant IFNγ, a dose dependent growth inhibition in CL-2 and CL-19 cells was observed; this effect was not observed in Renca cells. Growth inhibition in CL-2 and CL-19 cell lines was associated with the intracellular induction of nitric oxide synthase (iNOS) protein, resulting in a sustained elevation of nitric oxide (NO) and citrulline, and a decrease in arginase activity. The inhibition of cell proliferation appears to be due to an arrest in the cell cycle. The results indicate that in certain RCC cell lines, IFNγ modulates L-arginine metabolism by shifting from arginase to iNOS activity, thereby developing a potent inhibitory mechanism to encumber tumor cell proliferation and survival. Elucidating the cellular events triggered by IFNγ in murine RCC cell lines will permit anti-tumor effects to be exploited in the development of new combination therapies that interfere with L-arginine metabolism to effectively combat RCC in patients.
    Keywords Biology (General) ; QH301-705.5
    Subject code 616 ; 610
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Ivyspring International Publisher
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Alcohol coverage in California newspapers: frequency, prominence, and framing.

    Myhre, Sonja L / Saphir, Melissa Nichols / Flora, June A / Howard, Kim Ammann / Gonzalez, Emily McChesney

    Journal of public health policy

    2002  Volume 23, Issue 2, Page(s) 172–190

    Abstract: The purpose of this study was to investigate the nature and extent of alcohol coverage in California newspapers by examining the frequency, positioning, and framing of alcohol-related articles. A content analysis assessed the frequency and nature of ... ...

    Abstract The purpose of this study was to investigate the nature and extent of alcohol coverage in California newspapers by examining the frequency, positioning, and framing of alcohol-related articles. A content analysis assessed the frequency and nature of alcohol references in news content drawn from a random sample of nine California newspaper issues from September 1997 to June 1998. The study findings indicate that alcohol is mentioned at least once a day in daily newspapers with more frequent mention in smaller newspapers. Alcohol is most often discussed in relation to trauma or in the context of promoting alcohol consumption. Articles on trauma and driving while intoxicated receive more prominence than other stories mentioning alcohol. Despite the relative frequency of alcohol content in trauma news, these stories are rarely framed with any sort of health context. Public health advocates should work toward increasing the frequency and improving the framing of alcohol in newspaper coverage.
    MeSH term(s) Alcohol Drinking ; Bibliometrics ; California ; Humans ; Newspapers as Topic
    Language English
    Publishing date 2002
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603208-4
    ISSN 0197-5897
    ISSN 0197-5897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Generation of LexA enhancer-trap lines in Drosophila by an international scholastic network.

    Kim, Ella S / Rajan, Arjun / Chang, Kathleen / Govindarajan, Sanath / Gulick, Clara / English, Eva / Rodriguez, Bianca / Bloomfield, Orion / Nakada, Stella / Beard, Charlotte / O'Connor, Sarah / Mastroianni, Sophia / Downey, Emma / Feigenbaum, Matthew / Tolentino, Caitlin / Pace, Abigail / Khan, Marina / Moon, Soyoun / DiPrima, Jordan /
    Syed, Amber / Lin, Flora / Abukhadra, Yasmina / Bacon, Isabella / Beckerle, John / Cho, Sophia / Donkor, Nana Esi / Garberg, Lucy / Harrington, Ava / Hoang, Mai / Lawani, Nosa / Noori, Ayush / Park, Euwie / Parsons, Ella / Oravitan, Philip / Chen, Matthew / Molina, Cristian / Richmond, Caleb / Reddi, Adith / Huang, Jason / Shugrue, Cooper / Coviello, Rose / Unver, Selma / Indelicarto, Matthew / Islamovic, Emir / McIlroy, Rosemary / Yang, Alana / Hamad, Mahdi / Griffin, Elizabeth / Ahmed, Zara / Alla, Asha / Fitzgerald, Patricia / Choi, Audrey / Das, Tanya / Cheng, Yuchen / Yu, Joshua / Roderiques, Tabor / Lee, Ethan / Liu, Longchao / Harper, Jaekeb / Wang, Jason / Suhr, Chris / Tan, Max / Luque, Jacqueline / Tam, A Russell / Chen, Emma / Triff, Max / Zimmermann, Lyric / Zhang, Eric / Wood, Jackie / Clark, Kaitlin / Kpodonu, Nat / Dey, Antar / Ecker, Alexander / Chuang, Maximilian / López, Ramón Kodi Suzuki / Sun, Harry / Wei, Zijing / Stone, Henry / Chi, Chia Yu Joy / Silvestri, Aiden / Orloff, Petra / Nedumaran, Neha / Zou, Aletheia / Ünver, Leyla / Page, Oscair / Kim, Minseo / Chan, Terence Yan Tao / Tulloch, Akili / Hernandez, Andrea / Pillai, Aruli / Chen, Caitlyn / Chowdhury, Neil / Huang, Lina / Mudide, Anish / Paik, Garrett / Wingate, Alexandra / Quinn, Lily / Conybere, Chris / Baumgardt, Luca Laiza / Buckley, Rollo / Kolberg, Zara / Pattison, Ruth / Shazli, Ashlyn Ahmad / Ganske, Pia / Sfragara, Luca / Strub, Annina / Collier, Barney / Tamana, Hari / Ravindran, Dylan / Howden, James / Stewart, Madeleine / Shimizu, Sakura / Braniff, Julia / Fong, Melanie / Gutman, Lucy / Irvine, Danny / Malholtra, Sahil / Medina, Jillian / Park, John / Yin, Alicia / Abromavage, Harrison / Barrett, Breanna / Chen, Jacqueline / Cho, Rachelle / Dilatush, Mac / Gaw, Gabriel / Gu, Caitlin / Huang, Jupiter / Kilby, Houston / Markel, Ethan / McClure, Katie / Phillips, William / Polaski, Benjamin / Roselli, Amelia / Saint-Cyr, Soleil / Shin, Ellie / Tatum, Kylan / Tumpunyawat, Tai / Wetherill, Lucia / Ptaszynska, Sara / Zeleznik, Maddie / Pesendorfer, Alexander / Nolan, Anna / Tao, Jeffrey / Sammeta, Divya / Nicholson, Laney / Dinh, Giao Vu / Foltz, Merrin / Vo, An / Ross, Maggie / Tokarski, Andrew / Hariharan, Samika / Wang, Elaine / Baziuk, Martha / Tay, Ashley / Wong, Yuk Hung Maximus / Floyd, Jax / Cui, Aileen / Pierre, Kieran / Coppisetti, Nikita / Kutam, Matthew / Khurjekar, Dhruv / Gadzi, Anthony / Gubbay, Ben / Pedretti, Sophia / Belovich, Sofiya / Yeung, Tiffany / Fey, Mercy / Shaffer, Layla / Li, Arthur / Beritela, Giancarlo / Huyghue, Kyle / Foster, Greg / Durso-Finley, Garrett / Thierfelder, Quinn / Kiernan, Holly / Lenkowsky, Andrew / Thomas, Tesia / Cheng, Nicole / Chao, Olivia / L'Etoile-Goga, Pia / King, Alexa / McKinley, Paris / Read, Nicole / Milberg, David / Lin, Leila / Wong, Melinda / Gilman, Io / Brown, Samantha / Chen, Lila / Kosai, Jordyn / Verbinsky, Mark / Belshaw-Hood, Alice / Lee, Honon / Zhou, Cathy / Lobo, Maya / Tse, Asia / Tran, Kyle / Lewis, Kira / Sonawane, Pratmesh / Ngo, Jonathan / Zuzga, Sophia / Chow, Lillian / Huynh, Vianne / Yang, Wenyi / Lim, Samantha / Stites, Brandon / Chang, Shannon / Cruz-Balleza, Raenalyn / Pelta, Michaela / Kujawski, Stella / Yuan, Christopher / Standen-Bloom, Elio / Witt, Oliver / Anders, Karina / Duane, Audrey / Huynh, Nancy / Lester, Benjamin / Fung-Lee, Samantha / Fung, Melanie / Situ, Mandy / Canigiula, Paolo / Dijkgraaf, Matijs / Romero, Wilbert / Baula, Samantha Karmela / Wong, Kimberly / Xu, Ivana / Martinez, Benjamin / Nuygen, Reena / Norris, Lucy / Nijensohn, Noah / Altman, Naomi / Maajid, Elise / Burkhardt, Olivia / Chanda, Jullian / Doscher, Catherine / Gopal, Alex / Good, Aaron / Good, Jonah / Herrera, Nate / Lanting, Lucas / Liem, Sophia / Marks, Anila / McLaughlin, Emma / Lee, Audrey / Mohr, Collin / Patton, Emma / Pyarali, Naima / Oczon, Claire / Richards, Daniel / Good, Nathan / Goss, Spencer / Khan, Adeeb / Madonia, Reagan / Mitchell, Vivian / Sun, Natasha / Vranka, Tarik / Garcia, Diogo / Arroyo, Frida / Morales, Eric / Camey, Steven / Cano, Giovanni / Bernabe, Angelica / Arroyo, Jennifer / Lopez, Yadira / Gonzalez, Emily / Zumba, Bryan / Garcia, Josue / Vargas, Esmeralda / Trinidad, Allen / Candelaria, Noel / Valdez, Vanessa / Campuzano, Faith / Pereznegron, Emily / Medrano, Jenifer / Gutierrez, Jonathan / Gutierrez, Evelyn / Abrego, Ericka Taboada / Gutierrez, Dayanara / Ortiz, Cristian / Barnes, Angelica / Arms, Eleanor / Mitchell, Leo / Balanzá, Ciara / Bradford, Jake / Detroy, Harrison / Ferguson, Devin / Guillermo, Ethel / Manapragada, Anusha / Nanula, Daniella / Serna, Brigitte / Singh, Khushi / Sramaty, Emily / Wells, Brian / Wiggins, Matthew / Dowling, Melissa / Schmadeke, Geraldine / Cafferky, Samantha / Good, Stephanie / Reese, Margaret / Fleig, Miranda / Gannett, Alex / Cain, Cory / Lee, Melody / Oberto, Paul / Rinehart, Jennifer / Pan, Elaine / Mathis, Sallie Anne / Joiner, Jessica / Barr, Leslie / Evans, Cory J / Baena-Lopez, Alberto / Beatty, Andrea / Collette, Jeanette / Smullen, Robert / Suttie, Jeanne / Chisholm, Townley / Rotondo, Cheryl / Lewis, Gareth / Turner, Victoria / Stark, Lloyd / Fox, Elizabeth / Amirapu, Anjana / Park, Sangbin / Lantz, Nicole / Rankin, Anne E / Kim, Seung K / Kockel, Lutz

    G3 (Bethesda, Md.)

    2023  Volume 13, Issue 9

    Abstract: Conditional gene regulation in Drosophila through binary expression systems like the LexA-LexAop system provides a superb tool for investigating gene and tissue function. To increase the availability of defined LexA enhancer trap insertions, we present ... ...

    Abstract Conditional gene regulation in Drosophila through binary expression systems like the LexA-LexAop system provides a superb tool for investigating gene and tissue function. To increase the availability of defined LexA enhancer trap insertions, we present molecular, genetic, and tissue expression studies of 301 novel Stan-X LexA enhancer traps derived from mobilization of the index SX4 line. This includes insertions into distinct loci on the X, II, and III chromosomes that were not previously associated with enhancer traps or targeted LexA constructs, an insertion into ptc, and seventeen insertions into natural transposons. A subset of enhancer traps was expressed in CNS neurons known to produce and secrete insulin, an essential regulator of growth, development, and metabolism. Fly lines described here were generated and characterized through studies by students and teachers in an international network of genetics classes at public, independent high schools, and universities serving a diversity of students, including those underrepresented in science. Thus, a unique partnership between secondary schools and university-based programs has produced and characterized novel resources in Drosophila, establishing instructional paradigms devoted to unscripted experimental science.
    MeSH term(s) Animals ; Drosophila/genetics ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Gene Expression Regulation ; Enhancer Elements, Genetic
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1093/g3journal/jkad124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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