Artikel ; Online: Therapeutic Approaches for Intravascular Microthrombi-induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19 Infection.
Current pharmaceutical biotechnology
2022 Band 24, Heft 8, Seite(n) 970–987
Abstract: The COVID-19 pandemic has overwhelmed our health care capacity in an unprecedented way due to the sheer number of critically infected patients admitted to hospitals during the last two years. Endothelial injury is seen as one of the central hallmarks of ... ...
| Abstract | The COVID-19 pandemic has overwhelmed our health care capacity in an unprecedented way due to the sheer number of critically infected patients admitted to hospitals during the last two years. Endothelial injury is seen as one of the central hallmarks of COVID-19 infection that is the starting point in the generation of microthrombi and sepsis eventually leading to acute respiratory distress syndrome (ARDs) and multi-organ failure. The dramatic fall in lung function during ARDs is attributed to the microthrombi-induced coagulopathy primed by a hyperactive immune system. Due to the lack of effective antiviral agents, the line of treatment is limited to the management of two key risk factors i.e., immune activation and coagulopathy. In the present review, we describe the mechanistic role, therapeutic targets, and opportunities to control immune activation and coagulopathy during the pathogenesis of COVID-19-induced ARDs. |
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| Mesh-Begriff(e) | Humans ; COVID-19/complications ; SARS-CoV-2 ; Pandemics ; Respiratory Distress Syndrome/etiology ; Multiple Organ Failure | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2022-07-15 | |||||
| Erscheinungsland | Netherlands | |||||
| Dokumenttyp | Review ; Journal Article | |||||
| ZDB-ID | 2132197-8 | |||||
| ISSN | 1873-4316 ; 1389-2010 | |||||
| ISSN (online) | 1873-4316 | |||||
| ISSN | 1389-2010 | |||||
| DOI | 10.2174/1389201023666220713113713 | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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