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  1. Article ; Online: Response of the trial innovation network to the COVID-19 pandemic

    Rachel G. Greenberg / Lori Poole / Daniel E. Ford / Daniel Hanley / Harry P. Selker / Karen Lane / J. Michael Dean / Jeri Burr / Paul Harris / Consuelo H. Wilkins / Gordon Bernard / Terri Edwards / Daniel K. Benjamin

    Journal of Clinical and Translational Science, Vol

    2021  Volume 5

    Abstract: Abstract Introduction: The COVID-19 pandemic prompted the development and implementation of hundreds of clinical trials across the USA. The Trial Innovation Network (TIN), funded by the National Center for Advancing Translational Sciences, was an ... ...

    Abstract Abstract Introduction: The COVID-19 pandemic prompted the development and implementation of hundreds of clinical trials across the USA. The Trial Innovation Network (TIN), funded by the National Center for Advancing Translational Sciences, was an established clinical research network that pivoted to respond to the pandemic. Methods: The TIN’s three Trial Innovation Centers, Recruitment Innovation Center, and 66 Clinical and Translational Science Award Hub institutions, collaborated to adapt to the pandemic’s rapidly changing landscape, playing central roles in the planning and execution of pivotal studies addressing COVID-19. Our objective was to summarize the results of these collaborations and lessons learned. Results: The TIN provided 29 COVID-related consults between March 2020 and December 2020, including 6 trial participation expressions of interest and 8 community engagement studios from the Recruitment Innovation Center. Key lessons learned from these experiences include the benefits of leveraging an established infrastructure, innovations surrounding remote research activities, data harmonization and central safety reviews, and early community engagement and involvement. Conclusions: Our experience highlighted the benefits and challenges of a multi-institutional approach to clinical research during a pandemic.
    Keywords Trial innovation network ; COVID-19 ; clinical trial ; SARS-CoV-2 ; CTSA ; Medicine ; R
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: A high-risk trade policy

    Gordon, Bernard K

    Asia-Pacific economic co-operation , p. 207-216

    2007  , Page(s) 207–216

    Author's details Bernard K. Gordon
    Language English
    Publisher Routledge
    Publishing place London [u.a.]
    Document type Article
    ISBN 978-041-541-575-0 ; 041-541-575-6
    Database ECONomics Information System

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    Inter-library loan at ZB MED

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  3. Article: US perspectives on East Asian economic integration

    Gordon, Bernard K

    Journal of economic development Vol. 31, No. 2 , p. 149-168 ; Journal of economic development

    2006  

    Author's details Bernard K. Gordon
    Keywords Internationale Wirtschaftsbeziehungen ; Wirtschaftsintegration ; Freihandelszone ; APEC-Staaten ; CAFTA-Staaten ; Internationale Handelspolitik ; USA
    Language English
    Size graph. Darst.
    Publishing place Seoul, Korea
    Document type Article
    ZDB-ID 872015-0
    Database ECONomics Information System

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  4. Article ; Online: Cognitive Outcomes in the Pragmatic Investigation of optimaL Oxygen Targets (CO-PILOT) trial

    Li Wang / E Wesley Ely / Wesley H Self / Todd W Rice / Matthew W Semler / Jin Ho Han / Jonathan D Casey / Gordon Bernard / Cathy Jenkins / James C Jackson / Joanna Stollings / Jonathan P Wanderer / Christopher Lindsell / Matthew F Mart / Robert Freundlich / Amy Kiehl / Guanchao Wang / Patsy Bryant

    BMJ Open, Vol 12, Iss

    protocol and statistical analysis plan

    2022  Volume 11

    Abstract: Introduction Long-term cognitive impairment is one of the most common complications of critical illness among survivors who receive mechanical ventilation. Recommended oxygen targets during mechanical ventilation vary among international guidelines. ... ...

    Abstract Introduction Long-term cognitive impairment is one of the most common complications of critical illness among survivors who receive mechanical ventilation. Recommended oxygen targets during mechanical ventilation vary among international guidelines. Different oxygen targets during mechanical ventilation have the potential to alter long-term cognitive function due to cerebral hypoxemia or hyperoxemia. Whether higher, intermediate or lower SpO2 targets are associated with better cognitive function at 12-month follow-up is unknown.Methods and analysis The Pragmatic Investigation of optimaL Oxygen Targets (PILOT) trial is an ongoing pragmatic, cluster-randomised, cluster-crossover trial comparing the effect of a higher SpO2 target (target 98%, goal range 96%–100%), an intermediate SpO2 target (target 94%, goal range 92%–96%) and a lower SpO2 target (target 90%, goal range 88%–92%) on clinical outcomes in mechanically ventilated patients admitted to the medical intensive care unit at a single centre in the USA. For this ancillary study of long-term Cognitive Outcomes (CO-PILOT), survivors of critical illness who are in the PILOT trial and who do not meet exclusion criteria for CO-PILOT are approached for consent. The anticipated number of patients for whom assessment of long-term cognition will be performed in CO-PILOT is 612 patients over 36 months of enrolment. Cognitive, functional and quality of life assessments are assessed via telephone interview at approximately 12 months after enrolment in PILOT. The primary outcome of CO-PILOT is the telephone version of the Montreal Cognitive Assessment. A subset of patients will also complete a comprehensive neuropsychological telephone battery to better characterise the cognitive domains affected.Ethics and dissemination The CO-PILOT ancillary study was approved by the Vanderbilt Institutional Review Board. The results will be submitted for publication in a peer-reviewed journal and presented at one or more scientific conferences.
    Keywords Medicine ; R
    Subject code 150
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: A high-risk trade policy

    Gordon, Bernard K

    Foreign affairs Vol. 82, No. 4 , p. 105-118

    2003  Volume 82, Issue 4, Page(s) 105–118

    Author's details Bernard K. Gordon
    Keywords Außenwirtschaftspolitik ; Regionale Wirtschaftsintegration ; USA
    Language English
    Size graph. Darst
    Publisher Council
    Publishing place New York, NY
    Document type Article
    ZDB-ID 214-8
    Database ECONomics Information System

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  6. Book ; Online: America's Trade Follies

    Gordon, Bernard K

    2002  

    Abstract: This book controversially argues that the global political economy is hardening into distinct regional blocs, which threatens American prosperity and dangers US security by dividing the globe along economic and political ... ...

    Abstract This book controversially argues that the global political economy is hardening into distinct regional blocs, which threatens American prosperity and dangers US security by dividing the globe along economic and political lines
    Language English
    Size Online-Ressource (193 p)
    Publisher Taylor and Francis
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780415232722 ; 0415232724
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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    Order via subito

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    Inter-library loan at ZB MED

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  7. Book: America's trade follies

    Gordon, Bernard K

    turning economic leadership into strategic weakness

    2001  

    Author's details Bernard K. Gordon
    Keywords Außenwirtschaftspolitik ; Internationale Wirtschaft ; Handelsbilanz ; USA ; Regionale Wirtschaftsintegration ; Globalisierung ; Welt
    Language English
    Size XI, 177 S, graph. Darst, 24cm
    Publisher Routledge
    Publishing place London u.a.
    Document type Book
    ISBN 0415232724 ; 0415253209 ; 9780415232722 ; 9780415253208
    Database ECONomics Information System

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

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  8. Book ; Online: America's trade follies

    Gordon, Bernard K

    turning economic leadership into strategic weakness

    2001  

    Abstract: This book controversially argues that the global political economy is hardening into distinct regional blocs, which threatens American prosperity and dangers US security by dividing the globe along economic and political ... ...

    Institution ebrary, Inc
    Author's details Bernard K. Gordon
    Abstract This book controversially argues that the global political economy is hardening into distinct regional blocs, which threatens American prosperity and dangers US security by dividing the globe along economic and political lines
    Keywords Balance of trade ; Regionalism ; Trade blocs ; United States
    Language English
    Size Online-Ressource (xi, 177 p), ill, 24 cm
    Publisher Routledge
    Publishing place London, U.K
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 0415232724 ; 0415253209 ; 9780415232722 ; 9780415253208
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Article ; Online: Protocol and statistical analysis plan for the Antibiotic Choice On ReNal outcomes (ACORN) randomised clinical trial

    Sunil Kripalani / Li Wang / Ruth Kleinpell / Wesley H Self / Todd W Rice / Matthew W Semler / Edward D Siew / Paul Harris / Jonathan D Casey / Adam Wright / Tina Hartert / Gordon Bernard / Joanna Stollings / Russell Rothman / Jay Morrison / Christopher Lindsell / Todd Rice / Robert Freundlich / Edward Tang Qian /
    Justin Siemann / Mary Lynn Dear / Bradley Daniel Lloyd / Kevin Seitz / George Nelson / Patty Wright / Bradley Dennis / Jesse Wrenn / Jonathan Andereck / Bob Dittus / Shon Dwyer / Cheryl Gatto / Frank Harrell / Jim Hayman / Catherine Ivory / Lee Ann Liska / Patrick Luther / Thomas Nantais / Jill Pulley / Kris Rehm / Matt Semler / Robin Steaban / Philip Walker / Consuelo Wilkins / Autumn Zuckerman

    BMJ Open, Vol 13, Iss

    2023  Volume 3

    Abstract: Introduction Antibiotics are time-critical in the management of sepsis. When infectious organisms are unknown, patients are treated with empiric antibiotics to include coverage for gram-negative organisms, such as antipseudomonal cephalosporins and ... ...

    Abstract Introduction Antibiotics are time-critical in the management of sepsis. When infectious organisms are unknown, patients are treated with empiric antibiotics to include coverage for gram-negative organisms, such as antipseudomonal cephalosporins and penicillins. However, in observational studies, some antipseudomonal cephalosporins (eg, cefepime) are associated with neurologic dysfunction while the most common antipseudomonal penicillin (piperacillin–tazobactam) is associated with acute kidney injury (AKI). No randomised control trials have compared these regimens. This manuscript describes the protocol and analysis plan for a trial designed to compare the effects of antipseudomonal cephalosporins and antipseudomonal penicillins among acutely ill patients receiving empiric antibiotics.Methods and analysis The Antibiotic Choice On ReNal outcomes trial is a prospective, single-centre, non-blinded randomised trial being conducted at Vanderbilt University Medical Center. The trial will enrol 2500 acutely ill adults receiving gram-negative coverage for treatment of infection. Eligible patients are randomised 1:1 to receive cefepime or piperacillin–tazobactam on first order entry of a broad-spectrum antibiotic covering gram-negative organisms. The primary outcome is the highest stage of AKI and death occurring between enrolment and 14 days after enrolment. This will be compared between patients randomised to cefepime and randomised to piperacillin–tazobactam using an unadjusted proportional odds regression model. The secondary outcomes are major adverse kidney events through day 14 and number of days alive and free of delirium and coma in 14 days after enrolment. Enrolment began on 10 November 2021 and is expected to be completed in December 2022.Ethics and dissemination The trial was approved by the Vanderbilt University Medical Center institutional review board (IRB#210591) with a waiver of informed consent. Results will be submitted to a peer-reviewed journal and presented at scientific conferences.Trial ...
    Keywords Medicine ; R
    Subject code 170
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article: The natural market fallacy

    Gordon, Bernard K

    Foreign affairs 77 ,3, S. 13-16

    slim pickings in Latin America

    1998  

    Author's details Bernard K. Gordon
    Keywords Internationaler Markt ; Export ; USA ; Import ; Lateinamerika
    Language English
    Publisher Council on Foreign Relations
    Publishing place New York, NY
    Document type Article
    ZDB-ID 214-8 ; 2050780-X
    ISSN 0015-7120
    ISSN 0015-7120
    Database ECONomics Information System

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