Artikel ; Online: T helper cell immunity in pregnancy and influence on autoimmune disease progression.
2021 Band 121, Seite(n) 102651
Abstract: Pregnancy presents the maternal immune system with a unique immunological challenge since it has to defend against pathogens while tolerating paternal allo-antigens expressed by fetal tissues. T helper (Th) cells play a central role in modulating immune ... ...
Abstract | Pregnancy presents the maternal immune system with a unique immunological challenge since it has to defend against pathogens while tolerating paternal allo-antigens expressed by fetal tissues. T helper (Th) cells play a central role in modulating immune responses and recent advances have defined distinct contributions of various Th cell subsets throughout each phase of human pregnancy, while dysregulation in Th responses show association with multiple obstetrical complications. In addition to localized decidual mechanisms, modulation of Th cell immunity during gestation is mediated largely by oscillations in sex hormone concentrations. Aberrant Th cell responses also underlie several autoimmune disorders while pregnancy-induced changes in the balance of Th cell immunity has been shown to exert favorable outcomes in the progression Th1 and Th17 driven autoimmune conditions only to be followed by post-partal exacerbations in disease. |
---|---|
Mesh-Begriff(e) | Autoimmune Diseases/blood ; Autoimmune Diseases/immunology ; Disease Progression ; Female ; Gonadal Steroid Hormones/blood ; Humans ; Pregnancy ; Pregnancy Complications/blood ; Pregnancy Complications/immunology ; T-Lymphocytes, Helper-Inducer/immunology |
Chemische Substanzen | Gonadal Steroid Hormones |
Sprache | Englisch |
Erscheinungsdatum | 2021-05-18 |
Erscheinungsland | England |
Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
ZDB-ID | 639452-8 |
ISSN | 1095-9157 ; 0896-8411 |
ISSN (online) | 1095-9157 |
ISSN | 0896-8411 |
DOI | 10.1016/j.jaut.2021.102651 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Zs.A 2368: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.